Saturated fatty acids enhance TLR4 immune pathways in human trophoblasts

Human Reproduction

Volumn 30, Issue 9, 2015, Pages 2152-2159

  Yang, Xiaohua ^a   Haghiac, Maricela ^a   Glazebrook, Patricia ^a   Minium, Judi ^a   Catalano, Patrick M ^a   Hauguel de Mouzon, Sylvie ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cytokine; fatty acids; human; inflammation; NF B; placenta; toll like receptor 4; trophoblasts

Indexed keywords

CARBON; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; LINOLEIC ACID; MESSENGER RNA; MYRISTIC ACID; OLEIC ACID; PALMITIC ACID; PALMITOLEIC ACID; SATURATED FATTY ACID; STEARIC ACID; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; FATTY ACID; IL6 PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN; TNF PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

ADULT; ARTICLE; BIRTH WEIGHT; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; FEMALE; GENE EXPRESSION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; LIGAND BINDING; LIMIT OF DETECTION; PHOSPHOLIPID MEMBRANE; PLACENTA; PLACENTA WEIGHT; PREGNANT WOMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TROPHOBLAST; WESTERN BLOTTING; IMMUNOLOGY; INFLAMMATION; METABOLISM; PHYSIOLOGY; PREGNANCY;

ADULT; CYTOKINES; FATTY ACIDS; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN-6; INTERLEUKIN-8; NF-KAPPA B; PREGNANCY; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TROPHOBLASTS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84940779522     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dev173     Document Type: Article

References (42)

1. Alvino G, Cozzi V, Radaelli T, Ortega H, Herrera E, Cetin I. Maternal and fetal fatty acid profile in normal and intrauterine growth restriction pregnancies with and without preeclampsia. Pediatr Res 2008; 64: 615-620
2. Basu S, Haghiac M, Surace P, Challier JC, Guerre-Millo M, Singh K, Waters T, Minium J, Presley L, Catalano PM et al. Pregravid obesity associates with increased maternal endotoxemia and metabolic inflammation. Obesity (Silver Spring) 2011; 19: 476-482
3. Beijar EC, Mallard C, Powell TL. Expression and subcellular localization of TLR-4 in term and first trimester human placenta. Placenta 2006; 27: 322-326
4. Calder PC. n-3 fatty acids, inflammation and immunity: new mechanisms to explain old actions. Proc Nutr Soc 2013; 72: 326-336
5. Challier JC, Basu S, Bintein T, Minium J, Hotmire K, Catalano PM, Hauguel-de Mouzon S. Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta 2008; 29: 274-281
6. Chen X, Scholl TO. Association of elevated free fatty acids during late pregnancy with preterm delivery. Obstet Gynecol 2008; 112: 297-303
7. Coleman RA. Placental metabolism and transport of lipid. Fed Proc 1986; 45: 2519-2523
8. De Jong AJ, Kloppenburg M, Toes RE, Ioan-Facsinay A. Fatty acids, lipid mediators, and T-cell function. Front Immunol 2014; 5: 483
9. Delmastro-Greenwood M, Freeman BA, Wendell SG. Redox-dependent anti-inflammatory signaling actions of unsaturated fatty acids. Annu Rev Physiol 2014; 76: 79-105
10. Eaton S. Control of mitochondrial beta-oxidation flux. Prog Lipid Res 2002; 41: 197-239
11. Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, Ogata F, Yagi N, Ohto U, Kimoto M, Miyake K et al. Saturated fatty acid and TLR signaling link b cell dysfunction and islet inflammation. Cell Metab 2012; 15: 518-533
12. Field CJ, Angel A, Clandinin MT. Relationship of diet to the fatty acid composition of human adipose tissue structural and stored lipids. Am J Clin Nutr 1985; 42: 1206-1220
13. Forman BM, Chen J, Evans R. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-Activated receptors alpha and delta. Proc Natl Acad Sci USA 1997; 94: 4312-4317
14. Gil-Sánchez A, Koletzko B, Larqué E. Current understanding of placental fatty acid transport. Curr Opin Clin Nutr Metab Care 2012; 15: 265-272
15. Haggarty P, Page K, Abramovich DR, Ashton J, Brown D. Long-chain polyunsaturated fatty acid transport across the perfused human placenta. Placenta 1997; 18: 635-642
16. Haus JM, Kashyap SR, Kasumov T, Zhang R, Kelly KR, Defronzo RA, Kirwan JP. Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance. Diabetes 2009; 58: 337-343
17. Herrera E. Implications of dietary fatty acids during pregnancy on placental, fetal and postnatal development-A review. Placenta 2002; 23(Suppl A): S9-S19
18. Hwang D, Rhee SH. Receptor-mediated signaling pathways: potential targets of modulation by dietary fatty acids. Am J Clin Nutr 1999; 70: 545-556
19. Innis SM. Metabolic programming of long-Term outcomes due to fatty acid nutrition in early life. Matern Child Nutr 2011; 7(Suppl 2): 112-123
20. Kalkhoff RK. Impact of maternal fuels and nutritional state on fetal growth. Diabetes 1991; 40(Suppl 2): 61-65
21. Kien CL, Bunn JY, Stevens R, Bain J, Ikayeva O, Crain K, Koves TR, Muoio DM. Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans. Am J Clin Nutr 2014; 99: 436-445
22. Kliman HJ, Nestler JE, Sermasi E, Sanger JM, Strauss JF. Purification, characterization and in vitro. Differentiation of cytotrophoblasts from human term placenta. Endocrinology 1986; 118: 1567-1582
23. Lakin V, Haggarty P, Abramovich DR, Ashton J, Moffat CF, McNeill G, Danielian PJ, Grubb D. Dietary intake and tissue concentration of fatty acids in omnivore, vegetarian and diabetic pregnancy. Prostaglandins Leukot Essent Fatty Acids 1998; 59: 209-220
24. Larqué E, Gil-Sánchez A, Prieto-Sánchez MT, Koletzko B. Omega 3 fatty acids, gestation and pregnancy outcomes. Br J Nutr 2012; 107(Suppl 2): S77-S84
25. Lee JY, Hwang DH. The modulation of inflammatory gene expression by lipids: mediation through Toll-like receptors. Mol Cells 2006; 21: 174-185
26. Lee JY, Sohn KH, Rhee SH, Hwang D. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem 2001; 276: 16683-16689
27. McKeegan PJ, Sturmey RG. The role of fatty acids in oocyte and early embryo development. Reprod Fertil Dev 2011; 24: 59-67
28. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. Ahuman homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997; 388: 394-397
29. Pathmaperuma AN, Maña P, Cheung SN, Kugathas K, Josiah A, Koina ME, Broomfield A, Delghingaro-Augusto V, Ellwood DA, Dahlstrom JE et al. Fatty acids alter glycerolipid metabolism and induce lipid droplet formation, syncytialisation and cytokine production in human trophoblasts with minimal glucose effect or interaction. Placenta 2010; 31: 230-239
30. Phelps RL, Metzger BE, Freinkel N. Carbohydrate metabolism in pregnancy. XVII. Diurnal profiles of plasma glucose, insulin, free fatty acids, triglycerides, cholesterol, and individual amino acids in late normal pregnancy. Am J Obstet Gynecol 1981; 140: 730-736
31. Pietsch J, Batra A, Stroh T, Fedke I, Glauben R, Okur B, Zeitz M, Siegmund B. Toll-like receptor expression and response to specific stimulation in adipocytes and preadipocytes: on the role of fat in inflammation. Ann N Y Acad Sci 2006; 1072: 407-409
32. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCR mice: mutations in Tlr4 gene. Science 1998; 282: 2085-2088
33. Potter JM, Nestel PJ. The hyperlipidemia of pregnancy in normal and complicated pregnancies. Am J Obstet Gynecol 1979; 133: 165-170
34. Schaeffler A, Gross P, Buettner R, Bollheimer C, Buechler C, Neumeier M, Kopp A, Schoelmerich J, Falk W. Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity. Immunology 2009; 126: 233-245
35. Schilling JD, Machkovech HM, He L, Sidhu R, Fujiwara H, Weber K, Ory DS, Schaffer JE. Palmitate and lipopolysaccharide trigger synergistic ceramide production in primary macrophages. J Biol Chem 2013; 288: 2923-2932
36. Sessler AM, Ntambi JM. Polyunsaturated fatty acid regulation of gene expression. J Nutr 1998; 128: 923-926
37. Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 2006; 116: 3015-3025
38. Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K, Kimoto M. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 1999; 189: 1777-1782
39. Sivan E, Homko CJ, Whittaker PG, Reece EA, Chen X, Boden G. Free fatty acids and insulin resistance during pregnancy. J Clin Endocrinol Metab 1998; 83: 2338-2342
40. Skeaff CM, Hodson L, McKenzie JE. Dietary-induced changes in fatty acid composition of human plasma, platelet, and erythrocyte lipids follow a similar time course. J Nutr 2006; 136: 565-569
41. Szabo AJ, De Lellis R, Grimaldi RD. Triglyceride synthesis by the human placenta. I. Incorporation of labelled palmitate into placental triglycerides. Obstet Gynecol 1973; 115: 257-262
42. Villa PM, Laivuori H, Kajantie E, Kaaja R. Free fatty acid profiles in preeclampsia. Prostaglandins Leukot Essent Fatty Acids 2009; 81: 17-21