Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1842, Issue 2, 2014, Pages 304-317

  Dahlhoff, M ^b   Pfister, S ^a   Blutke, A ^b   Rozman, J ^c,d   Klingenspor, M ^d   Deutsch, M J ^a   Rathkolb, B ^b,c   Fink, B ^a   Gimpfl, M ^a   Hrabe de Angelis M ^c,d,e   Roscher, A A ^a   Wolf, E ^b   Ensenauer, R ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

Author keywords

Obesity; Offspring; Peri conceptional; Pregnancy; Programming; Sex specificity

Indexed keywords

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ARTICLE; BODY COMPOSITION; BODY WEIGHT; COMPUTER ASSISTED TOMOGRAPHY; CONCEPTION; CONTROLLED STUDY; DIGESTION; DISEASE PREDISPOSITION; FAT CONTENT; FAT MASS; FATTY LIVER; FEMALE; FETUS; GENE EXPRESSION; GLUCOSE TOLERANCE TEST; HYPERLEPTINEMIA; HYPERURICEMIA; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LIPID DIET; LIPID STORAGE; LIVER; MALE; MATERNAL NUTRITION; MATERNAL OBESITY; MOUSE; NONHUMAN; OBESITY; PERI CONCEPTIONAL OBESOGENIC EXPOSURE; PRIORITY JOURNAL; PROGENY; SEX DIFFERENCE;

ACACA; ACETYL-COENZYME A CARBOXYLASE 1; ACLY; ACTB; ANALYSIS OF VARIANCE; ANOVA; AREA UNDER THE CURVE; ATP CITRATE LYASE; AUC; B CELL LEUKEMIA/LYMPHOMA 2; BAX; BCL2; BCL2-ASSOCIATED X PROTEIN; BERARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 (ALSO KNOWN AS SEIPIN); BETA-ACTIN; BODY WEIGHT; BSCL2; BW; CARBON DIOXIDE PRODUCTION; CARNITINE PALMITOYLTRANSFERASE 1; CD; CD36; CD36 ANTIGEN; CELL DEATH-INDUCING DNA FRAGMENTATION FACTOR, ALPHA SUBUNIT-LIKE EFFECTOR A; CENTRAL EUROPEAN TIME; CET; CIDEA; COMPUTED TOMOGRAPHY; CONTROL DIET; CPT1; CT; DAY POST COITUM; DPC; EEC; EUROPEAN ECONOMIC COMMISSION; EXPOSURE TO MATERNAL CONTROL DIET; EXPOSURE TO MATERNAL HIGH-FAT, HIGH-CALORIE DIET; FA; FABP4; FASN; FATTY ACID; FATTY ACID BINDING PROTEIN 4; FATTY ACID SYNTHASE; GLUCOCORTICOID RECEPTOR; GLUCOSE TOLERANCE TEST; GR; GTT; H&E; HAIRY AND ENHANCER OF SPLIT 1; HEAT PRODUCTION; HEMATOXYLIN-EOSIN; HES1; HFD; HIGH-FAT, HIGH-CALORIE DIET; HIGH-MOLECULAR-WEIGHT; HMW; HOMA-IR; HOMEOSTATIC MODEL ASSESSMENT OF INSULIN RESISTANCE; HP; LEP; LEPTIN; MAGNETIC RESONANCE IMAGING; MAINTENANCE DIET; MALIC ENZYME 1; MALONDIALDEHYDE; MAT-CD; MAT-HFD; MD; MDA; ME1; MESODERM-SPECIFIC TRANSCRIPT/IMPRINTED PATERNALLY EXPRESSED GENE 1 (ALSO KNOWN AS PEG1); MEST; MRI; N; NAFLD; NAVAL MEDICAL RESEARCH INSTITUTE; NEFA; NITROGEN; NMRI; NON-ALCOHOLIC FATTY LIVER DISEASE; NON-ESTERIFIED FATTY ACID; NOSE-RUMP-LENGTH; NR1H3; NR3C1; NRL; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP H, MEMBER 3 (ALSO KNOWN AS LXRA, LIVER X RECEPTOR ALPHA); NUCLEAR RECEPTOR SUBFAMILY 3, GROUP C, MEMBER 1 (ALSO KNOWN AS GR, GLUCOCORTICOID RECEPTOR); OBESITY; OFFSPRING; OXYGEN CONSUMPTION; PARAFORMALDEHYDE; PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 2 (ALSO KNOWN AS ATGL, ADIPOSE TRIGLYCERIDE LIPASE); PEPTIDYLPROLYL ISOMERASE A; PERI-CONCEPTIONAL; PERILIPIN 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PFA; PLIN2; PNPLA2; PPARA; PPARG; PPIA; PREGNANCY; PROGRAMMING; REGION OF INTEREST; RER; RESPIRATORY EXCHANGE RATIO; ROI; S.E.M.; SCD2; SECRETED FRIZZLED-RELATED SEQUENCE PROTEIN 5; SEX-SPECIFICITY; SFRP5; SREBF1; STANDARD ERROR OF THE MEAN; STEAROYL-COENZYME A DESATURASE 2; STEROL REGULATORY ELEMENT BINDING TRANSCRIPTION FACTOR 1; TBARS; THIOBARBITURIC ACID-REACTIVE SUBSTANCES; UBE2D2; UBIQUITIN-CONJUGATING ENZYME E2D 2; VCO(2); VO(2);

ADIPOCYTES; ANIMALS; BODY WEIGHT; CELL SIZE; DIET, HIGH-FAT; DISEASE SUSCEPTIBILITY; FATTY LIVER; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUCOSE TOLERANCE TEST; HYPERURICEMIA; INSULIN RESISTANCE; LEPTIN; MALE; MICE, INBRED STRAINS; OBESITY; OVERWEIGHT; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEX FACTORS; SUBCUTANEOUS FAT; TIME FACTORS;

EID: 84890879744     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2013.11.021     Document Type: Article

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