Mechanisms of nutritional and hormonal regulation of lipogenesis

EMBO Reports

Volumn 2, Issue 4, 2001, Pages 282-286

  Kersten, S ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLATION STIMULATING PROTEIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; FARNESYL DIPHOSPHATE; FAT; FATTY ACID; GLUCOSE; GROWTH HORMONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INSULIN; LEPTIN; LOW DENSITY LIPOPROTEIN RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; POLYUNSATURATED FATTY ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR; TRIACYLGLYCEROL;

ADIPOCYTE; ANIMAL CELL; CARBOHYDRATE DIET; DIET RESTRICTION; DRUG TARGETING; FATTY ACID OXIDATION; FEMALE; HORMONAL REGULATION; HUMAN; HUMAN TISSUE; HYPERTRIGLYCERIDEMIA; INHIBITION KINETICS; LIPOGENESIS; LIPOLYSIS; LIVER CELL; MEDICAL RESEARCH; MOUSE; NONHUMAN; NUTRITIONAL PARAMETERS; OBESITY; PRIORITY JOURNAL; REVIEW; STIMULATION; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

ADIPOCYTES; ANIMALS; CCAAT-ENHANCER-BINDING PROTEINS; DIET; DNA-BINDING PROTEINS; FATTY ACIDS; HEPATOCYTES; HUMANS; LIPIDS; MODELS, BIOLOGICAL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0035038782     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kve071     Document Type: Review

References (53)

1. In vivo effects of hyperinsulinemia on lipogenic enzymes and glucose transporter expression in rat liver and adipose tissues
2. Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes
3. Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones
4. Essential role in vivo of upstream stimulatory factors for a normal dietary response of the fatty acid synthase gene in the liver
5. Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones
6. The biology of somatotropin in adipose tissue growth and nutrient partitioning
7. Regulation of peroxisome proliferator-activated receptor γ expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: Implications for adipocyte differentiation and metabolism
8. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
9. ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose
10. Clinical efficacy of new thiazolidinediones and glinides in the treatment of type 2 diabetes mellitus
11. Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level
12. Sterol regulatory element binding proteins: Activators of cholesterol and fatty acid biosynthesis
13. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
14. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element
15. Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids
16. Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets
17. Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting
18. Roles of PPARs in health and disease
19. Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene
20. Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs
21. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
22. Glucose regulation of mouse S(14) gene expression in hepatocytes. Involvement of a novel transcription factor complex
23. Obesity as a medical problem
24. PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
25. Insulin-receptor tyrosine kinase and glucose transport
26. Nutritional regulation of the fatty acid synthase promoter in vivo: Sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element
27. Sterol response element-binding protein 1c (SREBP1c) is involved in the polyunsaturated fatty acid suppression of hepatic S14 gene transcription
28. Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency
29. Enhanced triglyceride clearance with intraperitoneal human acylation stimulating protein in C57BL/6 mice
30. Mice lacking acylation stimulating protein (ASP) have delayed postprandial triglyceride clearance
31. Reduced body weight, adipose tissue, and leptin levels despite increased energy intake in female mice lacking acylation-stimulating protein
32. The mechanism of insulin action
33. Molecular regulation of adipogenesis
34. MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro
35. Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene
36. Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
37. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: Model for congenital generalized lipodystrophy
38. Direct effects of leptin on brown and white adipose tissue
39. Of mice and men (and women) and the acylation-stimulating protein pathway
40. Leptin-specific patterns of gene expression in white adipose tissue
41. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
42. Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element binding proteins
43. ADD1: A novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation
44. Mechanisms involved in the regulation of free fatty acid release from isolated human fat cells by acylation-stimulating protein and insulin
45. Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids
46. Upstream stimulatory factor binding to the E-box at -65 is required for insulin regulation of the fatty acid synthase promoter
47. Novel form of lipolysis induced by leptin
48. Genetic deficiency of acylation stimulating protein (ASP(C3ades-Arg)) does not cause hyperapobetalipoproteinemia in mice
49. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats
50. A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids
51. Somatotropin-dependent decrease in fatty acid synthase mRNA abundance in 3T3-F442A adipocytes is the result of a decrease in both gene transcription and mRNA stability
52. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene
53. Peroxisome proliferator-activated receptor γ target gene encoding a novel angiopoietin-related protein associated with adipose differentiation