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Volumn 118, Issue , 2016, Pages 163-204

SCL/TAL1 in Hematopoiesis and Cellular Reprogramming

Author keywords

Cellular reprogramming; Developmental hematopoiesis; E2A TCF3; HEB TCF12; Hematopoietic stem cells; NOTCH1; Preleukemic stem cells; SCL TAL1; Self renewal; VEGF

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; LIM PROTEIN; LMO2 PROTEIN, HUMAN; ONCOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TAL1 PROTEIN, HUMAN; TAL1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR RUNX1; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2;

EID: 85012003502     PISSN: 00702153     EISSN: None     Source Type: Book Series    
DOI: 10.1016/bs.ctdb.2016.01.004     Document Type: Chapter
Times cited : (47)

References (220)
  • 1
    • 42649124306 scopus 로고    scopus 로고
    • Molecular pathogenesis of T-cell leukaemia and lymphoma
    • Aifantis, I., Raetz, E., Buonamici, S., Molecular pathogenesis of T-cell leukaemia and lymphoma. Nature Reviews. Immunology 8:5 (2008), 380–390.
    • (2008) Nature Reviews. Immunology , vol.8 , Issue.5 , pp. 380-390
    • Aifantis, I.1    Raetz, E.2    Buonamici, S.3
  • 4
    • 0026673933 scopus 로고
    • The SCL gene product: A positive regulator of erythroid differentiation
    • Aplan, P.D., Nakahara, K., Orkin, S.H., Kirsch, I.R., The SCL gene product: A positive regulator of erythroid differentiation. The EMBO Journal 11:11 (1992), 4073–4081.
    • (1992) The EMBO Journal , vol.11 , Issue.11 , pp. 4073-4081
    • Aplan, P.D.1    Nakahara, K.2    Orkin, S.H.3    Kirsch, I.R.4
  • 5
    • 84915791031 scopus 로고    scopus 로고
    • Direct reprogramming of murine fibroblasts to hematopoietic progenitor cells
    • Batta, K., Florkowska, M., Kouskoff, V., Lacaud, G., Direct reprogramming of murine fibroblasts to hematopoietic progenitor cells. Cell Reports 9:5 (2014), 1871–1884, 10.1016/j.celrep.2014.11.002.
    • (2014) Cell Reports , vol.9 , Issue.5 , pp. 1871-1884
    • Batta, K.1    Florkowska, M.2    Kouskoff, V.3    Lacaud, G.4
  • 8
    • 0033135847 scopus 로고    scopus 로고
    • The SCL gene: From case report to critical hematopoietic regulator
    • Begley, C.G., Green, A.R., The SCL gene: From case report to critical hematopoietic regulator. Blood 93:9 (1999), 2760–2770.
    • (1999) Blood , vol.93 , Issue.9 , pp. 2760-2770
    • Begley, C.G.1    Green, A.R.2
  • 9
    • 73049110615 scopus 로고    scopus 로고
    • Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential
    • Benveniste, P., Frelin, C., Janmohamed, S., Barbara, M., Herrington, R., Hyam, D., Iscove, N.N., Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential. Cell Stem Cell 6:1 (2010), 48–58, 10.1016/j.stem.2009.11.014.
    • (2010) Cell Stem Cell , vol.6 , Issue.1 , pp. 48-58
    • Benveniste, P.1    Frelin, C.2    Janmohamed, S.3    Barbara, M.4    Herrington, R.5    Hyam, D.6    Iscove, N.N.7
  • 11
    • 77949895151 scopus 로고    scopus 로고
    • Haematopoietic stem cells derive directly from aortic endothelium during development
    • Bertrand, J.Y., Chi, N.C., Santoso, B., Teng, S., Stainier, D.Y., Traver, D., Haematopoietic stem cells derive directly from aortic endothelium during development. Nature 464:7285 (2010), 108–111, 10.1038/nature08738.
    • (2010) Nature , vol.464 , Issue.7285 , pp. 108-111
    • Bertrand, J.Y.1    Chi, N.C.2    Santoso, B.3    Teng, S.4    Stainier, D.Y.5    Traver, D.6
  • 12
    • 33644842282 scopus 로고    scopus 로고
    • From stem cell to T cell: One route or many?
    • Bhandoola, A., Sambandam, A., From stem cell to T cell: One route or many?. Nature Reviews. Immunology 6:2 (2006), 117–126.
    • (2006) Nature Reviews. Immunology , vol.6 , Issue.2 , pp. 117-126
    • Bhandoola, A.1    Sambandam, A.2
  • 13
    • 0029832815 scopus 로고    scopus 로고
    • Erythropoiesis and vasculogenesis in embryoid bodies lacking visceral yolk sac endoderm
    • Bielinska, M., Narita, N., Heikinheimo, M., Porter, S.B., Wilson, D.B., Erythropoiesis and vasculogenesis in embryoid bodies lacking visceral yolk sac endoderm. Blood 88:10 (1996), 3720–3730.
    • (1996) Blood , vol.88 , Issue.10 , pp. 3720-3730
    • Bielinska, M.1    Narita, N.2    Heikinheimo, M.3    Porter, S.B.4    Wilson, D.B.5
  • 14
    • 77949911441 scopus 로고    scopus 로고
    • In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium
    • Boisset, J.C., van Cappellen, W., Andrieu-Soler, C., Galjart, N., Dzierzak, E., Robin, C., In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium. Nature 464:7285 (2010), 116–120.
    • (2010) Nature , vol.464 , Issue.7285 , pp. 116-120
    • Boisset, J.C.1    van Cappellen, W.2    Andrieu-Soler, C.3    Galjart, N.4    Dzierzak, E.5    Robin, C.6
  • 15
    • 0029346879 scopus 로고
    • Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells
    • Brady, G., Billia, F., Knox, J., Hoang, T., Kirsch, I.R., Voura, E.B., Siminovitch, K., Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells. Current Biology 5:8 (1995), 909–922.
    • (1995) Current Biology , vol.5 , Issue.8 , pp. 909-922
    • Brady, G.1    Billia, F.2    Knox, J.3    Hoang, T.4    Kirsch, I.R.5    Voura, E.B.6    Siminovitch, K.7
  • 16
    • 84938746499 scopus 로고    scopus 로고
    • Runx1 deficiency decreases ribosome biogenesis and confers stress Resistance to hematopoietic stem and progenitor cells
    • Cai, X., Gao, L., Teng, L., Ge, J., Oo, Z.M., Kumar, A.R., Speck, N.A., Runx1 deficiency decreases ribosome biogenesis and confers stress Resistance to hematopoietic stem and progenitor cells. Cell Stem Cell 17:2 (2015), 165–177.
    • (2015) Cell Stem Cell , vol.17 , Issue.2 , pp. 165-177
    • Cai, X.1    Gao, L.2    Teng, L.3    Ge, J.4    Oo, Z.M.5    Kumar, A.R.6    Speck, N.A.7
  • 19
    • 0343920277 scopus 로고    scopus 로고
    • Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    • Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Nagy, A., Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380:6573 (1996), 435–439, 10.1038/380435a0.
    • (1996) Nature , vol.380 , Issue.6573 , pp. 435-439
    • Carmeliet, P.1    Ferreira, V.2    Breier, G.3    Pollefeyt, S.4    Kieckens, L.5    Gertsenstein, M.6    Nagy, A.7
  • 20
    • 1642306055 scopus 로고    scopus 로고
    • VEGF-A165 augments erythropoietic development from human embryonic stem cells
    • Cerdan, C., Rouleau, A., Bhatia, M., VEGF-A165 augments erythropoietic development from human embryonic stem cells. Blood 103:7 (2004), 2504–2512, 10.1182/blood-2003-07-2563.
    • (2004) Blood , vol.103 , Issue.7 , pp. 2504-2512
    • Cerdan, C.1    Rouleau, A.2    Bhatia, M.3
  • 21
    • 0037871588 scopus 로고    scopus 로고
    • Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells
    • Chadwick, K., Wang, L., Li, L., Menendez, P., Murdoch, B., Rouleau, A., Bhatia, M., Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells. Blood 102:3 (2003), 906–915, 10.1182/blood-2003-03-0832.
    • (2003) Blood , vol.102 , Issue.3 , pp. 906-915
    • Chadwick, K.1    Wang, L.2    Li, L.3    Menendez, P.4    Murdoch, B.5    Rouleau, A.6    Bhatia, M.7
  • 22
    • 79960674169 scopus 로고    scopus 로고
    • SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis
    • Chagraoui, H., Kassouf, M., Banerjee, S., Goardon, N., Clark, K., Atzberger, A., Porcher, C., SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis. Blood 118:3 (2011), 723–735.
    • (2011) Blood , vol.118 , Issue.3 , pp. 723-735
    • Chagraoui, H.1    Kassouf, M.2    Banerjee, S.3    Goardon, N.4    Clark, K.5    Atzberger, A.6    Porcher, C.7
  • 23
    • 33847419981 scopus 로고    scopus 로고
    • The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl −/− phenotype
    • Chan, W.Y., Follows, G.A., Lacaud, G., Pimanda, J.E., Landry, J.R., Kinston, S., Gottgens, B., The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl −/− phenotype. Blood 109:5 (2007), 1908–1916.
    • (2007) Blood , vol.109 , Issue.5 , pp. 1908-1916
    • Chan, W.Y.1    Follows, G.A.2    Lacaud, G.3    Pimanda, J.E.4    Landry, J.R.5    Kinston, S.6    Gottgens, B.7
  • 24
    • 0025014636 scopus 로고
    • The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein
    • Chen, Q., Cheng, J.T., Tasi, L.H., Schneider, N., Buchanan, G., Carroll, A., Baer, R., The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. The EMBO Journal 9:2 (1990), 415–424.
    • (1990) The EMBO Journal , vol.9 , Issue.2 , pp. 415-424
    • Chen, Q.1    Cheng, J.T.2    Tasi, L.H.3    Schneider, N.4    Buchanan, G.5    Carroll, A.6    Baer, R.7
  • 25
    • 0025036904 scopus 로고
    • Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia
    • Chen, Q., Yang, C.Y., Tsan, J.T., Xia, Y., Ragab, A.H., Peiper, S.C., Baer, R., Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia. The Journal of Experimental Medicine 172:5 (1990), 1403–1408.
    • (1990) The Journal of Experimental Medicine , vol.172 , Issue.5 , pp. 1403-1408
    • Chen, Q.1    Yang, C.Y.2    Tsan, J.T.3    Xia, Y.4    Ragab, A.H.5    Peiper, S.C.6    Baer, R.7
  • 26
    • 60149100010 scopus 로고    scopus 로고
    • Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter
    • Chen, M.J., Yokomizo, T., Zeigler, B.M., Dzierzak, E., Speck, N.A., Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature 457:7231 (2009), 887–891.
    • (2009) Nature , vol.457 , Issue.7231 , pp. 887-891
    • Chen, M.J.1    Yokomizo, T.2    Zeigler, B.M.3    Dzierzak, E.4    Speck, N.A.5
  • 27
    • 0027480618 scopus 로고
    • Products of the TAL1 oncogene: Basic helix-loop-helix proteins phosphorylated at serine residues
    • Cheng, J.T., Hsu, H.L., Hwang, L.Y., Baer, R., Products of the TAL1 oncogene: Basic helix-loop-helix proteins phosphorylated at serine residues. Oncogene 8:3 (1993), 677–683.
    • (1993) Oncogene , vol.8 , Issue.3 , pp. 677-683
    • Cheng, J.T.1    Hsu, H.L.2    Hwang, L.Y.3    Baer, R.4
  • 28
    • 0033043388 scopus 로고    scopus 로고
    • Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: Parallels with E2A-deficient mice
    • Chervinsky, D.S., Zhao, X.F., Lam, D.H., Ellsworth, M., Gross, K.W., Aplan, P.D., Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: Parallels with E2A-deficient mice. Molecular and Cellular Biology 19:7 (1999), 5025–5035.
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.7 , pp. 5025-5035
    • Chervinsky, D.S.1    Zhao, X.F.2    Lam, D.H.3    Ellsworth, M.4    Gross, K.W.5    Aplan, P.D.6
  • 29
    • 0031932209 scopus 로고    scopus 로고
    • A common precursor for hematopoietic and endothelial cells
    • Choi, K., Kennedy, M., Kazarov, A., Papadimitriou, J.C., Keller, G., A common precursor for hematopoietic and endothelial cells. Development 125:4 (1998), 725–732.
    • (1998) Development , vol.125 , Issue.4 , pp. 725-732
    • Choi, K.1    Kennedy, M.2    Kazarov, A.3    Papadimitriou, J.C.4    Keller, G.5
  • 30
    • 0036929373 scopus 로고    scopus 로고
    • Lineage analysis of the hemangioblast as defined by FLK1 and SCL expression
    • Chung, Y.S., Zhang, W.J., Arentson, E., Kingsley, P.D., Palis, J., Choi, K., Lineage analysis of the hemangioblast as defined by FLK1 and SCL expression. Development 129:23 (2002), 5511–5520.
    • (2002) Development , vol.129 , Issue.23 , pp. 5511-5520
    • Chung, Y.S.1    Zhang, W.J.2    Arentson, E.3    Kingsley, P.D.4    Palis, J.5    Choi, K.6
  • 31
    • 84905185118 scopus 로고    scopus 로고
    • Developmental hematopoiesis: Ontogeny, genetic programming and conservation
    • Ciau-Uitz, A., Monteiro, R., Kirmizitas, A., Patient, R., Developmental hematopoiesis: Ontogeny, genetic programming and conservation. Experimental Hematology 42:8 (2014), 669–683.
    • (2014) Experimental Hematology , vol.42 , Issue.8 , pp. 669-683
    • Ciau-Uitz, A.1    Monteiro, R.2    Kirmizitas, A.3    Patient, R.4
  • 32
    • 77951903935 scopus 로고    scopus 로고
    • Tel1/ETV6 specifies blood stem cells through the agency of VEGF signaling
    • Ciau-Uitz, A., Pinheiro, P., Gupta, R., Enver, T., Patient, R., Tel1/ETV6 specifies blood stem cells through the agency of VEGF signaling. Developmental Cell 18:4 (2010), 569–578.
    • (2010) Developmental Cell , vol.18 , Issue.4 , pp. 569-578
    • Ciau-Uitz, A.1    Pinheiro, P.2    Gupta, R.3    Enver, T.4    Patient, R.5
  • 33
    • 84878286239 scopus 로고    scopus 로고
    • VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus
    • Ciau-Uitz, A., Pinheiro, P., Kirmizitas, A., Zuo, J., Patient, R., VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus. Development 140:12 (2013), 2632–2642.
    • (2013) Development , vol.140 , Issue.12 , pp. 2632-2642
    • Ciau-Uitz, A.1    Pinheiro, P.2    Kirmizitas, A.3    Zuo, J.4    Patient, R.5
  • 34
    • 77956172807 scopus 로고    scopus 로고
    • Determining gammadelta versus alphass T cell development
    • Ciofani, M., Zuniga-Pflucker, J.C., Determining gammadelta versus alphass T cell development. Nature Reviews. Immunology 10:9 (2010), 657–663.
    • (2010) Nature Reviews. Immunology , vol.10 , Issue.9 , pp. 657-663
    • Ciofani, M.1    Zuniga-Pflucker, J.C.2
  • 35
    • 84876571061 scopus 로고    scopus 로고
    • Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia
    • Cleveland, S.M., Smith, S., Tripathi, R., Mathias, E.M., Goodings, C., Elliott, N., Dave, U.P., Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia. Stem Cells 31:5 (2013), 882–894, 10.1002/stem.1345.
    • (2013) Stem Cells , vol.31 , Issue.5 , pp. 882-894
    • Cleveland, S.M.1    Smith, S.2    Tripathi, R.3    Mathias, E.M.4    Goodings, C.5    Elliott, N.6    Dave, U.P.7
  • 37
    • 0030907392 scopus 로고    scopus 로고
    • Ectopic TAL-1/SCL expression in phenotypically normal or leukemic myeloid precursors: Proliferative and antiapoptotic effects coupled with a differentiation blockade
    • Condorelli, G.L., Tocci, A., Botta, R., Facchiano, F., Testa, U., Vitelli, L., Peschle, C., Ectopic TAL-1/SCL expression in phenotypically normal or leukemic myeloid precursors: Proliferative and antiapoptotic effects coupled with a differentiation blockade. Molecular and Cellular Biology 17:5 (1997), 2954–2969.
    • (1997) Molecular and Cellular Biology , vol.17 , Issue.5 , pp. 2954-2969
    • Condorelli, G.L.1    Tocci, A.2    Botta, R.3    Facchiano, F.4    Testa, U.5    Vitelli, L.6    Peschle, C.7
  • 39
    • 1942425445 scopus 로고    scopus 로고
    • SCL is required for normal function of short-term repopulating hematopoietic stem cells
    • Curtis, D.J., Hall, M.A., Van Stekelenburg, L.J., Robb, L., Jane, S.M., Begley, C.G., SCL is required for normal function of short-term repopulating hematopoietic stem cells. Blood 103:9 (2004), 3342–3348.
    • (2004) Blood , vol.103 , Issue.9 , pp. 3342-3348
    • Curtis, D.J.1    Hall, M.A.2    Van Stekelenburg, L.J.3    Robb, L.4    Jane, S.M.5    Begley, C.G.6
  • 40
    • 0036340212 scopus 로고    scopus 로고
    • Insufficient VEGFA activity in yolk sac endoderm compromises haematopoietic and endothelial differentiation
    • Damert, A., Miquerol, L., Gertsenstein, M., Risau, W., Nagy, A., Insufficient VEGFA activity in yolk sac endoderm compromises haematopoietic and endothelial differentiation. Development 129:8 (2002), 1881–1892.
    • (2002) Development , vol.129 , Issue.8 , pp. 1881-1892
    • Damert, A.1    Miquerol, L.2    Gertsenstein, M.3    Risau, W.4    Nagy, A.5
  • 41
    • 84863707683 scopus 로고    scopus 로고
    • Angiopoietin-2 is a direct transcriptional target of TAL1, LYL1 and LMO2 in endothelial cells
    • Deleuze, V., El-Hajj, R., Chalhoub, E., Dohet, C., Pinet, V., Couttet, P., Mathieu, D., Angiopoietin-2 is a direct transcriptional target of TAL1, LYL1 and LMO2 in endothelial cells. PLoS One, 7(7), 2012, e40484.
    • (2012) PLoS One , vol.7 , Issue.7 , pp. e40484
    • Deleuze, V.1    El-Hajj, R.2    Chalhoub, E.3    Dohet, C.4    Pinet, V.5    Couttet, P.6    Mathieu, D.7
  • 42
    • 77950636717 scopus 로고    scopus 로고
    • The TAL1/SCL transcription factor regulates cell cycle progression and proliferation in differentiating murine bone marrow monocyte precursors
    • Dey, S., Curtis, D.J., Jane, S.M., Brandt, S.J., The TAL1/SCL transcription factor regulates cell cycle progression and proliferation in differentiating murine bone marrow monocyte precursors. Molecular and Cellular Biology 30:9 (2010), 2181–2192.
    • (2010) Molecular and Cellular Biology , vol.30 , Issue.9 , pp. 2181-2192
    • Dey, S.1    Curtis, D.J.2    Jane, S.M.3    Brandt, S.J.4
  • 43
    • 0029074681 scopus 로고
    • Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice
    • Dickson, M.C., Martin, J.S., Cousins, F.M., Kulkarni, A.B., Karlsson, S., Akhurst, R.J., Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. Development 121:6 (1995), 1845–1854.
    • (1995) Development , vol.121 , Issue.6 , pp. 1845-1854
    • Dickson, M.C.1    Martin, J.S.2    Cousins, F.M.3    Kulkarni, A.B.4    Karlsson, S.5    Akhurst, R.J.6
  • 44
    • 84885115285 scopus 로고    scopus 로고
    • Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors
    • Doulatov, S., Vo, L.T., Chou, S.S., Kim, P.G., Arora, N., Li, H., Daley, G.Q., Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors. Cell Stem Cell 13:4 (2013), 459–470.
    • (2013) Cell Stem Cell , vol.13 , Issue.4 , pp. 459-470
    • Doulatov, S.1    Vo, L.T.2    Chou, S.S.3    Kim, P.G.4    Arora, N.5    Li, H.6    Daley, G.Q.7
  • 45
    • 0034161361 scopus 로고    scopus 로고
    • Vasculogenesis in the day 6.5 to 9.5 mouse embryo
    • Drake, C.J., Fleming, P.A., Vasculogenesis in the day 6.5 to 9.5 mouse embryo. Blood 95:5 (2000), 1671–1679.
    • (2000) Blood , vol.95 , Issue.5 , pp. 1671-1679
    • Drake, C.J.1    Fleming, P.A.2
  • 46
    • 0034985595 scopus 로고    scopus 로고
    • Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo
    • Dyer, M.A., Farrington, S.M., Mohn, D., Munday, J.R., Baron, M.H., Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo. Development 128:10 (2001), 1717–1730.
    • (2001) Development , vol.128 , Issue.10 , pp. 1717-1730
    • Dyer, M.A.1    Farrington, S.M.2    Mohn, D.3    Munday, J.R.4    Baron, M.H.5
  • 47
    • 84924908363 scopus 로고    scopus 로고
    • Transcription factor-mediated reprogramming toward hematopoietic stem cells
    • Ebina, W., Rossi, D.J., Transcription factor-mediated reprogramming toward hematopoietic stem cells. The EMBO Journal 34:6 (2015), 694–709.
    • (2015) The EMBO Journal , vol.34 , Issue.6 , pp. 694-709
    • Ebina, W.1    Rossi, D.J.2
  • 49
    • 84904489277 scopus 로고    scopus 로고
    • Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators
    • Elcheva, I., Brok-Volchanskaya, V., Kumar, A., Liu, P., Lee, J.H., Tong, L., Slukvin, I., Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators. Nature Communications, 5, 2014, 4372.
    • (2014) Nature Communications , vol.5 , pp. 4372
    • Elcheva, I.1    Brok-Volchanskaya, V.2    Kumar, A.3    Liu, P.4    Lee, J.H.5    Tong, L.6    Slukvin, I.7
  • 50
    • 0033485333 scopus 로고    scopus 로고
    • SCL expression in the mouse embryo detected with a targeted lacZ reporter gene demonstrates its localization to hematopoietic, vascular, and neural tissues
    • Elefanty, A.G., Begley, C.G., Hartley, L., Papaevangeliou, B., Robb, L., SCL expression in the mouse embryo detected with a targeted lacZ reporter gene demonstrates its localization to hematopoietic, vascular, and neural tissues. Blood 94:11 (1999), 3754–3763.
    • (1999) Blood , vol.94 , Issue.11 , pp. 3754-3763
    • Elefanty, A.G.1    Begley, C.G.2    Hartley, L.3    Papaevangeliou, B.4    Robb, L.5
  • 52
    • 84892445532 scopus 로고    scopus 로고
    • Structural basis for LMO2-driven recruitment of the SCL:E47bHLH heterodimer to hematopoietic-specific transcriptional targets
    • El Omari, K., Hoosdally, S.J., Tuladhar, K., Karia, D., Hall-Ponsele, E., Platonova, O., Mancini, E.J., Structural basis for LMO2-driven recruitment of the SCL:E47bHLH heterodimer to hematopoietic-specific transcriptional targets. Cell Reports 4:1 (2013), 135–147.
    • (2013) Cell Reports , vol.4 , Issue.1 , pp. 135-147
    • El Omari, K.1    Hoosdally, S.J.2    Tuladhar, K.3    Karia, D.4    Hall-Ponsele, E.5    Platonova, O.6    Mancini, E.J.7
  • 53
    • 0032525313 scopus 로고    scopus 로고
    • Enhanced megakaryocyte and erythroid development from normal human CD34(+) cells: Consequence of enforced expression of SCL
    • Elwood, N.J., Zogos, H., Pereira, D.S., Dick, J.E., Begley, C.G., Enhanced megakaryocyte and erythroid development from normal human CD34(+) cells: Consequence of enforced expression of SCL. Blood 91:10 (1998), 3756–3765.
    • (1998) Blood , vol.91 , Issue.10 , pp. 3756-3765
    • Elwood, N.J.1    Zogos, H.2    Pereira, D.S.3    Dick, J.E.4    Begley, C.G.5
  • 54
    • 0037311959 scopus 로고    scopus 로고
    • Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse
    • Ema, M., Faloon, P., Zhang, W.J., Hirashima, M., Reid, T., Stanford, W.L., Rossant, J., Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. Genes & Development 17:3 (2003), 380–393.
    • (2003) Genes & Development , vol.17 , Issue.3 , pp. 380-393
    • Ema, M.1    Faloon, P.2    Zhang, W.J.3    Hirashima, M.4    Reid, T.5    Stanford, W.L.6    Rossant, J.7
  • 55
    • 0034071346 scopus 로고    scopus 로고
    • Basic fibroblast growth factor positively regulates hematopoietic development
    • Faloon, P., Arentson, E., Kazarov, A., Deng, C.X., Porcher, C., Orkin, S., Choi, K., Basic fibroblast growth factor positively regulates hematopoietic development. Development 127:9 (2000), 1931–1941.
    • (2000) Development , vol.127 , Issue.9 , pp. 1931-1941
    • Faloon, P.1    Arentson, E.2    Kazarov, A.3    Deng, C.X.4    Porcher, C.5    Orkin, S.6    Choi, K.7
  • 56
    • 0030004485 scopus 로고    scopus 로고
    • Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    • Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O'Shea, K.S., Moore, M.W., Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380:6573 (1996), 439–442.
    • (1996) Nature , vol.380 , Issue.6573 , pp. 439-442
    • Ferrara, N.1    Carver-Moore, K.2    Chen, H.3    Dowd, M.4    Lu, L.5    O'Shea, K.S.6    Moore, M.W.7
  • 59
    • 0942266030 scopus 로고    scopus 로고
    • Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development
    • Fujiwara, Y., Chang, A.N., Williams, A.M., Orkin, S.H., Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development. Blood 103:2 (2004), 583–585, 10.1182/blood-2003-08-2870.
    • (2004) Blood , vol.103 , Issue.2 , pp. 583-585
    • Fujiwara, Y.1    Chang, A.N.2    Williams, A.M.3    Orkin, S.H.4
  • 63
    • 0032528275 scopus 로고    scopus 로고
    • The SCL gene specifies haemangioblast development from early mesoderm
    • Gering, M., Rodaway, A.R., Gottgens, B., Patient, R.K., Green, A.R., The SCL gene specifies haemangioblast development from early mesoderm. The EMBO Journal 17:14 (1998), 4029–4045.
    • (1998) The EMBO Journal , vol.17 , Issue.14 , pp. 4029-4045
    • Gering, M.1    Rodaway, A.R.2    Gottgens, B.3    Patient, R.K.4    Green, A.R.5
  • 64
    • 0346888544 scopus 로고    scopus 로고
    • Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1
    • Gering, M., Yamada, Y., Rabbitts, T.H., Patient, R.K., Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1. Development 130:25 (2003), 6187–6199.
    • (2003) Development , vol.130 , Issue.25 , pp. 6187-6199
    • Gering, M.1    Yamada, Y.2    Rabbitts, T.H.3    Patient, R.K.4
  • 66
    • 0037100309 scopus 로고    scopus 로고
    • Ectopic expression of TAL-1 protein in Ly-6E.1-htal-1 transgenic mice induces defects in B- and T-lymphoid differentiation
    • Goardon, N., Schuh, A., Hajar, I., Ma, X., Jouault, H., Dzierzak, E., Maouche-Chretien, L., Ectopic expression of TAL-1 protein in Ly-6E.1-htal-1 transgenic mice induces defects in B- and T-lymphoid differentiation. Blood 100:2 (2002), 491–500.
    • (2002) Blood , vol.100 , Issue.2 , pp. 491-500
    • Goardon, N.1    Schuh, A.2    Hajar, I.3    Ma, X.4    Jouault, H.5    Dzierzak, E.6    Maouche-Chretien, L.7
  • 67
    • 0030066615 scopus 로고    scopus 로고
    • Determinants of helix-loop-helix dimerization affinity. Random mutational analysis of SCL/tal
    • Goldfarb, A.N., Lewandowska, K., Shoham, M., Determinants of helix-loop-helix dimerization affinity. Random mutational analysis of SCL/tal. The Journal of Biological Chemistry 271:5 (1996), 2683–2688.
    • (1996) The Journal of Biological Chemistry , vol.271 , Issue.5 , pp. 2683-2688
    • Goldfarb, A.N.1    Lewandowska, K.2    Shoham, M.3
  • 69
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • Greaves, M., Maley, C.C., Clonal evolution in cancer. Nature 481:7381 (2012), 306–313.
    • (2012) Nature , vol.481 , Issue.7381 , pp. 306-313
    • Greaves, M.1    Maley, C.C.2
  • 70
    • 0026578516 scopus 로고
    • SCL is coexpressed with GATA-1 in hemopoietic cells but is also expressed in developing brain
    • Green, A.R., Lints, T., Visvader, J., Harvey, R., Begley, C.G., SCL is coexpressed with GATA-1 in hemopoietic cells but is also expressed in developing brain. Oncogene 7:4 (1992), 653–660.
    • (1992) Oncogene , vol.7 , Issue.4 , pp. 653-660
    • Green, A.R.1    Lints, T.2    Visvader, J.3    Harvey, R.4    Begley, C.G.5
  • 71
    • 0026090726 scopus 로고
    • Erythroid expression of the ‘helix-loop-helix' gene, SCL
    • Green, A.R., Salvaris, E., Begley, C.G., Erythroid expression of the ‘helix-loop-helix' gene, SCL. Oncogene 6:3 (1991), 475–479.
    • (1991) Oncogene , vol.6 , Issue.3 , pp. 475-479
    • Green, A.R.1    Salvaris, E.2    Begley, C.G.3
  • 73
    • 52649097448 scopus 로고    scopus 로고
    • The Immunological Genome Project: networks of gene expression in immune cells
    • Heng, T.S., Painter, M.W., Immunological Genome Project Consortium, The Immunological Genome Project: networks of gene expression in immune cells. Nature Immunology 9:10 (2008), 1091–1094.
    • (2008) Nature Immunology , vol.9 , Issue.10 , pp. 1091-1094
    • Heng, T.S.1    Painter, M.W.2    Immunological Genome Project Consortium3
  • 75
    • 0034252945 scopus 로고    scopus 로고
    • SCL and LMO1 alter thymocyte differentiation: Inhibition of E2A-HEB function and pre-T alpha chain expression
    • Herblot, S., Steff, A.M., Hugo, P., Aplan, P.D., Hoang, T., SCL and LMO1 alter thymocyte differentiation: Inhibition of E2A-HEB function and pre-T alpha chain expression. Nature Immunology 1:2 (2000), 138–144.
    • (2000) Nature Immunology , vol.1 , Issue.2 , pp. 138-144
    • Herblot, S.1    Steff, A.M.2    Hugo, P.3    Aplan, P.D.4    Hoang, T.5
  • 78
    • 77952999900 scopus 로고    scopus 로고
    • Of mice and men: How an oncogene transgresses the limits and predisposes to T cell acute lymphoblastic leukemia
    • Hoang, T., Of mice and men: How an oncogene transgresses the limits and predisposes to T cell acute lymphoblastic leukemia. Science Translational Medicine, 2(21), 2010, 21ps10.
    • (2010) Science Translational Medicine , vol.2 , Issue.21 , pp. 21ps10
    • Hoang, T.1
  • 79
    • 0030042608 scopus 로고    scopus 로고
    • Opposing effects of the basic helix-loop-helix transcription factor SCL on erythroid and monocytic differentiation
    • Hoang, T., Paradis, E., Brady, G., Billia, F., Nakahara, K., Iscove, N.N., Kirsch, I.R., Opposing effects of the basic helix-loop-helix transcription factor SCL on erythroid and monocytic differentiation. Blood 87:1 (1996), 102–111.
    • (1996) Blood , vol.87 , Issue.1 , pp. 102-111
    • Hoang, T.1    Paradis, E.2    Brady, G.3    Billia, F.4    Nakahara, K.5    Iscove, N.N.6    Kirsch, I.R.7
  • 80
    • 0025804491 scopus 로고
    • Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins
    • Hsu, H.L., Cheng, J.T., Chen, Q., Baer, R., Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins. Molecular and Cellular Biology 11:6 (1991), 3037–3042.
    • (1991) Molecular and Cellular Biology , vol.11 , Issue.6 , pp. 3037-3042
    • Hsu, H.L.1    Cheng, J.T.2    Chen, Q.3    Baer, R.4
  • 85
    • 0034671643 scopus 로고    scopus 로고
    • P/CAF-mediated acetylation regulates the function of the basic helix-loop-helix transcription factor TAL1/SCL
    • Huang, S., Qiu, Y., Shi, Y., Xu, Z., Brandt, S.J., P/CAF-mediated acetylation regulates the function of the basic helix-loop-helix transcription factor TAL1/SCL. The EMBO Journal 19:24 (2000), 6792–6803.
    • (2000) The EMBO Journal , vol.19 , Issue.24 , pp. 6792-6803
    • Huang, S.1    Qiu, Y.2    Shi, Y.3    Xu, Z.4    Brandt, S.J.5
  • 86
    • 0033517369 scopus 로고    scopus 로고
    • p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein
    • Huang, S., Qiu, Y., Stein, R.W., Brandt, S.J., p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein. Oncogene 18:35 (1999), 4958–4967, 10.1038/sj.onc.1202889.
    • (1999) Oncogene , vol.18 , Issue.35 , pp. 4958-4967
    • Huang, S.1    Qiu, Y.2    Stein, R.W.3    Brandt, S.J.4
  • 88
    • 0028970392 scopus 로고
    • Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development
    • Johansson, B.M., Wiles, M.V., Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development. Molecular and Cellular Biology 15:1 (1995), 141–151.
    • (1995) Molecular and Cellular Biology , vol.15 , Issue.1 , pp. 141-151
    • Johansson, B.M.1    Wiles, M.V.2
  • 89
    • 37049034259 scopus 로고    scopus 로고
    • Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors
    • Jones, M.E., Zhuang, Y., Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors. Immunity 27:6 (2007), 860–870.
    • (2007) Immunity , vol.27 , Issue.6 , pp. 860-870
    • Jones, M.E.1    Zhuang, Y.2
  • 90
    • 1842293350 scopus 로고    scopus 로고
    • Flk-1 expression defines a population of early embryonic hematopoietic precursors
    • Kabrun, N., Buhring, H.J., Choi, K., Ullrich, A., Risau, W., Keller, G., Flk-1 expression defines a population of early embryonic hematopoietic precursors. Development 124:10 (1997), 2039–2048.
    • (1997) Development , vol.124 , Issue.10 , pp. 2039-2048
    • Kabrun, N.1    Buhring, H.J.2    Choi, K.3    Ullrich, A.4    Risau, W.5    Keller, G.6
  • 91
    • 0028123474 scopus 로고
    • The SCL/TAL-1 gene is expressed in progenitors of both the hematopoietic and vascular systems during embryogenesis
    • Kallianpur, A.R., Jordan, J.E., Brandt, S.J., The SCL/TAL-1 gene is expressed in progenitors of both the hematopoietic and vascular systems during embryogenesis. Blood 83:5 (1994), 1200–1208.
    • (1994) Blood , vol.83 , Issue.5 , pp. 1200-1208
    • Kallianpur, A.R.1    Jordan, J.E.2    Brandt, S.J.3
  • 92
    • 13344260695 scopus 로고    scopus 로고
    • In vitro analysis of epiblast tissue potency for hematopoietic cell differentiation
    • Kanatsu, M., Nishikawa, S.I., In vitro analysis of epiblast tissue potency for hematopoietic cell differentiation. Development 122:3 (1996), 823–830.
    • (1996) Development , vol.122 , Issue.3 , pp. 823-830
    • Kanatsu, M.1    Nishikawa, S.I.2
  • 93
    • 51649130774 scopus 로고    scopus 로고
    • Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis
    • Kassouf, M.T., Chagraoui, H., Vyas, P., Porcher, C., Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis. Blood 112:4 (2008), 1056–1067.
    • (2008) Blood , vol.112 , Issue.4 , pp. 1056-1067
    • Kassouf, M.T.1    Chagraoui, H.2    Vyas, P.3    Porcher, C.4
  • 94
    • 77955131763 scopus 로고    scopus 로고
    • Genome-wide identification of TAL1's functional targets: Insights into its mechanisms of action in primary erythroid cells
    • Kassouf, M.T., Hughes, J.R., Taylor, S., McGowan, S.J., Soneji, S., Green, A.L., Porcher, C., Genome-wide identification of TAL1's functional targets: Insights into its mechanisms of action in primary erythroid cells. Genome Research 20:8 (2010), 1064–1083.
    • (2010) Genome Research , vol.20 , Issue.8 , pp. 1064-1083
    • Kassouf, M.T.1    Hughes, J.R.2    Taylor, S.3    McGowan, S.J.4    Soneji, S.5    Green, A.L.6    Porcher, C.7
  • 95
    • 33750456216 scopus 로고    scopus 로고
    • Multipotent flk-1 + cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages
    • Kattman, S.J., Huber, T.L., Keller, G.M., Multipotent flk-1 + cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages. Developmental Cell 11:5 (2006), 723–732.
    • (2006) Developmental Cell , vol.11 , Issue.5 , pp. 723-732
    • Kattman, S.J.1    Huber, T.L.2    Keller, G.M.3
  • 96
    • 0032896679 scopus 로고    scopus 로고
    • Development of the hematopoietic system in the mouse
    • Keller, G., Lacaud, G., Robertson, S., Development of the hematopoietic system in the mouse. Experimental Hematology 27:5 (1999), 777–787.
    • (1999) Experimental Hematology , vol.27 , Issue.5 , pp. 777-787
    • Keller, G.1    Lacaud, G.2    Robertson, S.3
  • 97
    • 0030942527 scopus 로고    scopus 로고
    • A common precursor for primitive erythropoiesis and definitive haematopoiesis
    • Kennedy, M., Firpo, M., Choi, K., Wall, C., Robertson, S., Kabrun, N., Keller, G., A common precursor for primitive erythropoiesis and definitive haematopoiesis. Nature 386:6624 (1997), 488–493.
    • (1997) Nature , vol.386 , Issue.6624 , pp. 488-493
    • Kennedy, M.1    Firpo, M.2    Choi, K.3    Wall, C.4    Robertson, S.5    Kabrun, N.6    Keller, G.7
  • 99
    • 21244463426 scopus 로고    scopus 로고
    • SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    • Kiel, M.J., Yilmaz, O.H., Iwashita, T., Yilmaz, O.H., Terhorst, C., Morrison, S.J., SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121:7 (2005), 1109–1121.
    • (2005) Cell , vol.121 , Issue.7 , pp. 1109-1121
    • Kiel, M.J.1    Yilmaz, O.H.2    Iwashita, T.3    Yilmaz, O.H.4    Terhorst, C.5    Morrison, S.J.6
  • 101
    • 0032750166 scopus 로고    scopus 로고
    • The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo
    • Kinder, S.J., Tsang, T.E., Quinlan, G.A., Hadjantonakis, A.K., Nagy, A., Tam, P.P., The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo. Development 126:21 (1999), 4691–4701.
    • (1999) Development , vol.126 , Issue.21 , pp. 4691-4701
    • Kinder, S.J.1    Tsang, T.E.2    Quinlan, G.A.3    Hadjantonakis, A.K.4    Nagy, A.5    Tam, P.P.6
  • 102
    • 84941962226 scopus 로고    scopus 로고
    • ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation
    • Knudsen, K.J., Rehn, M., Hasemann, M.S., Rapin, N., Bagger, F.O., Ohlsson, E., Porse, B.T., ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation. Genes & Development 29:18 (2015), 1915–1929.
    • (2015) Genes & Development , vol.29 , Issue.18 , pp. 1915-1929
    • Knudsen, K.J.1    Rehn, M.2    Hasemann, M.S.3    Rapin, N.4    Bagger, F.O.5    Ohlsson, E.6    Porse, B.T.7
  • 107
    • 0032533914 scopus 로고    scopus 로고
    • Molecular identity of hematopoietic precursor cells emerging in the human embryo
    • Labastie, M.C., Cortes, F., Romeo, P.H., Dulac, C., Peault, B., Molecular identity of hematopoietic precursor cells emerging in the human embryo. Blood 92:10 (1998), 3624–3635.
    • (1998) Blood , vol.92 , Issue.10 , pp. 3624-3635
    • Labastie, M.C.1    Cortes, F.2    Romeo, P.H.3    Dulac, C.4    Peault, B.5
  • 108
    • 77949322674 scopus 로고    scopus 로고
    • Scl regulates the quiescence and the long-term competence of hematopoietic stem cells
    • Lacombe, J., Herblot, S., Rojas-Sutterlin, S., Haman, A., Barakat, S., Iscove, N.N., Hoang, T., Scl regulates the quiescence and the long-term competence of hematopoietic stem cells. Blood 115:4 (2010), 792–803.
    • (2010) Blood , vol.115 , Issue.4 , pp. 792-803
    • Lacombe, J.1    Herblot, S.2    Rojas-Sutterlin, S.3    Haman, A.4    Barakat, S.5    Iscove, N.N.6    Hoang, T.7
  • 110
    • 0842304226 scopus 로고    scopus 로고
    • SCL assembles a multifactorial complex that determines glycophorin A expression
    • Lahlil, R., Lecuyer, E., Herblot, S., Hoang, T., SCL assembles a multifactorial complex that determines glycophorin A expression. Molecular and Cellular Biology 24:4 (2004), 1439–1452.
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.4 , pp. 1439-1452
    • Lahlil, R.1    Lecuyer, E.2    Herblot, S.3    Hoang, T.4
  • 111
    • 60149110371 scopus 로고    scopus 로고
    • The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage
    • Lancrin, C., Sroczynska, P., Stephenson, C., Allen, T., Kouskoff, V., Lacaud, G., The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage. Nature 457:7231 (2009), 892–895.
    • (2009) Nature , vol.457 , Issue.7231 , pp. 892-895
    • Lancrin, C.1    Sroczynska, P.2    Stephenson, C.3    Allen, T.4    Kouskoff, V.5    Lacaud, G.6
  • 113
    • 0036785404 scopus 로고    scopus 로고
    • The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1
    • Lecuyer, E., Herblot, S., Saint-Denis, M., Martin, R., Begley, C.G., Porcher, C., Hoang, T., The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1. Blood 100:7 (2002), 2430–2440.
    • (2002) Blood , vol.100 , Issue.7 , pp. 2430-2440
    • Lecuyer, E.1    Herblot, S.2    Saint-Denis, M.3    Martin, R.4    Begley, C.G.5    Porcher, C.6    Hoang, T.7
  • 114
    • 6044275816 scopus 로고    scopus 로고
    • SCL: From the origin of hematopoiesis to stem cells and leukemia
    • Lecuyer, E., Hoang, T., SCL: From the origin of hematopoiesis to stem cells and leukemia. Experimental Hematology 32:1 (2004), 11–24.
    • (2004) Experimental Hematology , vol.32 , Issue.1 , pp. 11-24
    • Lecuyer, E.1    Hoang, T.2
  • 116
    • 0029064971 scopus 로고
    • Loss of TAL-1 protein activity induces premature apoptosis of Jurkat leukemic T cells upon medium depletion
    • Leroy-Viard, K., Vinit, M.A., Lecointe, N., Jouault, H., Hibner, U., Romeo, P.H., Mathieu-Mahul, D., Loss of TAL-1 protein activity induces premature apoptosis of Jurkat leukemic T cells upon medium depletion. The EMBO Journal 14:10 (1995), 2341–2349.
    • (1995) The EMBO Journal , vol.14 , Issue.10 , pp. 2341-2349
    • Leroy-Viard, K.1    Vinit, M.A.2    Lecointe, N.3    Jouault, H.4    Hibner, U.5    Romeo, P.H.6    Mathieu-Mahul, D.7
  • 117
    • 0037673984 scopus 로고    scopus 로고
    • Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
    • Lessard, J., Sauvageau, G., Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423:6937 (2003), 255–260, 10.1038/nature01572.
    • (2003) Nature , vol.423 , Issue.6937 , pp. 255-260
    • Lessard, J.1    Sauvageau, G.2
  • 118
    • 84873094555 scopus 로고    scopus 로고
    • Uncoupling VEGFA functions in arteriogenesis and hematopoietic stem cell specification
    • Leung, A., Ciau-Uitz, A., Pinheiro, P., Monteiro, R., Zuo, J., Vyas, P., Porcher, C., Uncoupling VEGFA functions in arteriogenesis and hematopoietic stem cell specification. Developmental Cell 24:2 (2013), 144–158.
    • (2013) Developmental Cell , vol.24 , Issue.2 , pp. 144-158
    • Leung, A.1    Ciau-Uitz, A.2    Pinheiro, P.3    Monteiro, R.4    Zuo, J.5    Vyas, P.6    Porcher, C.7
  • 119
    • 0031040497 scopus 로고    scopus 로고
    • The zebrafish gene cloche acts upstream of a flk-1 homologue to regulate endothelial cell differentiation
    • Liao, W., Bisgrove, B.W., Sawyer, H., Hug, B., Bell, B., Peters, K., Stainier, D.Y., The zebrafish gene cloche acts upstream of a flk-1 homologue to regulate endothelial cell differentiation. Development 124:2 (1997), 381–389.
    • (1997) Development , vol.124 , Issue.2 , pp. 381-389
    • Liao, W.1    Bisgrove, B.W.2    Sawyer, H.3    Hug, B.4    Bell, B.5    Peters, K.6    Stainier, D.Y.7
  • 120
    • 0032032466 scopus 로고    scopus 로고
    • SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish
    • Liao, E.C., Paw, B.H., Oates, A.C., Pratt, S.J., Postlethwait, J.H., Zon, L.I., SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish. Genes & Development 12:5 (1998), 621–626.
    • (1998) Genes & Development , vol.12 , Issue.5 , pp. 621-626
    • Liao, E.C.1    Paw, B.H.2    Oates, A.C.3    Pratt, S.J.4    Postlethwait, J.H.5    Zon, L.I.6
  • 121
    • 33644756556 scopus 로고    scopus 로고
    • Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma
    • Lin, Y.W., Nichols, R.A., Letterio, J.J., Aplan, P.D., Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma. Blood 107:6 (2006), 2540–2543.
    • (2006) Blood , vol.107 , Issue.6 , pp. 2540-2543
    • Lin, Y.W.1    Nichols, R.A.2    Letterio, J.J.3    Aplan, P.D.4
  • 122
    • 84928919854 scopus 로고    scopus 로고
    • Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71/ETV2
    • Liu, F., Li, D., Yu, Y.Y., Kang, I., Cha, M.J., Kim, J.Y., Choi, K., Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71/ETV2. EMBO Reports 16:5 (2015), 654–669.
    • (2015) EMBO Reports , vol.16 , Issue.5 , pp. 654-669
    • Liu, F.1    Li, D.2    Yu, Y.Y.3    Kang, I.4    Cha, M.J.5    Kim, J.Y.6    Choi, K.7
  • 123
    • 0030658039 scopus 로고    scopus 로고
    • Oncogenic transcription factors in the human acute leukemias
    • Look, A.T., Oncogenic transcription factors in the human acute leukemias. Science 278:5340 (1997), 1059–1064.
    • (1997) Science , vol.278 , Issue.5340 , pp. 1059-1064
    • Look, A.T.1
  • 124
    • 84891159436 scopus 로고    scopus 로고
    • Ldb1 complexes: The new master regulators of erythroid gene transcription
    • Love, P.E., Warzecha, C., Li, L., Ldb1 complexes: The new master regulators of erythroid gene transcription. Trends in Genetics 30:1 (2014), 1–9.
    • (2014) Trends in Genetics , vol.30 , Issue.1 , pp. 1-9
    • Love, P.E.1    Warzecha, C.2    Li, L.3
  • 125
    • 1242285120 scopus 로고    scopus 로고
    • SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis
    • Martin, R., Lahlil, R., Damert, A., Miquerol, L., Nagy, A., Keller, G., Hoang, T., SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis. Development 131:3 (2004), 693–702.
    • (2004) Development , vol.131 , Issue.3 , pp. 693-702
    • Martin, R.1    Lahlil, R.2    Damert, A.3    Miquerol, L.4    Nagy, A.5    Keller, G.6    Hoang, T.7
  • 127
    • 84933677570 scopus 로고    scopus 로고
    • Distinct sources of hematopoietic progenitors emerge before HSCs and provide functional Blood cells in the mammalian embryo
    • McGrath, K.E., Frame, J.M., Fegan, K.H., Bowen, J.R., Conway, S.J., Catherman, S.C., Palis, J., Distinct sources of hematopoietic progenitors emerge before HSCs and provide functional Blood cells in the mammalian embryo. Cell Reports 11:12 (2015), 1892–1904.
    • (2015) Cell Reports , vol.11 , Issue.12 , pp. 1892-1904
    • McGrath, K.E.1    Frame, J.M.2    Fegan, K.H.3    Bowen, J.R.4    Conway, S.J.5    Catherman, S.C.6    Palis, J.7
  • 128
    • 0034932701 scopus 로고    scopus 로고
    • Primitive erythropoiesis in the xenopus embryo: The synergistic role of LMO-2, SCL and GATA-binding proteins
    • Mead, P.E., Deconinck, A.E., Huber, T.L., Orkin, S.H., Zon, L.I., Primitive erythropoiesis in the xenopus embryo: The synergistic role of LMO-2, SCL and GATA-binding proteins. Development 128:12 (2001), 2301–2308.
    • (2001) Development , vol.128 , Issue.12 , pp. 2301-2308
    • Mead, P.E.1    Deconinck, A.E.2    Huber, T.L.3    Orkin, S.H.4    Zon, L.I.5
  • 129
    • 0031825761 scopus 로고    scopus 로고
    • SCL specifies hematopoietic mesoderm in Xenopus embryos
    • Mead, P.E., Kelley, C.M., Hahn, P.S., Piedad, O., Zon, L.I., SCL specifies hematopoietic mesoderm in Xenopus embryos. Development 125:14 (1998), 2611–2620.
    • (1998) Development , vol.125 , Issue.14 , pp. 2611-2620
    • Mead, P.E.1    Kelley, C.M.2    Hahn, P.S.3    Piedad, O.4    Zon, L.I.5
  • 130
    • 0030595341 scopus 로고    scopus 로고
    • Definitive hematopoiesis is autonomously initiated by the AGM region
    • Medvinsky, A., Dzierzak, E., Definitive hematopoiesis is autonomously initiated by the AGM region. Cell 86:6 (1996), 897–906.
    • (1996) Cell , vol.86 , Issue.6 , pp. 897-906
    • Medvinsky, A.1    Dzierzak, E.2
  • 131
    • 0037472895 scopus 로고    scopus 로고
    • Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene
    • Mikkola, H.K., Klintman, J., Yang, H., Hock, H., Schlaeger, T.M., Fujiwara, Y., Orkin, S.H., Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature 421:6922 (2003), 547–551.
    • (2003) Nature , vol.421 , Issue.6922 , pp. 547-551
    • Mikkola, H.K.1    Klintman, J.2    Yang, H.3    Hock, H.4    Schlaeger, T.M.5    Fujiwara, Y.6    Orkin, S.H.7
  • 132
    • 84876471008 scopus 로고    scopus 로고
    • Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis
    • Moignard, V., Macaulay, I.C., Swiers, G., Buettner, F., Schutte, J., Calero-Nieto, F.J., Gottgens, B., Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis. Nature Cell Biology 15:4 (2013), 363–372.
    • (2013) Nature Cell Biology , vol.15 , Issue.4 , pp. 363-372
    • Moignard, V.1    Macaulay, I.C.2    Swiers, G.3    Buettner, F.4    Schutte, J.5    Calero-Nieto, F.J.6    Gottgens, B.7
  • 134
    • 0034252597 scopus 로고    scopus 로고
    • Intertwining proteins in thymocyte development and cancer
    • Murre, C., Intertwining proteins in thymocyte development and cancer. Nature Immunology 1:2 (2000), 97–98.
    • (2000) Nature Immunology , vol.1 , Issue.2 , pp. 97-98
    • Murre, C.1
  • 135
    • 84919360111 scopus 로고    scopus 로고
    • The analysis, roles and regulation of quiescence in hematopoietic stem cells
    • Nakamura-Ishizu, A., Takizawa, H., Suda, T., The analysis, roles and regulation of quiescence in hematopoietic stem cells. Development 141:24 (2014), 4656–4666.
    • (2014) Development , vol.141 , Issue.24 , pp. 4656-4666
    • Nakamura-Ishizu, A.1    Takizawa, H.2    Suda, T.3
  • 136
    • 0034177522 scopus 로고    scopus 로고
    • Vascular endothelial growth factor synergistically enhances bone morphogenetic protein-4-dependent lymphohematopoietic cell generation from embryonic stem cells in vitro
    • Nakayama, N., Lee, J., Chiu, L., Vascular endothelial growth factor synergistically enhances bone morphogenetic protein-4-dependent lymphohematopoietic cell generation from embryonic stem cells in vitro. Blood 95:7 (2000), 2275–2283.
    • (2000) Blood , vol.95 , Issue.7 , pp. 2275-2283
    • Nakayama, N.1    Lee, J.2    Chiu, L.3
  • 137
    • 0031833476 scopus 로고    scopus 로고
    • Progressive lineage analysis by cell sorting and culture identifies FLK1+VE-cadherin + cells at a diverging point of endothelial and hemopoietic lineages
    • Nishikawa, S.I., Nishikawa, S., Hirashima, M., Matsuyoshi, N., Kodama, H., Progressive lineage analysis by cell sorting and culture identifies FLK1+VE-cadherin + cells at a diverging point of endothelial and hemopoietic lineages. Development 125:9 (1998), 1747–1757.
    • (1998) Development , vol.125 , Issue.9 , pp. 1747-1757
    • Nishikawa, S.I.1    Nishikawa, S.2    Hirashima, M.3    Matsuyoshi, N.4    Kodama, H.5
  • 138
    • 0017709071 scopus 로고
    • Preleukemia. Cytogenetic clues in some confusing disorders
    • Nowell, P.C., Preleukemia. Cytogenetic clues in some confusing disorders. The American Journal of Pathology 89:2 (1977), 459–476.
    • (1977) The American Journal of Pathology , vol.89 , Issue.2 , pp. 459-476
    • Nowell, P.C.1
  • 139
    • 0033533891 scopus 로고    scopus 로고
    • Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
    • Nutt, S.L., Heavey, B., Rolink, A.G., Busslinger, M., Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 401:6753 (1999), 556–562.
    • (1999) Nature , vol.401 , Issue.6753 , pp. 556-562
    • Nutt, S.L.1    Heavey, B.2    Rolink, A.G.3    Busslinger, M.4
  • 140
    • 0033556697 scopus 로고    scopus 로고
    • Expression of alpha4-integrin defines the earliest precursor of hematopoietic cell lineage diverged from endothelial cells
    • Ogawa, M., Kizumoto, M., Nishikawa, S., Fujimoto, T., Kodama, H., Nishikawa, S.I., Expression of alpha4-integrin defines the earliest precursor of hematopoietic cell lineage diverged from endothelial cells. Blood 93:4 (1999), 1168–1177.
    • (1999) Blood , vol.93 , Issue.4 , pp. 1168-1177
    • Ogawa, M.1    Kizumoto, M.2    Nishikawa, S.3    Fujimoto, T.4    Kodama, H.5    Nishikawa, S.I.6
  • 141
    • 2942579675 scopus 로고    scopus 로고
    • TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB
    • O'Neil, J., Shank, J., Cusson, N., Murre, C., Kelliher, M., TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB. Cancer Cell 5:6 (2004), 587–596.
    • (2004) Cancer Cell , vol.5 , Issue.6 , pp. 587-596
    • O'Neil, J.1    Shank, J.2    Cusson, N.3    Murre, C.4    Kelliher, M.5
  • 142
  • 143
    • 79551605803 scopus 로고    scopus 로고
    • Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages
    • Palii, C.G., Perez-Iratxeta, C., Yao, Z., Cao, Y., Dai, F., Davison, J., Brand, M., Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages. The EMBO Journal 30:3 (2011), 494–509.
    • (2011) The EMBO Journal , vol.30 , Issue.3 , pp. 494-509
    • Palii, C.G.1    Perez-Iratxeta, C.2    Yao, Z.3    Cao, Y.4    Dai, F.5    Davison, J.6    Brand, M.7
  • 144
    • 84893457195 scopus 로고    scopus 로고
    • Primitive and definitive erythropoiesis in mammals
    • Palis, J., Primitive and definitive erythropoiesis in mammals. Frontiers in Physiology, 5, 2014, 3.
    • (2014) Frontiers in Physiology , vol.5 , pp. 3
    • Palis, J.1
  • 145
    • 33746656195 scopus 로고    scopus 로고
    • Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia
    • Palomero, T., Odom, D.T., O'Neil, J., Ferrando, A.A., Margolin, A., Neuberg, D.S., Look, A.T., Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia. Blood 108:3 (2006), 986–992.
    • (2006) Blood , vol.108 , Issue.3 , pp. 986-992
    • Palomero, T.1    Odom, D.T.2    O'Neil, J.3    Ferrando, A.A.4    Margolin, A.5    Neuberg, D.S.6    Look, A.T.7
  • 146
    • 0032969660 scopus 로고    scopus 로고
    • Manipulation of the angiopoietic/hemangiopoietic commitment in the avian embryo
    • Pardanaud, L., Dieterlen-Lievre, F., Manipulation of the angiopoietic/hemangiopoietic commitment in the avian embryo. Development 126:4 (1999), 617–627.
    • (1999) Development , vol.126 , Issue.4 , pp. 617-627
    • Pardanaud, L.1    Dieterlen-Lievre, F.2
  • 147
  • 148
    • 3042733135 scopus 로고    scopus 로고
    • A hierarchical order of factors in the generation of FLK1- and SCL-expressing hematopoietic and endothelial progenitors from embryonic stem cells
    • Park, C., Afrikanova, I., Chung, Y.S., Zhang, W.J., Arentson, E., Fong Gh, G., Choi, K., A hierarchical order of factors in the generation of FLK1- and SCL-expressing hematopoietic and endothelial progenitors from embryonic stem cells. Development 131:11 (2004), 2749–2762.
    • (2004) Development , vol.131 , Issue.11 , pp. 2749-2762
    • Park, C.1    Afrikanova, I.2    Chung, Y.S.3    Zhang, W.J.4    Arentson, E.5    Fong Gh, G.6    Choi, K.7
  • 149
    • 0038349957 scopus 로고    scopus 로고
    • Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    • Park, I.K., Qian, D., Kiel, M., Becker, M.W., Pihalja, M., Weissman, I.L., Clarke, M.F., Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423:6937 (2003), 302–305.
    • (2003) Nature , vol.423 , Issue.6937 , pp. 302-305
    • Park, I.K.1    Qian, D.2    Kiel, M.3    Becker, M.W.4    Pihalja, M.5    Weissman, I.L.6    Clarke, M.F.7
  • 151
    • 34247882592 scopus 로고    scopus 로고
    • Zoned out: Functional mapping of stromal signaling microenvironments in the thymus
    • Petrie, H.T., Zuniga-Pflucker, J.C., Zoned out: Functional mapping of stromal signaling microenvironments in the thymus. Annual Review of Immunology 25 (2007), 649–679, 10.1146/annurev.immunol.23.021704.115715.
    • (2007) Annual Review of Immunology , vol.25 , pp. 649-679
    • Petrie, H.T.1    Zuniga-Pflucker, J.C.2
  • 152
    • 0025977563 scopus 로고
    • Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1
    • Pevny, L., Simon, M.C., Robertson, E., Klein, W.H., Tsai, S.F., D'Agati, V., Costantini, F., Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature 349:6306 (1991), 257–260.
    • (1991) Nature , vol.349 , Issue.6306 , pp. 257-260
    • Pevny, L.1    Simon, M.C.2    Robertson, E.3    Klein, W.H.4    Tsai, S.F.5    D'Agati, V.6    Costantini, F.7
  • 154
    • 0034960583 scopus 로고    scopus 로고
    • The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors
    • Pola, R., Ling, L.E., Silver, M., Corbley, M.J., Kearney, M., Blake Pepinsky, R., Isner, J.M., The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. Nature Medicine 7:6 (2001), 706–711.
    • (2001) Nature Medicine , vol.7 , Issue.6 , pp. 706-711
    • Pola, R.1    Ling, L.E.2    Silver, M.3    Corbley, M.J.4    Kearney, M.5    Blake Pepinsky, R.6    Isner, J.M.7
  • 155
    • 0032722671 scopus 로고    scopus 로고
    • Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding
    • Porcher, C., Liao, E.C., Fujiwara, Y., Zon, L.I., Orkin, S.H., Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. Development 126:20 (1999), 4603–4615.
    • (1999) Development , vol.126 , Issue.20 , pp. 4603-4615
    • Porcher, C.1    Liao, E.C.2    Fujiwara, Y.3    Zon, L.I.4    Orkin, S.H.5
  • 156
    • 0030581174 scopus 로고    scopus 로고
    • The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages
    • Porcher, C., Swat, W., Rockwell, K., Fujiwara, Y., Alt, F.W., Orkin, S.H., The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell 86:1 (1996), 47–57.
    • (1996) Cell , vol.86 , Issue.1 , pp. 47-57
    • Porcher, C.1    Swat, W.2    Rockwell, K.3    Fujiwara, Y.4    Alt, F.W.5    Orkin, S.H.6
  • 158
    • 1942521618 scopus 로고    scopus 로고
    • Characterization of DNA-binding-dependent and -independent functions of SCL/TAL1 during human erythropoiesis
    • Ravet, E., Reynaud, D., Titeux, M., Izac, B., Fichelson, S., Romeo, P.H., Pflumio, F., Characterization of DNA-binding-dependent and -independent functions of SCL/TAL1 during human erythropoiesis. Blood 103:9 (2004), 3326–3335.
    • (2004) Blood , vol.103 , Issue.9 , pp. 3326-3335
    • Ravet, E.1    Reynaud, D.2    Titeux, M.3    Izac, B.4    Fichelson, S.5    Romeo, P.H.6    Pflumio, F.7
  • 160
    • 27144449956 scopus 로고    scopus 로고
    • SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment
    • Reynaud, D., Ravet, E., Titeux, M., Mazurier, F., Renia, L., Dubart-Kupperschmitt, A., Pflumio, F., SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment. Blood 106:7 (2005), 2318–2328.
    • (2005) Blood , vol.106 , Issue.7 , pp. 2318-2328
    • Reynaud, D.1    Ravet, E.2    Titeux, M.3    Mazurier, F.4    Renia, L.5    Dubart-Kupperschmitt, A.6    Pflumio, F.7
  • 161
    • 84899527626 scopus 로고    scopus 로고
    • Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors
    • Riddell, J., Gazit, R., Garrison, B.S., Guo, G., Saadatpour, A., Mandal, P.K., Rossi, D.J., Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Cell 157:3 (2014), 549–564.
    • (2014) Cell , vol.157 , Issue.3 , pp. 549-564
    • Riddell, J.1    Gazit, R.2    Garrison, B.S.3    Guo, G.4    Saadatpour, A.5    Mandal, P.K.6    Rossi, D.J.7
  • 162
    • 0029781248 scopus 로고    scopus 로고
    • The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse
    • Robb, L., Elwood, N.J., Elefanty, A.G., Kontgen, F., Li, R., Barnett, L.D., Begley, C.G., The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse. The EMBO Journal 15:16 (1996), 4123–4129.
    • (1996) The EMBO Journal , vol.15 , Issue.16 , pp. 4123-4129
    • Robb, L.1    Elwood, N.J.2    Elefanty, A.G.3    Kontgen, F.4    Li, R.5    Barnett, L.D.6    Begley, C.G.7
  • 164
    • 0034045599 scopus 로고    scopus 로고
    • A transitional stage in the commitment of mesoderm to hematopoiesis requiring the transcription factor SCL/tal-1
    • Robertson, S.M., Kennedy, M., Shannon, J.M., Keller, G., A transitional stage in the commitment of mesoderm to hematopoiesis requiring the transcription factor SCL/tal-1. Development 127:11 (2000), 2447–2459.
    • (2000) Development , vol.127 , Issue.11 , pp. 2447-2459
    • Robertson, S.M.1    Kennedy, M.2    Shannon, J.M.3    Keller, G.4
  • 166
    • 84902262072 scopus 로고    scopus 로고
    • Hematopoietic stem cell quiescence and long term maintenance: Role of SCL/TAL1
    • H. MA Springer Science Company Netherlands
    • Rojas-Sutterlin, S., Hoang, T., Hematopoietic stem cell quiescence and long term maintenance: Role of SCL/TAL1. MA, H., (eds.) Tumor dormancy and cellular quiescence, Vol. V, 2013, Springer Science Company, Netherlands, 87–105.
    • (2013) Tumor dormancy and cellular quiescence , vol.Vol. V , pp. 87-105
    • Rojas-Sutterlin, S.1    Hoang, T.2
  • 168
    • 84896979169 scopus 로고    scopus 로고
    • Transcriptional control of early T and B cell developmental choices
    • Rothenberg, E.V., Transcriptional control of early T and B cell developmental choices. Annual Review of Immunology 32 (2014), 283–321, 10.1146/annurev-immunol-032712-100024.
    • (2014) Annual Review of Immunology , vol.32 , pp. 283-321
    • Rothenberg, E.V.1
  • 170
    • 0028168540 scopus 로고
    • Transcriptional activation by TAL1 and FUS-CHOP proteins expressed in acute malignancies as a result of chromosomal abnormalities
    • Sanchez-Garcia, I., Rabbitts, T.H., Transcriptional activation by TAL1 and FUS-CHOP proteins expressed in acute malignancies as a result of chromosomal abnormalities. Proceedings of the National Academy of Sciences of the United States of America 91:17 (1994), 7869–7873.
    • (1994) Proceedings of the National Academy of Sciences of the United States of America , vol.91 , Issue.17 , pp. 7869-7873
    • Sanchez-Garcia, I.1    Rabbitts, T.H.2
  • 171
    • 84865109759 scopus 로고    scopus 로고
    • Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia
    • Sanda, T., Lawton, L.N., Barrasa, M.I., Fan, Z.P., Kohlhammer, H., Gutierrez, A., Look, A.T., Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. Cancer Cell 22:2 (2012), 209–221.
    • (2012) Cancer Cell , vol.22 , Issue.2 , pp. 209-221
    • Sanda, T.1    Lawton, L.N.2    Barrasa, M.I.3    Fan, Z.P.4    Kohlhammer, H.5    Gutierrez, A.6    Look, A.T.7
  • 172
    • 0029091845 scopus 로고
    • Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo
    • Sauvageau, G., Thorsteinsdottir, U., Eaves, C.J., Lawrence, H.J., Largman, C., Lansdorp, P.M., Humphries, R.K., Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes & Development 9:14 (1995), 1753–1765.
    • (1995) Genes & Development , vol.9 , Issue.14 , pp. 1753-1765
    • Sauvageau, G.1    Thorsteinsdottir, U.2    Eaves, C.J.3    Lawrence, H.J.4    Largman, C.5    Lansdorp, P.M.6    Humphries, R.K.7
  • 173
    • 0037079696 scopus 로고    scopus 로고
    • Multiple hematopoietic cell lineages develop in vivo from transplanted Pax5-deficient pre-B I-cell clones
    • Schaniel, C., Bruno, L., Melchers, F., Rolink, A.G., Multiple hematopoietic cell lineages develop in vivo from transplanted Pax5-deficient pre-B I-cell clones. Blood 99:2 (2002), 472–478.
    • (2002) Blood , vol.99 , Issue.2 , pp. 472-478
    • Schaniel, C.1    Bruno, L.2    Melchers, F.3    Rolink, A.G.4
  • 174
    • 0037089220 scopus 로고    scopus 로고
    • Extensive in vivo self-renewal, long-term reconstitution capacity, and hematopoietic multipotency of Pax5-deficient precursor B-cell clones
    • Schaniel, C., Gottar, M., Roosnek, E., Melchers, F., Rolink, A.G., Extensive in vivo self-renewal, long-term reconstitution capacity, and hematopoietic multipotency of Pax5-deficient precursor B-cell clones. Blood 99:8 (2002), 2760–2766.
    • (2002) Blood , vol.99 , Issue.8 , pp. 2760-2766
    • Schaniel, C.1    Gottar, M.2    Roosnek, E.3    Melchers, F.4    Rolink, A.G.5
  • 176
    • 34547482623 scopus 로고    scopus 로고
    • Vessel and blood specification override cardiac potential in anterior mesoderm
    • Schoenebeck, J.J., Keegan, B.R., Yelon, D., Vessel and blood specification override cardiac potential in anterior mesoderm. Developmental Cell 13:2 (2007), 254–267.
    • (2007) Developmental Cell , vol.13 , Issue.2 , pp. 254-267
    • Schoenebeck, J.J.1    Keegan, B.R.2    Yelon, D.3
  • 178
    • 27944475459 scopus 로고    scopus 로고
    • ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis
    • Schuh, A.H., Tipping, A.J., Clark, A.J., Hamlett, I., Guyot, B., Iborra, F.J., Porcher, C., ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis. Molecular and Cellular Biology 25:23 (2005), 10235–10250.
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.23 , pp. 10235-10250
    • Schuh, A.H.1    Tipping, A.J.2    Clark, A.J.3    Hamlett, I.4    Guyot, B.5    Iborra, F.J.6    Porcher, C.7
  • 180
    • 0030831104 scopus 로고    scopus 로고
    • A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis
    • Shalaby, F., Ho, J., Stanford, W.L., Fischer, K.D., Schuh, A.C., Schwartz, L., Rossant, J., A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis. Cell 89:6 (1997), 981–990.
    • (1997) Cell , vol.89 , Issue.6 , pp. 981-990
    • Shalaby, F.1    Ho, J.2    Stanford, W.L.3    Fischer, K.D.4    Schuh, A.C.5    Schwartz, L.6    Rossant, J.7
  • 181
  • 182
    • 0028858855 scopus 로고
    • Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
    • Shivdasani, R.A., Mayer, E.L., Orkin, S.H., Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature 373:6513 (1995), 432–434, 10.1038/373432a0.
    • (1995) Nature , vol.373 , Issue.6513 , pp. 432-434
    • Shivdasani, R.A.1    Mayer, E.L.2    Orkin, S.H.3
  • 184
    • 0031048644 scopus 로고    scopus 로고
    • Initiation of murine embryonic erythropoiesis: A spatial analysis
    • Silver, L., Palis, J., Initiation of murine embryonic erythropoiesis: A spatial analysis. Blood 89:4 (1997), 1154–1164.
    • (1997) Blood , vol.89 , Issue.4 , pp. 1154-1164
    • Silver, L.1    Palis, J.2
  • 185
    • 0344061505 scopus 로고    scopus 로고
    • Distinct 5' SCL enhancers direct transcription to developing brain, spinal cord, and endothelium: Neural expression Is mediated by GATA factor binding sites
    • Sinclair, A.M., Gottgens, B., Barton, L.M., Stanley, M.L., Pardanaud, L., Klaine, M., Green, A.R., Distinct 5' SCL enhancers direct transcription to developing brain, spinal cord, and endothelium: Neural expression Is mediated by GATA factor binding sites. Developmental Biology 209:1 (1999), 128–142.
    • (1999) Developmental Biology , vol.209 , Issue.1 , pp. 128-142
    • Sinclair, A.M.1    Gottgens, B.2    Barton, L.M.3    Stanley, M.L.4    Pardanaud, L.5    Klaine, M.6    Green, A.R.7
  • 186
    • 84940030328 scopus 로고    scopus 로고
    • Two new routes to make blood: Hematopoietic specification from pluripotent cell lines versus reprogramming of somatic cells
    • Singbrant, S., van Galen, P., Lucas, D., Challen, G., Rossi, D.J., Daley, G.Q., Two new routes to make blood: Hematopoietic specification from pluripotent cell lines versus reprogramming of somatic cells. Experimental Hematology 43:9 (2015), 756–759.
    • (2015) Experimental Hematology , vol.43 , Issue.9 , pp. 756-759
    • Singbrant, S.1    van Galen, P.2    Lucas, D.3    Challen, G.4    Rossi, D.J.5    Daley, G.Q.6
  • 187
    • 84928275441 scopus 로고    scopus 로고
    • Transcriptional network control of normal and leukaemic haematopoiesis
    • Sive, J.I., Gottgens, B., Transcriptional network control of normal and leukaemic haematopoiesis. Experimental Cell Research 329:2 (2014), 255–264.
    • (2014) Experimental Cell Research , vol.329 , Issue.2 , pp. 255-264
    • Sive, J.I.1    Gottgens, B.2
  • 189
    • 77950533581 scopus 로고    scopus 로고
    • Scl and stem cell quiescence
    • Sorrentino, B.P., Scl and stem cell quiescence. Blood 115:4 (2010), 751–752.
    • (2010) Blood , vol.115 , Issue.4 , pp. 751-752
    • Sorrentino, B.P.1
  • 190
    • 58949098459 scopus 로고    scopus 로고
    • Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival
    • Souroullas, G.P., Salmon, J.M., Sablitzky, F., Curtis, D.J., Goodell, M.A., Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival. Cell Stem Cell 4:2 (2009), 180–186.
    • (2009) Cell Stem Cell , vol.4 , Issue.2 , pp. 180-186
    • Souroullas, G.P.1    Salmon, J.M.2    Sablitzky, F.3    Curtis, D.J.4    Goodell, M.A.5
  • 192
    • 0028954460 scopus 로고
    • Differential regulation of macrophage differentiation in response to leukemia inhibitory factor/oncostatin-M/interleukin-6: The effect of enforced expression of the SCL transcription factor
    • Tanigawa, T., Nicola, N., McArthur, G.A., Strasser, A., Begley, C.G., Differential regulation of macrophage differentiation in response to leukemia inhibitory factor/oncostatin-M/interleukin-6: The effect of enforced expression of the SCL transcription factor. Blood 85:2 (1995), 379–390.
    • (1995) Blood , vol.85 , Issue.2 , pp. 379-390
    • Tanigawa, T.1    Nicola, N.2    McArthur, G.A.3    Strasser, A.4    Begley, C.G.5
  • 193
    • 79551585898 scopus 로고    scopus 로고
    • ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification
    • Taoudi, S., Bee, T., Hilton, A., Knezevic, K., Scott, J., Willson, T.A., Hilton, D.J., ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes & Development 25:3 (2011), 251–262.
    • (2011) Genes & Development , vol.25 , Issue.3 , pp. 251-262
    • Taoudi, S.1    Bee, T.2    Hilton, A.3    Knezevic, K.4    Scott, J.5    Willson, T.A.6    Hilton, D.J.7
  • 196
    • 77649119006 scopus 로고    scopus 로고
    • Awakening dormant haematopoietic stem cells
    • Trumpp, A., Essers, M., Wilson, A., Awakening dormant haematopoietic stem cells. Nature Reviews. Immunology 10:3 (2010), 201–209.
    • (2010) Nature Reviews. Immunology , vol.10 , Issue.3 , pp. 201-209
    • Trumpp, A.1    Essers, M.2    Wilson, A.3
  • 197
    • 0032005207 scopus 로고    scopus 로고
    • Enforced TAL-1 expression stimulates primitive, erythroid and megakaryocytic progenitors but blocks the granulopoietic differentiation program
    • Valtieri, M., Tocci, A., Gabbianelli, M., Luchetti, L., Masella, B., Vitelli, L., Peschle, C., Enforced TAL-1 expression stimulates primitive, erythroid and megakaryocytic progenitors but blocks the granulopoietic differentiation program. Cancer Research 58:3 (1998), 562–569.
    • (1998) Cancer Research , vol.58 , Issue.3 , pp. 562-569
    • Valtieri, M.1    Tocci, A.2    Gabbianelli, M.3    Luchetti, L.4    Masella, B.5    Vitelli, L.6    Peschle, C.7
  • 200
    • 84867179824 scopus 로고    scopus 로고
    • The molecular basis of T cell acute lymphoblastic leukemia
    • Van Vlierberghe, P., Ferrando, A., The molecular basis of T cell acute lymphoblastic leukemia. The Journal of Clinical Investigation 122:10 (2012), 3398–3406.
    • (2012) The Journal of Clinical Investigation , vol.122 , Issue.10 , pp. 3398-3406
    • Van Vlierberghe, P.1    Ferrando, A.2
  • 202
    • 0026023097 scopus 로고
    • Differential expression of the LYL, SCL and E2A helix-loop-helix genes within the hemopoietic system
    • Visvader, J., Begley, C.G., Adams, J.M., Differential expression of the LYL, SCL and E2A helix-loop-helix genes within the hemopoietic system. Oncogene 6:2 (1991), 187–194.
    • (1991) Oncogene , vol.6 , Issue.2 , pp. 187-194
    • Visvader, J.1    Begley, C.G.2    Adams, J.M.3
  • 203
    • 0032520080 scopus 로고    scopus 로고
    • Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development
    • Visvader, J.E., Fujiwara, Y., Orkin, S.H., Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes & Development 12:4 (1998), 473–479.
    • (1998) Genes & Development , vol.12 , Issue.4 , pp. 473-479
    • Visvader, J.E.1    Fujiwara, Y.2    Orkin, S.H.3
  • 204
    • 84928910821 scopus 로고    scopus 로고
    • De novo generation of HSCs from somatic and pluripotent stem cell sources
    • Vo, L.T., Daley, G.Q., De novo generation of HSCs from somatic and pluripotent stem cell sources. Blood 125:17 (2015), 2641–2648.
    • (2015) Blood , vol.125 , Issue.17 , pp. 2641-2648
    • Vo, L.T.1    Daley, G.Q.2
  • 205
    • 0028276834 scopus 로고
    • The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by Id proteins during interleukin 6-induced myeloid differentiation
    • Voronova, A.F., Lee, F., The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by Id proteins during interleukin 6-induced myeloid differentiation. Proceedings of the National Academy of Sciences of the United States of America 91:13 (1994), 5952–5956.
    • (1994) Proceedings of the National Academy of Sciences of the United States of America , vol.91 , Issue.13 , pp. 5952-5956
    • Voronova, A.F.1    Lee, F.2
  • 206
    • 0032789064 scopus 로고    scopus 로고
    • Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene
    • Vyas, P., McDevitt, M.A., Cantor, A.B., Katz, S.G., Fujiwara, Y., Orkin, S.H., Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene. Development 126:12 (1999), 2799–2811.
    • (1999) Development , vol.126 , Issue.12 , pp. 2799-2811
    • Vyas, P.1    McDevitt, M.A.2    Cantor, A.B.3    Katz, S.G.4    Fujiwara, Y.5    Orkin, S.H.6
  • 207
    • 0028113973 scopus 로고
    • The MAP kinase phosphorylation site of TAL1 occurs within a transcriptional activation domain
    • Wadman, I.A., Hsu, H.L., Cobb, M.H., Baer, R., The MAP kinase phosphorylation site of TAL1 occurs within a transcriptional activation domain. Oncogene 9:12 (1994), 3713–3716.
    • (1994) Oncogene , vol.9 , Issue.12 , pp. 3713-3716
    • Wadman, I.A.1    Hsu, H.L.2    Cobb, M.H.3    Baer, R.4
  • 208
    • 0030999645 scopus 로고    scopus 로고
    • The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins
    • Wadman, I.A., Osada, H., Grutz, G.G., Agulnick, A.D., Westphal, H., Forster, A., Rabbitts, T.H., The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. The EMBO Journal 16:11 (1997), 3145–3157.
    • (1997) The EMBO Journal , vol.16 , Issue.11 , pp. 3145-3157
    • Wadman, I.A.1    Osada, H.2    Grutz, G.G.3    Agulnick, A.D.4    Westphal, H.5    Forster, A.6    Rabbitts, T.H.7
  • 209
    • 3142776112 scopus 로고    scopus 로고
    • Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties
    • Wang, L., Li, L., Shojaei, F., Levac, K., Cerdan, C., Menendez, P., Bhatia, M., Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties. Immunity 21:1 (2004), 31–41.
    • (2004) Immunity , vol.21 , Issue.1 , pp. 31-41
    • Wang, L.1    Li, L.2    Shojaei, F.3    Levac, K.4    Cerdan, C.5    Menendez, P.6    Bhatia, M.7
  • 210
    • 84865366974 scopus 로고    scopus 로고
    • ETV2 expression marks blood and endothelium precursors, including hemogenic endothelium, at the onset of blood development
    • Wareing, S., Eliades, A., Lacaud, G., Kouskoff, V., ETV2 expression marks blood and endothelium precursors, including hemogenic endothelium, at the onset of blood development. Developmental Dynamics 241:9 (2012), 1454–1464.
    • (2012) Developmental Dynamics , vol.241 , Issue.9 , pp. 1454-1464
    • Wareing, S.1    Eliades, A.2    Lacaud, G.3    Kouskoff, V.4
  • 211
    • 84862878344 scopus 로고    scopus 로고
    • The Flk1-Cre-mediated deletion of ETV2 defines its narrow temporal requirement during embryonic hematopoietic development
    • Wareing, S., Mazan, A., Pearson, S., Gottgens, B., Lacaud, G., Kouskoff, V., The Flk1-Cre-mediated deletion of ETV2 defines its narrow temporal requirement during embryonic hematopoietic development. Stem Cells 30:7 (2012), 1521–1531.
    • (2012) Stem Cells , vol.30 , Issue.7 , pp. 1521-1531
    • Wareing, S.1    Mazan, A.2    Pearson, S.3    Gottgens, B.4    Lacaud, G.5    Kouskoff, V.6
  • 212
    • 77957348625 scopus 로고    scopus 로고
    • Combinatorial transcriptional control in Blood stem/progenitor cells: Genome-wide analysis of ten major transcriptional regulators
    • Wilson, N.K., Foster, S.D., Wang, X., Knezevic, K., Schutte, J., Kaimakis, P., Gottgens, B., Combinatorial transcriptional control in Blood stem/progenitor cells: Genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell 7:4 (2010), 532–544.
    • (2010) Cell Stem Cell , vol.7 , Issue.4 , pp. 532-544
    • Wilson, N.K.1    Foster, S.D.2    Wang, X.3    Knezevic, K.4    Schutte, J.5    Kaimakis, P.6    Gottgens, B.7
  • 213
    • 0029149656 scopus 로고
    • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
    • Winnier, G., Blessing, M., Labosky, P.A., Hogan, B.L., Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes & Development 9:17 (1995), 2105–2116.
    • (1995) Genes & Development , vol.9 , Issue.17 , pp. 2105-2116
    • Winnier, G.1    Blessing, M.2    Labosky, P.A.3    Hogan, B.L.4
  • 214
    • 0028880455 scopus 로고
    • Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
    • Wu, H., Liu, X., Jaenisch, R., Lodish, H.F., Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 83:1 (1995), 59–67.
    • (1995) Cell , vol.83 , Issue.1 , pp. 59-67
    • Wu, H.1    Liu, X.2    Jaenisch, R.3    Lodish, H.F.4
  • 215
    • 0142091497 scopus 로고    scopus 로고
    • Identification of a TAL1 target gene reveals a positive role for the LIM domain-binding protein Ldb1 in erythroid gene expression and differentiation
    • Xu, Z., Huang, S., Chang, L.S., Agulnick, A.D., Brandt, S.J., Identification of a TAL1 target gene reveals a positive role for the LIM domain-binding protein Ldb1 in erythroid gene expression and differentiation. Molecular and Cellular Biology 23:21 (2003), 7585–7599.
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.21 , pp. 7585-7599
    • Xu, Z.1    Huang, S.2    Chang, L.S.3    Agulnick, A.D.4    Brandt, S.J.5
  • 216
    • 0034597798 scopus 로고    scopus 로고
    • Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors
    • Yamashita, J., Itoh, H., Hirashima, M., Ogawa, M., Nishikawa, S., Yurugi, T., Nishikawa, S., Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature 408:6808 (2000), 92–96.
    • (2000) Nature , vol.408 , Issue.6808 , pp. 92-96
    • Yamashita, J.1    Itoh, H.2    Hirashima, M.3    Ogawa, M.4    Nishikawa, S.5    Yurugi, T.6    Nishikawa, S.7
  • 218
    • 84898989110 scopus 로고    scopus 로고
    • The hematopoietic regulator TAL1 is required for chromatin looping between the beta-globin LCR and human gamma-globin genes to activate transcription
    • Yun, W.J., Kim, Y.W., Kang, Y., Lee, J., Dean, A., Kim, A., The hematopoietic regulator TAL1 is required for chromatin looping between the beta-globin LCR and human gamma-globin genes to activate transcription. Nucleic Acids Research 42:7 (2014), 4283–4293.
    • (2014) Nucleic Acids Research , vol.42 , Issue.7 , pp. 4283-4293
    • Yun, W.J.1    Kim, Y.W.2    Kang, Y.3    Lee, J.4    Dean, A.5    Kim, A.6
  • 219
    • 4344669438 scopus 로고    scopus 로고
    • E protein silencing by the leukemogenic AML1-ETO fusion protein
    • Zhang, J., Kalkum, M., Yamamura, S., Chait, B.T., Roeder, R.G., E protein silencing by the leukemogenic AML1-ETO fusion protein. Science 305:5688 (2004), 1286–1289.
    • (2004) Science , vol.305 , Issue.5688 , pp. 1286-1289
    • Zhang, J.1    Kalkum, M.2    Yamamura, S.3    Chait, B.T.4    Roeder, R.G.5
  • 220
    • 84859157183 scopus 로고    scopus 로고
    • Dynamic transformations of genome-wide epigenetic marking and transcriptional control establish T cell identity
    • Zhang, J.A., Mortazavi, A., Williams, B.A., Wold, B.J., Rothenberg, E.V., Dynamic transformations of genome-wide epigenetic marking and transcriptional control establish T cell identity. Cell 149:2 (2012), 467–482.
    • (2012) Cell , vol.149 , Issue.2 , pp. 467-482
    • Zhang, J.A.1    Mortazavi, A.2    Williams, B.A.3    Wold, B.J.4    Rothenberg, E.V.5


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