Characterization of DNA-binding-dependent and -independent functions of SCL/TAL1 during human erythropoiesis

Blood

Volumn 103, Issue 9, 2004, Pages 3326-3335

  Ravet, Emmanuel ^a   Reynaud, Damien ^a   Titeux, Monique ^a   Izac, Brigitte ^a   Fichelson, Serge ^a   Roméo, Paul Henri ^a   Dubart Kupperschmitt, Anne ^a   Pflumio, Françoise ^a  

^a INSTITUT COCHIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; DNA BINDING PROTEIN; GLYCOPHORIN A; LENTIVIRUS VECTOR; PORPHOBILINOGEN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TAL1; UNCLASSIFIED DRUG;

ARTICLE; BURST FORMING UNIT E; CELL DIFFERENTIATION; COLONY FORMING UNIT E; CONTROLLED STUDY; DOWN REGULATION; ERYTHROPOIESIS; FEMALE; GENE EXPRESSION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 1942521618     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-05-1689     Document Type: Article

References (39)

1. Begley CG, Green AR. The SCL gene: from case report to critical hematopoietic regulator. Blood. 1999;93:2760-2770.
2. Elefanty AG, Begley CG, Metcalf D, Barnett L, Köntgen F, Robb L. Characterization of hematopoietic progenitor cells that express the transcription factor SCL, using a lacZ "knock-in" strategy. Proc Natl Acad Sci U S A. 1998;95:11897-11902.
3. Elefanty AG, Begley CG, Hartley L, Papaevangeliou B, Robb L. SCL expression in the mouse embryo detected with a targeted lacZ reporter gene demonstrates its localization to hematopoietic, vascular, and neural tissues. Blood. 1999;94:3754-3763.
4. Robb L, Lyons I, Li R, et al. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A. 1995;92:7075-7079.
5. Robb L, Elwood NJ, Elefanty AG, et al. The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse. EMBO J. 1996;15:4123-4129.
6. Porcher C, Swat W, Rockwell K, Fuiiwara Y, Alt FW, Orkin SH. The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell. 1996;86:47-57.
7. Mikkola HK, Klintman J, Yang H, et al. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature. 2003;421:547-551.
8. Hall MA, Curtis DJ, Metcalf D, et al. The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc Natl Acad Sci U S A. 2003;100:992-997.
9. Hsu HL, Wadman I, Baer R. Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells. Proc Natl Acad Sci U S A. 1994;91:3181-3185.
10. Hsu HL, Huang L, Tsan JT, et al. Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins. Mol Cell Biol. 1994;14:1256-1265.
11. Porcher C, Liao EC, Fujiwara Y, Zon LI, Orkin SH. Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. Development. 1999;126:4603-4615.
12. O'Neil J, Billa M, Oikemus S, Kelliher M. The DNA binding activity of TAL1 is not required to induce leukemia/lymphoma in mice. Oncogene. 2001;20:3897-3905.
13. Hsu HL, Wadman I, Tsan JT, Baer R. Positive and negative transcriptional control by the TAL1 helix-loop-helix protein. Proc Natl Acad Sci U S A. 1994;91:5947-5951.
14. Wadman IA, Osada H, Grutz GG, et al. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins, EMBO J. 1997;16:3145-3157.
15. Ono Y, Fukuhara N, Yoshie O. TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. Mol Cell Biol. 1998;18:6939-6950.
16. Elwood NJ, Zogos H, Pereira DS, Dick JE, Begley CG. Enhanced megakaryocyte and erythroid development from normal human CD34(+) cells: consequence of enforced expression of SCL. Blood. 1998;91:3756-3765.
17. Valtieri M, Tocci A, Gabbianelli M, et al. Enforced TAL1 expression stimulates primitive, erythroid and megakaryocytic progenitors but blocks the granulopoietic differentiation program. Cancer Res. 1998;58:562-569.
18. Sirven A, Pflumio F, Zennou V, et al. The human immunodeficiency virus type-1 central DNA flap is a crucial determinant for lentiviral vector nuclear import and gene transduction of human hematopoietic stem cells. Blood. 2000;96:4103-4110.
19. Amselem S, Ravet E, Fichelson S, Pflumio F, Dubart-Kupperschmitt A. Maximal lentivirus-mediated gene transfer and sustained transgene expression in human hematopoietic primitive cells and their progeny. Mol Ther. 2002;6:673-677.
20. Freyssinier JM, Lecoq-Lafon C, Amsellem S, et al. Purification, amplification and characterization of a population of human erythroid progenitors. Br J Haematol. 1999;106:912-922.
21. +-derived hematopoietic cells, including developing T cells and NOD-SCID mouse repopulating cells, following transduction with modified TRIP lentiviral vectors. Mol Ther. 2001;3:438-448.
22. Robin C, Pflumio F, Vainchenker W, Coulombel L. Identification of lymphomyeloid primitive progenitor cells in fresh human cord blood and in the marrow of nonobese diabetic-severe combined immunodeficient (NOD-SCID) mice transplanted with human CD34(+) cord blood cells. J Exp Med. 1999;189:1601-1610.
23. Cwirla, SE, Balasubramanian P, Duffin DJ, et al. Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine, Science. 1997;276:1696-1699.
24. Leroy-Viard K, Vinit MA, Lecointe N, et al. Loss of TAL1 protein activity induces premature apoptosis of Jurkat leukemic T cells upon medium depletion. EMBO J. 1995;14:2341-2349.
25. - progenitor cells in long-term cultures and semisolid assays. Blood. 1993;81:2916-2924.
26. low primitive cells capable of reconstituting long-term cultures in vitro and nonobese diabetic-severe combined immunodeficiency mice in vivo. Hum Gene Ther. 1998;9:1497-1511.
27. Nocka K, Majumder S, Chabot B, et al. Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice-evidence for an impaired c-kit kinase in mutant mice. Genes Dev. 1989;3:816-826.
28. Condorelli GL, Tocci A, Botta R, et al. Ectopic TAL1/SCL expression in phenotypically normal or leukemic myeloid precursors: proliferative and antiapoptotic effects coupled with a differentiation blockade. Mol Cell Biol. 1997;17:2954-2969.
29. Hoang T, Paradis E, Brady G, et al. Opposing effects of the basic helix-loop-helix transcription factor SCL on erythroid and monocytic differentiation. Blood. 1996;87:102-111.
30. Tanigawa T, Nicola N, McArthur GA, Strasser A, Begley CG. Differential regulation of macrophage differentiation in response to leukemia inhibitory factor/oncostatin-M/interleukin-6: the effect of enforced expression of the SCL transcription factor. Blood. 1995;85:379-390.
31. Kitajima K, Masuhara M, Era T, Enver T, Nakano T. GATA-2 and GATA-2/ER display opposing activities in the development and differentiation of blood progenitors. EMBO J. 2002;21:3060-3069.
32. Lecuyer E, Herblot S, Saint-Denis M, et al. The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Spl. Blood. 2002;100:2430-2440.
33. Lahlil R, Lecuyer E, Herblot S, Hoang T. SCL assembles a multifactorial complex that determines glycophorin A expression. Mol Cell Biol. 2004;24:1439-1452.
34. + bone marrow cells in the absence of detectable cell differentiation. Stem Cells. 2001;19:59-70.
35. Miller EA, Floros J, Cheung JY, et al. Steel factor affects SCL expression during normal erythroid differentiation. Blood. 1994;84:2971-2976.
36. Krosl G, He G, Lefrancois M, et al. Transcription factor SCL is required for c-kit expression and c-Kit function in hemopoietic cells. J Exp Med. 1998;188:439-450.
37. Vitelli L, Condorelli G, Lulli V, et al. A pentamer transcriptional complex including tal1 and retinoblastoma protein downmodulates c-kit expression in normal erythroblasts. Mol Cell Biol. 2000;20:5330-5342.
38. Wu H, Klingmüller U, Acurio A, Hsiao JG, Lodish HF. Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation. Proc Natl Acad Sci USA. 1995;94:1806-1810.
39. Lyman SD, Jacobsen SEW. c-kit ligand and Flt3 ligand: setm/progenitor cell factors with overlapping yet distinct activities. Blood. 1998;91:1101-1134.