Genetic interaction between Kit and Scl

Blood

Volumn 122, Issue 7, 2013, Pages 1150-1161

  Lacombe, Julie ^a   Krosl, Gorazd ^a,b   Tremblay, Mathieu ^a   Gerby, Bastien ^a   Martin, Richard ^a   Aplan, Peter D ^c   Lemieux, Sebastien ^a   Hoang, Trang ^a,d  

^a INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^b UNIVERSITY OF MONTREAL   (Canada)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; INTERLEUKIN 3; STEM CELL FACTOR; TRANSCRIPTION FACTOR TAL1; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BIOLOGICAL MARKER; MESSENGER RNA; ONCOPROTEIN; STEM CELL FACTOR RECEPTOR; TAL1 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL SURVIVAL; CHIMERA; CHROMATIN IMMUNOPRECIPITATION; FLOW CYTOMETRY; GENE EXPRESSION; GENE INTERACTION; GENE TRANSFER; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MEGAKARYOCYTE ERYTHROID PROGENITOR; MOUSE; MULTIPOTENT STEM CELL; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; RECEPTOR UPREGULATION; STEM CELL EXPANSION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; DNA MICROARRAY; ENZYME IMMUNOASSAY; ERYTHROID PRECURSOR CELL; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; ERYTHROID PRECURSOR CELLS; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HUMANS; IMMUNOENZYME TECHNIQUES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MULTIPOTENT STEM CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-KIT; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEM CELL FACTOR;

EID: 84887140173     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-01-331819     Document Type: Article

References (56)

1. Laslo P, Spooner CJ, Warmflash A, et al. Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell. 2006;126(4):755-766.
2. Kent D, Copley M, Benz C, Dykstra B, Bowie M, Eaves C. Regulation of hematopoietic stem cells by the steel factor/KIT signaling pathway. Clin Cancer Res. 2008;14(7):1926-1930.
3. McCulloch EA, Siminovitch L, Till JE, Russell ES, Bernstein SE. The cellular basis of the genetically determined hemopoietic defect in anemic mice of genotype Sl-Sld. Blood. 1965;26(4):399-410.
4. McCulloch EA, Siminovitch L, Till JE. Spleencolony formation in anemic mice of genotype WW. Science. 1964;144(3620):844-846.
5. Nocka K, Majumder S, Chabot B, et al. Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice - evidence for an impaired c-kit kinase in mutant mice. Genes Dev. 1989;3(6): 816-826.
6. Miller CL, Rebel VI, Helgason CD, Lansdorp PM, Eaves CJ. Impaired steel factor responsiveness differentially affects the detection and long-term maintenance of fetal liver hematopoietic stem cells in vivo. Blood. 1997;89(4):1214-1223.
7. Cáceres-Cortés J, Rajotte D, Dumouchel J, Haddad P, Hoang T. Product of the steel locus suppresses apoptosis in hemopoietic cells. Comparison with pathways activated by granulocyte macrophage colony-stimulating factor. J Biol Chem. 1994;269(16):12084-12091.
8. Borge OJ, Ramsfjell V, Cui L, Jacobsen SE. Ability of early acting cytokines to directly promote survival and suppress apoptosis of human primitive CD341CD38-bone marrow cells with multilineage potential at the single-cell level: key role of thrombopoietin. Blood. 1997;90(6): 2282-2292.
9. Li CL, Johnson GR. Stem cell factor enhances the survival but not the self-renewal of murine hematopoietic long-term repopulating cells. Blood. 1994;84(2):408-414.
10. Carson WE, Haldar S, Baiocchi RA, Croce CM, Caligiuri MA. The c-kit ligand suppresses apoptosis of human natural killer cells through the upregulation of bcl-2. Proc Natl Acad Sci USA. 1994;91(16):7553-7557.
11. Gommerman JL, Berger SA. Protection from apoptosis by steel factor but not interleukin-3 is reversed through blockade of calcium influx. Blood. 1998;91(6):1891-1900.
12. Robb L, Lyons I, Li R, et al. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci USA. 1995;92(15):7075-7079.
13. Shivdasani RA, Mayer EL, Orkin SH. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature. 1995; 373(6513):432-434.
14. Brady G, Billia F, Knox J, et al. Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells. Curr Biol. 1995;5(8):909-922.
15. Elefanty AG, Begley CG, Metcalf D, Barnett L, Köntgen F, Robb L. Characterization of hematopoietic progenitor cells that express the transcription factor SCL, using a lacZ "knock-in" strategy. Proc Natl Acad Sci USA. 1998;95(20): 11897-11902.
16. Lacombe J, Herblot S, Rojas-Sutterlin S, et al. Scl regulates the quiescence and the long-term competence of hematopoietic stem cells. Blood. 2010;115(4):792-803.
17. Souroullas GP, Salmon JM, Sablitzky F, Curtis DJ, Goodell MA. Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival. Cell Stem Cell. 2009;4(2):180-186.
18. Elwood NJ, Zogos H, Pereira DS, Dick JE, Begley CG. Enhanced megakaryocyte and erythroid development from normal human CD34(1) cells: consequence of enforced expression of SCL. Blood. 1998;91(10):3756-3765.
19. Aplan PD, Nakahara K, Orkin SH, Kirsch IR. The SCL gene product: a positive regulator of erythroid differentiation. EMBO J. 1992;11(11): 4073-4081.
20. Hall MA, Curtis DJ, Metcalf D, et al. The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc Natl Acad Sci USA. 2003;100(3):992-997.
21. Mikkola HK, Klintman J, Yang H, et al. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature. 2003;421(6922):547-551.
22. Curtis DJ, Hall MA, Van Stekelenburg LJ, Robb L, Jane SM, Begley CG. SCL is required for normal function of short-term repopulating hematopoietic stem cells. Blood. 2004;103(9):3342-3348.
23. Bernard M, Delabesse E, Novault S, Hermine O, Macintyre EA. Antiapoptotic effect of ectopic TAL1/SCL expression in a human leukemic T-cell line. Cancer Res. 1998;58(12):2680-2687.
24. Martin R, Lahlil R, Damert A, et al. SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis. Development. 2004;131(3): 693-702.
25. Liao EC, Paw BH, Oates AC, Pratt SJ, Postlethwait JH, Zon LI. SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish. Genes Dev. 1998;12(5):621-626.
26. Lécuyer E, Herblot S, Saint-Denis M, et al. The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1. Blood. 2002;100(7):2430-2440.
27. Kassouf MT, Hughes JR, Taylor S, et al. Genomewide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells. Genome Res. 2010;20(8): 1064-1083.
28. Krosl G, He G, Lefrancois M, et al. Transcription factor SCL is required for c-kit expression and c-Kit function in hemopoietic cells. J Exp Med. 1998;188(3):439-450.
29. Miller BA, Floros J, Cheung JY, et al. Steel factor affects SCL expression during normal erythroid differentiation. Blood. 1994;84(9):2971-2976.
30. Caceres-Cortes JR, Krosl G, Tessier N, Hugo P, Hoang T. Steel factor sustains SCL expression and the survival of purified CD341 bone marrow cells in the absence of detectable cell differentiation. Stem Cells. 2001;19(1):59-70.
31. Aplan PD, Jones CA, Chervinsky DS, et al. An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice. EMBO J. 1997;16(9):2408-2419.
32. Akashi K, Traver D, Miyamoto T, Weissman IL. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 2000; 404(6774):193-197.
33. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc B. 1995;57(1): 289-300.
34. Goardon N, Lambert JA, Rodriguez P, et al. ETO2 coordinates cellular proliferation and differentiation during erythropoiesis. EMBO J. 2006;25(2):357-366.
35. Wilson NK, Foster SD, Wang X, et al. Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell. 2010;7(4):532-544.
36. Geissler EN, McFarland EC, Russell ES. Analysis of pleiotropism at the dominant white-spotting (W) locus of the house mouse: a description of ten new W alleles. Genetics. 1981;97(2):337-361.
37. Reith AD, Rottapel R, Giddens E, Brady C, Forrester L, Bernstein A. W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor. Genes Dev. 1990;4(3):390-400.
38. Miller CL, Rebel VI, Lemieux ME, Helgason CD, Lansdorp PM, Eaves CJ. Studies of W mutant mice provide evidence for alternate mechanisms capable of activating hematopoietic stem cells. Exp Hematol. 1996;24(2):185-194.
39. Dey S, Curtis DJ, Jane SM, Brandt SJ. The TAL1/SCL transcription factor regulates cell cycle progression and proliferation in differentiating murine bone marrow monocyte precursors. Mol Cell Biol. 2010;30(9):2181-2192.
40. Agosti V, Karur V, Sathyanarayana P, Besmer P, Wojchowski DM. A KIT juxtamembrane PY567-directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis. Exp Hematol. 2009;37(2): 159-171.
41. Williams DE, Eisenman J, Baird A, et al. Identification of a ligand for the c-kit protooncogene. Cell. 1990;63(1):167-174.
42. Thorén LA, Liuba K, Bryder D, et al. Kit regulates maintenance of quiescent hematopoietic stem cells. J Immunol. 2008;180(4):2045-2053.
43. Condorelli GL, Tocci A, Botta R, et al. Ectopic TAL-1/SCL expression in phenotypically normal or leukemic myeloid precursors: proliferative and antiapoptotic effects coupled with a differentiation blockade. Mol Cell Biol. 1997;17(5):2954-2969.
44. Capron C, Lécluse Y, Kaushik AL, et al. The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation. Blood. 2006;107(12):4678-4686.
45. Capron C, Lacout C, Lécluse Y, et al. LYL-1 deficiency induces a stress erythropoiesis. Exp Hematol. 2011;39(6):629-642.
46. Zeuner A, Eramo A, Testa U, et al. Control of erythroid cell production via caspase-mediated cleavage of transcription factor SCL/Tal-1. Cell Death Differ. 2003;10(8):905-913.
47. Cardoso BA, de Almeida SF, Laranjeira AB, et al. TAL1/SCL is downregulated upon histone deacetylase inhibition in T-cell acute lymphoblastic leukemia cells. Leukemia. 2011;25(10): 1578-1586.
48. Leroy-Viard K, Vinit MA, Lecointe N, et al. Loss of TAL-1 protein activity induces premature apoptosis of Jurkat leukemic T cells upon medium depletion. EMBO J. 1995;14(10):2341-2349.
49. Patterson LJ, Gering M, Eckfeldt CE, et al. The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish. Blood. 2007;109(6):2389-2398.
50. Porcher C, Liao EC, Fujiwara Y, Zon LI, Orkin SH. Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. Development. 1999;126(20):4603-4615.
51. Lécuyer E, Larivi ère S, Sincennes MC, et al. Protein stability and transcription factor complex assembly determined by the SCL-LMO2 interaction. J Biol Chem. 2007;282(46): 33649-33658.
52. Ferrell JE Jr. Simple rules for complex processes: new lessons from the budding yeast cell cycle. Mol Cell. 2011;43(4):497-500.
53. Green YS, Vetter ML. EBF proteins participate in transcriptional regulation of Xenopus muscle development. Dev Biol. 2011;358(1):240-250.
54. Nakajima H, Ihle JN. Granulocyte colonystimulating factor regulates myeloid differentiation through CCAAT/enhancer-binding protein epsilon. Blood. 2001;98(4):897-905.
55. Zhang P, Iwama A, Datta MW, Darlington GJ, Link DC, Tenen DG. Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha (C/EBP alpha) is critical for granulopoiesis. J Exp Med. 1998;188(6): 1173-1184.
56. Verbeek W, Gombart AF, Chumakov AM, Müller C, Friedman AD, Koeffler HP. C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters. Blood. 1999;93(10): 3327-3337.