-
1
-
-
0030903602
-
Clinical features and treatment outcome of childhood T-lineage acute lymphoblastic leukemia according to the apparent maturational stage of T-lineage leukemic blasts: A Children's Cancer Group study
-
Uckun, F. M. et al. Clinical features and treatment outcome of childhood T-lineage acute lymphoblastic leukemia according to the apparent maturational stage of T-lineage leukemic blasts: a Children's Cancer Group study. J. Clin. Oncol. 15, 2214-2221 (1997).
-
(1997)
J. Clin. Oncol
, vol.15
, pp. 2214-2221
-
-
Uckun, F.M.1
-
2
-
-
0024209927
-
Clinical features and outcome in childhood T-cell leukemia-lymphoma according to stage of thymocyte differentiation: A Pediatric Oncology Group Study
-
Crist, W. M. et al. Clinical features and outcome in childhood T-cell leukemia-lymphoma according to stage of thymocyte differentiation: a Pediatric Oncology Group Study. Blood 72, 1891-1897 (1988).
-
(1988)
Blood
, vol.72
, pp. 1891-1897
-
-
Crist, W.M.1
-
3
-
-
33747608619
-
Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: From thymocyte to lymphoblast
-
Graux, C., Cools, J., Michaux, L., Vandenberghe, P. & Hagemeijer, A. Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast. Leukemia 20, 1496-1510 (2006).
-
(2006)
Leukemia
, vol.20
, pp. 1496-1510
-
-
Graux, C.1
Cools, J.2
Michaux, L.3
Vandenberghe, P.4
Hagemeijer, A.5
-
4
-
-
34548009617
-
The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children
-
Clappier, E. et al. The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children. Blood 110, 1251-1261 (2007).
-
(2007)
Blood
, vol.110
, pp. 1251-1261
-
-
Clappier, E.1
-
5
-
-
34247641748
-
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
-
Lahortiga, I. et al. Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. Nature Genet. 39, 593-595 (2007).
-
(2007)
Nature Genet
, vol.39
, pp. 593-595
-
-
Lahortiga, I.1
-
6
-
-
37549060588
-
Alu elements mediate MYB gene tandem duplication in human T-ALL
-
O'Neil, J. et al. Alu elements mediate MYB gene tandem duplication in human T-ALL. J. Exp. Med. (2007).
-
(2007)
J. Exp. Med
-
-
O'Neil, J.1
-
7
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
Weng, A. P. et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306, 269-271 (2004).
-
(2004)
Science
, vol.306
, pp. 269-271
-
-
Weng, A.P.1
-
8
-
-
0034010517
-
Lymphoid precursors
-
Akashi, K., Reya, T., Dalma-Weiszhausz, D. & Weissman, I. L. Lymphoid precursors. Curr. Opin. Immunol. 12, 144-150 (2000).
-
(2000)
Curr. Opin. Immunol
, vol.12
, pp. 144-150
-
-
Akashi, K.1
Reya, T.2
Dalma-Weiszhausz, D.3
Weissman, I.L.4
-
9
-
-
34247882592
-
Zoned out: Functional mapping of stromal signaling microenvironments in the thymus
-
Petrie, H. T. & Zúñiga-Pflücker, J. C. Zoned out: functional mapping of stromal signaling microenvironments in the thymus. Annu. Rev. Immunol. 25, 649-679 (2007).
-
(2007)
Annu. Rev. Immunol
, vol.25
, pp. 649-679
-
-
Petrie, H.T.1
Zúñiga-Pflücker, J.C.2
-
10
-
-
33646480885
-
A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus
-
Scimone, M. L., Aifantis, I., Apostolou, I., von Boehmer, H. & von Andrian, U. H. A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus. Proc. Natl Acad. Sci. USA 103, 7006-7011 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 7006-7011
-
-
Scimone, M.L.1
Aifantis, I.2
Apostolou, I.3
von Boehmer, H.4
von Andrian, U.H.5
-
11
-
-
0037304536
-
Thymic selection revisited: How essential is it?
-
Von Boehmer, H. et al. Thymic selection revisited: how essential is it? Immunol. Rev. 191, 62-78 (2003).
-
(2003)
Immunol. Rev
, vol.191
, pp. 62-78
-
-
Von Boehmer, H.1
-
12
-
-
0034010697
-
To be or not to be a pro-T?
-
Di Santo, J. P., Radtke, F. & Rodewald, H. R. To be or not to be a pro-T? Curr. Opin. Immunol. 12, 159-165 (2000).
-
(2000)
Curr. Opin. Immunol
, vol.12
, pp. 159-165
-
-
Di Santo, J.P.1
Radtke, F.2
Rodewald, H.R.3
-
13
-
-
33645095936
-
Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus
-
El Andaloussi, A. et al. Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nature Immunol. 7, 418-426 (2006).
-
(2006)
Nature Immunol
, vol.7
, pp. 418-426
-
-
El Andaloussi, A.1
-
14
-
-
0023996419
-
The molecular biology of the Notch locus and the fine tuning of differentiation in Drosophila
-
Artavanis-Tsakonas, S. The molecular biology of the Notch locus and the fine tuning of differentiation in Drosophila. Trends Genet. 4, 95-100 (1988).
-
(1988)
Trends Genet
, vol.4
, pp. 95-100
-
-
Artavanis-Tsakonas, S.1
-
15
-
-
33947241465
-
SnapShot: Notch signaling pathway
-
Ilagan, M. X. & Kopan, R. SnapShot: notch signaling pathway. Cell 128, 1246 (2007).
-
(2007)
Cell
, vol.128
, pp. 1246
-
-
Ilagan, M.X.1
Kopan, R.2
-
16
-
-
33644764891
-
-
Barrick, D. & Kopan, R. The Notch transcription activation complex makes its move. Cell 124, 883-885 (2006). This Review summarizes the papers that described for the first time the crystal structure of a Notch-CSL-MAML1 complex.
-
Barrick, D. & Kopan, R. The Notch transcription activation complex makes its move. Cell 124, 883-885 (2006). This Review summarizes the papers that described for the first time the crystal structure of a Notch-CSL-MAML1 complex.
-
-
-
-
17
-
-
0025856717
-
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
-
Ellisen, L. W. et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66, 649-661 (1991).
-
(1991)
Cell
, vol.66
, pp. 649-661
-
-
Ellisen, L.W.1
-
18
-
-
0030297895
-
An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
-
Robey, E. et al. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell 87, 483-492 (1996).
-
(1996)
Cell
, vol.87
, pp. 483-492
-
-
Robey, E.1
-
19
-
-
0034599854
-
Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells
-
Radtke, F. et al. Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells. J. Exp. Med. 191, 1085-1094 (2000).
-
(2000)
J. Exp. Med
, vol.191
, pp. 1085-1094
-
-
Radtke, F.1
-
20
-
-
20244389684
-
Notch1 expression in early lymphopoiesis influences B versus T lineage determination
-
Pui, J. C. et al. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 11, 299-308 (1999).
-
(1999)
Immunity
, vol.11
, pp. 299-308
-
-
Pui, J.C.1
-
21
-
-
34248550433
-
-
Maillard, I. & Pear, W. S. Immunology. Keeping a tight leash on Notch. Science 316, 840-842 (2007).
-
Maillard, I. & Pear, W. S. Immunology. Keeping a tight leash on Notch. Science 316, 840-842 (2007).
-
-
-
-
22
-
-
24944444760
-
Notch promotes survival of pre-T cells at the β-selection checkpoint by regulating cellular metabolism
-
Ciofani, M. & Zúñiga-Pflücker, J. C. Notch promotes survival of pre-T cells at the β-selection checkpoint by regulating cellular metabolism. Nature Immunol. 6, 881-888 (2005).
-
(2005)
Nature Immunol
, vol.6
, pp. 881-888
-
-
Ciofani, M.1
Zúñiga-Pflücker, J.C.2
-
23
-
-
33845306813
-
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
-
Palomero, T. et al. NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc. Natl Acad. Sci. USA 103, 18261-18266 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 18261-18266
-
-
Palomero, T.1
-
24
-
-
33749327182
-
The requirement for Notch signaling at the β-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor
-
Maillard, I. et al. The requirement for Notch signaling at the β-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor. J. Exp. Med. 203, 2239-2245 (2006).
-
(2006)
J. Exp. Med
, vol.203
, pp. 2239-2245
-
-
Maillard, I.1
-
25
-
-
0036533389
-
On the brink of becoming a T cell
-
Borowski, C. et al. On the brink of becoming a T cell. Curr. Opin. Immunol. 14, 200-206 (2002).
-
(2002)
Curr. Opin. Immunol
, vol.14
, pp. 200-206
-
-
Borowski, C.1
-
26
-
-
30044441433
-
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76
-
Yokosuka, T. et al. Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nature Immunol. 6, 1253-1262 (2005).
-
(2005)
Nature Immunol
, vol.6
, pp. 1253-1262
-
-
Yokosuka, T.1
-
27
-
-
2142654263
-
Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation
-
Ciofani, M. et al. Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. J. Immunol. 172, 5230-5239 (2004).
-
(2004)
J. Immunol
, vol.172
, pp. 5230-5239
-
-
Ciofani, M.1
-
28
-
-
0036070308
-
Inactivation of Notch1 impairs VDJβ rearrangement and allows pre-TCR-independent survival of early αβ lineage thymocytes
-
Wolfer, A., Wilson, A., Nemir, M., MacDonald, H. R. & Radtke, F. Inactivation of Notch1 impairs VDJβ rearrangement and allows pre-TCR-independent survival of early αβ lineage thymocytes. Immunity 16, 869-879 (2002).
-
(2002)
Immunity
, vol.16
, pp. 869-879
-
-
Wolfer, A.1
Wilson, A.2
Nemir, M.3
MacDonald, H.R.4
Radtke, F.5
-
29
-
-
33645067911
-
Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor
-
Aifantis, I., Mandal, M., Sawai, K., Ferrando, A. & Vilimas, T. Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor. Immunol. Rev. 209, 159-169 (2006).
-
(2006)
Immunol. Rev
, vol.209
, pp. 159-169
-
-
Aifantis, I.1
Mandal, M.2
Sawai, K.3
Ferrando, A.4
Vilimas, T.5
-
30
-
-
33646374372
-
Notch1 promotes survival of E2A-deficient T cell lymphomas through Pre-T cell receptor dependent and independent mechanisms
-
Reschly, E. J. et al. Notch1 promotes survival of E2A-deficient T cell lymphomas through Pre-T cell receptor dependent and independent mechanisms. Blood 107, 4115-4121 (2006).
-
(2006)
Blood
, vol.107
, pp. 4115-4121
-
-
Reschly, E.J.1
-
31
-
-
0036467663
-
Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway
-
Reizis, B. & Leder, P. Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. Genes Dev. 16, 295-300 (2002).
-
(2002)
Genes Dev
, vol.16
, pp. 295-300
-
-
Reizis, B.1
Leder, P.2
-
32
-
-
0035796488
-
Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells
-
Allman, D. et al. Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells. J. Exp. Med. 194, 99-106 (2001).
-
(2001)
J. Exp. Med
, vol.194
, pp. 99-106
-
-
Allman, D.1
-
33
-
-
33846048039
-
-
Vilimas, T. et al. Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia. Nature Med. 13, 70-77 (2007). This report shows that the NF-κB pathway is a downstream target of Notch1 activation. It also suggests that drugs that affect NF-βB activation, including the proteasome inhibitor Velcade could be useful in T-ALL therapy.
-
Vilimas, T. et al. Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia. Nature Med. 13, 70-77 (2007). This report shows that the NF-κB pathway is a downstream target of Notch1 activation. It also suggests that drugs that affect NF-βB activation, including the proteasome inhibitor Velcade could be useful in T-ALL therapy.
-
-
-
-
35
-
-
34250025396
-
Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia
-
This report identifies a potential role for the calcineurin-NFAT signalling pathway in T-cell leukaemia and suggests that drugs that target this pathway could affect disease progression
-
Medyouf, H. et al. Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia. Nature Med. 13, 736-741 (2007). This report identifies a potential role for the calcineurin-NFAT signalling pathway in T-cell leukaemia and suggests that drugs that target this pathway could affect disease progression.
-
(2007)
Nature Med
, vol.13
, pp. 736-741
-
-
Medyouf, H.1
-
36
-
-
9144229104
-
Requirement for cyclin D3 in lymphocyte development and T cell leukemias
-
Sicinska, E. et al. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell 4, 451-461 (2003).
-
(2003)
Cancer Cell
, vol.4
, pp. 451-461
-
-
Sicinska, E.1
-
37
-
-
20044368218
-
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
-
Mandal, M. et al. The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J. Exp. Med. 201, 603-614 (2005).
-
(2005)
J. Exp. Med
, vol.201
, pp. 603-614
-
-
Mandal, M.1
-
38
-
-
33646366173
-
Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia
-
Grabher, C., von Boehmer, H. & Look, A. T. Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nature Rev. Cancer 5, 347-359 (2006).
-
(2006)
Nature Rev. Cancer
, vol.5
, pp. 347-359
-
-
Grabher, C.1
von Boehmer, H.2
Look, A.T.3
-
39
-
-
0025040167
-
The t(1;14)(p34;q11) is nonrandom and restricted to T-cell acute lymphoblastic leukemia: A Pediatric Oncology Group study
-
Carroll, A. J. et al. The t(1;14)(p34;q11) is nonrandom and restricted to T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. Blood 76, 1220-1224 (1990).
-
(1990)
Blood
, vol.76
, pp. 1220-1224
-
-
Carroll, A.J.1
-
40
-
-
0025151168
-
Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia
-
Brown, L. et al. Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia. EMBO J. 9, 3343-3351 (1990).
-
(1990)
EMBO J
, vol.9
, pp. 3343-3351
-
-
Brown, L.1
-
41
-
-
0027201165
-
SIL-TAL1 deletion in T-cell acute lymphoblastic leukemia
-
Janssen, J. W., Ludwig, W. D., Sterry, W. & Bartram, C.R. SIL-TAL1 deletion in T-cell acute lymphoblastic leukemia. Leukemia 7, 1204-1210 (1993).
-
(1993)
Leukemia
, vol.7
, pp. 1204-1210
-
-
Janssen, J.W.1
Ludwig, W.D.2
Sterry, W.3
Bartram, C.R.4
-
42
-
-
0031454577
-
The CD2-scl transgene alters the phenotype and frequency of T-lymphomas in N-ras transgenic or p53 deficient mice
-
Curtis, D. J., Robb, L., Strasser, A. & Begley, C. G. The CD2-scl transgene alters the phenotype and frequency of T-lymphomas in N-ras transgenic or p53 deficient mice. Oncogene 15, 2975-2983 (1997).
-
(1997)
Oncogene
, vol.15
, pp. 2975-2983
-
-
Curtis, D.J.1
Robb, L.2
Strasser, A.3
Begley, C.G.4
-
43
-
-
0028821133
-
Reconstitution of mice with bone marrow cells expressing the SCL gene is insufficient to cause leukemia
-
Elwood, N. J. & Begley, C. G. Reconstitution of mice with bone marrow cells expressing the SCL gene is insufficient to cause leukemia. Cell Growth Differ. 6, 19-25 (1995).
-
(1995)
Cell Growth Differ
, vol.6
, pp. 19-25
-
-
Elwood, N.J.1
Begley, C.G.2
-
44
-
-
0029815976
-
Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIα
-
Kelliher, M. A., Seldin, D. C. & Leder, P. Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIα. EMBO J. 15, 5160-5166 (1996).
-
(1996)
EMBO J
, vol.15
, pp. 5160-5166
-
-
Kelliher, M.A.1
Seldin, D.C.2
Leder, P.3
-
45
-
-
0029981648
-
Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice
-
Larson, R. C. et al. Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice. EMBO J. 15, 1021-1027 (1996).
-
(1996)
EMBO J
, vol.15
, pp. 1021-1027
-
-
Larson, R.C.1
-
46
-
-
0030921503
-
An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice
-
Aplan, P. D. et al. An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice. EMBO J. 16, 2408-2419 (1997).
-
(1997)
EMBO J
, vol.16
, pp. 2408-2419
-
-
Aplan, P.D.1
-
47
-
-
0035418581
-
Scid thymocytes with TCRβ gene rearrangements are targets for the oncogenic effect of SCL and LMO1 transgenes
-
Chervinsky, D. S., Lam, D. H., Melman, M. P., Gross, K. W. & Aplan, P. D. Scid thymocytes with TCRβ gene rearrangements are targets for the oncogenic effect of SCL and LMO1 transgenes. Cancer Res. 61, 6382-6387 (2001).
-
(2001)
Cancer Res
, vol.61
, pp. 6382-6387
-
-
Chervinsky, D.S.1
Lam, D.H.2
Melman, M.P.3
Gross, K.W.4
Aplan, P.D.5
-
48
-
-
0035140870
-
Development and characterization of T cell leukemia cell lines established from SCL/LMO1 double transgenic mice
-
Chervinsky, D. S., Lam, D. H., Zhao, X. F., Melman, M. P. & Aplan, P. D. Development and characterization of T cell leukemia cell lines established from SCL/LMO1 double transgenic mice. Leukemia 15, 141-147 (2001).
-
(2001)
Leukemia
, vol.15
, pp. 141-147
-
-
Chervinsky, D.S.1
Lam, D.H.2
Zhao, X.F.3
Melman, M.P.4
Aplan, P.D.5
-
49
-
-
0033043388
-
Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: Parallels with E2A-deficient mice
-
Chervinsky, D. S. et al. Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice. Mol. Cell Biol. 19, 5025-5035 (1999).
-
(1999)
Mol. Cell Biol
, vol.19
, pp. 5025-5035
-
-
Chervinsky, D.S.1
-
50
-
-
0032584080
-
Deregulated expression of TCL1 causes T cell leukemia in mice
-
Virgilio, L. et al. Deregulated expression of TCL1 causes T cell leukemia in mice. Proc. Natl Acad. Sci. USA 95, 3885-3889 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 3885-3889
-
-
Virgilio, L.1
-
51
-
-
0029844127
-
T-cell-directed TAL-1 expression induces T-cell malignancies in transgenic mice
-
Condorelli, G. L. et al. T-cell-directed TAL-1 expression induces T-cell malignancies in transgenic mice. Cancer Res. 56, 5113-5119 (1996).
-
(1996)
Cancer Res
, vol.56
, pp. 5113-5119
-
-
Condorelli, G.L.1
-
52
-
-
34948889311
-
p16INK4A tumor suppressor gene expression and CD3ε deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis
-
Fasseu, M. et al. p16INK4A tumor suppressor gene expression and CD3ε deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis. Blood 110, 2610-2619 (2007).
-
(2007)
Blood
, vol.110
, pp. 2610-2619
-
-
Fasseu, M.1
-
53
-
-
33646877029
-
p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice
-
Shank-Calvo, J. A., Draheim, K., Bhasin, M. & Kelliher, M. A. p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice. Oncogene 25, 3023-3031 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 3023-3031
-
-
Shank-Calvo, J.A.1
Draheim, K.2
Bhasin, M.3
Kelliher, M.A.4
-
54
-
-
0031051552
-
Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL
-
Ono, Y., Fukuhara, N. & Yoshie, O. Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL. J. Biol. Chem. 272, 4576-4581 (1997).
-
(1997)
J. Biol. Chem
, vol.272
, pp. 4576-4581
-
-
Ono, Y.1
Fukuhara, N.2
Yoshie, O.3
-
56
-
-
0028276834
-
The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by Id proteins during interleukin 6-induced myeloid differentiation
-
Voronova, A. F. & Lee, F. The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by Id proteins during interleukin 6-induced myeloid differentiation. Proc. Natl Acad. Sci. USA 91, 5952-5956 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 5952-5956
-
-
Voronova, A.F.1
Lee, F.2
-
57
-
-
0025804491
-
Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins
-
Hsu, H. L., Cheng, J. T., Chen, Q. & Baer, R. Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins. Mol. Cell Biol. 11, 3037-3042 (1991).
-
(1991)
Mol. Cell Biol
, vol.11
, pp. 3037-3042
-
-
Hsu, H.L.1
Cheng, J.T.2
Chen, Q.3
Baer, R.4
-
58
-
-
0028348648
-
Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells
-
Hsu, H. L., Wadman, I. & Baer, R. Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells. Proc. Natl Acad. Sci. USA 91, 3181-3185 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 3181-3185
-
-
Hsu, H.L.1
Wadman, I.2
Baer, R.3
-
59
-
-
0032549655
-
The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition
-
Park, S. T. & Sun, X. H. The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition. J. Biol. Chem. 273, 7030-7037 (1998).
-
(1998)
J. Biol. Chem
, vol.273
, pp. 7030-7037
-
-
Park, S.T.1
Sun, X.H.2
-
60
-
-
2942579675
-
TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB
-
O'Neil, J., Shank, J., Cusson, N., Murre, C. & Kelliher, M. TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB. Cancer Cell 5, 587-596 (2004).
-
(2004)
Cancer Cell
, vol.5
, pp. 587-596
-
-
O'Neil, J.1
Shank, J.2
Cusson, N.3
Murre, C.4
Kelliher, M.5
-
61
-
-
33746656195
-
Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia
-
Palomero, T. et al. Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia. Blood 108, 986-992 (2006).
-
(2006)
Blood
, vol.108
, pp. 986-992
-
-
Palomero, T.1
-
62
-
-
0024308990
-
lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif
-
Mellentin, J. D., Smith, S. D. & Cleary, M. L. lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif. Cell 58, 77-83 (1989).
-
(1989)
Cell
, vol.58
, pp. 77-83
-
-
Mellentin, J.D.1
Smith, S.D.2
Cleary, M.L.3
-
63
-
-
33751558834
-
lyl-1 and tal-1/scl, two genes encoding closely related bHLH transcription factors, display highly overlapping expression patterns during cardiovascular and hematopoietic ontogeny
-
Giroux, S. et al. lyl-1 and tal-1/scl, two genes encoding closely related bHLH transcription factors, display highly overlapping expression patterns during cardiovascular and hematopoietic ontogeny. Gene Expr. Patterns 7, 215-226 (2007).
-
(2007)
Gene Expr. Patterns
, vol.7
, pp. 215-226
-
-
Giroux, S.1
-
64
-
-
35349002806
-
Overexpression of a transcription factor LYL1 induces T- and B-cell lymphoma in mice
-
Zhong, Y., Jiang, L., Hiai, H., Toyokuni, S. & Yamada, Y. Overexpression of a transcription factor LYL1 induces T- and B-cell lymphoma in mice. Oncogene 26, 6937-6947 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 6937-6947
-
-
Zhong, Y.1
Jiang, L.2
Hiai, H.3
Toyokuni, S.4
Yamada, Y.5
-
65
-
-
27644497232
-
Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia
-
Meng, Y. S., Khoury, H., Dick, J. E. & Minden, M. D. Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia. Leukemia 19, 1941-1947 (2005).
-
(2005)
Leukemia
, vol.19
, pp. 1941-1947
-
-
Meng, Y.S.1
Khoury, H.2
Dick, J.E.3
Minden, M.D.4
-
66
-
-
0023953685
-
The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor Cδ locus on human chromosome 14q11 and a transcribed region of chromosome 11p15
-
Boehm, T. et al. The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor Cδ locus on human chromosome 14q11 and a transcribed region of chromosome 11p15. EMBO J. 7, 385-394 (1988).
-
(1988)
EMBO J
, vol.7
, pp. 385-394
-
-
Boehm, T.1
-
67
-
-
0025759278
-
The rhombotin family of cysteine-rich LIM-domain oncogenes: Distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13
-
Boehm, T., Foroni, L., Kaneko, Y., Perutz, M. F. & Rabbitts, T. H. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc. Natl Acad. Sci. USA 88, 4367-4371 (1991).
-
(1991)
Proc. Natl Acad. Sci. USA
, vol.88
, pp. 4367-4371
-
-
Boehm, T.1
Foroni, L.2
Kaneko, Y.3
Perutz, M.F.4
Rabbitts, T.H.5
-
68
-
-
0025933456
-
TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11)
-
Royer-Pokora, B., Loos, U. & Ludwig, W. D. TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). Oncogene 6, 1887-1893 (1991).
-
(1991)
Oncogene
, vol.6
, pp. 1887-1893
-
-
Royer-Pokora, B.1
Loos, U.2
Ludwig, W.D.3
-
69
-
-
0142084745
-
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
-
Hacein-Bey-Abina, S. et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302, 415-419 (2003).
-
(2003)
Science
, vol.302
, pp. 415-419
-
-
Hacein-Bey-Abina, S.1
-
70
-
-
0030999645
-
The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins
-
Wadman, I. A. et al. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J. 16, 3145-3157 (1997).
-
(1997)
EMBO J
, vol.16
, pp. 3145-3157
-
-
Wadman, I.A.1
-
71
-
-
0032542215
-
The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11)
-
Valge-Archer, V., Forster, A. & Rabbitts, T. H. The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11). Oncogene 17, 3199-3202 (1998).
-
(1998)
Oncogene
, vol.17
, pp. 3199-3202
-
-
Valge-Archer, V.1
Forster, A.2
Rabbitts, T.H.3
-
72
-
-
0027980311
-
The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells
-
Valge-Archer, V. E. et al. The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. Proc. Natl Acad. Sci. USA 91, 8617-8621 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 8617-8621
-
-
Valge-Archer, V.E.1
-
73
-
-
0028799441
-
Association of erythroid transcription factors: Complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1
-
Osada, H., Grutz, G., Axelson, H., Forster, A. & Rabbitts, T. H. Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. Proc. Natl Acad. Sci. USA 92, 9585-9589 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 9585-9589
-
-
Osada, H.1
Grutz, G.2
Axelson, H.3
Forster, A.4
Rabbitts, T.H.5
-
74
-
-
0032541488
-
The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells
-
Grutz, G. G. et al. The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells. EMBO J. 17, 4594-4605 (1998).
-
(1998)
EMBO J
, vol.17
, pp. 4594-4605
-
-
Grutz, G.G.1
-
75
-
-
0036383331
-
HOX and non-HOX homeobox genes in leukemic hematopoiesis
-
Owens, B. M. & Hawley, R. G. HOX and non-HOX homeobox genes in leukemic hematopoiesis. Stem Cells 20, 364-379 (2002).
-
(2002)
Stem Cells
, vol.20
, pp. 364-379
-
-
Owens, B.M.1
Hawley, R.G.2
-
76
-
-
0028103855
-
Homeodomain-DNA recognition
-
Gehring, W. J. et al. Homeodomain-DNA recognition. Cell 78, 211-223 (1994).
-
(1994)
Cell
, vol.78
, pp. 211-223
-
-
Gehring, W.J.1
-
77
-
-
22044457152
-
HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL)
-
Soulier, J. et al. HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL). Blood 106, 274-286 (2005).
-
(2005)
Blood
, vol.106
, pp. 274-286
-
-
Soulier, J.1
-
78
-
-
20144363957
-
A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias
-
Speleman, F. et al. A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias. Leukemia 19, 358-366 (2005).
-
(2005)
Leukemia
, vol.19
, pp. 358-366
-
-
Speleman, F.1
-
79
-
-
0030658039
-
Oncogenic transcription factors in the human acute leukemias
-
Look, A. T. Oncogenic transcription factors in the human acute leukemias. Science 278, 1059-1064 (1997).
-
(1997)
Science
, vol.278
, pp. 1059-1064
-
-
Look, A.T.1
-
80
-
-
0028335821
-
Hox11 controls the genesis of the spleen
-
Roberts, C. W., Shutter, J. R. & Korsmeyer, S. J. Hox11 controls the genesis of the spleen. Nature 368, 747-749 (1994).
-
(1994)
Nature
, vol.368
, pp. 747-749
-
-
Roberts, C.W.1
Shutter, J.R.2
Korsmeyer, S.J.3
-
81
-
-
33746852153
-
Transforming potential of the T-cell acute lymphoblastic leukemia-associated homeobox genes HOXA13, TLX1, and TLX3
-
Su, X. et al. Transforming potential of the T-cell acute lymphoblastic leukemia-associated homeobox genes HOXA13, TLX1, and TLX3. Genes Chromosomes Cancer 45, 846-855 (2006).
-
(2006)
Genes Chromosomes Cancer
, vol.45
, pp. 846-855
-
-
Su, X.1
-
82
-
-
0028155997
-
The HOX11 homeobox-containing gene of human leukemia immortalizes murine hematopoietic precursors
-
Hawley, R. G., Fong, A. Z., Lu, M. & Hawley, T. S. The HOX11 homeobox-containing gene of human leukemia immortalizes murine hematopoietic precursors. Oncogene 9, 1-12 (1994).
-
(1994)
Oncogene
, vol.9
, pp. 1-12
-
-
Hawley, R.G.1
Fong, A.Z.2
Lu, M.3
Hawley, T.S.4
-
83
-
-
0031014272
-
Transforming function of the HOX11/TCL3 homeobox gene
-
Hawley, R. G. et al. Transforming function of the HOX11/TCL3 homeobox gene. Cancer Res. 57, 337-345 (1997).
-
(1997)
Cancer Res
, vol.57
, pp. 337-345
-
-
Hawley, R.G.1
-
84
-
-
34250016544
-
TLX1/HOX11 transcription factor inhibits differentiation and promotes a non-haemopoietic phenotype in murine bone marrow cells
-
Dixon, D. N. et al. TLX1/HOX11 transcription factor inhibits differentiation and promotes a non-haemopoietic phenotype in murine bone marrow cells. Br. J. Haematol. 138, 54-67 (2007).
-
(2007)
Br. J. Haematol
, vol.138
, pp. 54-67
-
-
Dixon, D.N.1
-
85
-
-
0029942842
-
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
-
Pear, W. S. et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J. Exp. Med. 183, 2283-2291 (1996).
-
(1996)
J. Exp. Med
, vol.183
, pp. 2283-2291
-
-
Pear, W.S.1
-
86
-
-
0029819876
-
Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma
-
Rohn, J. L., Lauring, A. S., Linenberger, M. L. & Overbaugh, J. Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma. J. Virol. 70, 8071-8080 (1996).
-
(1996)
J. Virol
, vol.70
, pp. 8071-8080
-
-
Rohn, J.L.1
Lauring, A.S.2
Linenberger, M.L.3
Overbaugh, J.4
-
87
-
-
0034600850
-
Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice
-
Bellavia, D. et al. Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J. 19, 3337-3348 (2000).
-
(2000)
EMBO J
, vol.19
, pp. 3337-3348
-
-
Bellavia, D.1
-
88
-
-
0037133497
-
Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis
-
Bellavia, D. et al. Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc. Natl Acad. Sci. USA 99, 3788-3793 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 3788-3793
-
-
Bellavia, D.1
-
89
-
-
33745045658
-
Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes
-
Malecki, M. J. et al. Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. Mol. Cell Biol. 26, 4642-4651 (2006).
-
(2006)
Mol. Cell Biol
, vol.26
, pp. 4642-4651
-
-
Malecki, M.J.1
-
90
-
-
17144474314
-
Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia
-
Ferrando, A. A. et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 1, 75-87 (2002).
-
(2002)
Cancer Cell
, vol.1
, pp. 75-87
-
-
Ferrando, A.A.1
-
91
-
-
33745131039
-
Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice
-
Klinakis, A. et al. Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc. Natl Acad. Sci. USA 103, 9262-9267 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 9262-9267
-
-
Klinakis, A.1
-
92
-
-
33746546368
-
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
-
Weng, A. P. et al. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev. 20, 2096-2109 (2006).
-
(2006)
Genes Dev
, vol.20
, pp. 2096-2109
-
-
Weng, A.P.1
-
93
-
-
33750317437
-
-
Sharma, V. M. et al. Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc. Mol. Cell Biol. 26, 8022-8031 (2006). These three reports (references 91-93) together with Palomero et al. (reference 23) demonstrate that MYC is a direct transcriptional target of Notch1 in T-ALL and breast cancer.
-
Sharma, V. M. et al. Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc. Mol. Cell Biol. 26, 8022-8031 (2006). These three reports (references 91-93) together with Palomero et al. (reference 23) demonstrate that MYC is a direct transcriptional target of Notch1 in T-ALL and breast cancer.
-
-
-
-
94
-
-
34948908663
-
-
Palomero, T. et al. Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nature Med. 13, 1203-1210 (2007). This report identifies PTEN mutations in patients with T-ALL and connects them to resistance to γ-secretase inhibitors.
-
Palomero, T. et al. Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nature Med. 13, 1203-1210 (2007). This report identifies PTEN mutations in patients with T-ALL and connects them to resistance to γ-secretase inhibitors.
-
-
-
-
95
-
-
0035860804
-
Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor
-
Gupta-Rossi, N. et al. Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J. Biol. Chem. 276, 34371-34378 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 34371-34378
-
-
Gupta-Rossi, N.1
-
96
-
-
0030659821
-
sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins
-
Hubbard, E. J., Wu, G., Kitajewski, J. & Greenwald, I. sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. Genes Dev. 11, 3182-3193 (1997).
-
(1997)
Genes Dev
, vol.11
, pp. 3182-3193
-
-
Hubbard, E.J.1
Wu, G.2
Kitajewski, J.3
Greenwald, I.4
-
97
-
-
1542409037
-
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein
-
Tetzlaff, M. T. et al. Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc. Natl Acad. Sci. USA 101, 3338-3345 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 3338-3345
-
-
Tetzlaff, M.T.1
-
98
-
-
34547780475
-
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors
-
O'Neil, J. et al. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors. J. Exp. Med. 204, 1813-1824 (2007).
-
(2007)
J. Exp. Med
, vol.204
, pp. 1813-1824
-
-
O'Neil, J.1
-
99
-
-
34547820257
-
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
-
Thompson, B. J. et al. The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J. Exp. Med. 204, 1825-1835 (2007).
-
(2007)
J. Exp. Med
, vol.204
, pp. 1825-1835
-
-
Thompson, B.J.1
-
100
-
-
34250863886
-
-
Maser, R. S. et al. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature 447, 966-971 (2007). References 98-100 are the first to show that FBW7 is an E3 ubiquitin ligase specific for oncogenic Notch1 and identify FBW7 inactivating mutations in T-ALL patients.
-
Maser, R. S. et al. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature 447, 966-971 (2007). References 98-100 are the first to show that FBW7 is an E3 ubiquitin ligase specific for oncogenic Notch1 and identify FBW7 inactivating mutations in T-ALL patients.
-
-
-
-
101
-
-
36549071481
-
Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis
-
Onoyama, I. et al. Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J. Exp. Med. 204, 2875-2888 (2007).
-
(2007)
J. Exp. Med
, vol.204
, pp. 2875-2888
-
-
Onoyama, I.1
|