메뉴 건너뛰기




Volumn 8, Issue 5, 2008, Pages 380-390

Molecular pathogenesis of T-cell leukaemia and lymphoma

Author keywords

[No Author keywords available]

Indexed keywords

ADAM PROTEIN; HELIX LOOP HELIX PROTEIN; HOMEODOMAIN PROTEIN; NOTCH1 RECEPTOR; T LYMPHOCYTE RECEPTOR;

EID: 42649124306     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri2304     Document Type: Review
Times cited : (344)

References (101)
  • 1
    • 0030903602 scopus 로고    scopus 로고
    • Clinical features and treatment outcome of childhood T-lineage acute lymphoblastic leukemia according to the apparent maturational stage of T-lineage leukemic blasts: A Children's Cancer Group study
    • Uckun, F. M. et al. Clinical features and treatment outcome of childhood T-lineage acute lymphoblastic leukemia according to the apparent maturational stage of T-lineage leukemic blasts: a Children's Cancer Group study. J. Clin. Oncol. 15, 2214-2221 (1997).
    • (1997) J. Clin. Oncol , vol.15 , pp. 2214-2221
    • Uckun, F.M.1
  • 2
    • 0024209927 scopus 로고
    • Clinical features and outcome in childhood T-cell leukemia-lymphoma according to stage of thymocyte differentiation: A Pediatric Oncology Group Study
    • Crist, W. M. et al. Clinical features and outcome in childhood T-cell leukemia-lymphoma according to stage of thymocyte differentiation: a Pediatric Oncology Group Study. Blood 72, 1891-1897 (1988).
    • (1988) Blood , vol.72 , pp. 1891-1897
    • Crist, W.M.1
  • 3
    • 33747608619 scopus 로고    scopus 로고
    • Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: From thymocyte to lymphoblast
    • Graux, C., Cools, J., Michaux, L., Vandenberghe, P. & Hagemeijer, A. Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast. Leukemia 20, 1496-1510 (2006).
    • (2006) Leukemia , vol.20 , pp. 1496-1510
    • Graux, C.1    Cools, J.2    Michaux, L.3    Vandenberghe, P.4    Hagemeijer, A.5
  • 4
    • 34548009617 scopus 로고    scopus 로고
    • The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children
    • Clappier, E. et al. The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children. Blood 110, 1251-1261 (2007).
    • (2007) Blood , vol.110 , pp. 1251-1261
    • Clappier, E.1
  • 5
    • 34247641748 scopus 로고    scopus 로고
    • Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
    • Lahortiga, I. et al. Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. Nature Genet. 39, 593-595 (2007).
    • (2007) Nature Genet , vol.39 , pp. 593-595
    • Lahortiga, I.1
  • 6
    • 37549060588 scopus 로고    scopus 로고
    • Alu elements mediate MYB gene tandem duplication in human T-ALL
    • O'Neil, J. et al. Alu elements mediate MYB gene tandem duplication in human T-ALL. J. Exp. Med. (2007).
    • (2007) J. Exp. Med
    • O'Neil, J.1
  • 7
    • 5044225888 scopus 로고    scopus 로고
    • Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
    • Weng, A. P. et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306, 269-271 (2004).
    • (2004) Science , vol.306 , pp. 269-271
    • Weng, A.P.1
  • 9
    • 34247882592 scopus 로고    scopus 로고
    • Zoned out: Functional mapping of stromal signaling microenvironments in the thymus
    • Petrie, H. T. & Zúñiga-Pflücker, J. C. Zoned out: functional mapping of stromal signaling microenvironments in the thymus. Annu. Rev. Immunol. 25, 649-679 (2007).
    • (2007) Annu. Rev. Immunol , vol.25 , pp. 649-679
    • Petrie, H.T.1    Zúñiga-Pflücker, J.C.2
  • 11
    • 0037304536 scopus 로고    scopus 로고
    • Thymic selection revisited: How essential is it?
    • Von Boehmer, H. et al. Thymic selection revisited: how essential is it? Immunol. Rev. 191, 62-78 (2003).
    • (2003) Immunol. Rev , vol.191 , pp. 62-78
    • Von Boehmer, H.1
  • 13
    • 33645095936 scopus 로고    scopus 로고
    • Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus
    • El Andaloussi, A. et al. Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nature Immunol. 7, 418-426 (2006).
    • (2006) Nature Immunol , vol.7 , pp. 418-426
    • El Andaloussi, A.1
  • 14
    • 0023996419 scopus 로고
    • The molecular biology of the Notch locus and the fine tuning of differentiation in Drosophila
    • Artavanis-Tsakonas, S. The molecular biology of the Notch locus and the fine tuning of differentiation in Drosophila. Trends Genet. 4, 95-100 (1988).
    • (1988) Trends Genet , vol.4 , pp. 95-100
    • Artavanis-Tsakonas, S.1
  • 15
    • 33947241465 scopus 로고    scopus 로고
    • SnapShot: Notch signaling pathway
    • Ilagan, M. X. & Kopan, R. SnapShot: notch signaling pathway. Cell 128, 1246 (2007).
    • (2007) Cell , vol.128 , pp. 1246
    • Ilagan, M.X.1    Kopan, R.2
  • 16
    • 33644764891 scopus 로고    scopus 로고
    • Barrick, D. & Kopan, R. The Notch transcription activation complex makes its move. Cell 124, 883-885 (2006). This Review summarizes the papers that described for the first time the crystal structure of a Notch-CSL-MAML1 complex.
    • Barrick, D. & Kopan, R. The Notch transcription activation complex makes its move. Cell 124, 883-885 (2006). This Review summarizes the papers that described for the first time the crystal structure of a Notch-CSL-MAML1 complex.
  • 17
    • 0025856717 scopus 로고
    • TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
    • Ellisen, L. W. et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66, 649-661 (1991).
    • (1991) Cell , vol.66 , pp. 649-661
    • Ellisen, L.W.1
  • 18
    • 0030297895 scopus 로고    scopus 로고
    • An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
    • Robey, E. et al. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell 87, 483-492 (1996).
    • (1996) Cell , vol.87 , pp. 483-492
    • Robey, E.1
  • 19
    • 0034599854 scopus 로고    scopus 로고
    • Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells
    • Radtke, F. et al. Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells. J. Exp. Med. 191, 1085-1094 (2000).
    • (2000) J. Exp. Med , vol.191 , pp. 1085-1094
    • Radtke, F.1
  • 20
    • 20244389684 scopus 로고    scopus 로고
    • Notch1 expression in early lymphopoiesis influences B versus T lineage determination
    • Pui, J. C. et al. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 11, 299-308 (1999).
    • (1999) Immunity , vol.11 , pp. 299-308
    • Pui, J.C.1
  • 21
    • 34248550433 scopus 로고    scopus 로고
    • Maillard, I. & Pear, W. S. Immunology. Keeping a tight leash on Notch. Science 316, 840-842 (2007).
    • Maillard, I. & Pear, W. S. Immunology. Keeping a tight leash on Notch. Science 316, 840-842 (2007).
  • 22
    • 24944444760 scopus 로고    scopus 로고
    • Notch promotes survival of pre-T cells at the β-selection checkpoint by regulating cellular metabolism
    • Ciofani, M. & Zúñiga-Pflücker, J. C. Notch promotes survival of pre-T cells at the β-selection checkpoint by regulating cellular metabolism. Nature Immunol. 6, 881-888 (2005).
    • (2005) Nature Immunol , vol.6 , pp. 881-888
    • Ciofani, M.1    Zúñiga-Pflücker, J.C.2
  • 23
    • 33845306813 scopus 로고    scopus 로고
    • NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
    • Palomero, T. et al. NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc. Natl Acad. Sci. USA 103, 18261-18266 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 18261-18266
    • Palomero, T.1
  • 24
    • 33749327182 scopus 로고    scopus 로고
    • The requirement for Notch signaling at the β-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor
    • Maillard, I. et al. The requirement for Notch signaling at the β-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor. J. Exp. Med. 203, 2239-2245 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 2239-2245
    • Maillard, I.1
  • 25
    • 0036533389 scopus 로고    scopus 로고
    • On the brink of becoming a T cell
    • Borowski, C. et al. On the brink of becoming a T cell. Curr. Opin. Immunol. 14, 200-206 (2002).
    • (2002) Curr. Opin. Immunol , vol.14 , pp. 200-206
    • Borowski, C.1
  • 26
    • 30044441433 scopus 로고    scopus 로고
    • Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76
    • Yokosuka, T. et al. Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nature Immunol. 6, 1253-1262 (2005).
    • (2005) Nature Immunol , vol.6 , pp. 1253-1262
    • Yokosuka, T.1
  • 27
    • 2142654263 scopus 로고    scopus 로고
    • Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation
    • Ciofani, M. et al. Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. J. Immunol. 172, 5230-5239 (2004).
    • (2004) J. Immunol , vol.172 , pp. 5230-5239
    • Ciofani, M.1
  • 28
    • 0036070308 scopus 로고    scopus 로고
    • Inactivation of Notch1 impairs VDJβ rearrangement and allows pre-TCR-independent survival of early αβ lineage thymocytes
    • Wolfer, A., Wilson, A., Nemir, M., MacDonald, H. R. & Radtke, F. Inactivation of Notch1 impairs VDJβ rearrangement and allows pre-TCR-independent survival of early αβ lineage thymocytes. Immunity 16, 869-879 (2002).
    • (2002) Immunity , vol.16 , pp. 869-879
    • Wolfer, A.1    Wilson, A.2    Nemir, M.3    MacDonald, H.R.4    Radtke, F.5
  • 29
    • 33645067911 scopus 로고    scopus 로고
    • Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor
    • Aifantis, I., Mandal, M., Sawai, K., Ferrando, A. & Vilimas, T. Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor. Immunol. Rev. 209, 159-169 (2006).
    • (2006) Immunol. Rev , vol.209 , pp. 159-169
    • Aifantis, I.1    Mandal, M.2    Sawai, K.3    Ferrando, A.4    Vilimas, T.5
  • 30
    • 33646374372 scopus 로고    scopus 로고
    • Notch1 promotes survival of E2A-deficient T cell lymphomas through Pre-T cell receptor dependent and independent mechanisms
    • Reschly, E. J. et al. Notch1 promotes survival of E2A-deficient T cell lymphomas through Pre-T cell receptor dependent and independent mechanisms. Blood 107, 4115-4121 (2006).
    • (2006) Blood , vol.107 , pp. 4115-4121
    • Reschly, E.J.1
  • 31
    • 0036467663 scopus 로고    scopus 로고
    • Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway
    • Reizis, B. & Leder, P. Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. Genes Dev. 16, 295-300 (2002).
    • (2002) Genes Dev , vol.16 , pp. 295-300
    • Reizis, B.1    Leder, P.2
  • 32
    • 0035796488 scopus 로고    scopus 로고
    • Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells
    • Allman, D. et al. Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells. J. Exp. Med. 194, 99-106 (2001).
    • (2001) J. Exp. Med , vol.194 , pp. 99-106
    • Allman, D.1
  • 33
    • 33846048039 scopus 로고    scopus 로고
    • Vilimas, T. et al. Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia. Nature Med. 13, 70-77 (2007). This report shows that the NF-κB pathway is a downstream target of Notch1 activation. It also suggests that drugs that affect NF-βB activation, including the proteasome inhibitor Velcade could be useful in T-ALL therapy.
    • Vilimas, T. et al. Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia. Nature Med. 13, 70-77 (2007). This report shows that the NF-κB pathway is a downstream target of Notch1 activation. It also suggests that drugs that affect NF-βB activation, including the proteasome inhibitor Velcade could be useful in T-ALL therapy.
  • 35
    • 34250025396 scopus 로고    scopus 로고
    • Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia
    • This report identifies a potential role for the calcineurin-NFAT signalling pathway in T-cell leukaemia and suggests that drugs that target this pathway could affect disease progression
    • Medyouf, H. et al. Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia. Nature Med. 13, 736-741 (2007). This report identifies a potential role for the calcineurin-NFAT signalling pathway in T-cell leukaemia and suggests that drugs that target this pathway could affect disease progression.
    • (2007) Nature Med , vol.13 , pp. 736-741
    • Medyouf, H.1
  • 36
    • 9144229104 scopus 로고    scopus 로고
    • Requirement for cyclin D3 in lymphocyte development and T cell leukemias
    • Sicinska, E. et al. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell 4, 451-461 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 451-461
    • Sicinska, E.1
  • 37
    • 20044368218 scopus 로고    scopus 로고
    • The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
    • Mandal, M. et al. The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J. Exp. Med. 201, 603-614 (2005).
    • (2005) J. Exp. Med , vol.201 , pp. 603-614
    • Mandal, M.1
  • 38
    • 33646366173 scopus 로고    scopus 로고
    • Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia
    • Grabher, C., von Boehmer, H. & Look, A. T. Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nature Rev. Cancer 5, 347-359 (2006).
    • (2006) Nature Rev. Cancer , vol.5 , pp. 347-359
    • Grabher, C.1    von Boehmer, H.2    Look, A.T.3
  • 39
    • 0025040167 scopus 로고
    • The t(1;14)(p34;q11) is nonrandom and restricted to T-cell acute lymphoblastic leukemia: A Pediatric Oncology Group study
    • Carroll, A. J. et al. The t(1;14)(p34;q11) is nonrandom and restricted to T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. Blood 76, 1220-1224 (1990).
    • (1990) Blood , vol.76 , pp. 1220-1224
    • Carroll, A.J.1
  • 40
    • 0025151168 scopus 로고
    • Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia
    • Brown, L. et al. Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia. EMBO J. 9, 3343-3351 (1990).
    • (1990) EMBO J , vol.9 , pp. 3343-3351
    • Brown, L.1
  • 41
    • 0027201165 scopus 로고
    • SIL-TAL1 deletion in T-cell acute lymphoblastic leukemia
    • Janssen, J. W., Ludwig, W. D., Sterry, W. & Bartram, C.R. SIL-TAL1 deletion in T-cell acute lymphoblastic leukemia. Leukemia 7, 1204-1210 (1993).
    • (1993) Leukemia , vol.7 , pp. 1204-1210
    • Janssen, J.W.1    Ludwig, W.D.2    Sterry, W.3    Bartram, C.R.4
  • 42
    • 0031454577 scopus 로고    scopus 로고
    • The CD2-scl transgene alters the phenotype and frequency of T-lymphomas in N-ras transgenic or p53 deficient mice
    • Curtis, D. J., Robb, L., Strasser, A. & Begley, C. G. The CD2-scl transgene alters the phenotype and frequency of T-lymphomas in N-ras transgenic or p53 deficient mice. Oncogene 15, 2975-2983 (1997).
    • (1997) Oncogene , vol.15 , pp. 2975-2983
    • Curtis, D.J.1    Robb, L.2    Strasser, A.3    Begley, C.G.4
  • 43
    • 0028821133 scopus 로고
    • Reconstitution of mice with bone marrow cells expressing the SCL gene is insufficient to cause leukemia
    • Elwood, N. J. & Begley, C. G. Reconstitution of mice with bone marrow cells expressing the SCL gene is insufficient to cause leukemia. Cell Growth Differ. 6, 19-25 (1995).
    • (1995) Cell Growth Differ , vol.6 , pp. 19-25
    • Elwood, N.J.1    Begley, C.G.2
  • 44
    • 0029815976 scopus 로고    scopus 로고
    • Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIα
    • Kelliher, M. A., Seldin, D. C. & Leder, P. Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIα. EMBO J. 15, 5160-5166 (1996).
    • (1996) EMBO J , vol.15 , pp. 5160-5166
    • Kelliher, M.A.1    Seldin, D.C.2    Leder, P.3
  • 45
    • 0029981648 scopus 로고    scopus 로고
    • Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice
    • Larson, R. C. et al. Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice. EMBO J. 15, 1021-1027 (1996).
    • (1996) EMBO J , vol.15 , pp. 1021-1027
    • Larson, R.C.1
  • 46
    • 0030921503 scopus 로고    scopus 로고
    • An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice
    • Aplan, P. D. et al. An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice. EMBO J. 16, 2408-2419 (1997).
    • (1997) EMBO J , vol.16 , pp. 2408-2419
    • Aplan, P.D.1
  • 47
    • 0035418581 scopus 로고    scopus 로고
    • Scid thymocytes with TCRβ gene rearrangements are targets for the oncogenic effect of SCL and LMO1 transgenes
    • Chervinsky, D. S., Lam, D. H., Melman, M. P., Gross, K. W. & Aplan, P. D. Scid thymocytes with TCRβ gene rearrangements are targets for the oncogenic effect of SCL and LMO1 transgenes. Cancer Res. 61, 6382-6387 (2001).
    • (2001) Cancer Res , vol.61 , pp. 6382-6387
    • Chervinsky, D.S.1    Lam, D.H.2    Melman, M.P.3    Gross, K.W.4    Aplan, P.D.5
  • 48
    • 0035140870 scopus 로고    scopus 로고
    • Development and characterization of T cell leukemia cell lines established from SCL/LMO1 double transgenic mice
    • Chervinsky, D. S., Lam, D. H., Zhao, X. F., Melman, M. P. & Aplan, P. D. Development and characterization of T cell leukemia cell lines established from SCL/LMO1 double transgenic mice. Leukemia 15, 141-147 (2001).
    • (2001) Leukemia , vol.15 , pp. 141-147
    • Chervinsky, D.S.1    Lam, D.H.2    Zhao, X.F.3    Melman, M.P.4    Aplan, P.D.5
  • 49
    • 0033043388 scopus 로고    scopus 로고
    • Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: Parallels with E2A-deficient mice
    • Chervinsky, D. S. et al. Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice. Mol. Cell Biol. 19, 5025-5035 (1999).
    • (1999) Mol. Cell Biol , vol.19 , pp. 5025-5035
    • Chervinsky, D.S.1
  • 50
    • 0032584080 scopus 로고    scopus 로고
    • Deregulated expression of TCL1 causes T cell leukemia in mice
    • Virgilio, L. et al. Deregulated expression of TCL1 causes T cell leukemia in mice. Proc. Natl Acad. Sci. USA 95, 3885-3889 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 3885-3889
    • Virgilio, L.1
  • 51
    • 0029844127 scopus 로고    scopus 로고
    • T-cell-directed TAL-1 expression induces T-cell malignancies in transgenic mice
    • Condorelli, G. L. et al. T-cell-directed TAL-1 expression induces T-cell malignancies in transgenic mice. Cancer Res. 56, 5113-5119 (1996).
    • (1996) Cancer Res , vol.56 , pp. 5113-5119
    • Condorelli, G.L.1
  • 52
    • 34948889311 scopus 로고    scopus 로고
    • p16INK4A tumor suppressor gene expression and CD3ε deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis
    • Fasseu, M. et al. p16INK4A tumor suppressor gene expression and CD3ε deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis. Blood 110, 2610-2619 (2007).
    • (2007) Blood , vol.110 , pp. 2610-2619
    • Fasseu, M.1
  • 53
    • 33646877029 scopus 로고    scopus 로고
    • p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice
    • Shank-Calvo, J. A., Draheim, K., Bhasin, M. & Kelliher, M. A. p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice. Oncogene 25, 3023-3031 (2006).
    • (2006) Oncogene , vol.25 , pp. 3023-3031
    • Shank-Calvo, J.A.1    Draheim, K.2    Bhasin, M.3    Kelliher, M.A.4
  • 54
    • 0031051552 scopus 로고    scopus 로고
    • Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL
    • Ono, Y., Fukuhara, N. & Yoshie, O. Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL. J. Biol. Chem. 272, 4576-4581 (1997).
    • (1997) J. Biol. Chem , vol.272 , pp. 4576-4581
    • Ono, Y.1    Fukuhara, N.2    Yoshie, O.3
  • 56
    • 0028276834 scopus 로고
    • The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by Id proteins during interleukin 6-induced myeloid differentiation
    • Voronova, A. F. & Lee, F. The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by Id proteins during interleukin 6-induced myeloid differentiation. Proc. Natl Acad. Sci. USA 91, 5952-5956 (1994).
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 5952-5956
    • Voronova, A.F.1    Lee, F.2
  • 57
    • 0025804491 scopus 로고
    • Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins
    • Hsu, H. L., Cheng, J. T., Chen, Q. & Baer, R. Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins. Mol. Cell Biol. 11, 3037-3042 (1991).
    • (1991) Mol. Cell Biol , vol.11 , pp. 3037-3042
    • Hsu, H.L.1    Cheng, J.T.2    Chen, Q.3    Baer, R.4
  • 58
    • 0028348648 scopus 로고
    • Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells
    • Hsu, H. L., Wadman, I. & Baer, R. Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells. Proc. Natl Acad. Sci. USA 91, 3181-3185 (1994).
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 3181-3185
    • Hsu, H.L.1    Wadman, I.2    Baer, R.3
  • 59
    • 0032549655 scopus 로고    scopus 로고
    • The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition
    • Park, S. T. & Sun, X. H. The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition. J. Biol. Chem. 273, 7030-7037 (1998).
    • (1998) J. Biol. Chem , vol.273 , pp. 7030-7037
    • Park, S.T.1    Sun, X.H.2
  • 60
    • 2942579675 scopus 로고    scopus 로고
    • TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB
    • O'Neil, J., Shank, J., Cusson, N., Murre, C. & Kelliher, M. TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB. Cancer Cell 5, 587-596 (2004).
    • (2004) Cancer Cell , vol.5 , pp. 587-596
    • O'Neil, J.1    Shank, J.2    Cusson, N.3    Murre, C.4    Kelliher, M.5
  • 61
    • 33746656195 scopus 로고    scopus 로고
    • Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia
    • Palomero, T. et al. Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia. Blood 108, 986-992 (2006).
    • (2006) Blood , vol.108 , pp. 986-992
    • Palomero, T.1
  • 62
    • 0024308990 scopus 로고
    • lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif
    • Mellentin, J. D., Smith, S. D. & Cleary, M. L. lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif. Cell 58, 77-83 (1989).
    • (1989) Cell , vol.58 , pp. 77-83
    • Mellentin, J.D.1    Smith, S.D.2    Cleary, M.L.3
  • 63
    • 33751558834 scopus 로고    scopus 로고
    • lyl-1 and tal-1/scl, two genes encoding closely related bHLH transcription factors, display highly overlapping expression patterns during cardiovascular and hematopoietic ontogeny
    • Giroux, S. et al. lyl-1 and tal-1/scl, two genes encoding closely related bHLH transcription factors, display highly overlapping expression patterns during cardiovascular and hematopoietic ontogeny. Gene Expr. Patterns 7, 215-226 (2007).
    • (2007) Gene Expr. Patterns , vol.7 , pp. 215-226
    • Giroux, S.1
  • 64
    • 35349002806 scopus 로고    scopus 로고
    • Overexpression of a transcription factor LYL1 induces T- and B-cell lymphoma in mice
    • Zhong, Y., Jiang, L., Hiai, H., Toyokuni, S. & Yamada, Y. Overexpression of a transcription factor LYL1 induces T- and B-cell lymphoma in mice. Oncogene 26, 6937-6947 (2007).
    • (2007) Oncogene , vol.26 , pp. 6937-6947
    • Zhong, Y.1    Jiang, L.2    Hiai, H.3    Toyokuni, S.4    Yamada, Y.5
  • 65
    • 27644497232 scopus 로고    scopus 로고
    • Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia
    • Meng, Y. S., Khoury, H., Dick, J. E. & Minden, M. D. Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia. Leukemia 19, 1941-1947 (2005).
    • (2005) Leukemia , vol.19 , pp. 1941-1947
    • Meng, Y.S.1    Khoury, H.2    Dick, J.E.3    Minden, M.D.4
  • 66
    • 0023953685 scopus 로고
    • The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor Cδ locus on human chromosome 14q11 and a transcribed region of chromosome 11p15
    • Boehm, T. et al. The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor Cδ locus on human chromosome 14q11 and a transcribed region of chromosome 11p15. EMBO J. 7, 385-394 (1988).
    • (1988) EMBO J , vol.7 , pp. 385-394
    • Boehm, T.1
  • 67
    • 0025759278 scopus 로고
    • The rhombotin family of cysteine-rich LIM-domain oncogenes: Distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13
    • Boehm, T., Foroni, L., Kaneko, Y., Perutz, M. F. & Rabbitts, T. H. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc. Natl Acad. Sci. USA 88, 4367-4371 (1991).
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 4367-4371
    • Boehm, T.1    Foroni, L.2    Kaneko, Y.3    Perutz, M.F.4    Rabbitts, T.H.5
  • 68
    • 0025933456 scopus 로고
    • TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11)
    • Royer-Pokora, B., Loos, U. & Ludwig, W. D. TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). Oncogene 6, 1887-1893 (1991).
    • (1991) Oncogene , vol.6 , pp. 1887-1893
    • Royer-Pokora, B.1    Loos, U.2    Ludwig, W.D.3
  • 69
    • 0142084745 scopus 로고    scopus 로고
    • LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    • Hacein-Bey-Abina, S. et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302, 415-419 (2003).
    • (2003) Science , vol.302 , pp. 415-419
    • Hacein-Bey-Abina, S.1
  • 70
    • 0030999645 scopus 로고    scopus 로고
    • The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins
    • Wadman, I. A. et al. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J. 16, 3145-3157 (1997).
    • (1997) EMBO J , vol.16 , pp. 3145-3157
    • Wadman, I.A.1
  • 71
    • 0032542215 scopus 로고    scopus 로고
    • The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11)
    • Valge-Archer, V., Forster, A. & Rabbitts, T. H. The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11). Oncogene 17, 3199-3202 (1998).
    • (1998) Oncogene , vol.17 , pp. 3199-3202
    • Valge-Archer, V.1    Forster, A.2    Rabbitts, T.H.3
  • 72
    • 0027980311 scopus 로고
    • The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells
    • Valge-Archer, V. E. et al. The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. Proc. Natl Acad. Sci. USA 91, 8617-8621 (1994).
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 8617-8621
    • Valge-Archer, V.E.1
  • 73
    • 0028799441 scopus 로고
    • Association of erythroid transcription factors: Complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1
    • Osada, H., Grutz, G., Axelson, H., Forster, A. & Rabbitts, T. H. Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. Proc. Natl Acad. Sci. USA 92, 9585-9589 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 9585-9589
    • Osada, H.1    Grutz, G.2    Axelson, H.3    Forster, A.4    Rabbitts, T.H.5
  • 74
    • 0032541488 scopus 로고    scopus 로고
    • The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells
    • Grutz, G. G. et al. The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells. EMBO J. 17, 4594-4605 (1998).
    • (1998) EMBO J , vol.17 , pp. 4594-4605
    • Grutz, G.G.1
  • 75
    • 0036383331 scopus 로고    scopus 로고
    • HOX and non-HOX homeobox genes in leukemic hematopoiesis
    • Owens, B. M. & Hawley, R. G. HOX and non-HOX homeobox genes in leukemic hematopoiesis. Stem Cells 20, 364-379 (2002).
    • (2002) Stem Cells , vol.20 , pp. 364-379
    • Owens, B.M.1    Hawley, R.G.2
  • 76
    • 0028103855 scopus 로고
    • Homeodomain-DNA recognition
    • Gehring, W. J. et al. Homeodomain-DNA recognition. Cell 78, 211-223 (1994).
    • (1994) Cell , vol.78 , pp. 211-223
    • Gehring, W.J.1
  • 77
    • 22044457152 scopus 로고    scopus 로고
    • HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL)
    • Soulier, J. et al. HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL). Blood 106, 274-286 (2005).
    • (2005) Blood , vol.106 , pp. 274-286
    • Soulier, J.1
  • 78
    • 20144363957 scopus 로고    scopus 로고
    • A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias
    • Speleman, F. et al. A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias. Leukemia 19, 358-366 (2005).
    • (2005) Leukemia , vol.19 , pp. 358-366
    • Speleman, F.1
  • 79
    • 0030658039 scopus 로고    scopus 로고
    • Oncogenic transcription factors in the human acute leukemias
    • Look, A. T. Oncogenic transcription factors in the human acute leukemias. Science 278, 1059-1064 (1997).
    • (1997) Science , vol.278 , pp. 1059-1064
    • Look, A.T.1
  • 80
    • 0028335821 scopus 로고
    • Hox11 controls the genesis of the spleen
    • Roberts, C. W., Shutter, J. R. & Korsmeyer, S. J. Hox11 controls the genesis of the spleen. Nature 368, 747-749 (1994).
    • (1994) Nature , vol.368 , pp. 747-749
    • Roberts, C.W.1    Shutter, J.R.2    Korsmeyer, S.J.3
  • 81
    • 33746852153 scopus 로고    scopus 로고
    • Transforming potential of the T-cell acute lymphoblastic leukemia-associated homeobox genes HOXA13, TLX1, and TLX3
    • Su, X. et al. Transforming potential of the T-cell acute lymphoblastic leukemia-associated homeobox genes HOXA13, TLX1, and TLX3. Genes Chromosomes Cancer 45, 846-855 (2006).
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 846-855
    • Su, X.1
  • 82
    • 0028155997 scopus 로고
    • The HOX11 homeobox-containing gene of human leukemia immortalizes murine hematopoietic precursors
    • Hawley, R. G., Fong, A. Z., Lu, M. & Hawley, T. S. The HOX11 homeobox-containing gene of human leukemia immortalizes murine hematopoietic precursors. Oncogene 9, 1-12 (1994).
    • (1994) Oncogene , vol.9 , pp. 1-12
    • Hawley, R.G.1    Fong, A.Z.2    Lu, M.3    Hawley, T.S.4
  • 83
    • 0031014272 scopus 로고    scopus 로고
    • Transforming function of the HOX11/TCL3 homeobox gene
    • Hawley, R. G. et al. Transforming function of the HOX11/TCL3 homeobox gene. Cancer Res. 57, 337-345 (1997).
    • (1997) Cancer Res , vol.57 , pp. 337-345
    • Hawley, R.G.1
  • 84
    • 34250016544 scopus 로고    scopus 로고
    • TLX1/HOX11 transcription factor inhibits differentiation and promotes a non-haemopoietic phenotype in murine bone marrow cells
    • Dixon, D. N. et al. TLX1/HOX11 transcription factor inhibits differentiation and promotes a non-haemopoietic phenotype in murine bone marrow cells. Br. J. Haematol. 138, 54-67 (2007).
    • (2007) Br. J. Haematol , vol.138 , pp. 54-67
    • Dixon, D.N.1
  • 85
    • 0029942842 scopus 로고    scopus 로고
    • Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
    • Pear, W. S. et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J. Exp. Med. 183, 2283-2291 (1996).
    • (1996) J. Exp. Med , vol.183 , pp. 2283-2291
    • Pear, W.S.1
  • 86
    • 0029819876 scopus 로고    scopus 로고
    • Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma
    • Rohn, J. L., Lauring, A. S., Linenberger, M. L. & Overbaugh, J. Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma. J. Virol. 70, 8071-8080 (1996).
    • (1996) J. Virol , vol.70 , pp. 8071-8080
    • Rohn, J.L.1    Lauring, A.S.2    Linenberger, M.L.3    Overbaugh, J.4
  • 87
    • 0034600850 scopus 로고    scopus 로고
    • Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice
    • Bellavia, D. et al. Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J. 19, 3337-3348 (2000).
    • (2000) EMBO J , vol.19 , pp. 3337-3348
    • Bellavia, D.1
  • 88
    • 0037133497 scopus 로고    scopus 로고
    • Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis
    • Bellavia, D. et al. Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc. Natl Acad. Sci. USA 99, 3788-3793 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 3788-3793
    • Bellavia, D.1
  • 89
    • 33745045658 scopus 로고    scopus 로고
    • Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes
    • Malecki, M. J. et al. Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. Mol. Cell Biol. 26, 4642-4651 (2006).
    • (2006) Mol. Cell Biol , vol.26 , pp. 4642-4651
    • Malecki, M.J.1
  • 90
    • 17144474314 scopus 로고    scopus 로고
    • Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia
    • Ferrando, A. A. et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 1, 75-87 (2002).
    • (2002) Cancer Cell , vol.1 , pp. 75-87
    • Ferrando, A.A.1
  • 91
    • 33745131039 scopus 로고    scopus 로고
    • Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice
    • Klinakis, A. et al. Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc. Natl Acad. Sci. USA 103, 9262-9267 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 9262-9267
    • Klinakis, A.1
  • 92
    • 33746546368 scopus 로고    scopus 로고
    • c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
    • Weng, A. P. et al. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev. 20, 2096-2109 (2006).
    • (2006) Genes Dev , vol.20 , pp. 2096-2109
    • Weng, A.P.1
  • 93
    • 33750317437 scopus 로고    scopus 로고
    • Sharma, V. M. et al. Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc. Mol. Cell Biol. 26, 8022-8031 (2006). These three reports (references 91-93) together with Palomero et al. (reference 23) demonstrate that MYC is a direct transcriptional target of Notch1 in T-ALL and breast cancer.
    • Sharma, V. M. et al. Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc. Mol. Cell Biol. 26, 8022-8031 (2006). These three reports (references 91-93) together with Palomero et al. (reference 23) demonstrate that MYC is a direct transcriptional target of Notch1 in T-ALL and breast cancer.
  • 94
    • 34948908663 scopus 로고    scopus 로고
    • Palomero, T. et al. Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nature Med. 13, 1203-1210 (2007). This report identifies PTEN mutations in patients with T-ALL and connects them to resistance to γ-secretase inhibitors.
    • Palomero, T. et al. Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nature Med. 13, 1203-1210 (2007). This report identifies PTEN mutations in patients with T-ALL and connects them to resistance to γ-secretase inhibitors.
  • 95
    • 0035860804 scopus 로고    scopus 로고
    • Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor
    • Gupta-Rossi, N. et al. Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J. Biol. Chem. 276, 34371-34378 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 34371-34378
    • Gupta-Rossi, N.1
  • 96
    • 0030659821 scopus 로고    scopus 로고
    • sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins
    • Hubbard, E. J., Wu, G., Kitajewski, J. & Greenwald, I. sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. Genes Dev. 11, 3182-3193 (1997).
    • (1997) Genes Dev , vol.11 , pp. 3182-3193
    • Hubbard, E.J.1    Wu, G.2    Kitajewski, J.3    Greenwald, I.4
  • 97
    • 1542409037 scopus 로고    scopus 로고
    • Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein
    • Tetzlaff, M. T. et al. Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc. Natl Acad. Sci. USA 101, 3338-3345 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 3338-3345
    • Tetzlaff, M.T.1
  • 98
    • 34547780475 scopus 로고    scopus 로고
    • FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors
    • O'Neil, J. et al. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors. J. Exp. Med. 204, 1813-1824 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 1813-1824
    • O'Neil, J.1
  • 99
    • 34547820257 scopus 로고    scopus 로고
    • The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
    • Thompson, B. J. et al. The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J. Exp. Med. 204, 1825-1835 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 1825-1835
    • Thompson, B.J.1
  • 100
    • 34250863886 scopus 로고    scopus 로고
    • Maser, R. S. et al. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature 447, 966-971 (2007). References 98-100 are the first to show that FBW7 is an E3 ubiquitin ligase specific for oncogenic Notch1 and identify FBW7 inactivating mutations in T-ALL patients.
    • Maser, R. S. et al. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature 447, 966-971 (2007). References 98-100 are the first to show that FBW7 is an E3 ubiquitin ligase specific for oncogenic Notch1 and identify FBW7 inactivating mutations in T-ALL patients.
  • 101
    • 36549071481 scopus 로고    scopus 로고
    • Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis
    • Onoyama, I. et al. Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J. Exp. Med. 204, 2875-2888 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 2875-2888
    • Onoyama, I.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.