Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells

Cell Stem Cell

Volumn 17, Issue 2, 2015, Pages 165-177

  Cai, Xiongwei ^a   Gao, Long ^b   Teng, Li ^c   Ge, Jingping ^d   Oo, Zaw Min ^a   Kumar, Ashish R ^e   Gilliland, D Gary ^a   Mason, Philip J ^d   Tan, Kai ^c   Speck, Nancy A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b University of Iowa   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^e CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; RIBOSOME DNA; RIBOSOME PROTEIN; RIBOSOME RNA; TRANSCRIPTION FACTOR RUNX1; MUTAGENIC AGENT; PROTEIN P53; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOPHAGY; BIOGENESIS; BONE MARROW; CELL GROWTH; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GENOTOXICITY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE REPEAT; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; RIBOSOME; RIBOSOME BIOGENESIS; STEM CELL EXPANSION; UNFOLDED PROTEIN RESPONSE; WILD TYPE; ANIMAL; DEFICIENCY; DRUG EFFECTS; GENETICS; METABOLISM; ORGANELLE BIOGENESIS; PHYSIOLOGICAL STRESS; SIGNAL TRANSDUCTION;

ANIMALS; AUTOPHAGY; CORE BINDING FACTOR ALPHA 2 SUBUNIT; HEMATOPOIETIC STEM CELLS; HUMANS; MICE; MUTAGENS; ORGANELLE BIOGENESIS; REPETITIVE SEQUENCES, NUCLEIC ACID; RIBOSOMES; RNA, MESSENGER; RNA, RIBOSOMAL; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84938746499     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2015.06.002     Document Type: Article

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