Tel1/ETV6 Specifies Blood Stem Cells through the Agency of VEGF Signaling

Developmental Cell

Volumn 18, Issue 4, 2010, Pages 569-578

  Ciau Uitz, Aldo ^a   Pinheiro, Philip ^a   Gupta, Rajeev ^a   Enver, Tariq ^a   Patient, Roger ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Devbio; Stemcell

Indexed keywords

ALPHA GLOBIN; ANGIOPOIETIN RECEPTOR; EPHRIN; EPHRIN 2; GENE PRODUCT; NOTCH4 RECEPTOR; PROTEIN DII4; PROTEIN LMO2; TRANSCRIPTION FACTOR ERG; TRANSCRIPTION FACTOR ERG 1; TRANSCRIPTION FACTOR ETV6; TRANSCRIPTION FACTOR GATA 2; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR TAL1; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR ETS;

ANIMAL CELL; ANIMAL TISSUE; AORTA; ARTICLE; CELL SPECIFICITY; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; HEMANGIOBLAST; HEMATOPOIETIC STEM CELL; MESODERM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEPLETION; SIGNAL TRANSDUCTION; SOMITE; TRANSCRIPTION REGULATION; BIOLOGICAL MODEL; BLOOD CELL; CYTOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; IN SITU HYBRIDIZATION; METABOLISM; MOLECULAR GENETICS; PHENOTYPE; PHYSIOLOGY;

BLOOD CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEMANGIOBLASTS; HEMATOPOIETIC STEM CELLS; HUMANS; IN SITU HYBRIDIZATION; MESODERM; MODELS, BIOLOGICAL; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-ETS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SOMITES; TRANSCRIPTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77951903935     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.devcel.2010.02.009     Document Type: Article

References (35)

1. Abe M., Sato Y. cDNA microarray analysis of the gene expression profile of VEGF-activated human umbilical vein endothelial cells. Angiogenesis 2001, 4:289-298.
2. Boily G., Larose J., Langlois S., Sinnett D. Identification of transcripts modulated by ETV6 expression. Br. J. Haematol. 2007, 136:48-62.
3. Chakrabarti S.R., Nucifora G. The leukemia-associated gene TEL encodes a transcription repressor which associates with SMRT and mSin3A. Biochem. Biophys. Res. Commun. 1999, 264:871-877.
4. Ciau-Uitz A., Walmsley M., Patient R. Distinct origins of adult and embryonic blood in Xenopus. Cell 2000, 102:787-796.
5. Cleaver O., Krieg P.A. VEGF mediates angioblast migration during development of the dorsal aorta in Xenopus. Development 1998, 125:3905-3914.
6. Dzierzak E., Speck N.A. Of lineage and legacy: the development of mammalian hematopoietic stem cells. Nat. Immunol. 2008, 9:129-136.
7. Ema M., Faloon P., Zhang W.J., Hirashima M., Reid T., Stanford W.L., Orkin S., Choi K., Rossant J. Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. Genes Dev. 2003, 17:380-393.
8. Gerber H.P., Malik A.K., Solar G.P., Sherman D., Liang X.H., Meng G., Hong K., Marsters J.C., Ferrara N. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature 2002, 417:954-958.
9. Gering M., Patient R. Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos. Dev Cell 2005, 8:389-4000.
10. Golub T.R., Barker G.F., Lovett M., Gilliland D.G. Fusion of PDGF receptor beta to a novel ETS-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 1994, 77:307-316.
11. Hashiya N., Jo N., Aoki M., Matsumoto K., Nakamura T., Sato Y., Ogata N., Ogihara T., Kaneda Y., Morishita R. In vivo evidence of angiogenesis induced by transcription factor Ets-1: Ets-1 is located upstream of angiogenesis cascade. Circulation 2004, 109:3035-3041.
12. Hellsten U., Khokha M.K., Grammer T.C., Harland R.M., Richardson P., Rokhsar D.S. Accelerated gene evolution and subfunctionalization in the pseudotetraploid frog Xenopus laevis. BMC Biol. 2007, 5:31. 10.1186/1741-7007-5-31.
13. Hidaka M., Stanford W.L., Bernstein A. Conditional requirement for the Flk-1 receptor in the in vitro generation of early hematopoietic cells. Proc. Natl. Acad. Sci. USA 1999, 96:7370-7375.
14. Hock H., Meade E., Medeiros S., Schindler J.W., Valk P.J., Fujiwara Y., Orkin S.H. Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev. 2004, 18:2336-2341.
15. Kälin R.E., Kretz M.P., Meyer A.M., Kispert A., Heppner F.L., Brandli A.W. Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis. Dev. Biol. 2007, 305:599-614.
16. Kanno S., Oda N., Abe M., Terai Y., Ito M., Shitara K., Tabayashi K., Shibuya M., Sato Y. Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells. Oncogene 2000, 19:2138-2146.
17. Lanner F., Sohl M., Farnebo F. Functional arterial and venous fate is determined by graded VEGF signaling and notch status during embryonic stem cell differentiation. Arterioscler. Thromb. Vasc. Biol. 2007, 27:487-493.
18. Lee S., Chen T.T., Barber C.L., Jordan M.C., Murdock J., Desai S., Ferrara N., Nagy A., Roos K.P., Iruela-Arispe M.L. Autocrine VEGF signaling is required for vascular homeostasis. Cell 2007, 130:691-703.
19. Lopez R.G., Carron C., Oury C., Gardellin P., Bernard O., Ghysdael J. TEL is a sequence-specific transcriptional repressor. J. Biol. Chem. 1999, 274:30132-30138.
20. Mallory B.P., Mead T.J., Wiginton D.A., Kulkarni R.M., Greenberg J.M., Akeson A.L. Lymphangiogenesis in the developing lung promoted by VEGF-A. Microvasc. Res. 2006, 72:62-73.
21. Nieuwkoop P.D., Faber J. Normal Table of Xenopus laevis (Daudin) 1967, North-Holland, Amsterdam. Second Edition.
22. Olsson A.K., Dimberg A., Kreuger J., Claesson-Welsh L. VEGF receptor signalling-in control of vascular function. Nat. Rev. Mol. Cell Biol. 2006, 7:359-371.
23. Park C., Afrikanova I., Chung Y.S., Zhang W.J., Arentson E., Fong Gh G., Rosendahl A., Choi K. A hierarchical order of factors in the generation of FLK1- and SCL-expressing hematopoietic and endothelial progenitors from embryonic stem cells. Development 2004, 131:2749-2762.
24. Pearson S., Sroczynska P., Lacaud G., Kouskoff V. The stepwise specification of embryonic stem cells to hematopoietic fate is driven by sequential exposure to Bmp4, activin A, bFGF and VEGF. Development 2008, 135:1525-1535.
25. Pina C., Enver T. Differential contributions of haematopoietic stem cells to foetal and adult haematopoiesis: insights from functional analysis of transcriptional regulators. Oncogene 2007, 26:6750-6765.
26. Ramirez-Bergeron D.L., Runge A., Adelman D.M., Gohil M., Simon M.C. HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature. Dev. Cell 2006, 11:81-92.
27. Schuh A.C., Faloon P., Hu Q.L., Bhimani M., Choi K. In vitro hematopoietic and endothelial potential of flk-1(-/-) embryonic stem cells and embryos. Proc. Natl. Acad. Sci. USA 1999, 96:2159-2164.
28. Shalaby F., Rossant J., Yamaguchi T.P., Gertsenstein M., Wu X.F., Breitman M.L., Schuh A.C. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 1995, 376:62-66.
29. Shalaby F., Ho J., Stanford W.L., Fischer K.D., Schuh A.C., Schwartz L., Bernstein A., Rossant J. A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis. Cell 1997, 89:981-990.
30. Taniguchi H., Fujiwara Y., Doki Y., Sugita Y., Sohma I., Miyata H., Takiguchi S., Yasuda T., Tomita N., Morishita R., et al. Gene therapy using ets-1 transcription factor decoy for peritoneal dissemination of gastric cancer. Int. J. Cancer 2007, 121:1609-1617.
31. Walmsley M.E., Guille M.J., Bertwistle D., Smith J.C., Pizzey J.A., Patient R.K. Negative control of Xenopus GATA-2 by activin and noggin with eventual expression in precursors of the ventral blood islands. Development 1994, 120:2519-2529.
32. Walmsley M., Ciau-Uitz A., Patient R. Adult and embryonic blood and endothelium derive from distinct precursor populations which are differentially programmed by BMP in Xenopus. Development 2002, 129:5683-5695.
33. Wang L.C., Kuo F., Fujiwara Y., Gilliland D.G., Golub T.R., Orkin S.H. Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL. EMBO J. 1997, 16:4374-4383.
34. Wang L.C., Swat W., Fujiwara Y., Davidson L., Visvader J., Kuo F., Alt F.W., Gilliland D.G., Golub T.R., Orkin S.H. The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow. Genes Dev. 1998, 12:2392-2402.
35. Zippo A., De Robertis A., Bardelli M., Galvagni F., Oliviero S. Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro. Blood 2004, 103:4536-4544.