The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse

EMBO Journal

Volumn 15, Issue 16, 1996, Pages 4123-4129

  Robb, Lorraine ^a   Elwood, Ngaire J ^a   Elefanty, Andrew G ^a   Köntgen, Frank ^a   Li, Ruili ^a   Barnett, Louise D ^a   Begley, C Glenn ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Chimera; Gene targeting; Hematopoiesis; scl; tal 1

Indexed keywords

HELIX LOOP HELIX PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; EMBRYO; GENE MUTATION; GENE TARGETING; HEMATOPOIESIS; HOMOZYGOSITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL;

EID: 0029781248     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00787.x     Document Type: Article

References (42)

1. Aplan, P.D., Lombardi, D.P., Ginsberg, A.M., Cossman, J., Bertness, V. and Kirsch, I.R. (1990) Disruption of the human SCL locus by 'illegitimate' V-(D)-J recombinase activity. Science, 250, 1426-1429.
2. Aplan, P.D., Nakahara, K., Orkin, S.H. and Kirsch, I.R. (1992) The SCL gene product: a positive regulator of erythroid differentiation. EMBO J., 11, 4073-4081.
3. Bash, R., Hall, S., Timmons, C., Crist, W., Amylon, M., Smith, R. and Baer, R. (1995) Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A Pediatric Oncology Group Study. Blood, 86, 666-676.
4. Begley, C.G., Aplan, P.D., Denning, S.M., Haynes, B.F., Waldmann, T.A. and Kirsch, I.R. (1989) The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. Proc. Natl Acad. Sci. USA, 86, 10128-10132.
5. Bernard, O., Guglielmi, P., Jonveaux, P., Cherif, D., Gisselbrecht, S., Mauchauffe, M., Berger, R., Larsen, C.-J. and Mathieu-Mahul, D. (1990) Two distinct mechanisms for the SCL gene activation in the t(1:14) translocation of T-cell leukemias. Genes Chromosomes Cancer, 1, 194-208.
6. Boehm, T., Foroni, L., Kaneko, Y., Perutz, M.F. and Rabbits, T.H. (1991) The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc. Natl Acad. Sci. USA, 88, 4367-4371.
7. Brown, L., Cheng, J.-T., Chen, Q., Siciliano, M., Crist, W., Buchanan, G. and Baer, R. (1990) Site specific recombination of the tal-1 gene is a common occurrence in the human T cell leukemia. EMBO J., 9, 3343-3351.
8. Chen, Q., Yang, C.-C., Tsan, J.T., Xia, Y., Ragab, A.H., Peiper, S.C., Carroll, A. and Baer, R. (1990) Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia. J. Exp. Med., 172, 1403-1408.
9. Chiba, T., Nagata, Y., Kishi, A., Sakamaki, K., Miyajima, A., Yamamoto, M., Engel, J.D. and Todokoro, K. (1993) Induction of erythroid-specific gene expression in lymphoid cells. Proc. Natl Acad. Sci. USA, 90, 11593-11597.
10. Durda, P.J., Boos, S.C. and Gottlieb, P.D. (1979) T100: a new murine cell surface glycoprotein detected by anti-Ly-2.1 serum. J. Immunol., 122, 1407-1412.
11. Finger, L.R., Kagan, J., Christopher, G., Kurtzberg, J., Hershfield, M.S., Nowell, P.C. and Croce, C.M. (1989) Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc. Natl Acad. Sci. USA, 86, 5039-5043.
12. Green, A.R., DeLuca, E. and Begley, C.G. (1991a) Antisense SCL suppresses self-renewal and enhances spontaneous erythroid differentiation of the human leukaemic cell line K562. EMBO J., 10, 4153-4158.
13. Green, A.R., Salvaris, E. and Begley, C.G. (1991b) Erythroid expression of the 'helix-loop-helix' gene SCL. Oncogene, 6, 475-479.
14. Green, A.R., Lints, T., Visvader, J., Harvey, R. and Begley, C.G. (1992) SCL is coexpressed with GATA-1 in hemopoietic cells but is also expressed in developing brain. Oncogene, 7, 653-660.
15. Hoang, T., Paradis, E., Brady, G., Billia, F., Nakahara, K., Iscove, N. and Kirsch, I. (1996) Opposing effects of the basic helix-loop-helix transcription factor SCL on erythroid and monocytic differentiation. Blood, 87, 102-111.
16. Jan, Y.N. and Jan, L.Y. (1993) HLH proteins, fly neurogenesis and vertebrate myogenesis. Cell, 75, 827-830.
17. Kadesch, T. (1993) Consequences of heterodimeric interactions among helix-loop-helix proteins. Cell Growth Differ., 4, 49-55.
18. Kaiho, S.-I. and Mizuno, K. (1985) Sensitive assay systems for detection of hemoglobin with 2,7-diaminofluorene: histochemistry and colorimetry for erythrodifferentiation. Anal. Biochem., 149, 117-120.
19. Kallianpur, A.R., Jordan, J.E. and Brandt, S.J. (1994) The SCL/TAL-1 gene is expressed in progenitors of both the hematopoietic and vascular systems during embryogenesis. Blood, 83, 1200-1208.
20. Keller, G., Kennedy, M., Payayannopoulou, T. and Wiles, M.V. (1993) Hematopoietic commitment during embryonic stem cell differentiation in culture. Mol. Cell. Biol., 13, 473-486.
21. Ledbetter, J.A., Goding, J.W., Tsu, T.T. and Herzenberg, L.A. (1979) A new mouse lymphoid alloantigen (Lgp100) recognized by a monoclonal rat antibody. Immunogenetics, 8, 347-360.
22. Metcalf, D. (1984) Clonal Culture of Hemopoietic cells: Techniques and Applications. Elsevier, Amsterdam, The Netherlands.
23. Mouthon, M.-A., Bernard, O., Mitjavila, M.-T., Romeo, P.-H., Vainchenker, W. and Mathieu-Mahul, D. (1993) Expression of tal-1 and GATA binding proteins during human hematopoiesis. Blood, 81, 647-655.
24. Nagy, A. and Rossant, J. (1993) Gene Targeting: A Practical Approach. IRL Press at Oxford University Press, pp. 107-146.
25. Olsen, E.N., Arnold, H.-H., Rigby, P.W.J. and Wold, B.J. (1996) Know your neighbors: three phenotypes in null mutants of the myogenic bHLH gene MRF4. Cell, 85, 1-4.
26. Orkin, S.H. (1992) GATA-binding transcription factors in hematopoietic cells. Blood, 60, 575-581.
27. Pevny, L., Simon, M.C., Robertson, E., Klein, W.H., Tsai, S.-F., D'Agati, V., Orkin, S.H. and Costantini, F. (1991) Erythroid differentiation in chimeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature, 349, 257-260.
28. Pevny, L., Lin, C.-S., D'Agati, V., Simon, M.C., Orkin, S.H. and Costantini, F. (1995) Development of hemopoietic cells lacking transcription factor GATA-1. Development, 121, 163-172.
29. Robb, L., Lyons, I., Li, R., Hartley, L., Harvey, R.P., Kontgen, F. and Begley, C.G. (1995) Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc. Natl Acad. Sci. USA, 92, 7075-7079.
30. Rossant, J. and Nagy, A. (1995) Genome engineering: the new mouse genetics. Nature Med., 1, 592-594.
31. Royer-Pokora, B., Loos, U. and Ludwig, W.D. (1991) Ttg-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). Oncogene, 6, 1887-1893.
32. Shivdasani, R.A., Mayer, E.L. and Orkin, S.H. (1995) Absence of blood formation in mice with the T-cell leukaemia oncoprotein tal-1/SCL. Nature, 373, 432-434.
33. Strasser, A., Harris, A.W. and Cory, S. (1991) bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell, 67, 889-899.
34. Tanigawa, T., Elwood, N.E., Metcalf, D., Cary, D., DeLuca, E., Nicola, N.A. and Begley, C.G. (1993) The SCL gene product is regulated by and differentially regulates cytokine responses during myeloid leukemic cell differentiation. Proc. Natl Acad. Sci. USA, 90, 7864-7868.
35. Tsai, F.Y., Keller, G., Kuo, F.C., Weiss, M., Chen, J., Rosenblatt, M., Alt, F.W. and Orkin, S.H. (1994) An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature, 371, 221-226.
36. Valge-Archer, V.E., Osada, H., Warren, A.J., Forster, A., Li, J., Baer, R. and Rabbitts, T.H. (1994) The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. Proc. Natl Acad. Sci. USA, 91, 8617-8621.
37. Visvader, J.E., Begley, C.G. and Adams, J.M. (1991) Differential expression of the LYL, SCL and E2A helix-loop-helix genes within the hemopoietic system. Oncogene, 6, 195-204.
38. Wadman, I., Li, J., Bash, R.O., Forster, A., Osada, H., Rabbitts, T.H. and Baer, R. (1994) Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. EMBO J., 13, 4831-4839.
39. Warren, A.J., Colledge, W.H., Carlton, M.B.L., Evans, M.J., Smith, A.J.H. and Rabbitts, T.H. (1994) The oncogenic cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development. Cell, 78, 45-57.
40. Weiss, M.J., Keller, G. and Orkin, S.H. (1994) Novel insights into erythroid development revealed through in vitro differentiation of GATA-1-embryonic stem cells. Genes Dev., 8, 1184-1197.
41. Whitney, J.B., III (1978) Simplified typing of mouse hemoglobin (Hbb) phenotypes using cystamine. Biochem Genet., 16, 667-672.
42. Williams, B.O., Schmitt, E.M., Remington, L., Bronson, R.T., Albert, D.M., Weinberg, R.A. and Jacks, T. (1994) Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J., 13, 4251-4259.