Ectopic expression of TAL-1 protein in Ly-6E.1-htal-1 transgenic mice induces defects in B- and T-lymphoid differentiation

Blood

Volumn 100, Issue 2, 2002, Pages 491-500

  Goardon, Nicolas ^a,b,c   Schuh, Annette ^a,b,c   Hajar, Iman ^a,b,c   Ma, Xiaoqian ^a,b,c   Jouault, Hélène ^a,b,c   Dzierzak, Elaine ^a,b,c   Roméo, Paul Henri ^a,b,c   Maouche Chrétien, Leïla ^a,b,c,d  

^a CNRS   (France)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c HENRI MONDOR HOSPITAL   (France)

^d INSTITUT COCHIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; TAL1 PROTEIN; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CELL COMPARTMENTALIZATION; CELL LINEAGE; CONTROLLED STUDY; GENE ISOLATION; GENE SWITCHING; GENETIC RECOMBINATION; IMMUNOGLOBULIN GENE; LYMPHOCYTE DIFFERENTIATION; LYMPHOID CELL; LYMPHOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN CELL; STEM CELL; T LYMPHOCYTE; TAL1 GENE; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

EID: 0037100309     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V100.2.491     Document Type: Article

References (35)

1. An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice
2. Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: Parallels with E2A-deficient mice
3. T-cell-directed TAL-1 expression induces T-cell malignancies in transgenic mice
4. Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase llalpha
5. Protein dimerization between Lmo2 (Rbtn2) and Tall alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice
6. scl, a gene frequently activated in human T cell leukaemia, does not induce lymphomas in transgenic mice
7. Characterization of hematopoietic progenitor cells that express the transcription factor SCL, using a lacZ "knock-in" strategy
8. Expression of tal-1 and GATA-binding proteins during human hematopoiesis
9. Expression of TAL-1 proteins in human tissues
10. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene
11. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
12. The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages
13. Products of the TAL1 oncogene: Basic helix-loop-helix proteins phosphorylated at serine residues
14. Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins
15. The protein Id: A negative regulator of helix-loop-helix DNA binding proteins
16. Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding
17. Cloning of the complete Ly-6E.1 gene and identification of DNase I hypersensitive sites corresponding to expression in hematopoietic cells
18. Expression of the Ly-6E.1 (Sca-1) transgene in adult hematopoietic stem cells and the developing mouse embryo
19. The Ly-6E.1 (Sca-1) gene requires a 3′ chromatin-dependent region for high-level gamma-interferon-induced hematopoietic cell expression
20. Loss of TAL-1 protein activity induces premature apoptosis of Jurkat leukemic T cells upon medium depletion
21. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells
22. The SCL gene product: A positive regulator of erythroid differentiation
23. Antiapoptotic effect of ectopic TAL1/SCL expression in a human leukemic T-cell line
24. Ectopic TAL-1/SCL expression in phenotypically normal or leukemic myeloid precursors: Proliferative and antiapoptotic effects coupled with a differentiation blockade
25. Positive and negative transcriptional control by the TAL1 helix-loop-helix protein
26. Preferred sequences for DNA recognition by the TALl helix-loop-helix proteins
27. The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition
28. The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by Id proteins during interleukin 6-induced myeloid differentiation
29. E2A deficiency leads to abnormalities in alpha-beta T-cell development and to rapid development of T-cell lymphomas
30. SCL and LMO1 alter thymocytes differentiation: Inhibition of E2A-HEB function and pre-Tα chain expression
31. Essential functions of Pax-5 (BSAP) in pro-B cell development
32. Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments
33. TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3
34. B-cell-specific coactivator OBF-1/ OCA-B/Bob1 required for immune response and germinal centre formation
35. E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination