LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 25, 2009, Pages 10141-10146

  Hu, Xin ^a,c   Li, Xingguo ^a   Valverde, Kristell ^a   Fu, Xueqi ^c   Noguchi, Constance ^d   Qiu, Yi ^a,b   Huang, Suming ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c JILIN UNIVERSITY   (China)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Erythroid differentiation; H3K4 methylation; Histone demethylation; Stem cell leukemia (SCL); Transcriptional regulation

Indexed keywords

HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE H3; LYSINE; LYSINE SPECIFIC DEMETHYLASE 1; METHYLTRANSFERASE; THYMIDINE KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR COREST; TRANSCRIPTION FACTOR TAL1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; COMPLEX FORMATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; EPIGENETICS; ERYTHROID CELL; ERYTHROLEUKEMIA CELL; GENE EXPRESSION; HEMATOPOIESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; T CELL LEUKEMIA;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; ERYTHROID CELLS; ERYTHROPOIESIS; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HUMANS; JURKAT CELLS; OXIDOREDUCTASES, N-DEMETHYLATING; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; TRANSCRIPTION, GENETIC;

MURINAE;

EID: 67649834041     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0900437106     Document Type: Article

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