-
1
-
-
80054025654
-
The role of Atg proteins in autophagosome formation
-
Mizushima, N., et al. The role of Atg proteins in autophagosome formation. Annu. Rev. Cell Dev. Biol. 27 (2011), 107–132.
-
(2011)
Annu. Rev. Cell Dev. Biol.
, vol.27
, pp. 107-132
-
-
Mizushima, N.1
-
2
-
-
84891747382
-
The machinery of macroautophagy
-
Feng, Y., et al. The machinery of macroautophagy. Cell Res. 24 (2014), 24–41.
-
(2014)
Cell Res.
, vol.24
, pp. 24-41
-
-
Feng, Y.1
-
3
-
-
85003429997
-
ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington's disease models
-
Wold, M.S., et al. ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington's disease models. Mol. Neurodegener., 11, 2016, 76.
-
(2016)
Mol. Neurodegener.
, vol.11
, pp. 76
-
-
Wold, M.S.1
-
4
-
-
84962675891
-
The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14
-
Park, J.M., et al. The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14. Autophagy 12 (2016), 547–564.
-
(2016)
Autophagy
, vol.12
, pp. 547-564
-
-
Park, J.M.1
-
5
-
-
84880331368
-
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
-
Russell, R.C., et al. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat. Cell Biol. 15 (2013), 741–750.
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 741-750
-
-
Russell, R.C.1
-
6
-
-
84892161646
-
The Atg8 family: multifunctional ubiquitin-like key regulators of autophagy
-
Slobodkin, M.R., Elazar, Z., The Atg8 family: multifunctional ubiquitin-like key regulators of autophagy. Essays Biochem. 55 (2013), 51–64.
-
(2013)
Essays Biochem.
, vol.55
, pp. 51-64
-
-
Slobodkin, M.R.1
Elazar, Z.2
-
7
-
-
84891461247
-
The LC3 interactome at a glance
-
Wild, P., et al. The LC3 interactome at a glance. J. Cell. Sci. 127 (2014), 3–9.
-
(2014)
J. Cell. Sci.
, vol.127
, pp. 3-9
-
-
Wild, P.1
-
8
-
-
84971524977
-
GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/GM130
-
Justin Joachim, S.A.T., GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/GM130. Autophagy 12 (2016), 892–893.
-
(2016)
Autophagy
, vol.12
, pp. 892-893
-
-
Justin Joachim, S.A.T.1
-
9
-
-
77953122645
-
LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis
-
Weidberg, H., et al. LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis. EMBO J. 29 (2010), 1792–1802.
-
(2010)
EMBO J.
, vol.29
, pp. 1792-1802
-
-
Weidberg, H.1
-
10
-
-
84901815187
-
Cargo recognition and trafficking in selective autophagy
-
Stolz, A., et al. Cargo recognition and trafficking in selective autophagy. Nat. Cell Biol. 16 (2014), 495–501.
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 495-501
-
-
Stolz, A.1
-
11
-
-
77954237882
-
Network organization of the human autophagy system
-
Behrends, C., et al. Network organization of the human autophagy system. Nature 466 (2010), 68–76.
-
(2010)
Nature
, vol.466
, pp. 68-76
-
-
Behrends, C.1
-
12
-
-
38349114036
-
Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases
-
Tan, J.M., et al. Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases. Hum. Mol. Genet. 17 (2008), 431–439.
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 431-439
-
-
Tan, J.M.1
-
13
-
-
78049495046
-
Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection
-
Riley, B.E., et al. Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. J. Cell Biol. 191 (2010), 537–552.
-
(2010)
J. Cell Biol.
, vol.191
, pp. 537-552
-
-
Riley, B.E.1
-
14
-
-
84955242756
-
Ubiquitin-dependent and independent signals in selective autophagy
-
Khaminets, A., et al. Ubiquitin-dependent and independent signals in selective autophagy. Trends Cell Biol. 26 (2016), 6–16.
-
(2016)
Trends Cell Biol.
, vol.26
, pp. 6-16
-
-
Khaminets, A.1
-
15
-
-
77955875002
-
Regulation of the autophagy protein LC3 by phosphorylation
-
Cherra, S.J. III, et al. Regulation of the autophagy protein LC3 by phosphorylation. J. Cell Biol. 190 (2010), 533–539.
-
(2010)
J. Cell Biol.
, vol.190
, pp. 533-539
-
-
Cherra, S.J.1
-
16
-
-
84924415434
-
Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates
-
Lim, J., et al. Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates. PLoS Genet., 11, 2015, e1004987.
-
(2015)
PLoS Genet.
, vol.11
, pp. e1004987
-
-
Lim, J.1
-
17
-
-
84898006751
-
SQSTM1/p62/A170 regulates the severity of Legionella pneumophila pneumonia by modulating inflammasome activity
-
Ohtsuka, S., et al. SQSTM1/p62/A170 regulates the severity of Legionella pneumophila pneumonia by modulating inflammasome activity. Eur. J. Immunol. 44 (2014), 1084–1092.
-
(2014)
Eur. J. Immunol.
, vol.44
, pp. 1084-1092
-
-
Ohtsuka, S.1
-
18
-
-
84942456107
-
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
-
Kang, C., et al. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science, 349, 2015, aaa5612.
-
(2015)
Science
, vol.349
, pp. aaa5612
-
-
Kang, C.1
-
19
-
-
84939800232
-
Amino acid activation of mTORC1 by a PB1-domain-driven kinase complex cascade
-
Linares, J.F., et al. Amino acid activation of mTORC1 by a PB1-domain-driven kinase complex cascade. Cell Rep. 12 (2015), 1339–1352.
-
(2015)
Cell Rep.
, vol.12
, pp. 1339-1352
-
-
Linares, J.F.1
-
20
-
-
82455172117
-
Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins
-
Matsumoto, G., et al. Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins. Mol. Cell 44 (2011), 279–289.
-
(2011)
Mol. Cell
, vol.44
, pp. 279-289
-
-
Matsumoto, G.1
-
21
-
-
84865357562
-
TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation
-
Pilli, M., et al. TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation. Immunity 37 (2012), 223–234.
-
(2012)
Immunity
, vol.37
, pp. 223-234
-
-
Pilli, M.1
-
22
-
-
84883830467
-
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy
-
Ichimura, Y., et al. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol. Cell 51 (2013), 618–631.
-
(2013)
Mol. Cell
, vol.51
, pp. 618-631
-
-
Ichimura, Y.1
-
23
-
-
84959490134
-
TRIM21 ubiquitylates SQSTM1/p62 and suppresses protein sequestration to regulate redox homeostasis
-
Pan, J.A., et al. TRIM21 ubiquitylates SQSTM1/p62 and suppresses protein sequestration to regulate redox homeostasis. Mol Cell 61 (2016), 720–733.
-
(2016)
Mol Cell
, vol.61
, pp. 720-733
-
-
Pan, J.A.1
-
24
-
-
84982851750
-
RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS
-
Ito, Y., et al. RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Science 353 (2016), 603–608.
-
(2016)
Science
, vol.353
, pp. 603-608
-
-
Ito, Y.1
-
25
-
-
79960804104
-
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth
-
Wild, P., et al. Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science 333 (2011), 228–233.
-
(2011)
Science
, vol.333
, pp. 228-233
-
-
Wild, P.1
-
26
-
-
84963566230
-
Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria
-
Richter, B., et al. Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Proc. Natl. Acad. Sci. U. S. A. 113 (2016), 4039–4044.
-
(2016)
Proc. Natl. Acad. Sci. U. S. A.
, vol.113
, pp. 4039-4044
-
-
Richter, B.1
-
27
-
-
62849123093
-
Polo-like kinases: conservation and divergence in their functions and regulation
-
Archambault, V., Glover, D.M., Polo-like kinases: conservation and divergence in their functions and regulation. Nat. Rev. Mol. Cell Biol. 10 (2009), 265–275.
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 265-275
-
-
Archambault, V.1
Glover, D.M.2
-
28
-
-
84904256742
-
Ubiquitylation of autophagy receptor optineurin by HACE1 activates selective autophagy for tumor suppression
-
Liu, Z., et al. Ubiquitylation of autophagy receptor optineurin by HACE1 activates selective autophagy for tumor suppression. Cancer Cell 26 (2014), 106–120.
-
(2014)
Cancer Cell
, vol.26
, pp. 106-120
-
-
Liu, Z.1
-
29
-
-
84903627153
-
Phosphorylation of NBR1 by GSK3 modulates protein aggregation
-
Nicot, A.S., et al. Phosphorylation of NBR1 by GSK3 modulates protein aggregation. Autophagy 10 (2014), 1036–1053.
-
(2014)
Autophagy
, vol.10
, pp. 1036-1053
-
-
Nicot, A.S.1
-
30
-
-
84880037292
-
Optineurin and amyotrophic lateral sclerosis
-
Maruyama, H., Kawakami, H., Optineurin and amyotrophic lateral sclerosis. Geriatr. Gerontol. Int. 13 (2013), 528–532.
-
(2013)
Geriatr. Gerontol. Int.
, vol.13
, pp. 528-532
-
-
Maruyama, H.1
Kawakami, H.2
-
31
-
-
84864557483
-
Toward an integrative view of optineurin functions
-
Kachaner, D., et al. Toward an integrative view of optineurin functions. Cell Cycle 11 (2012), 2808–2818.
-
(2012)
Cell Cycle
, vol.11
, pp. 2808-2818
-
-
Kachaner, D.1
-
32
-
-
84901832434
-
SQSTM1 mutations – bridging Paget disease of bone and ALS/FTLD
-
Rea, S.L., et al. SQSTM1 mutations – bridging Paget disease of bone and ALS/FTLD. Exp.Cell Res. 325 (2014), 27–37.
-
(2014)
Exp.Cell Res.
, vol.325
, pp. 27-37
-
-
Rea, S.L.1
-
33
-
-
84906313820
-
Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration
-
van der Zee, J., et al. Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration. Acta Neuropathol. 128 (2014), 397–410.
-
(2014)
Acta Neuropathol.
, vol.128
, pp. 397-410
-
-
van der Zee, J.1
-
34
-
-
80052580969
-
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
-
Deng, H.X., et al. Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature 477 (2011), 211–215.
-
(2011)
Nature
, vol.477
, pp. 211-215
-
-
Deng, H.X.1
-
35
-
-
84875279430
-
Explorative genetic study of UBQLN2 and PFN1 in an extended Flanders-Belgian cohort of frontotemporal lobar degeneration patients
-
1711 e1711–1715
-
Dillen, L., et al. Explorative genetic study of UBQLN2 and PFN1 in an extended Flanders-Belgian cohort of frontotemporal lobar degeneration patients. Neurobiol. Aging, 34, 2013 1711 e1711–1715.
-
(2013)
Neurobiol. Aging
, vol.34
-
-
Dillen, L.1
-
36
-
-
84892808067
-
Clinicopathologic features of autosomal recessive amyotrophic lateral sclerosis associated with optineurin mutation
-
Kamada, M., et al. Clinicopathologic features of autosomal recessive amyotrophic lateral sclerosis associated with optineurin mutation. Neuropathology 34 (2014), 64–70.
-
(2014)
Neuropathology
, vol.34
, pp. 64-70
-
-
Kamada, M.1
-
37
-
-
84947484975
-
Optineurin mutations in patients with sporadic amyotrophic lateral sclerosis in China
-
Li, C., et al. Optineurin mutations in patients with sporadic amyotrophic lateral sclerosis in China. Amyotroph. Lateral Scler. Frontotemporal. Degener. 16 (2015), 485–489.
-
(2015)
Amyotroph. Lateral Scler. Frontotemporal. Degener.
, vol.16
, pp. 485-489
-
-
Li, C.1
-
38
-
-
84931007726
-
Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease
-
Pottier, C., et al. Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease. Acta Neuropathol. 130 (2015), 77–92.
-
(2015)
Acta Neuropathol.
, vol.130
, pp. 77-92
-
-
Pottier, C.1
-
39
-
-
84945749129
-
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
-
Cirulli, E.T., et al. Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways. Science 347 (2015), 1436–1441.
-
(2015)
Science
, vol.347
, pp. 1436-1441
-
-
Cirulli, E.T.1
-
40
-
-
84928695187
-
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
-
Freischmidt, A., et al. Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia. Nat. Neurosci. 18 (2015), 631–636.
-
(2015)
Nat. Neurosci.
, vol.18
, pp. 631-636
-
-
Freischmidt, A.1
-
41
-
-
84940751065
-
Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism
-
Shen, W.C., et al. Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism. Autophagy 11 (2015), 685–700.
-
(2015)
Autophagy
, vol.11
, pp. 685-700
-
-
Shen, W.C.1
-
42
-
-
84876085831
-
Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates
-
Korac, J., et al. Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates. J. Cell Sci. 126 (2013), 580–592.
-
(2013)
J. Cell Sci.
, vol.126
, pp. 580-592
-
-
Korac, J.1
-
43
-
-
84908065760
-
Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation
-
Wong, Y.C., Holzbaur, E.L., Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation. Proc. Natl. Acad. Sci. U. S. A. 111 (2014), E4439–4448.
-
(2014)
Proc. Natl. Acad. Sci. U. S. A.
, vol.111
, pp. E4439-4448
-
-
Wong, Y.C.1
Holzbaur, E.L.2
-
44
-
-
84884271969
-
New insights into the role of sequestosome 1/p62 mutant proteins in the pathogenesis of Paget's disease of bone
-
Rea, S.L., et al. New insights into the role of sequestosome 1/p62 mutant proteins in the pathogenesis of Paget's disease of bone. Endocr. Rev. 34 (2013), 501–524.
-
(2013)
Endocr. Rev.
, vol.34
, pp. 501-524
-
-
Rea, S.L.1
-
45
-
-
33749661651
-
Immunoreactivities of p62, an ubiqutin-binding protein, in the spinal anterior horn cells of patients with amyotrophic lateral sclerosis
-
Mizuno, Y., et al. Immunoreactivities of p62, an ubiqutin-binding protein, in the spinal anterior horn cells of patients with amyotrophic lateral sclerosis. J. Neurol. Sci. 249 (2006), 13–18.
-
(2006)
J. Neurol. Sci.
, vol.249
, pp. 13-18
-
-
Mizuno, Y.1
-
46
-
-
0242669211
-
Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62
-
Arai, T., et al. Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62. Neurosci. Lett. 342 (2003), 41–44.
-
(2003)
Neurosci. Lett.
, vol.342
, pp. 41-44
-
-
Arai, T.1
-
47
-
-
47949110973
-
White matter lesions in the brain with frontotemporal lobar degeneration with motor neuron disease: TDP-43-immunopositive inclusions co-localize with p62, but not ubiquitin
-
Hiji, M., et al. White matter lesions in the brain with frontotemporal lobar degeneration with motor neuron disease: TDP-43-immunopositive inclusions co-localize with p62, but not ubiquitin. Acta Neuropathol. 116 (2008), 183–191.
-
(2008)
Acta Neuropathol.
, vol.116
, pp. 183-191
-
-
Hiji, M.1
-
48
-
-
84923239496
-
Neuronal aggregates: formation, clearance, and spreading
-
Lim, J., Yue, Z., Neuronal aggregates: formation, clearance, and spreading. Dev. Cell 32 (2015), 491–501.
-
(2015)
Dev. Cell
, vol.32
, pp. 491-501
-
-
Lim, J.1
Yue, Z.2
-
49
-
-
84928761818
-
Sqstm1 knock-down causes a locomotor phenotype ameliorated by rapamycin in a zebrafish model of ALS/FTLD
-
Lattante, S., et al. Sqstm1 knock-down causes a locomotor phenotype ameliorated by rapamycin in a zebrafish model of ALS/FTLD. Hum. Mol. Genet. 24 (2015), 1682–1690.
-
(2015)
Hum. Mol. Genet.
, vol.24
, pp. 1682-1690
-
-
Lattante, S.1
-
50
-
-
84966713295
-
Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD
-
Goode, A., et al. Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD. Autophagy 12 (2016), 1094–1104.
-
(2016)
Autophagy
, vol.12
, pp. 1094-1104
-
-
Goode, A.1
-
51
-
-
84984626892
-
ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling
-
Goode, A., et al. ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling. Mol. Cell. Neurosci. 76 (2016), 52–58.
-
(2016)
Mol. Cell. Neurosci.
, vol.76
, pp. 52-58
-
-
Goode, A.1
-
52
-
-
78650680776
-
Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1
-
Brady, O.A., et al. Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1. J. Neurochem. 116 (2011), 248–259.
-
(2011)
J. Neurochem.
, vol.116
, pp. 248-259
-
-
Brady, O.A.1
-
53
-
-
85014404067
-
Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice
-
Hadano, S., et al. Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice. Hum. Mol. Genet. 25 (2016), 3321–3340.
-
(2016)
Hum. Mol. Genet.
, vol.25
, pp. 3321-3340
-
-
Hadano, S.1
-
54
-
-
59649110865
-
PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation
-
N'Diaye, E.N., et al. PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation. EMBO Rep. 10 (2009), 173–179.
-
(2009)
EMBO Rep.
, vol.10
, pp. 173-179
-
-
N'Diaye, E.N.1
-
55
-
-
77955023765
-
Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy
-
Rothenberg, C., et al. Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. Hum. Mol. Genet. 19 (2010), 3219–3232.
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 3219-3232
-
-
Rothenberg, C.1
-
56
-
-
84925514171
-
Pathogenic Ubqln2 gains toxic properties to induce neuron death
-
Wu, Q., et al. Pathogenic Ubqln2 gains toxic properties to induce neuron death. Acta Neuropathol. 129 (2015), 417–428.
-
(2015)
Acta Neuropathol.
, vol.129
, pp. 417-428
-
-
Wu, Q.1
-
57
-
-
84959488435
-
Disturbance of proteasomal and autophagic protein degradation pathways by amyotrophic lateral sclerosis-linked mutations in ubiquilin 2
-
Osaka, M., et al. Disturbance of proteasomal and autophagic protein degradation pathways by amyotrophic lateral sclerosis-linked mutations in ubiquilin 2. Biochem. Biophys. Res. Commun. 472 (2016), 324–331.
-
(2016)
Biochem. Biophys. Res. Commun.
, vol.472
, pp. 324-331
-
-
Osaka, M.1
-
58
-
-
84979730108
-
UBQLN2 Mediates autophagy-independent protein aggregate clearance by the proteasome
-
Hjerpe, R., et al. UBQLN2 Mediates autophagy-independent protein aggregate clearance by the proteasome. Cell 166 (2016), 935–949.
-
(2016)
Cell
, vol.166
, pp. 935-949
-
-
Hjerpe, R.1
-
59
-
-
36348978522
-
Psychopathology in verified Huntington's disease gene carriers
-
van Duijn, E.E.A., Psychopathology in verified Huntington's disease gene carriers. J. Neuropsychiatry Clin. Neurosci. 19 (2007), 441–448.
-
(2007)
J. Neuropsychiatry Clin. Neurosci.
, vol.19
, pp. 441-448
-
-
van Duijn, E.E.A.1
-
60
-
-
0027480960
-
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington“s disease chromosomes. The Huntington's Disease Collaborative Research Group
-
No authors listed, A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington“s disease chromosomes. The Huntington's Disease Collaborative Research Group. Cell 72 (1993), 971–983.
-
(1993)
Cell
, vol.72
, pp. 971-983
-
-
No authors listed1
-
61
-
-
0030752709
-
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
-
DiFiglia, M.E.A., Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277 (1997), 1990–1993.
-
(1997)
Science
, vol.277
, pp. 1990-1993
-
-
DiFiglia, M.E.A.1
-
62
-
-
0033025958
-
Distribution of inclusions in neuronal nuclei and dystrophic neurites in Huntington disease brain
-
Maat-Schieman, M.L.E.A., Distribution of inclusions in neuronal nuclei and dystrophic neurites in Huntington disease brain. J. Neuropathol. Exp. Neurol. 58 (1999), 129–137.
-
(1999)
J. Neuropathol. Exp. Neurol.
, vol.58
, pp. 129-137
-
-
Maat-Schieman, M.L.E.A.1
-
63
-
-
35448994487
-
Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity
-
Atwal, R.S., et al. Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity. Hum. Mol. Genet. 16 (2007), 2600–2615.
-
(2007)
Hum. Mol. Genet.
, vol.16
, pp. 2600-2615
-
-
Atwal, R.S.1
-
64
-
-
84923789937
-
Huntingtin functions as a scaffold for selective macroautophagy
-
Rui, Y.N., et al. Huntingtin functions as a scaffold for selective macroautophagy. Nat. Cell Biol. 17 (2015), 262–275.
-
(2015)
Nat. Cell Biol.
, vol.17
, pp. 262-275
-
-
Rui, Y.N.1
-
65
-
-
72149124383
-
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
-
Thompson, L.M., et al. IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J. Cell Biol. 187 (2009), 1083–1099.
-
(2009)
J. Cell Biol.
, vol.187
, pp. 1083-1099
-
-
Thompson, L.M.1
-
66
-
-
34447130222
-
Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons
-
Anne, S.L., et al. Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons. J. Neurosci. 27 (2007), 7318–7328.
-
(2007)
J. Neurosci.
, vol.27
, pp. 7318-7328
-
-
Anne, S.L.1
-
67
-
-
0036083379
-
The IGF-1 Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt
-
Humbert, S., et al. The IGF-1 Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt. Dev. Cell 2 (2002), 831–837.
-
(2002)
Dev. Cell
, vol.2
, pp. 831-837
-
-
Humbert, S.1
-
68
-
-
27944504351
-
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
-
Bjorkoy, G., et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 171 (2005), 603–614.
-
(2005)
J. Cell Biol.
, vol.171
, pp. 603-614
-
-
Bjorkoy, G.1
-
69
-
-
84922469339
-
Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice
-
Kurosawa, M., et al. Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice. Hum. Mol. Genet. 24 (2015), 1092–1105.
-
(2015)
Hum. Mol. Genet.
, vol.24
, pp. 1092-1105
-
-
Kurosawa, M.1
-
70
-
-
4944247868
-
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes
-
Simonsen, A.E.A., Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J. Cell. Sci. 117 (2004), 4239–4251.
-
(2004)
J. Cell. Sci.
, vol.117
, pp. 4239-4251
-
-
Simonsen, A.E.A.1
-
71
-
-
77952914565
-
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy
-
Clausen, T.H., et al. p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy. Autophagy 6 (2014), 330–344.
-
(2014)
Autophagy
, vol.6
, pp. 330-344
-
-
Clausen, T.H.1
-
72
-
-
77950903972
-
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy
-
Filimonenko, M., et al. The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol. Cell 38 (2010), 265–279.
-
(2010)
Mol. Cell
, vol.38
, pp. 265-279
-
-
Filimonenko, M.1
-
73
-
-
79952325055
-
Alfy-dependent elimination of aggregated proteins by macroautophagy: can there be too much of a good thing?
-
Yamamoto, A., Simonsen, A., Alfy-dependent elimination of aggregated proteins by macroautophagy: can there be too much of a good thing?. Autophagy 7 (2011), 346–350.
-
(2011)
Autophagy
, vol.7
, pp. 346-350
-
-
Yamamoto, A.1
Simonsen, A.2
-
74
-
-
84899821545
-
Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures
-
Lystad, A.H., et al. Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures. EMBO Rep. 15 (2014), 557–565.
-
(2014)
EMBO Rep.
, vol.15
, pp. 557-565
-
-
Lystad, A.H.1
-
75
-
-
0034649661
-
FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis
-
Hattula, K., Peranen, J., FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis. Curr. Biol. 10 (2000), 1603–1606.
-
(2000)
Curr. Biol.
, vol.10
, pp. 1603-1606
-
-
Hattula, K.1
Peranen, J.2
-
76
-
-
65249141171
-
Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatus
-
del Toro, D., et al. Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatus. Mol. Biol. Cell 20 (2009), 1478–1492.
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 1478-1492
-
-
del Toro, D.1
-
77
-
-
84855204007
-
Optineurin in Huntington's disease intranuclear inclusions
-
Schwab, C., et al. Optineurin in Huntington's disease intranuclear inclusions. Neurosci. Lett. 506 (2012), 149–154.
-
(2012)
Neurosci. Lett.
, vol.506
, pp. 149-154
-
-
Schwab, C.1
-
78
-
-
84905491871
-
Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family
-
Lu, K., et al. Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family. Cell 158 (2014), 549–563.
-
(2014)
Cell
, vol.158
, pp. 549-563
-
-
Lu, K.1
-
79
-
-
79960839810
-
Optineurin in neurodegenerative diseases
-
Osawa, T., et al. Optineurin in neurodegenerative diseases. Neuropathology 31 (2011), 569–574.
-
(2011)
Neuropathology
, vol.31
, pp. 569-574
-
-
Osawa, T.1
-
80
-
-
84865863969
-
Autophagic adapter protein NBR1 is localized in Lewy bodies and glial cytoplasmic inclusions and is involved in aggregate formation in alpha-synucleinopathy
-
Odagiri, S., et al. Autophagic adapter protein NBR1 is localized in Lewy bodies and glial cytoplasmic inclusions and is involved in aggregate formation in alpha-synucleinopathy. Acta Neuropathol. 124 (2012), 173–186.
-
(2012)
Acta Neuropathol.
, vol.124
, pp. 173-186
-
-
Odagiri, S.1
-
81
-
-
84939442884
-
p62 Deficiency enhances alpha-synuclein pathology in mice
-
Tanji, K., et al. p62 Deficiency enhances alpha-synuclein pathology in mice. Brain Pathol. 25 (2015), 552–564.
-
(2015)
Brain Pathol.
, vol.25
, pp. 552-564
-
-
Tanji, K.1
-
82
-
-
78649300971
-
p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
-
Narendra, D., et al. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 6 (2014), 1090–1106.
-
(2014)
Autophagy
, vol.6
, pp. 1090-1106
-
-
Narendra, D.1
-
83
-
-
77954695260
-
p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria
-
Okatsu, K., et al. p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells 15 (2010), 887–900.
-
(2010)
Genes Cells
, vol.15
, pp. 887-900
-
-
Okatsu, K.1
-
84
-
-
84939804206
-
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
-
Lazarou, M., et al. The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature 524 (2015), 309–314.
-
(2015)
Nature
, vol.524
, pp. 309-314
-
-
Lazarou, M.1
-
85
-
-
84856221632
-
A vesicular transport pathway shuttles cargo from mitochondria to lysosomes
-
Soubannier, V., et al. A vesicular transport pathway shuttles cargo from mitochondria to lysosomes. Curr. Biol. 22 (2012), 135–141.
-
(2012)
Curr. Biol.
, vol.22
, pp. 135-141
-
-
Soubannier, V.1
-
86
-
-
84897863239
-
Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control
-
McLelland, G.L., et al. Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control. EMBO J. 33 (2014), 282–295.
-
(2014)
EMBO J.
, vol.33
, pp. 282-295
-
-
McLelland, G.L.1
-
87
-
-
79955969705
-
Autophagy failure in Alzheimer's disease – locating the primary defect
-
Nixon, R.A., Yang, D.S., Autophagy failure in Alzheimer's disease – locating the primary defect. Neurobiol. Dis. 43 (2011), 38–45.
-
(2011)
Neurobiol. Dis.
, vol.43
, pp. 38-45
-
-
Nixon, R.A.1
Yang, D.S.2
-
88
-
-
14844303381
-
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study
-
Nixon, R.A., et al. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J. Neuropathol. Exp. Neurol. 64 (2005), 113–122.
-
(2005)
J. Neuropathol. Exp. Neurol.
, vol.64
, pp. 113-122
-
-
Nixon, R.A.1
-
89
-
-
83155185539
-
Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease
-
Salminen, A., et al. Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease. Prog. Neurobiol. 96 (2012), 87–95.
-
(2012)
Prog. Neurobiol.
, vol.96
, pp. 87-95
-
-
Salminen, A.1
-
90
-
-
84933180683
-
Genetic variability in SQSTM1 and risk of early-onset Alzheimer dementia: a European early-onset dementia consortium study
-
2005 e2015–2022
-
Cuyvers, E., et al. Genetic variability in SQSTM1 and risk of early-onset Alzheimer dementia: a European early-onset dementia consortium study. Neurobiol. Aging, 36, 2015 2005 e2015–2022.
-
(2015)
Neurobiol. Aging
, vol.36
-
-
Cuyvers, E.1
-
91
-
-
84921681202
-
Phosphorylation of serine 349 of p62 in Alzheimer's disease brain
-
Tanji, K., et al. Phosphorylation of serine 349 of p62 in Alzheimer's disease brain. Acta Neuropathol. Commun., 2, 2014, 50.
-
(2014)
Acta Neuropathol. Commun.
, vol.2
, pp. 50
-
-
Tanji, K.1
-
92
-
-
45249105920
-
Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration
-
Ramesh Babu, J., et al. Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration. J. Neurochem. 106 (2008), 107–120.
-
(2008)
J. Neurochem.
, vol.106
, pp. 107-120
-
-
Ramesh Babu, J.1
-
93
-
-
84984622157
-
p62 improves AD-like pathology by increasing autophagy
-
Caccamo, A., et al. p62 improves AD-like pathology by increasing autophagy. Mol. Psychiatry, 2016, 10.1038/mp.2016.139.
-
(2016)
Mol. Psychiatry
-
-
Caccamo, A.1
-
94
-
-
84897093101
-
Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52
-
Jo, C., et al. Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52. Nat. Commun., 5, 2014, 3496.
-
(2014)
Nat. Commun.
, vol.5
, pp. 3496
-
-
Jo, C.1
-
95
-
-
84996806746
-
Absence of the autophagy adaptor SQSTM1/p62 causes childhood-onset neurodegeneration with ataxia, dystonia, and gaze palsy
-
Haack, T.B., et al. Absence of the autophagy adaptor SQSTM1/p62 causes childhood-onset neurodegeneration with ataxia, dystonia, and gaze palsy. Am. J. Hum. Genet. 99 (2016), 735–743.
-
(2016)
Am. J. Hum. Genet.
, vol.99
, pp. 735-743
-
-
Haack, T.B.1
-
96
-
-
84873569630
-
Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease
-
Rue, L., et al. Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease. Neurobiol. Dis. 52 (2013), 219–228.
-
(2013)
Neurobiol. Dis.
, vol.52
, pp. 219-228
-
-
Rue, L.1
-
97
-
-
84857437068
-
Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression
-
Kachaner, D., et al. Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression. Mol. Cell 45 (2012), 553–566.
-
(2012)
Mol. Cell
, vol.45
, pp. 553-566
-
-
Kachaner, D.1
-
98
-
-
77952419246
-
Mutations of optineurin in amyotrophic lateral sclerosis
-
Maruyama, H., et al. Mutations of optineurin in amyotrophic lateral sclerosis. Nature 465 (2010), 223–226.
-
(2010)
Nature
, vol.465
, pp. 223-226
-
-
Maruyama, H.1
-
99
-
-
84897863195
-
Ubiquilin 2: a component of the ubiquitin-proteasome system with an emerging role in neurodegeneration
-
Zhang, K.Y., et al. Ubiquilin 2: a component of the ubiquitin-proteasome system with an emerging role in neurodegeneration. Int. J. Biochem. Cell Biol. 50 (2014), 123–126.
-
(2014)
Int. J. Biochem. Cell Biol.
, vol.50
, pp. 123-126
-
-
Zhang, K.Y.1
-
100
-
-
84925535114
-
Autophagy-linked FYVE protein (Alfy) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)
-
Han, H., et al. Autophagy-linked FYVE protein (Alfy) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS). In Vitro Cell. Dev. Biol. Anim. 51 (2015), 249–263.
-
(2015)
In Vitro Cell. Dev. Biol. Anim.
, vol.51
, pp. 249-263
-
-
Han, H.1
-
101
-
-
84910619569
-
NDP52 associates with phosphorylated tau in brains of an Alzheimer disease mouse model
-
Kim, S., et al. NDP52 associates with phosphorylated tau in brains of an Alzheimer disease mouse model. Biochem. Biophys. Res. Commun. 454 (2014), 196–201.
-
(2014)
Biochem. Biophys. Res. Commun.
, vol.454
, pp. 196-201
-
-
Kim, S.1
-
102
-
-
84966431237
-
Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin
-
Lin, L., et al. Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin. Brain Res. 1643 (2016), 103–112.
-
(2016)
Brain Res.
, vol.1643
, pp. 103-112
-
-
Lin, L.1
-
103
-
-
79960124086
-
Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation
-
Zucchelli, S., et al. Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation. J. Biol. Chem. 286 (2011), 25108–25117.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 25108-25117
-
-
Zucchelli, S.1
|