Ubiquilin 2: A component of the ubiquitin-proteasome system with an emerging role in neurodegeneration

International Journal of Biochemistry and Cell Biology

Volumn 50, Issue 1, 2014, Pages 123-126

  Zhang, Katharine Y ^a   Yang, Shu ^a   Warraich, Sadaf T ^a   Blair, Ian P ^a  

^a MACQUARIE UNIVERSITY   (Australia)

Author keywords

Amyotrophic lateral sclerosis; Autophagy; Dementia; Ubiquilin 2; Ubiquitin proteasome system

Indexed keywords

MESSENGER RNA; PROTEASOME; PROTEIN P53; UBIQUILIN 2; UBIQUITIN PROTEIN LIGASE; UBIQUITINATED PROTEIN; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; UBIQUITIN; UBQLN2 PROTEIN, HUMAN;

ALPHA HELIX; AMINO ACID SEQUENCE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL CYCLE PROGRESSION; CHAPERONE-MEDIATED AUTOPHAGY; DEGENERATIVE DISEASE; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENDOPLASMIC RETICULUM STRESS; FRONTOTEMPORAL DEMENTIA; GENE MUTATION; HUMAN; HUNTINGTON CHOREA; MACROAUTOPHAGY; NERVE DEGENERATION; NONHUMAN; PICK PRESENILE DEMENTIA; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; TANDEM REPEAT; ANIMAL; DEMENTIA; ENZYMOLOGY; METABOLISM;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL CYCLE PROTEINS; DEMENTIA; HUMANS; NEURODEGENERATIVE DISEASES; PROTEASOME ENDOPEPTIDASE COMPLEX; UBIQUITINS;

EID: 84897863195     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2014.02.018     Document Type: Short Survey

References (28)

1. O. Aitio, M. Hellman, A. Kazlauskas, D.F. Vingadassalom, J.M. Leong, and K. Saksela et al. Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly Proc Natl Acad Sci USA 107 2010 21743 21748
2. J. Brettschneider, V.M. Van Deerlin, J.L. Robinson, L. Kwong, E.B. Lee, and Y.O. Ali et al. Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion Acta Neuropathol 123 2012 825 839
3. J.A. Cassel, and A.B. Reitz Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolines Biochim Biophys Acta 1834 2013 964 971
4. H. Daoud, H. Suhail, A. Szuto, W. Camu, F. Salachas, and V. Meininger et al. UBQLN2 mutations are rare in French and French-Canadian amyotrophic lateral sclerosis Neurobiol Aging 33 2012 2230 e1-e5
5. H.X. Deng, W. Chen, S.T. Hong, K.M. Boycott, G.H. Gorrie, and N. Siddique et al. Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia Nature 477 2011 211 215
6. C. Gellera, C. Tiloca, R. Del Bo, L. Corrado, V. Pensato, and J. Agostini et al. Ubiquilin 2 mutations in Italian patients with amyotrophic lateral sclerosis and frontotemporal dementia J Neurol Neurosurg Psychiatry 84 2013 183 187
7. J.O. Johnson, J. Mandrioli, M. Benatar, Y. Abramzon, V.M. Van Deerlin, and J.Q. Trojanowski et al. Exome sequencing reveals VCP mutations as a cause of familial ALS Neuron 68 2010 857 864
8. F.J. Kaye, S. Modi, I. Ivanovska, E.V. Koonin, K. Thress, and A. Kubo et al. A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch FEBS Lett 467 2000 348 355
9. F.J. Kaye, and T.B. Shows Assignment of ubiquilin2 (UBQLN2) to human chromosome Xp11. 23 - >p11.1 by GeneBridge radiation hybrids Cytogenet Cell Genet 89 2000 116 117
10. T.Y. Kim, E. Kim, S.K. Yoon, and J.B. Yoon Herp enhances ER-associated protein degradation by recruiting ubiquilins Biochem Biophys Res Commun 369 2008 741 746
11. M.F. Kleijnen, R.M. Alarcon, and P.M. Howley The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome Mol Biol Cell 14 2003 3868 3875
12. M.F. Kleijnen, A.H. Shih, P. Zhou, S. Kumar, R.E. Soccio, and N.L. Kedersha et al. The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome Mol Cell 6 2000 409 419
13. P.J. Lim, R. Danner, J. Liang, H. Doong, C. Harman, and D. Srinivasan et al. Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD J Cell Biol 187 2009 201 217
14. H. Maruyama, H. Morino, H. Ito, Y. Izumi, H. Kato, and Y. Watanabe et al. Mutations of optineurin in amyotrophic lateral sclerosis Nature 465 2010 223 226
15. L.K. Massey, A.L. Mah, D.L. Ford, J. Miller, J. Liang, and H. Doong et al. Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins J Alzheimers Dis 6 2004 79 92
16. L.K. Massey, A.L. Mah, and M.J. Monteiro Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin Biochem J 391 2005 513 525
17. E.N. N'diaye, A.C. Hanyaloglu, K.K. Kajihara, M.A. Puthenveedu, P. Wu, and M. von Zastrow et al. The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis Mol Biol Cell 19 2008 1252 1260
18. E.N. N'diaye, K.K. Kajihara, I. Hsieh, H. Morisaki, J. Debnath, and E.J. Brown PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation EMBO Rep 10 2009 173 179
19. A. Nolle, E.S. Van Haastert, R. Zwart, J.J. Hoozemans, and W. Scheper Ubiquilin 2 is not associated with tau pathology PLoS ONE 8 2013 e76598
20. C. Rothenberg, D. Srinivasan, L. Mah, S. Kaushik, C.M. Peterhoff, and J. Ugolino et al. Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy Hum Mol Genet 19 2010 3219 3232
21. N.J. Rutherford, J. Lewis, A.K. Clippinger, M.A. Thomas, J. Adamson, and P.E. Cruz et al. Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions Brain Res 1524 2013 62 73
22. M. Synofzik, W. Maetzler, T. Grehl, J. Prudlo, J.M. Vom Hagen, and T. Haack et al. Screening in ALS and FTD patients reveals 3 novel UBQLN2 mutations outside the PXX domain and a pure FTD phenotype Neurobiol Aging 33 2012 2949 e13-7
23. K.J. Walters, A.M. Goh, Q. Wang, G. Wagner, and P.M. Howley Ubiquitin family proteins and their relationship to the proteasome: a structural perspective Biochim Biophys Acta 1695 2004 73 87
24. K.J. Walters, M.F. Kleijnen, A.M. Goh, G. Wagner, and P.M. Howley Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a Biochemistry 41 2002 1767 1777
25. K.L. Williams, S.T. Warraich, S. Yang, J.A. Solski, R. Fernando, and G.A. Rouleau et al. UBQLN2/ubiquilin 2 mutation and pathology in familial amyotrophic lateral sclerosis Neurobiol Aging 33 2012 2527 e3-10
26. A.L. Wu, J. Wang, A. Zheleznyak, and E.J. Brown Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane Mol Cell 4 1999 619 625
27. Y. Xia, L.H. Yan, B. Huang, M. Liu, X. Liu, and C. Huang Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation J Neurochem 2013 10.1111/jnc.12606 [Epub ahead of print]
28. C. Zhang, and A.J. Saunders An emerging role for ubiquilin 1 in regulating protein quality control system and in disease pathogenesis Discov Med 8 2009 18 22