Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy- mediated degradation of misfolded proteins by a dominant-negative mechanism

Autophagy

Volumn 11, Issue 4, 2015, Pages 685-700

  Shen, Wen Chuan ^a,b   Li, Huei Ying ^b   Chen, Guang Chao ^c   Chern, Yijuang ^a,b   Tu, Pang Hsien ^a,b  

^a ACADEMIA SINICA   (Taiwan)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

Author keywords

Autophagy; Dominant negative; Huntingtin; Optineurin; TARDBP TDP 43

Indexed keywords

MYOSIN VI; OPTINEURIN; DNA BINDING PROTEIN; EYE PROTEIN; MUTANT PROTEIN; OPTN PROTEIN, HUMAN; OPTN PROTEIN, MOUSE; PROTEIN BINDING; TRANSCRIPTION FACTOR IIIA;

ANIMAL EXPERIMENT; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL MATURATION; CONTROLLED STUDY; MOUSE; MUTATION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL; BINDING SITE; CYTOPLASM; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN FOLDING;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; AUTOPHAGY; BINDING SITES; CYTOPLASM; DNA-BINDING PROTEINS; EYE PROTEINS; HUMANS; MICE; MUTANT PROTEINS; MUTATION; PROTEIN BINDING; PROTEIN FOLDING; TRANSCRIPTION FACTOR TFIIIA;

EID: 84940751065     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.36098     Document Type: Article

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