Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: Cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice

Human Molecular Genetics

Volumn 25, Issue 15, 2016, Pages 3321-3340

  Hadano, Shinji ^a,b,c   Mitsui, Shun ^a   Pan, Lei ^a   Otomo, Asako ^a,c   Kubo, Mizuki ^a   Sato, Kai ^a   Ono, Suzuka ^a   Onodera, Wakana ^a   Abe, Koichiro ^a   Chen, XuePing ^d   Koike, Masato ^e   Uchiyama, Yasuo ^e   Aoki, Masashi ^f   Warabi, Eiji ^g   Yamamoto, Masayuki ^f   Ishii, Tetsuro ^g   Yanagawa, Toru ^g   Shang, Hui Fang ^d   Yoshii, Fumihito ^a,c  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKAI UNIVERSITY   (Japan)

^c TOKAI UNIVERSITY   (Japan)

^d SICHUAN UNIVERSITY   (China)

^e JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^g UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALS2 PROTEIN; PROTEIN; SEQUESTOSOME 1; TRANSCRIPTION FACTOR NRF2; UBIQUITIN; UNCLASSIFIED DRUG; ALS2 PROTEIN, MOUSE; COPPER ZINC SUPEROXIDE DISMUTASE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; NFE2L2 PROTEIN, MOUSE; SOD1 G93A PROTEIN; SOD1 PROTEIN, HUMAN; SOD1 PROTEIN, MOUSE; SQSTM1 PROTEIN, MOUSE; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BIOCHEMICAL ANALYSIS; CONTROLLED STUDY; DISEASE EXACERBATION; FEMALE; GENE INACTIVATION; GENE LOSS; GENE REPRESSION; GENETIC LINKAGE; HISTOPATHOLOGY; IN VIVO STUDY; MALE; MOTOR DYSFUNCTION; MOUSE; MSOD1 MOUSE; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; PROTEIN AGGREGATION; SPINAL CORD MOTONEURON; ANIMAL; BRAIN; ENDOSOME; GENETICS; HUMAN; LYSOSOME; METABOLISM; MISSENSE MUTATION; MOTONEURON; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; AUTOPHAGY; BRAIN; ENDOSOMES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; LYSOSOMES; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUTATION, MISSENSE; NF-E2-RELATED FACTOR 2; SEQUESTOSOME-1 PROTEIN; SUPEROXIDE DISMUTASE; SUPEROXIDE DISMUTASE-1;

EID: 85014404067     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddw180     Document Type: Article

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