The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

Autophagy

Volumn 12, Issue 3, 2016, Pages 547-564

  Park, Ji Man ^a   Jung, Chang Hwa ^a,b   Seo, Minchul ^a,e   Otto, Neil Michael ^a   Grunwald, Douglas ^a   Kim, Kwan Hyun ^a   Moriarity, Branden ^c,d   Kim, Young Mi ^a   Starker, Colby ^a,c   Nho, Richard Seonghun ^c,d   Voytas, Daniel ^a,c   Kim, Do Hyung ^a,d  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Korea Food Research Institute   (South Korea)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e Dongguk University College of Medicine   (South Korea)

Author keywords

ATG13; ATG14; BECN1; MTORC1; PIK3C3; ULK1

Indexed keywords

ATG13 PROTEIN; ATG14 PROTEIN; BECLIN 1; BIOLOGICAL MARKER; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL 3 KINASE; PIK3C3 PROTEIN; UNC 51 LIKE AUTOPHAGY ACTIVATING KINASE 1; UNCLASSIFIED DRUG; ATG13 PROTEIN, HUMAN; ATG14 PROTEIN, HUMAN; ATG14 PROTEIN, MOUSE; AUTOPHAGY RELATED PROTEIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PHOSPHOSERINE; PROTEIN BINDING; SERINE THREONINE PROTEIN KINASE ULK1; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE; ULK1 PROTEIN, HUMAN; ULK1 PROTEIN, MOUSE; VESICULAR TRANSPORT ADAPTOR PROTEIN; VESICULAR TRANSPORT PROTEIN;

ANIMAL CELL; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CONJUGATION; ENZYME ACTIVITY; IN VITRO STUDY; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; HUMAN; METABOLISM; PHOSPHORYLATION; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; AMINO ACID SEQUENCE; ANIMALS; AUTOPHAGOSOMES; AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN-1 HOMOLOG; AUTOPHAGY-RELATED PROTEINS; CELL LINE; CLASS I PHOSPHATIDYLINOSITOL 3-KINASES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MULTIPROTEIN COMPLEXES; PHOSPHATIDYLETHANOLAMINES; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN BINDING; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; UP-REGULATION; VESICULAR TRANSPORT PROTEINS;

EID: 84962675891     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.1080/15548627.2016.1140293     Document Type: Article

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