ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington's disease models

Molecular Neurodegeneration

Volumn 11, Issue 1, 2016, Pages

  Wold, Mitchell S ^a   Lim, Junghyun ^a,b   Lachance, Véronik ^a   Deng, Zhiqiang ^a,c   Yue, Zhenyu ^a,d  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b GENENTECH INC   (United States)

^c WUHAN UNIVERSITY   (China)

^d HESS CORPORATION   (United States)

Author keywords

ATG14; Autophagy; Huntington's; ULK1; Vps34

Indexed keywords

ATG14 PROTEIN; BECLIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PEPTIDES AND PROTEINS; PROTEASOME; PROTEIN KINASE; SERINE; UNC 51 LIKE AUTOPHAGY ACTIVATING KINASE 1; UNCLASSIFIED DRUG; ATG14 PROTEIN, HUMAN; AUTOPHAGY RELATED PROTEIN; SERINE THREONINE PROTEIN KINASE ULK1; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL FRACTIONATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HUNTINGTON CHOREA; IN VIVO STUDY; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; DISEASE MODEL; FLUORESCENCE MICROSCOPY; HUMAN; IMMUNOBLOTTING; IMMUNOPRECIPITATION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN-1 HOMOLOG; AUTOPHAGY-RELATED PROTEINS; CELL LINE; DISEASE MODELS, ANIMAL; HUMANS; HUNTINGTON DISEASE; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MICE; MICROSCOPY, FLUORESCENCE; PHOSPHORYLATION;

EID: 85003429997     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/s13024-016-0141-0     Document Type: Article

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