RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

Science

Volumn 353, Issue 6299, 2016, Pages 603-608

  Ito, Yasushi ^a   Ofengeim, Dimitry ^a   Najafov, Ayaz ^a   Das, Sudeshna ^b   Saberi, Shahram ^a,c   Li, Ying ^a,d   Hitomi, Junichi ^a   Zhu, Hong ^a   Chen, Hongbo ^a   Mayo, Lior ^e   Geng, Jiefei ^a   Amin, Palak ^a   DeWitt, Judy Park ^a   Mookhtiar, Adnan Kasim ^a   Florez, Marcus ^a   Ouchida, Amanda Tomie ^a   Fan, Jian Bing ^f   Pasparakis, Manolis ^g   Kelliher, Michelle A ^h   Ravits, John ^a,c   Yuan, Junying ^a,d   more..

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f ILLUMINA INC   (United States)

^g UNIVERSITY OF COLOGNE   (Germany)

^h UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; MIXED LINEAGE KINASE DOMAIN LIKE PROTEIN; PHOSPHOTRANSFERASE; PROTEIN; RECEPTOR INTERACTING KINASE 1; RECEPTOR INTERACTING KINASE 3; UNCLASSIFIED DRUG; COPPER ZINC SUPEROXIDE DISMUTASE; OPTN PROTEIN, HUMAN; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK1 PROTEIN, HUMAN; RIPK3 PROTEIN, HUMAN; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR IIIA;

ENZYME; HISTOPATHOLOGY; INHIBITION; MUTATION; NERVOUS SYSTEM; NERVOUS SYSTEM DISORDER; PHYSIOLOGY; PROTEIN; PUBLIC HEALTH;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LINEAGE; CONTROLLED STUDY; ENZYME METABOLISM; LUMBAR SPINAL CORD; MOUSE; MYELIN DEFICIENCY; NECROPTOSIS; NERVE FIBER DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NEUROPATHOLOGY; NEWBORN; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; ANIMAL; APOPTOSIS; AXON; GENE REPRESSION; GENETICS; HUMAN; INFLAMMATION; METABOLISM; NECROSIS; NERVE DEGENERATION; PATHOLOGY; PHYSIOLOGY; SPINAL CORD;

MUS MUSCULUS;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; APOPTOSIS; AXONS; HUMANS; INFLAMMATION; MICE; MICE, TRANSGENIC; NECROSIS; NERVE DEGENERATION; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SPINAL CORD; SUPEROXIDE DISMUTASE; SUPPRESSION, GENETIC; TRANSCRIPTION FACTOR TFIIIA;

EID: 84982851750     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf6803     Document Type: Article

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