Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 42, 2014, Pages E4439-E4448

  Wong, Yvette C ^a   Holzbaur, Erika L F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Amyotrophic lateral sclerosis; Autophagosome; Mitophagy; Optineurin; Parkinson's disease

Indexed keywords

DOUBLE FYVE CONTAINING PROTEIN 1; OPTINEURIN; PARKIN; PEPTIDES AND PROTEINS; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; GREEN FLUORESCENT PROTEIN; LIGHT CHAIN 3, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; OPTN PROTEIN, HUMAN; PROTEIN BINDING; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMALL INTERFERING RNA; SQSTM1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR IIIA; UBIQUITIN PROTEIN LIGASE;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; AUTOPHAGOSOME; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MITOCHONDRION; MITOPHAGY; PROTEIN DOMAIN; AUTOPHAGY; CONFOCAL MICROSCOPY; DEGENERATIVE DISEASE; GENETICS; HELA CELL LINE; METABOLISM; MICROTUBULE; MITOCHONDRIAL MEMBRANE; MUTATION; PARKINSON DISEASE; PHAGOSOME; PROTEIN TERTIARY STRUCTURE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMYOTROPHIC LATERAL SCLEROSIS; AUTOPHAGY; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; MICROSCOPY, CONFOCAL; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; MITOCHONDRIAL MEMBRANES; MUTATION; NEURODEGENERATIVE DISEASES; PARKINSON DISEASE; PHAGOSOMES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RNA, SMALL INTERFERING; TRANSCRIPTION FACTOR TFIIIA; UBIQUITIN-PROTEIN LIGASES;

EID: 84908065760     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1405752111     Document Type: Article

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