Pathogenic Ubqln2 gains toxic properties to induce neuron death

Acta Neuropathologica

Volumn 129, Issue 3, 2015, Pages 417-428

  Wu, Qinxue ^a   Liu, Mujun ^a   Huang, Cao ^a   Liu, Xionghao ^a   Huang, Bo ^a   Li, Niansheng ^a   Zhou, Hongxia ^a   Xia, Xu Gang ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

ALS; Amyotrophic lateral sclerosis; Autophagy; Frontotemporal lobar degeneration; FTLD; Knockout; p62; Protein aggregation; Rats; Ubqln2

Indexed keywords

MUTANT PROTEIN; PEPTIDES AND PROTEINS; PROTEIN AGGREGATE; PROTEIN P62; UBIQUILIN 2; UNCLASSIFIED DRUG; UBIQUITIN; UBQLN2 PROTEIN, RAT;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CELL LOSS; COGNITIVE DEFECT; CONTROLLED STUDY; ENDOSOME; FRONTOTEMPORAL DEMENTIA; GAIN OF FUNCTION MUTATION; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; KNOCKOUT RAT; NERVE CELL; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FUNCTION; RAT; TRANSGENIC RAT; ANIMAL; CELL DEATH; DEFICIENCY; GENE INACTIVATION; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOBLOTTING; IMMUNOPRECIPITATION; METABOLISM; MUTATION; NERVE DEGENERATION; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; CELL DEATH; GENE KNOCKOUT TECHNIQUES; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MICROSCOPY, ELECTRON, TRANSMISSION; MUTATION; NERVE DEGENERATION; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UBIQUITINS;

EID: 84925514171     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-014-1367-y     Document Type: Article

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