Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

Nature

Volumn 480, Issue 7378, 2011, Pages 565-569

  Nakashima, Ryosuke ^a   Sakurai, Keisuke ^a   Yamasaki, Seiji ^a   Nishino, Kunihiko ^a   Yamaguchi, Akihito ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; ERYTHROMYCIN; GLYCOPROTEIN P; MINOCYCLINE; MULTIDRUG TRANSPORTER ACRB; PHENYLALANINE; RIFAMPICIN; UNCLASSIFIED DRUG;

ANTIBIOTICS; BACTERIUM; CHEMICAL BINDING; DRUG; MEMBRANE; MOLECULAR ANALYSIS; SUBSTRATE; VOLUME;

ARTICLE; CRYSTAL STRUCTURE; DRUG BINDING; DRUG BINDING SITE; PERISTALSIS; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

ANTI-BACTERIAL AGENTS; ERYTHROMYCIN; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

NEGIBACTERIA;

EID: 84355166442     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10641     Document Type: Article

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