X-ray crystal structures of the Escherichia coli RNA polymerase in complex with benzoxazinorifamycins

Journal of Medicinal Chemistry

Volumn 56, Issue 11, 2013, Pages 4758-4763

  Molodtsov, Vadim ^a   Nawarathne, Irosha N ^b   Scharf, Nathan T ^b   Kirchhoff, Paul D ^b   Showalter, H D Hollis ^b   Garcia, George A ^b   Murakami, Katsuhiko S ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOXAZINORIFAMYCIN; HOLOENZYME; RIFABUTIN; RIFALAZIL; RIFAMPICIN; RIFAMYCIN; RIFAPENTINE; RNA POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DNA TEMPLATE; ENZYME INHIBITION; ESCHERICHIA COLI; IC 50; IN VITRO STUDY; NONHUMAN; RNA TRANSCRIPTION; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION INITIATION;

ANTIBIOTICS, ANTITUBERCULAR; CRYSTALLOGRAPHY, X-RAY; DNA-DIRECTED RNA POLYMERASES; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI PROTEINS; HOLOENZYMES; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; RIFAMYCINS; TRANSCRIPTION, GENETIC;

EID: 84879063733     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4004889     Document Type: Article

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