Evolutionary paths to antibiotic resistance under dynamically sustained drug selection

Nature Genetics

Volumn 44, Issue 1, 2012, Pages 101-105

  Toprak, Erdal ^a   Veres, Adrian ^b   Michel, Jean Baptiste ^a,b   Chait, Remy ^a   Hartl, Daniel L ^c   Kishony, Roy ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD UNIVERSITY   (United States)

^c HARVARD UNIVERSITY   (United States)

^d HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMPHENICOL; DIHYDROFOLATE REDUCTASE; DOXYCYCLINE; TRIMETHOPRIM;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; DEVICES; ESCHERICHIA COLI; GENE FUNCTION; GENE MUTATION; GENOME ANALYSIS; IC 50; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR EVOLUTION; MULTIDRUG RESISTANCE; MUTATIONAL ANALYSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ANTI-BACTERIAL AGENTS; BACTERIOLOGICAL TECHNIQUES; BIOLOGICAL EVOLUTION; CULTURE MEDIA; DNA, BACTERIAL; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; ESCHERICHIA COLI; MUTATION; SELECTION, GENETIC; SEQUENCE ANALYSIS, DNA; TETRAHYDROFOLATE DEHYDROGENASE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 84555171441     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.1034     Document Type: Article

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