Directed evolution of trimethoprim resistance in Escherichia coli

FEBS Journal

Volumn 274, Issue 10, 2007, Pages 2661-2671

  Watson, Morgan ^a   Liu, Jian Wei ^a   Ollis, David ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

Antibiotic resistance; Dihydrofolate reductase; Directed evolution; Trimethoprim

Indexed keywords

DIHYDROFOLATE REDUCTASE; TRIMETHOPRIM;

ANTIBIOTIC RESISTANCE; ARTICLE; BINDING AFFINITY; DNA LIBRARY; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME KINETICS; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR EVOLUTION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; DIRECTED MOLECULAR EVOLUTION; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; KINETICS; POINT MUTATION; TETRAHYDROFOLATE DEHYDROGENASE; TRIMETHOPRIM;

ESCHERICHIA COLI;

EID: 34247578707     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2007.05801.x     Document Type: Article

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