-
1
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
[1] Hanahan, D., Weinberg, R.A., Hallmarks of cancer: the next generation. Cell 144:5 (2011), 646–674.
-
(2011)
Cell
, vol.144
, Issue.5
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
20344396122
-
Preventing re-replication of chromosomal DNA
-
[2] Blow, J.J., Dutta, A., Preventing re-replication of chromosomal DNA. Nat. Rev. Mol. Cell Biol. 6:6 (2005), 476–486.
-
(2005)
Nat. Rev. Mol. Cell Biol.
, vol.6
, Issue.6
, pp. 476-486
-
-
Blow, J.J.1
Dutta, A.2
-
3
-
-
84870760092
-
DNA replication origins
-
[3] Leonard, A.C., Mechali, M., DNA replication origins. Cold Spring Harb. Perspect. Biol., 5(10), 2013, a010116.
-
(2013)
Cold Spring Harb. Perspect. Biol.
, vol.5
, Issue.10
, pp. a010116
-
-
Leonard, A.C.1
Mechali, M.2
-
4
-
-
80052006741
-
DNA replication: mammalian Treslin-TopBP1 interaction mirrors yeast Sld3-Dpb11
-
[4] Mueller, A.C., Keaton, M.A., Dutta, A., DNA replication: mammalian Treslin-TopBP1 interaction mirrors yeast Sld3-Dpb11. Curr. Biol. 21:16 (2011), R638–40.
-
(2011)
Curr. Biol.
, vol.21
, Issue.16
, pp. R638-40
-
-
Mueller, A.C.1
Keaton, M.A.2
Dutta, A.3
-
5
-
-
77953076932
-
Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly
-
[5] Lydeard, J.R., et al. Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly. Genes Dev. 24:11 (2010), 1133–1144.
-
(2010)
Genes Dev.
, vol.24
, Issue.11
, pp. 1133-1144
-
-
Lydeard, J.R.1
-
6
-
-
79959957543
-
Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases
-
[6] Heller, R.C., et al. Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases. Cell 146:1 (2011), 80–91.
-
(2011)
Cell
, vol.146
, Issue.1
, pp. 80-91
-
-
Heller, R.C.1
-
7
-
-
84876475703
-
The GINS complex: structure and function
-
[7] Kamada, K., The GINS complex: structure and function. Subcell. Biochem. 62 (2012), 135–156.
-
(2012)
Subcell. Biochem.
, vol.62
, pp. 135-156
-
-
Kamada, K.1
-
8
-
-
84865710342
-
Proteomic identification of a direct role for cyclin d1 in DNA damage repair
-
[8] Jirawatnotai, S., et al. Proteomic identification of a direct role for cyclin d1 in DNA damage repair. Cancer Res. 72:17 (2012), 4289–4293.
-
(2012)
Cancer Res.
, vol.72
, Issue.17
, pp. 4289-4293
-
-
Jirawatnotai, S.1
-
9
-
-
84931437298
-
Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase delta revealed in individual cells by cytometry
-
[9] Darzynkiewicz, Z., et al. Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase delta revealed in individual cells by cytometry. Oncotarget 6:14 (2015), 11735–11750.
-
(2015)
Oncotarget
, vol.6
, Issue.14
, pp. 11735-11750
-
-
Darzynkiewicz, Z.1
-
10
-
-
84880803198
-
Control of cell cycle transcription during G1 and S phases
-
[10] Bertoli, C., Skotheim, J.M., de Bruin, R.A., Control of cell cycle transcription during G1 and S phases. Nat. Rev. Mol. Cell Biol. 14:8 (2013), 518–528.
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, Issue.8
, pp. 518-528
-
-
Bertoli, C.1
Skotheim, J.M.2
de Bruin, R.A.3
-
11
-
-
84930012955
-
DNA replication origin activation in space and time
-
[11] Fragkos, M., et al. DNA replication origin activation in space and time. Nat. Rev. Mol. Cell Biol. 16:6 (2015), 360–374.
-
(2015)
Nat. Rev. Mol. Cell Biol.
, vol.16
, Issue.6
, pp. 360-374
-
-
Fragkos, M.1
-
12
-
-
84928551340
-
Replication stress and cancer
-
[12] Gaillard, H., Garcia-Muse, T., Aguilera, A., Replication stress and cancer. Nat. Rev. Cancer 15:5 (2015), 276–289.
-
(2015)
Nat. Rev. Cancer
, vol.15
, Issue.5
, pp. 276-289
-
-
Gaillard, H.1
Garcia-Muse, T.2
Aguilera, A.3
-
13
-
-
75149162077
-
A vertebrate gene, ticrr, is an essential checkpoint and replication regulator
-
[13] Sansam, C.L., et al. A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Genes Dev. 24:2 (2010), 183–194.
-
(2010)
Genes Dev.
, vol.24
, Issue.2
, pp. 183-194
-
-
Sansam, C.L.1
-
14
-
-
70349449240
-
Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins
-
[14] Im, J.S., et al. Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. Proc. Natl. Acad. Sci. U. S. A. 106:37 (2009), 15628–15632.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, Issue.37
, pp. 15628-15632
-
-
Im, J.S.1
-
15
-
-
33749075373
-
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression
-
[15] Sheu, Y.J., Stillman, B., Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression. Mol. Cell 24:1 (2006), 101–113.
-
(2006)
Mol. Cell
, vol.24
, Issue.1
, pp. 101-113
-
-
Sheu, Y.J.1
Stillman, B.2
-
16
-
-
61849173573
-
Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation
-
[16] Francis, L.I., et al. Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation. Genes Dev. 23:5 (2009), 643–654.
-
(2009)
Genes Dev.
, vol.23
, Issue.5
, pp. 643-654
-
-
Francis, L.I.1
-
17
-
-
73849129578
-
The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4
-
[17] Sheu, Y.J., Stillman, B., The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4. Nature 463:7277 (2010), 113–117.
-
(2010)
Nature
, vol.463
, Issue.7277
, pp. 113-117
-
-
Sheu, Y.J.1
Stillman, B.2
-
18
-
-
84874695795
-
Helicase activation and establishment of replication forks at chromosomal origins of replication
-
[18] Tanaka, S., Araki, H., Helicase activation and establishment of replication forks at chromosomal origins of replication. Cold Spring Harb. Perspect. Biol., 5(12), 2013, a010371.
-
(2013)
Cold Spring Harb. Perspect. Biol.
, vol.5
, Issue.12
, pp. a010371
-
-
Tanaka, S.1
Araki, H.2
-
19
-
-
75749103708
-
Treslin collaborates with TopBP1 in triggering the initiation of DNA replication
-
[19] Kumagai, A., Shevchenko, A., Dunphy, W.G., Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. Cell 140:3 (2010), 349–359.
-
(2010)
Cell
, vol.140
, Issue.3
, pp. 349-359
-
-
Kumagai, A.1
Shevchenko, A.2
Dunphy, W.G.3
-
20
-
-
84877888161
-
Controlling DNA replication origins in response to DNA damage—inhibit globally, activate locally
-
[20] Yekezare, M., Gomez-Gonzalez, B., Diffley, J.F., Controlling DNA replication origins in response to DNA damage—inhibit globally, activate locally. J. Cell Sci. 126:Pt. 6 (2013), 1297–1306.
-
(2013)
J. Cell Sci.
, vol.126
, pp. 1297-1306
-
-
Yekezare, M.1
Gomez-Gonzalez, B.2
Diffley, J.F.3
-
21
-
-
84920274525
-
RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response
-
[21] Marechal, A., Zou, L., RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response. Cell Res. 25:1 (2015), 9–23.
-
(2015)
Cell Res.
, vol.25
, Issue.1
, pp. 9-23
-
-
Marechal, A.1
Zou, L.2
-
22
-
-
0036849432
-
Checking on the fork: the DNA-replication stress-response pathway
-
[22] Osborn, A.J., Elledge, S.J., Zou, L., Checking on the fork: the DNA-replication stress-response pathway. Trends Cell Biol. 12:11 (2002), 509–516.
-
(2002)
Trends Cell Biol.
, vol.12
, Issue.11
, pp. 509-516
-
-
Osborn, A.J.1
Elledge, S.J.2
Zou, L.3
-
23
-
-
5044220936
-
Checking on DNA damage in S phase
-
[23] Bartek, J., Lukas, C., Lukas, J., Checking on DNA damage in S phase. Nat. Rev. Mol. Cell Biol. 5:10 (2004), 792–804.
-
(2004)
Nat. Rev. Mol. Cell Biol.
, vol.5
, Issue.10
, pp. 792-804
-
-
Bartek, J.1
Lukas, C.2
Lukas, J.3
-
24
-
-
5044224075
-
ATR: Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
-
[24] Sorensen, C.S., et al. ATR: Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage. Cell Cycle 3:7 (2004), 941–945.
-
(2004)
Cell Cycle
, vol.3
, Issue.7
, pp. 941-945
-
-
Sorensen, C.S.1
-
25
-
-
69949136023
-
Physical interactions between Mcm10, DNA, and DNA polymerase alpha
-
[25] Warren, E.M., et al. Physical interactions between Mcm10, DNA, and DNA polymerase alpha. J. Biol. Chem. 284:36 (2009), 24662–24672.
-
(2009)
J. Biol. Chem.
, vol.284
, Issue.36
, pp. 24662-24672
-
-
Warren, E.M.1
-
26
-
-
34548823811
-
Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication
-
[26] Zhu, W., et al. Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. Genes Dev. 21:18 (2007), 2288–2299.
-
(2007)
Genes Dev.
, vol.21
, Issue.18
, pp. 2288-2299
-
-
Zhu, W.1
-
27
-
-
0034723152
-
DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading
-
[27] Maga, G., et al. DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading. J. Mol. Biol. 295:4 (2000), 791–801.
-
(2000)
J. Mol. Biol.
, vol.295
, Issue.4
, pp. 791-801
-
-
Maga, G.1
-
28
-
-
33845496081
-
Roles of DNA polymerases in replication, repair, and recombination in eukaryotes
-
[28] Pavlov, Y.I., Shcherbakova, P.V., Rogozin, I.B., Roles of DNA polymerases in replication, repair, and recombination in eukaryotes. Int. Rev. Cytol. 255 (2006), 41–132.
-
(2006)
Int. Rev. Cytol.
, vol.255
, pp. 41-132
-
-
Pavlov, Y.I.1
Shcherbakova, P.V.2
Rogozin, I.B.3
-
29
-
-
79952832468
-
How protein kinases co-ordinate mitosis in animal cells
-
[29] Ma, H.T., Poon, R.Y., How protein kinases co-ordinate mitosis in animal cells. Biochem. J. 435:1 (2011), 17–31.
-
(2011)
Biochem. J.
, vol.435
, Issue.1
, pp. 17-31
-
-
Ma, H.T.1
Poon, R.Y.2
-
30
-
-
84904601445
-
Polo-like kinases: structural variations lead to multiple functions
-
[30] Zitouni, S., et al. Polo-like kinases: structural variations lead to multiple functions. Nat. Rev. Mol. Cell Biol. 15:7 (2014), 433–452.
-
(2014)
Nat. Rev. Mol. Cell Biol.
, vol.15
, Issue.7
, pp. 433-452
-
-
Zitouni, S.1
-
31
-
-
84962634357
-
Cdk1 phosphorylates SPAT-1/Bora to promote plk1 activation in C. elegans and human cells
-
[31] Thomas, Y., et al. Cdk1 phosphorylates SPAT-1/Bora to promote plk1 activation in C. elegans and human cells. Cell Rep. 15:3 (2016), 510–518.
-
(2016)
Cell Rep.
, vol.15
, Issue.3
, pp. 510-518
-
-
Thomas, Y.1
-
32
-
-
84930941365
-
Replication stress in Mammalian cells and its consequences for mitosis
-
[32] Gelot, C., Magdalou, I., Lopez, B.S., Replication stress in Mammalian cells and its consequences for mitosis. Genes (Basel) 6:2 (2015), 267–298.
-
(2015)
Genes (Basel)
, vol.6
, Issue.2
, pp. 267-298
-
-
Gelot, C.1
Magdalou, I.2
Lopez, B.S.3
-
33
-
-
84904459138
-
BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2
-
[33] Bhatia, V., et al. BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2. Nature 511:7509 (2014), 362–365.
-
(2014)
Nature
, vol.511
, Issue.7509
, pp. 362-365
-
-
Bhatia, V.1
-
34
-
-
84903795949
-
A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression
-
[34] Skourti-Stathaki, K., Proudfoot, N.J., A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression. Genes Dev. 28:13 (2014), 1384–1396.
-
(2014)
Genes Dev.
, vol.28
, Issue.13
, pp. 1384-1396
-
-
Skourti-Stathaki, K.1
Proudfoot, N.J.2
-
35
-
-
84876188716
-
Transcription-replication encounters: consequences and genomic instability
-
[35] Helmrich, A., et al. Transcription-replication encounters: consequences and genomic instability. Nat. Struct. Mol. Biol. 20:4 (2013), 412–418.
-
(2013)
Nat. Struct. Mol. Biol.
, vol.20
, Issue.4
, pp. 412-418
-
-
Helmrich, A.1
-
36
-
-
84941937809
-
R loops: new modulators of genome dynamics and function
-
[36] Santos-Pereira, J.M., Aguilera, A., R loops: new modulators of genome dynamics and function. Nat. Rev. Genet. 16:10 (2015), 583–597.
-
(2015)
Nat. Rev. Genet.
, vol.16
, Issue.10
, pp. 583-597
-
-
Santos-Pereira, J.M.1
Aguilera, A.2
-
37
-
-
79960823119
-
Tethered genes get checked during replication
-
[37] Lukas, J., Bartek, J., Tethered genes get checked during replication. Cell 146:2 (2011), 189–191.
-
(2011)
Cell
, vol.146
, Issue.2
, pp. 189-191
-
-
Lukas, J.1
Bartek, J.2
-
38
-
-
84859042868
-
Preventing replication stress to maintain genome stability: resolving conflicts between replication and transcription
-
[38] Bermejo, R., Lai, M.S., Foiani, M., Preventing replication stress to maintain genome stability: resolving conflicts between replication and transcription. Mol. Cell 45:6 (2012), 710–718.
-
(2012)
Mol. Cell
, vol.45
, Issue.6
, pp. 710-718
-
-
Bermejo, R.1
Lai, M.S.2
Foiani, M.3
-
39
-
-
38049090214
-
DNA replication stress, genome instability and aging
-
[39] Burhans, W.C., Weinberger, M., DNA replication stress, genome instability and aging. Nucleic Acids Res. 35:22 (2007), 7545–7556.
-
(2007)
Nucleic Acids Res.
, vol.35
, Issue.22
, pp. 7545-7556
-
-
Burhans, W.C.1
Weinberger, M.2
-
40
-
-
84919413650
-
DNA replication stress: causes, resolution and disease
-
[40] Mazouzi, A., Velimezi, G., Loizou, J.I., DNA replication stress: causes, resolution and disease. Exp. Cell Res. 329:1 (2014), 85–93.
-
(2014)
Exp. Cell Res.
, vol.329
, Issue.1
, pp. 85-93
-
-
Mazouzi, A.1
Velimezi, G.2
Loizou, J.I.3
-
41
-
-
84941809696
-
The replication checkpoint prevents two types of fork collapse without regulating replisome stability
-
[41] Dungrawala, H., et al. The replication checkpoint prevents two types of fork collapse without regulating replisome stability. Mol. Cell 59:6 (2015), 998–1010.
-
(2015)
Mol. Cell
, vol.59
, Issue.6
, pp. 998-1010
-
-
Dungrawala, H.1
-
42
-
-
84926226900
-
Replication fork reversal in eukaryotes: from dead end to dynamic response
-
[42] Neelsen, K.J., Lopes, M., Replication fork reversal in eukaryotes: from dead end to dynamic response. Nat. Rev. Mol. Cell Biol. 16:4 (2015), 207–220.
-
(2015)
Nat. Rev. Mol. Cell Biol.
, vol.16
, Issue.4
, pp. 207-220
-
-
Neelsen, K.J.1
Lopes, M.2
-
43
-
-
84864946159
-
Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress
-
[43] Ciccia, A., et al. Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Mol. Cell 47:3 (2012), 396–409.
-
(2012)
Mol. Cell
, vol.47
, Issue.3
, pp. 396-409
-
-
Ciccia, A.1
-
44
-
-
84876786426
-
Regulation of PCNA-protein interactions for genome stability
-
[44] Mailand, N., Gibbs-Seymour, I., Bekker-Jensen, S., Regulation of PCNA-protein interactions for genome stability. Nat. Rev. Mol. Cell Biol. 14:5 (2013), 269–282.
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, Issue.5
, pp. 269-282
-
-
Mailand, N.1
Gibbs-Seymour, I.2
Bekker-Jensen, S.3
-
45
-
-
84855901029
-
Inhibition of homologous recombination by the PCNA-interacting protein PARI
-
[45] Moldovan, G.L., et al. Inhibition of homologous recombination by the PCNA-interacting protein PARI. Mol. Cell 45:1 (2012), 75–86.
-
(2012)
Mol. Cell
, vol.45
, Issue.1
, pp. 75-86
-
-
Moldovan, G.L.1
-
46
-
-
84875197858
-
Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress
-
[46] Bruck, I., Kaplan, D.L., Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress. J. Biol. Chem. 288:11 (2013), 7550–7563.
-
(2013)
J. Biol. Chem.
, vol.288
, Issue.11
, pp. 7550-7563
-
-
Bruck, I.1
Kaplan, D.L.2
-
47
-
-
33749134033
-
A dynamic model for replication protein A (RPA) function in DNA processing pathways
-
[47] Fanning, E., Klimovich, V., Nager, A.R., A dynamic model for replication protein A (RPA) function in DNA processing pathways. Nucleic Acids Res. 34:15 (2006), 4126–4137.
-
(2006)
Nucleic Acids Res.
, vol.34
, Issue.15
, pp. 4126-4137
-
-
Fanning, E.1
Klimovich, V.2
Nager, A.R.3
-
48
-
-
84878548877
-
Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1
-
[48] Shiotani, B., et al. Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1. Cell Rep. 3:5 (2013), 1651–1662.
-
(2013)
Cell Rep.
, vol.3
, Issue.5
, pp. 1651-1662
-
-
Shiotani, B.1
-
49
-
-
84956887909
-
Replication stress: getting back on track
-
[49] Berti, M., Vindigni, A., Replication stress: getting back on track. Nat. Struct. Mol. Biol. 23:2 (2016), 103–109.
-
(2016)
Nat. Struct. Mol. Biol.
, vol.23
, Issue.2
, pp. 103-109
-
-
Berti, M.1
Vindigni, A.2
-
50
-
-
78649336706
-
The DNA damage response: making it safe to play with knives
-
[50] Ciccia, A., Elledge, S.J., The DNA damage response: making it safe to play with knives. Mol. Cell 40:2 (2010), 179–204.
-
(2010)
Mol. Cell
, vol.40
, Issue.2
, pp. 179-204
-
-
Ciccia, A.1
Elledge, S.J.2
-
51
-
-
79958694525
-
A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling
-
[51] Cotta-Ramusino, C., et al. A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. Science 332:6035 (2011), 1313–1317.
-
(2011)
Science
, vol.332
, Issue.6035
, pp. 1313-1317
-
-
Cotta-Ramusino, C.1
-
52
-
-
84864923437
-
The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress
-
[52] Yuan, J., Ghosal, G., Chen, J., The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress. Mol. Cell 47:3 (2012), 410–421.
-
(2012)
Mol. Cell
, vol.47
, Issue.3
, pp. 410-421
-
-
Yuan, J.1
Ghosal, G.2
Chen, J.3
-
53
-
-
84921849359
-
RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling
-
[53] Lindsey-Boltz, L.A., et al. RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling. Cell Cycle 14:1 (2015), 99–108.
-
(2015)
Cell Cycle
, vol.14
, Issue.1
, pp. 99-108
-
-
Lindsey-Boltz, L.A.1
-
54
-
-
84864393532
-
The conserved C terminus of claspin interacts with Rad9 and promotes rapid activation of Chk1
-
[54] Liu, S., Song, N., Zou, L., The conserved C terminus of claspin interacts with Rad9 and promotes rapid activation of Chk1. Cell Cycle 11:14 (2012), 2711–2716.
-
(2012)
Cell Cycle
, vol.11
, Issue.14
, pp. 2711-2716
-
-
Liu, S.1
Song, N.2
Zou, L.3
-
55
-
-
84880264045
-
Cdks, cyclins and CKIs: roles beyond cell cycle regulation
-
[55] Lim, S., Kaldis, P., Cdks, cyclins and CKIs: roles beyond cell cycle regulation. Development 140:15 (2013), 3079–3093.
-
(2013)
Development
, vol.140
, Issue.15
, pp. 3079-3093
-
-
Lim, S.1
Kaldis, P.2
-
56
-
-
72149111413
-
Cyclin E is stabilized in response to replication fork barriers leading to prolonged S phase arrest
-
[56] Lu, X., Liu, J., Legerski, R.J., Cyclin E is stabilized in response to replication fork barriers leading to prolonged S phase arrest. J. Biol. Chem. 284:51 (2009), 35325–35337.
-
(2009)
J. Biol. Chem.
, vol.284
, Issue.51
, pp. 35325-35337
-
-
Lu, X.1
Liu, J.2
Legerski, R.J.3
-
57
-
-
20244388673
-
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
-
[57] Syljuasen, R.G., et al. Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol. Cell. Biol. 25:9 (2005), 3553–3562.
-
(2005)
Mol. Cell. Biol.
, vol.25
, Issue.9
, pp. 3553-3562
-
-
Syljuasen, R.G.1
-
58
-
-
77952764443
-
Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress
-
[58] Kemp, M.G., et al. Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. J. Biol. Chem. 285:22 (2010), 16562–16571.
-
(2010)
J. Biol. Chem.
, vol.285
, Issue.22
, pp. 16562-16571
-
-
Kemp, M.G.1
-
59
-
-
3242878502
-
Claspin, a regulator of Chk1 in DNA replication stress pathway
-
[59] Chini, C.C., Chen, J., Claspin, a regulator of Chk1 in DNA replication stress pathway. DNA Repair (Amst.) 3:8–9 (2004), 1033–1037.
-
(2004)
DNA Repair (Amst.)
, vol.3
, Issue.8-9
, pp. 1033-1037
-
-
Chini, C.C.1
Chen, J.2
-
60
-
-
78649443528
-
The ATR barrier to replication-born DNA damage
-
[60] Lopez-Contreras, A.J., Fernandez-Capetillo, O., The ATR barrier to replication-born DNA damage. DNA Repair (Amst.) 9:12 (2010), 1249–1255.
-
(2010)
DNA Repair (Amst.)
, vol.9
, Issue.12
, pp. 1249-1255
-
-
Lopez-Contreras, A.J.1
Fernandez-Capetillo, O.2
-
61
-
-
84921450064
-
DNA damage checkpoint responses in the S phase of synchronized diploid human fibroblasts
-
[61] Chastain, P.D., et al. DNA damage checkpoint responses in the S phase of synchronized diploid human fibroblasts. Photochem. Photobiol. 91:1 (2015), 109–116.
-
(2015)
Photochem. Photobiol.
, vol.91
, Issue.1
, pp. 109-116
-
-
Chastain, P.D.1
-
62
-
-
84929000494
-
Phosphorylation of minichromosome maintenance 3 (MCM3) by checkpoint kinase 1 (Chk1) negatively regulates DNA replication and checkpoint activation
-
[62] Han, X., et al. Phosphorylation of minichromosome maintenance 3 (MCM3) by checkpoint kinase 1 (Chk1) negatively regulates DNA replication and checkpoint activation. J. Biol. Chem. 290:19 (2015), 12370–12378.
-
(2015)
J. Biol. Chem.
, vol.290
, Issue.19
, pp. 12370-12378
-
-
Han, X.1
-
63
-
-
84924873833
-
Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication
-
[63] Guo, C., et al. Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication. Mol. Cell 57:3 (2015), 492–505.
-
(2015)
Mol. Cell
, vol.57
, Issue.3
, pp. 492-505
-
-
Guo, C.1
-
64
-
-
77649237536
-
Chk1-cyclin A/Cdk1 axis regulates origin firing programs in mammals
-
[64] Nakanishi, M., et al. Chk1-cyclin A/Cdk1 axis regulates origin firing programs in mammals. Chromosome Res. 18:1 (2010), 103–113.
-
(2010)
Chromosome Res.
, vol.18
, Issue.1
, pp. 103-113
-
-
Nakanishi, M.1
-
65
-
-
79960192316
-
Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans
-
[65] Boos, D., et al. Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans. Curr. Biol. 21:13 (2011), 1152–1157.
-
(2011)
Curr. Biol.
, vol.21
, Issue.13
, pp. 1152-1157
-
-
Boos, D.1
-
66
-
-
62549132126
-
Cyclin A-Cdk1 regulates the origin firing program in mammalian cells
-
[66] Katsuno, Y., et al. Cyclin A-Cdk1 regulates the origin firing program in mammalian cells. Proc. Natl. Acad. Sci. U. S. A. 106:9 (2009), 3184–3189.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, Issue.9
, pp. 3184-3189
-
-
Katsuno, Y.1
-
67
-
-
84855908936
-
Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication
-
[67] Sorensen, C.S., Syljuasen, R.G., Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication. Nucleic Acids Res. 40:2 (2012), 477–486.
-
(2012)
Nucleic Acids Res.
, vol.40
, Issue.2
, pp. 477-486
-
-
Sorensen, C.S.1
Syljuasen, R.G.2
-
68
-
-
84902107009
-
The contribution of dormant origins to genome stability: from cell biology to human genetics
-
[68] Alver, R.C., Chadha, G.S., Blow, J.J., The contribution of dormant origins to genome stability: from cell biology to human genetics. DNA Repair (Amst.) 19 (2014), 182–189.
-
(2014)
DNA Repair (Amst.)
, vol.19
, pp. 182-189
-
-
Alver, R.C.1
Chadha, G.S.2
Blow, J.J.3
-
69
-
-
84889563685
-
ATR prohibits replication catastrophe by preventing global exhaustion of RPA
-
[69] Toledo, L.I., et al. ATR prohibits replication catastrophe by preventing global exhaustion of RPA. Cell 155:5 (2013), 1088–1103.
-
(2013)
Cell
, vol.155
, Issue.5
, pp. 1088-1103
-
-
Toledo, L.I.1
-
70
-
-
77956944025
-
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint
-
[70] Liu, H., et al. Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint. Nature 467:7313 (2010), 343–346.
-
(2010)
Nature
, vol.467
, Issue.7313
, pp. 343-346
-
-
Liu, H.1
-
71
-
-
84907960466
-
DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B
-
[71] Zuazua-Villar, P., et al. DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B. Cell. Death. Dis., 5, 2014, e1253.
-
(2014)
Cell. Death. Dis.
, vol.5
, pp. e1253
-
-
Zuazua-Villar, P.1
-
72
-
-
84883763847
-
Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription
-
[72] Bertoli, C., et al. Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription. Curr. Biol. 23:17 (2013), 1629–1637.
-
(2013)
Curr. Biol.
, vol.23
, Issue.17
, pp. 1629-1637
-
-
Bertoli, C.1
-
73
-
-
40449120350
-
An oncogene-induced DNA damage model for cancer development
-
[73] Halazonetis, T.D., Gorgoulis, V.G., Bartek, J., An oncogene-induced DNA damage model for cancer development. Science 319:5868 (2008), 1352–1355.
-
(2008)
Science
, vol.319
, Issue.5868
, pp. 1352-1355
-
-
Halazonetis, T.D.1
Gorgoulis, V.G.2
Bartek, J.3
-
74
-
-
34547159757
-
p53 mediates senescence-like arrest induced by chronic replicational stress
-
[74] Marusyk, A., et al. p53 mediates senescence-like arrest induced by chronic replicational stress. Mol. Cell. Biol. 27:15 (2007), 5336–5351.
-
(2007)
Mol. Cell. Biol.
, vol.27
, Issue.15
, pp. 5336-5351
-
-
Marusyk, A.1
-
75
-
-
33644539180
-
Stalled replication induces p53 accumulation through distinct mechanisms from DNA damage checkpoint pathways
-
[75] Ho, C.C., et al. Stalled replication induces p53 accumulation through distinct mechanisms from DNA damage checkpoint pathways. Cancer Res. 66:4 (2006), 2233–2241.
-
(2006)
Cancer Res.
, vol.66
, Issue.4
, pp. 2233-2241
-
-
Ho, C.C.1
-
76
-
-
28244497051
-
Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe
-
[76] Niida, H., et al. Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe. J. Biol. Chem. 280:47 (2005), 39246–39252.
-
(2005)
J. Biol. Chem.
, vol.280
, Issue.47
, pp. 39246-39252
-
-
Niida, H.1
-
77
-
-
84883780177
-
FANCD2 binds MCM proteins and controls replisome function upon activation of s phase checkpoint signaling
-
[77] Lossaint, G., et al. FANCD2 binds MCM proteins and controls replisome function upon activation of s phase checkpoint signaling. Mol. Cell 51:5 (2013), 678–690.
-
(2013)
Mol. Cell
, vol.51
, Issue.5
, pp. 678-690
-
-
Lossaint, G.1
-
78
-
-
84880440332
-
ATR phosphorylates SMARCAL1 to prevent replication fork collapse
-
[78] Couch, F.B., et al. ATR phosphorylates SMARCAL1 to prevent replication fork collapse. Genes Dev. 27:14 (2013), 1610–1623.
-
(2013)
Genes Dev.
, vol.27
, Issue.14
, pp. 1610-1623
-
-
Couch, F.B.1
-
79
-
-
34447115757
-
Role for BLM in replication-fork restart and suppression of origin firing after replicative stress
-
[79] Davies, S.L., North, P.S., Hickson, I.D., Role for BLM in replication-fork restart and suppression of origin firing after replicative stress. Nat. Struct. Mol. Biol. 14:7 (2007), 677–679.
-
(2007)
Nat. Struct. Mol. Biol.
, vol.14
, Issue.7
, pp. 677-679
-
-
Davies, S.L.1
North, P.S.2
Hickson, I.D.3
-
80
-
-
84880860938
-
ATR-dependent phosphorylation of FANCM at serine 1045 is essential for FANCM functions
-
[80] Singh, T.R., et al. ATR-dependent phosphorylation of FANCM at serine 1045 is essential for FANCM functions. Cancer Res. 73:14 (2013), 4300–4310.
-
(2013)
Cancer Res.
, vol.73
, Issue.14
, pp. 4300-4310
-
-
Singh, T.R.1
-
81
-
-
77149135723
-
ATR activation and replication fork restart are defective in FANCM-deficient cells
-
[81] Schwab, R.A., Blackford, A.N., Niedzwiedz, W., ATR activation and replication fork restart are defective in FANCM-deficient cells. EMBO J. 29:4 (2010), 806–818.
-
(2010)
EMBO J.
, vol.29
, Issue.4
, pp. 806-818
-
-
Schwab, R.A.1
Blackford, A.N.2
Niedzwiedz, W.3
-
82
-
-
84897996775
-
Fork reversal, too much of a good thing
-
[82] Couch, F.B., Cortez, D., Fork reversal, too much of a good thing. Cell Cycle 13:7 (2014), 1049–1050.
-
(2014)
Cell Cycle
, vol.13
, Issue.7
, pp. 1049-1050
-
-
Couch, F.B.1
Cortez, D.2
-
83
-
-
84902187810
-
Human RecQ helicases in DNA repair, recombination, and replication
-
[83] Croteau, D.L., et al. Human RecQ helicases in DNA repair, recombination, and replication. Annu. Rev. Biochem. 83 (2014), 519–552.
-
(2014)
Annu. Rev. Biochem.
, vol.83
, pp. 519-552
-
-
Croteau, D.L.1
-
84
-
-
79952281751
-
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress
-
[84] Lukas, C., et al. 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat. Cell Biol. 13:3 (2011), 243–253.
-
(2011)
Nat. Cell Biol.
, vol.13
, Issue.3
, pp. 243-253
-
-
Lukas, C.1
-
85
-
-
84924873531
-
DNA2 drives processing and restart of reversed replication forks in human cells
-
[85] Thangavel, S., et al. DNA2 drives processing and restart of reversed replication forks in human cells. J. Cell Biol. 208:5 (2015), 545–562.
-
(2015)
J. Cell Biol.
, vol.208
, Issue.5
, pp. 545-562
-
-
Thangavel, S.1
-
86
-
-
84950129508
-
The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation
-
[86] Iannascoli, C., et al. The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation. Nucleic Acids Res. 43:20 (2015), 9788–9803.
-
(2015)
Nucleic Acids Res.
, vol.43
, Issue.20
, pp. 9788-9803
-
-
Iannascoli, C.1
-
87
-
-
84861480857
-
RECQ1 plays a distinct role in cellular response to oxidative DNA damage
-
[87] Sharma, S., et al. RECQ1 plays a distinct role in cellular response to oxidative DNA damage. DNA Repair (Amst.) 11:6 (2012), 537–549.
-
(2012)
DNA Repair (Amst.)
, vol.11
, Issue.6
, pp. 537-549
-
-
Sharma, S.1
-
88
-
-
84875220657
-
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition
-
[88] Berti, M., et al. Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition. Nat. Struct. Mol. Biol. 20:3 (2013), 347–354.
-
(2013)
Nat. Struct. Mol. Biol.
, vol.20
, Issue.3
, pp. 347-354
-
-
Berti, M.1
-
89
-
-
84856246154
-
SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication
-
[89] Betous, R., et al. SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication. Genes Dev. 26:2 (2012), 151–162.
-
(2012)
Genes Dev.
, vol.26
, Issue.2
, pp. 151-162
-
-
Betous, R.1
-
90
-
-
84887204233
-
The DNA translocase FANCM/MHF promotes replication traverse of DNA interstrand crosslinks
-
[90] Huang, J., et al. The DNA translocase FANCM/MHF promotes replication traverse of DNA interstrand crosslinks. Mol. Cell 52:3 (2013), 434–446.
-
(2013)
Mol. Cell
, vol.52
, Issue.3
, pp. 434-446
-
-
Huang, J.1
-
91
-
-
84965163756
-
FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks
-
[91] Rohleder, F., et al. FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks. Nucleic Acids Res. 44:7 (2016), 3219–3232.
-
(2016)
Nucleic Acids Res.
, vol.44
, Issue.7
, pp. 3219-3232
-
-
Rohleder, F.1
-
92
-
-
84924911767
-
Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells
-
[92] Zellweger, R., et al. Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells. J. Cell Biol. 208:5 (2015), 563–579.
-
(2015)
J. Cell Biol.
, vol.208
, Issue.5
, pp. 563-579
-
-
Zellweger, R.1
-
93
-
-
84900816207
-
Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe
-
[93] Sarbajna, S., Davies, D., West, S.C., Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe. Genes Dev. 28:10 (2014), 1124–1136.
-
(2014)
Genes Dev.
, vol.28
, Issue.10
, pp. 1124-1136
-
-
Sarbajna, S.1
Davies, D.2
West, S.C.3
-
94
-
-
84937598041
-
Replication fork integrity and intra-S phase checkpoint suppress gene amplification
-
[94] Kondratova, A., et al. Replication fork integrity and intra-S phase checkpoint suppress gene amplification. Nucleic Acids Res. 43:5 (2015), 2678–2690.
-
(2015)
Nucleic Acids Res.
, vol.43
, Issue.5
, pp. 2678-2690
-
-
Kondratova, A.1
-
95
-
-
23944445368
-
A role for proapoptotic BID in the DNA-damage response
-
[95] Zinkel, S.S., et al. A role for proapoptotic BID in the DNA-damage response. Cell 122:4 (2005), 579–591.
-
(2005)
Cell
, vol.122
, Issue.4
, pp. 579-591
-
-
Zinkel, S.S.1
-
96
-
-
84930948486
-
Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice
-
[96] Tomimatsu, N., et al. Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice. Nat. Commun., 5, 2014, 3561.
-
(2014)
Nat. Commun.
, vol.5
, pp. 3561
-
-
Tomimatsu, N.1
-
97
-
-
84964335156
-
Enrichment of Cdk1-cyclins at DNA double-strand breaks stimulates Fun30 phosphorylation and DNA end resection
-
[97] Chen, X., et al. Enrichment of Cdk1-cyclins at DNA double-strand breaks stimulates Fun30 phosphorylation and DNA end resection. Nucleic Acids Res. 44:6 (2016), 2742–2753.
-
(2016)
Nucleic Acids Res.
, vol.44
, Issue.6
, pp. 2742-2753
-
-
Chen, X.1
-
98
-
-
84892983257
-
53BP1: pro choice in DNA repair
-
[98] Zimmermann, M., de Lange, T., 53BP1: pro choice in DNA repair. Trends Cell Biol. 24:2 (2014), 108–117.
-
(2014)
Trends Cell Biol.
, vol.24
, Issue.2
, pp. 108-117
-
-
Zimmermann, M.1
de Lange, T.2
-
99
-
-
66149114020
-
Human CtIP mediates cell cycle control of DNA end resection and double strand break repair
-
[99] Huertas, P., Jackson, S.P., Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J. Biol. Chem. 284:14 (2009), 9558–9565.
-
(2009)
J. Biol. Chem.
, vol.284
, Issue.14
, pp. 9558-9565
-
-
Huertas, P.1
Jackson, S.P.2
-
100
-
-
84919839708
-
BRCA1 accelerates ctIP-mediated DNA-end resection
-
[100] Cruz-Garcia, A., Lopez-Saavedra, A., Huertas, P., BRCA1 accelerates ctIP-mediated DNA-end resection. Cell Rep. 9:2 (2014), 451–459.
-
(2014)
Cell Rep.
, vol.9
, Issue.2
, pp. 451-459
-
-
Cruz-Garcia, A.1
Lopez-Saavedra, A.2
Huertas, P.3
-
101
-
-
84991729326
-
Cell cycle-dependent inhibition of 53BP1 signaling by BRCA1
-
[101] Feng, L., et al. Cell cycle-dependent inhibition of 53BP1 signaling by BRCA1. Cell Discov., 1, 2015, 15019.
-
(2015)
Cell Discov.
, vol.1
, pp. 15019
-
-
Feng, L.1
-
102
-
-
84905493192
-
End resection at double-strand breaks: mechanism and regulation
-
[102] Symington, L.S., End resection at double-strand breaks: mechanism and regulation. Cold Spring Harb. Perspect. Biol., 6(8), 2014.
-
(2014)
Cold Spring Harb. Perspect. Biol.
, vol.6
, Issue.8
-
-
Symington, L.S.1
-
103
-
-
79951688343
-
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair
-
[103] Nimonkar, A.V., et al. BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. Genes Dev. 25:4 (2011), 350–362.
-
(2011)
Genes Dev.
, vol.25
, Issue.4
, pp. 350-362
-
-
Nimonkar, A.V.1
-
104
-
-
79958254560
-
A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers
-
[104] Jirawatnotai, S., et al. A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature 474:7350 (2011), 230–234.
-
(2011)
Nature
, vol.474
, Issue.7350
, pp. 230-234
-
-
Jirawatnotai, S.1
-
105
-
-
84866911161
-
Complex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases
-
[105] Pardo, B., Aguilera, A., Complex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases. PLoS Genet., 8(9), 2012, e1002979.
-
(2012)
PLoS Genet.
, vol.8
, Issue.9
, pp. e1002979
-
-
Pardo, B.1
Aguilera, A.2
-
106
-
-
84892743776
-
Break-induced replication repair of damaged forks induces genomic duplications in human cells
-
[106] Costantino, L., et al. Break-induced replication repair of damaged forks induces genomic duplications in human cells. Science 343:6166 (2014), 88–91.
-
(2014)
Science
, vol.343
, Issue.6166
, pp. 88-91
-
-
Costantino, L.1
-
107
-
-
84949790002
-
Replication stress activates DNA repair synthesis in mitosis
-
[107] Minocherhomji, S., et al. Replication stress activates DNA repair synthesis in mitosis. Nature 528:7581 (2015), 286–290.
-
(2015)
Nature
, vol.528
, Issue.7581
, pp. 286-290
-
-
Minocherhomji, S.1
-
108
-
-
84902318918
-
Break-induced replication is a source of mutation clusters underlying kataegis
-
[108] Sakofsky, C.J., et al. Break-induced replication is a source of mutation clusters underlying kataegis. Cell Rep. 7:5 (2014), 1640–1648.
-
(2014)
Cell Rep.
, vol.7
, Issue.5
, pp. 1640-1648
-
-
Sakofsky, C.J.1
-
109
-
-
6344288785
-
Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination
-
[109] Watanabe, K., et al. Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination. EMBO J. 23:19 (2004), 3886–3896.
-
(2004)
EMBO J.
, vol.23
, Issue.19
, pp. 3886-3896
-
-
Watanabe, K.1
-
110
-
-
84930379261
-
Exploiting replicative stress to treat cancer
-
[110] Dobbelstein, M., Sorensen, C.S., Exploiting replicative stress to treat cancer. Nat. Rev. Drug Discov. 14:6 (2015), 405–423.
-
(2015)
Nat. Rev. Drug Discov.
, vol.14
, Issue.6
, pp. 405-423
-
-
Dobbelstein, M.1
Sorensen, C.S.2
-
111
-
-
44349119351
-
Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study
-
[111] Tsantoulis, P.K., et al. Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study. Oncogene 27:23 (2008), 3256–3264.
-
(2008)
Oncogene
, vol.27
, Issue.23
, pp. 3256-3264
-
-
Tsantoulis, P.K.1
-
112
-
-
33845269825
-
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
-
[112] Di Micco, R., et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 444:7119 (2006), 638–642.
-
(2006)
Nature
, vol.444
, Issue.7119
, pp. 638-642
-
-
Di Micco, R.1
-
113
-
-
33845235459
-
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
-
[113] Bartkova, J., et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444:7119 (2006), 633–637.
-
(2006)
Nature
, vol.444
, Issue.7119
, pp. 633-637
-
-
Bartkova, J.1
-
114
-
-
84855464193
-
Thresholds of replication stress signaling in cancer development and treatment
-
[114] Bartek, J., Mistrik, M., Bartkova, J., Thresholds of replication stress signaling in cancer development and treatment. Nat. Struct. Mol. Biol. 19:1 (2012), 5–7.
-
(2012)
Nat. Struct. Mol. Biol.
, vol.19
, Issue.1
, pp. 5-7
-
-
Bartek, J.1
Mistrik, M.2
Bartkova, J.3
-
115
-
-
3142552523
-
Chk1 is haploinsufficient for multiple functions critical to tumor suppression
-
[115] Lam, M.H., et al. Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell 6:1 (2004), 45–59.
-
(2004)
Cancer Cell
, vol.6
, Issue.1
, pp. 45-59
-
-
Lam, M.H.1
-
116
-
-
4143051517
-
ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background
-
[116] Fang, Y., et al. ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. EMBO J. 23:15 (2004), 3164–3174.
-
(2004)
EMBO J.
, vol.23
, Issue.15
, pp. 3164-3174
-
-
Fang, Y.1
-
117
-
-
82955203422
-
Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors
-
[117] Murga, M., et al. Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors. Nat. Struct. Mol. Biol. 18:12 (2011), 1331–1335.
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, Issue.12
, pp. 1331-1335
-
-
Murga, M.1
-
118
-
-
84858332163
-
Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis
-
[118] Tho, L.M., et al. Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis. Oncogene 31:11 (2012), 1366–1375.
-
(2012)
Oncogene
, vol.31
, Issue.11
, pp. 1366-1375
-
-
Tho, L.M.1
-
119
-
-
84949548631
-
Mitotic catastrophe and cancer drug resistance: a link that must to be broken
-
[119] Denisenko, T.V., et al. Mitotic catastrophe and cancer drug resistance: a link that must to be broken. Drug Resist. Updat. 24 (2016), 1–12.
-
(2016)
Drug Resist. Updat.
, vol.24
, pp. 1-12
-
-
Denisenko, T.V.1
-
120
-
-
84923357784
-
Untangling the ATR-CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer
-
[120] Abdel-Fatah, T.M., et al. Untangling the ATR-CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer. Mol. Oncol. 9:3 (2015), 569–585.
-
(2015)
Mol. Oncol.
, vol.9
, Issue.3
, pp. 569-585
-
-
Abdel-Fatah, T.M.1
-
121
-
-
84861527388
-
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
-
[121] Curtis, C., et al. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature 486:7403 (2012), 346–352.
-
(2012)
Nature
, vol.486
, Issue.7403
, pp. 346-352
-
-
Curtis, C.1
-
122
-
-
84917706821
-
ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses
-
[122] Josse, R., et al. ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses. Cancer Res. 74:23 (2014), 6968–6979.
-
(2014)
Cancer Res.
, vol.74
, Issue.23
, pp. 6968-6979
-
-
Josse, R.1
-
123
-
-
84898471903
-
Targeting DNA damage response in cancer therapy
-
[123] Hosoya, N., Miyagawa, K., Targeting DNA damage response in cancer therapy. Cancer Sci. 105:4 (2014), 370–388.
-
(2014)
Cancer Sci.
, vol.105
, Issue.4
, pp. 370-388
-
-
Hosoya, N.1
Miyagawa, K.2
-
124
-
-
84871234067
-
Phase I and pharmacologic trial of cytosine arabinoside with the selective checkpoint 1 inhibitor Sch 900776 in refractory acute leukemias
-
[124] Karp, J.E., et al. Phase I and pharmacologic trial of cytosine arabinoside with the selective checkpoint 1 inhibitor Sch 900776 in refractory acute leukemias. Clin. Cancer Res. 18:24 (2012), 6723–6731.
-
(2012)
Clin. Cancer Res.
, vol.18
, Issue.24
, pp. 6723-6731
-
-
Karp, J.E.1
-
125
-
-
84896031764
-
Phase I dose-escalation study of AZD776, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors
-
[125] Sausville, E., et al. Phase I dose-escalation study of AZD776, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors. Cancer Chemother. Pharmacol. 73:3 (2014), 539–549.
-
(2014)
Cancer Chemother. Pharmacol.
, vol.73
, Issue.3
, pp. 539-549
-
-
Sausville, E.1
-
126
-
-
84883487392
-
Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours
-
[126] Seto, T., et al. Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours. Cancer Chemother. Pharmacol. 72:3 (2013), 619–627.
-
(2013)
Cancer Chemother. Pharmacol.
, vol.72
, Issue.3
, pp. 619-627
-
-
Seto, T.1
-
127
-
-
84861547375
-
A phase II study of cell cycle inhibitor UCN-01 in patients with metastatic melanoma: a California Cancer Consortium trial
-
[127] Li, T., et al. A phase II study of cell cycle inhibitor UCN-01 in patients with metastatic melanoma: a California Cancer Consortium trial. Invest. New Drugs 30:2 (2012), 741–748.
-
(2012)
Invest. New Drugs
, vol.30
, Issue.2
, pp. 741-748
-
-
Li, T.1
-
128
-
-
84877947967
-
A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer
-
[128] Ma, C.X., et al. A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer. Breast Cancer Res. Treat. 137:2 (2013), 483–492.
-
(2013)
Breast Cancer Res. Treat.
, vol.137
, Issue.2
, pp. 483-492
-
-
Ma, C.X.1
-
129
-
-
84900540918
-
A phase I study of two dosing schedules of volasertib (BI 6727), an intravenous polo-like kinase inhibitor, in patients with advanced solid malignancies
-
[129] Lin, C.C., et al. A phase I study of two dosing schedules of volasertib (BI 6727), an intravenous polo-like kinase inhibitor, in patients with advanced solid malignancies. Br. J. Cancer 110:10 (2014), 2434–2440.
-
(2014)
Br. J. Cancer
, vol.110
, Issue.10
, pp. 2434-2440
-
-
Lin, C.C.1
-
130
-
-
79956014825
-
Phase I study of GSK461364, a specific and competitive Polo-like kinase 1 inhibitor, in patients with advanced solid malignancies
-
[130] Olmos, D., et al. Phase I study of GSK461364, a specific and competitive Polo-like kinase 1 inhibitor, in patients with advanced solid malignancies. Clin. Cancer Res. 17:10 (2011), 3420–3430.
-
(2011)
Clin. Cancer Res.
, vol.17
, Issue.10
, pp. 3420-3430
-
-
Olmos, D.1
-
131
-
-
84856905720
-
Phase i study of the Plk1 inhibitor BI 2536 administered intravenously on three consecutive days in advanced solid tumours
-
[131] Frost, A., et al. Phase i study of the Plk1 inhibitor BI 2536 administered intravenously on three consecutive days in advanced solid tumours. Curr. Oncol. 19:1 (2012), e28–35.
-
(2012)
Curr. Oncol.
, vol.19
, Issue.1
, pp. e28-35
-
-
Frost, A.1
-
132
-
-
84863720628
-
A randomised phase II trial of the Polo-like kinase inhibitor BI 2536 in chemo-naive patients with unresectable exocrine adenocarcinoma of the pancreas—a study within the Central European Society Anticancer Drug Research (CESAR) collaborative network
-
[132] Mross, K., et al. A randomised phase II trial of the Polo-like kinase inhibitor BI 2536 in chemo-naive patients with unresectable exocrine adenocarcinoma of the pancreas—a study within the Central European Society Anticancer Drug Research (CESAR) collaborative network. Br. J. Cancer 107:2 (2012), 280–286.
-
(2012)
Br. J. Cancer
, vol.107
, Issue.2
, pp. 280-286
-
-
Mross, K.1
-
133
-
-
84920740857
-
Molecularly targeted therapies in non-small-cell lung cancer annual update 2014
-
[133] Morgensztern, D., et al. Molecularly targeted therapies in non-small-cell lung cancer annual update 2014. J. Thorac. Oncol. 10:1 Suppl. 1 (2015), S1–63.
-
(2015)
J. Thorac. Oncol.
, vol.10
, Issue.1 Suppl. 1
, pp. S1-63
-
-
Morgensztern, D.1
-
134
-
-
84945181744
-
Phase I study of single-agent AZD1775 (MK-1775), a wee1 kinase inhibitor, in patients with refractory solid tumors
-
[134] Do, K., et al. Phase I study of single-agent AZD1775 (MK-1775), a wee1 kinase inhibitor, in patients with refractory solid tumors. J. Clin. Oncol. 33:30 (2015), 3409–3415.
-
(2015)
J. Clin. Oncol.
, vol.33
, Issue.30
, pp. 3409-3415
-
-
Do, K.1
-
135
-
-
84865680221
-
A phase 2 trial of flavopiridol (Alvocidib) and cisplatin in platin-resistant ovarian and primary peritoneal carcinoma: MC0261
-
[135] Bible, K.C., et al. A phase 2 trial of flavopiridol (Alvocidib) and cisplatin in platin-resistant ovarian and primary peritoneal carcinoma: MC0261. Gynecol. Oncol. 127:1 (2012), 55–62.
-
(2012)
Gynecol. Oncol.
, vol.127
, Issue.1
, pp. 55-62
-
-
Bible, K.C.1
-
136
-
-
85018232770
-
Randomized multicenter phase II study of flavopiridol (alvocidib): cytarabine, and mitoxantrone (FLAM) versus cytarabine/daunorubicin (7 + 3) in newly diagnosed acute myeloid leukemia
-
[136] Zeidner, J.F., et al. Randomized multicenter phase II study of flavopiridol (alvocidib): cytarabine, and mitoxantrone (FLAM) versus cytarabine/daunorubicin (7 + 3) in newly diagnosed acute myeloid leukemia. Haematologica 100:9 (2015), 1172–1179.
-
(2015)
Haematologica
, vol.100
, Issue.9
, pp. 1172-1179
-
-
Zeidner, J.F.1
-
137
-
-
78649634707
-
Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced malignancies
-
[137] Le Tourneau, C., et al. Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced malignancies. Eur. J. Cancer 46:18 (2010), 3243–3250.
-
(2010)
Eur. J. Cancer
, vol.46
, Issue.18
, pp. 3243-3250
-
-
Le Tourneau, C.1
-
138
-
-
80052697285
-
Mechanisms of action of a dual Cdc7/Cdk9 kinase inhibitor against quiescent and proliferating CLL cells
-
[138] Natoni, A., et al. Mechanisms of action of a dual Cdc7/Cdk9 kinase inhibitor against quiescent and proliferating CLL cells. Mol. Cancer Ther. 10:9 (2011), 1624–1634.
-
(2011)
Mol. Cancer Ther.
, vol.10
, Issue.9
, pp. 1624-1634
-
-
Natoni, A.1
-
139
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
[139] Farmer, H., et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434:7035 (2005), 917–921.
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 917-921
-
-
Farmer, H.1
-
140
-
-
77955019276
-
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial
-
[140] Tutt, A., et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet 376:9737 (2010), 235–244.
-
(2010)
Lancet
, vol.376
, Issue.9737
, pp. 235-244
-
-
Tutt, A.1
-
141
-
-
85007285037
-
OlympiA, Neo-Olympia and OlympiAD: randomized phase III trials of olaparib in patients (pts) with breast cancer (BC) and a germline BRCA1 /2 mutation (gBRCAm)
-
[141] Robson, M., et al. OlympiA, Neo-Olympia and OlympiAD: randomized phase III trials of olaparib in patients (pts) with breast cancer (BC) and a germline BRCA1 /2 mutation (gBRCAm). Cancer Res., 75, 2015.
-
(2015)
Cancer Res.
, vol.75
-
-
Robson, M.1
-
142
-
-
84939175214
-
PARP inhibitors in the management of breast cancer: current data and future prospects
-
[142] Livraghi, L., Garber, J.E., PARP inhibitors in the management of breast cancer: current data and future prospects. BMC Med., 13, 2015, 188.
-
(2015)
BMC Med.
, vol.13
, pp. 188
-
-
Livraghi, L.1
Garber, J.E.2
-
143
-
-
84938374495
-
Profile of veliparib and its potential in the treatment of solid tumors
-
[143] Wagner, L.M., Profile of veliparib and its potential in the treatment of solid tumors. Onco Targets Ther. 8 (2015), 1931–1939.
-
(2015)
Onco Targets Ther.
, vol.8
, pp. 1931-1939
-
-
Wagner, L.M.1
-
144
-
-
84920855943
-
Phase II study of olaparib in patients with refractory Ewing sarcoma following failure of standard chemotherapy
-
[144] Choy, E., et al. Phase II study of olaparib in patients with refractory Ewing sarcoma following failure of standard chemotherapy. BMC Cancer, 14, 2014, 813.
-
(2014)
BMC Cancer
, vol.14
, pp. 813
-
-
Choy, E.1
-
145
-
-
84912105634
-
Phase III study of iniparib plus gemcitabine and carboplatin versus gemcitabine and carboplatin in patients with metastatic triple-negative breast cancer
-
[145] O'Shaughnessy, J., et al. Phase III study of iniparib plus gemcitabine and carboplatin versus gemcitabine and carboplatin in patients with metastatic triple-negative breast cancer. J. Clin. Oncol. 32:34 (2014), 3840–3847.
-
(2014)
J. Clin. Oncol.
, vol.32
, Issue.34
, pp. 3840-3847
-
-
O'Shaughnessy, J.1
-
146
-
-
84907597103
-
Phase 1 dose-escalation study of the PARP inhibitor CEP-9722 as monotherapy or in combination with temozolomide in patients with solid tumors
-
[146] Plummer, R., et al. Phase 1 dose-escalation study of the PARP inhibitor CEP-9722 as monotherapy or in combination with temozolomide in patients with solid tumors. Cancer Chemother. Pharmacol. 74:2 (2014), 257–265.
-
(2014)
Cancer Chemother. Pharmacol.
, vol.74
, Issue.2
, pp. 257-265
-
-
Plummer, R.1
-
147
-
-
84880777712
-
The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial
-
[147] Sandhu, S.K., et al. The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial. Lancet Oncol. 14:9 (2013), 882–892.
-
(2013)
Lancet Oncol.
, vol.14
, Issue.9
, pp. 882-892
-
-
Sandhu, S.K.1
-
148
-
-
84861741887
-
Monitoring the spatiotemporal dynamics of proteins at replication forks and in assembled chromatin using isolation of proteins on nascent DNA
-
[148] Sirbu, B.M., Couch, F.B., Cortez, D., Monitoring the spatiotemporal dynamics of proteins at replication forks and in assembled chromatin using isolation of proteins on nascent DNA. Nat. Protoc. 7:3 (2012), 594–605.
-
(2012)
Nat. Protoc.
, vol.7
, Issue.3
, pp. 594-605
-
-
Sirbu, B.M.1
Couch, F.B.2
Cortez, D.3
|