Chk1-cyclin A/Cdk1 axis regulates origin firing programs in mammals

Chromosome Research

Volumn 18, Issue 1, 2010, Pages 103-113

  Nakanishi, Makoto ^a   Katsuno, Yuko ^a   Niida, Hiroyuki ^a   Murakami, Hiroshi ^a   Shimada, Midori ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

Checkpoint protein 1 (Chk1); Cyclin; Cyclin dependent kinase (CDK); DNA replication; S phase program

Indexed keywords

CHECKPOINT KINASE 1; CYCLIN A; CYCLIN DEPENDENT KINASE 1; DNA;

CELL CYCLE; CELL CYCLE S PHASE; DNA REPLICATION; ENZYME ACTIVITY; ENZYME REGULATION; MAMMAL; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SOMATIC CELL; VELOCITY;

ANIMALS; CDC2 PROTEIN KINASE; CYCLIN A; MAMMALS; PROTEIN KINASES; REPLICATION ORIGIN; S PHASE;

MAMMALIA;

EID: 77649237536     PISSN: 09673849     EISSN: 15736849     Source Type: Journal    
DOI: 10.1007/s10577-009-9086-2     Document Type: Review

References (58)

1. CJ Bakkenist MB Kastan 2003 DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation Nature 421 6922 499 506 10.1038/nature01368 1:CAS:528:DC%2BD3sXntFSqsQ%3D%3D 12556884 (Pubitemid 36168436)
2. A Chytil M Waltner-Law R West D Friedman M Aakre D Barker B Law 2004 Construction of a cyclin D1-Cdk2 fusion protein to model the biological functions of cyclin D1-Cdk2 complexes J Biol Chem 279 46 47688 47698 10.1074/jbc.M405938200 1:CAS:528:DC%2BD2cXptl2gu78%3D 15355984 (Pubitemid 39540915)
3. JE Cleaver R Rose DL Mitchell 1990 Replication of chromosomal and episomal DNA in X-ray-damaged human cells: a cis- or trans-acting mechanism? Radiat Res 124 3 294 299 10.2307/3577842 1:CAS:528:DyaK3MXlvVajug%3D%3D 2175922
4. S Courbet S Gay N Arnoult G Wronka M Anglana O Brison M Debatisse 2008 Replication fork movement sets chromatin loop size and origin choice in mammalian cells Nature 455 7212 557 560 10.1038/nature07233 1:CAS:528: DC%2BD1cXhtFKhtLbI 18716622
5. ML DePamphilis 2003 Eukaryotic DNA replication origins: reconciling disparate data Cell 114 3 274 275 10.1016/S0092-8674(03)00604-4 1:CAS:528:DC%2BD3sXmsFWqtrw%3D 12914691 (Pubitemid 36962925)
6. AD Donaldson MK Raghuraman KL Friedman FR Cross BJ Brewer WL Fangman 1998 CLB5-dependent activation of late replication origins in S. cerevisiae Mol Cell 2 2 173 182 10.1016/S1097-2765(00)80127-6 1:CAS:528:DyaK1cXmtVyju7k%3D 9734354
7. J Falck N Mailand RG Syljuasen J Bartek J Lukas 2001 The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis Nature 410 6830 842 847 10.1038/35071124 1:CAS:528:DC%2BD3MXjtVChsr0%3D 11298456 (Pubitemid 32303786)
8. W Feng D Collingwood ME Boeck LA Fox GM Alvino WL Fangman MK Raghuraman BJ Brewer 2006 Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication Nat Cell Biol 8 2 148 155 10.1038/ncb1358 1:CAS:528:DC%2BD28XptFOltQ%3D%3D 16429127
9. XQ Ge DA Jackson JJ Blow 2007 Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress Genes Dev 21 24 3331 3341 10.1101/gad.457807 1:CAS:528:DC%2BD2sXhsVOrsb%2FJ 18079179 (Pubitemid 350277759)
10. DM Gilbert 2004 In search of the holy replicator Nat Rev Mol Cell Biol 5 10 848 855 10.1038/nrm1495 1:CAS:528:DC%2BD2cXotVSlsrc%3D 15459665 (Pubitemid 39336278)
11. AA Goodarzi JC Jonnalagadda P Douglas D Young R Ye GB Moorhead SP Lees-Miller KK Khanna 2004 Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A EMBO J 23 22 4451 4461 10.1038/sj.emboj.7600455 1:CAS:528:DC%2BD2cXpsFahurg%3D 15510216 (Pubitemid 39601970)
12. JW Harper SJ Elledge 2007 The DNA damage response: ten years after Mol Cell 28 5 739 745 10.1016/j.molcel.2007.11.015 1:CAS:528:DC%2BD1cXktVWisQ%3D%3D 18082599 (Pubitemid 350217064)
13. M Hayashi Y Katou T Itoh A Tazumi Y Yamada T Takahashi T Nakagawa K Shirahige H Masukata 2007 Genome-wide localization of pre-RC sites and identification of replication origins in fission yeast EMBO J 26 5 1327 1339 10.1038/sj.emboj.7601585 1:CAS:528:DC%2BD2sXisVKqsr0%3D 17304213 (Pubitemid 46398708)
14. C Heichinger CJ Penkett J Bahler P Nurse 2006 Genome-wide characterization of fission yeast DNA replication origins EMBO J 25 21 5171 5179 10.1038/sj.emboj.7601390 1:CAS:528:DC%2BD28XhtFChsrrL 17053780 (Pubitemid 44658534)
15. H Hochegger D Dejsuphong E Sonoda A Saberi E Rajendra J Kirk T Hunt S Takeda 2007 An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells J Cell Biol 178 2 257 268 10.1083/jcb.200702034 1:CAS:528:DC%2BD2sXnvFCks7Y%3D 17635936 (Pubitemid 47076462)
16. JA Huberman 1998 DNA replication. Choosing a place to begin Science 281 5379 929 930 10.1126/science.281.5379.929 1:CAS:528:DyaK1cXlsVemu7k%3D 9722466
17. A Ibarra E Schwob J Mendez 2008 Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication Proc Natl Acad Sci U S A 105 26 8956 8961 10.1073/pnas.0803978105 1:CAS:528: DC%2BD1cXosVCitL0%3D 18579778
18. DA Jackson 1995 Nuclear organization: uniting replication foci, chromatin domains and chromosome structure Bioessays 17 7 587 591 10.1002/bies.950170704 1:STN:280:DyaK2MznsVCrsA%3D%3D 7646480
19. Y Jeon S Bekiranov N Karnani P Kapranov S Ghosh D MacAlpine C Lee DS Hwang TR Gingeras A Dutta 2005 Temporal profile of replication of human chromosomes Proc Natl Acad Sci U S A 102 18 6419 6424 10.1073/pnas.0405088102 1:CAS:528:DC%2BD2MXktlygt7s%3D 15845769 (Pubitemid 40617458)
20. J Jin XL Ang X Ye M Livingstone JW Harper 2008 Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase J Biol Chem 283 28 19322 19328 10.1074/jbc.M802474200 1:CAS:528:DC%2BD1cXotF2ks7s%3D 18480045
21. Y Katsuno A Suzuki K Sugimura K Okumura DH Zineldeen M Shimada H Niida T Mizuno F Hanaoka M Nakanishi 2009 Cyclin A-Cdk1 regulates the origin firing program in mammalian cells Proc Natl Acad Sci U S A 106 9 3184 3189 10.1073/pnas.0809350106 1:CAS:528:DC%2BD1MXivF2jsrw%3D 19221029
22. L Krasinska E Besnard E Cot C Dohet M Mechali JM Lemaitre D Fisher 2008 Cdk1 and Cdk2 activity levels determine the efficiency of replication origin firing in Xenopus EMBO J 27 5 758 769 10.1038/emboj.2008.16 1:CAS:528: DC%2BD1cXislGrs7k%3D 18256689
23. A Kumagai J Lee HY Yoo WG Dunphy 2006 TopBP1 activates the ATR-ATRIP complex Cell 124 5 943 955 10.1016/j.cell.2005.12.041 1:CAS:528: DC%2BD28Xislyjtbk%3D 16530042 (Pubitemid 43344235)
24. MH Lam Q Liu SJ Elledge JM Rosen 2004 Chk1 is haploinsufficient for multiple functions critical to tumor suppression Cancer Cell 6 1 45 59 10.1016/j.ccr.2004.06.015 1:CAS:528:DC%2BD2cXmtlKnt7g%3D 15261141 (Pubitemid 38903161)
25. JR Lamb C Petit-Frere BC Broughton AR Lehmann MH Green 1989 Inhibition of DNA replication by ionizing radiation is mediated by a trans-acting factor Int J Radiat Biol 56 2 125 130 10.1080/09553008914551271 1:CAS:528: DyaL1MXlslSiu7Y%3D 2569014
26. YJ Machida JL Hamlin A Dutta 2005 Right place, right time, and only once: replication initiation in metazoans Cell 123 1 13 24 10.1016/j.cell.2005.09.019 1:CAS:528:DC%2BD2MXhtFelt7nK 16213209 (Pubitemid 41414525)
27. N Mailand J Falck C Lukas RG Syljuasen M Welcker J Bartek J Lukas 2000 Rapid destruction of human Cdc25A in response to DNA damage Science 288 5470 1425 1429 10.1126/science.288.5470.1425 1:CAS:528:DC%2BD3cXjslGrsbs%3D 10827953 (Pubitemid 30366329)
28. K Marheineke O Hyrien 2004 Control of replication origin density and firing time in Xenopus egg extracts: role of a caffeine-sensitive, ATR-dependent checkpoint J Biol Chem 279 27 28071 28081 10.1074/jbc.M401574200 1:CAS:528:DC%2BD2cXlt1Clt7o%3D 15123715 (Pubitemid 38900079)
29. H Masumoto S Muramatsu Y Kamimura H Araki 2002 S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast Nature 415 6872 651 655 10.1038/nature713 1:CAS:528:DC%2BD38XhsVCjsbc%3D 11807498 (Pubitemid 34136393)
30. S Matsuoka BA Ballif A Smogorzewska ER McDonald 3rd KE Hurov J Luo CE Bakalarski Z Zhao N Solimini Y Lerenthal Y Shiloh SP Gygi SJ Elledge 2007 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage Science 316 5828 1160 1166 10.1126/science.1140321 1:CAS:528: DC%2BD2sXls1Kit7o%3D 17525332 (Pubitemid 46877472)
31. A Maya-Mendoza E Petermann DA Gillespie KW Caldecott DA Jackson 2007 Chk1 regulates the density of active replication origins during the vertebrate S phase EMBO J 26 11 2719 2731 10.1038/sj.emboj.7601714 1:CAS:528: DC%2BD2sXmtFSju78%3D 17491592 (Pubitemid 46884282)
32. KA Merrick S Larochelle C Zhang JJ Allen KM Shokat RP Fisher 2008 Distinct activation pathways confer cyclin-binding specificity on cdk1 and cdk2 in human cells Mol Cell 32 5 662 672 10.1016/j.molcel.2008.10.022 1:CAS:528:DC%2BD1cXhsFSntrrO 19061641
33. H Miao JA Seiler WC Burhans 2003 Regulation of cellular and SV40 virus origins of replication by Chk1-dependent intrinsic and UVC radiation-induced checkpoints J Biol Chem 278 6 4295 4304 10.1074/jbc.M204264200 1:CAS:528:DC%2BD3sXot1yrtg%3D%3D 12424256 (Pubitemid 36801167)
34. H Niida M Nakanishi 2006 DNA damage checkpoints in mammals Mutagenesis 21 1 3 9 10.1093/mutage/gei063 1:CAS:528:DC%2BD28XhtlOnsLY%3D 16314342 (Pubitemid 43288730)
35. H Niida S Tsuge Y Katsuno A Konishi N Takeda M Nakanishi 2005 Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe J Biol Chem 280 47 39246 39252 10.1074/jbc.M505009200 1:CAS:528: DC%2BD2MXht1emsrnN 16159883 (Pubitemid 41713877)
36. H Niida Y Katsuno B Banerjee MP Hande M Nakanishi 2007 Specific role of Chk1 phosphorylations in cell survival and checkpoint activation Mol Cell Biol 27 7 2572 2581 10.1128/MCB.01611-06 1:CAS:528:DC%2BD2sXjs1ajsLk%3D 17242188 (Pubitemid 46581348)
37. E Noguchi P Shanahan C Noguchi P Russell 2002 CDK phosphorylation of Drc1 regulates DNA replication in fission yeast Curr Biol 12 7 599 605 10.1016/S0960-9822(02)00739-X 1:CAS:528:DC%2BD38Xis1Ckur8%3D 11937031 (Pubitemid 34271376)
38. M O'Driscoll VL Ruiz-Perez CG Woods PA Jeggo JA Goodship 2003 A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome Nat Genet 33 4 497 501 10.1038/ng1129 12640452 (Pubitemid 36390012)
39. RB Painter BR Young 1976 Formation of nascent DNA molecules during inhibition of replicon initiation in mammalian cells Biochim Biophys Acta 418 2 146 153 1:CAS:528:DyaE28XhtVWlur4%3D 1247539
40. E Petermann KW Caldecott 2006 Evidence that the ATR/Chk1 pathway maintains normal replication fork progression during unperturbed S phase Cell Cycle 5 19 2203 2209 1:CAS:528:DC%2BD2sXjsVymsg%3D%3D 16969104
41. E Petermann A Maya-Mendoza G Zachos DA Gillespie DA Jackson KW Caldecott 2006 Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase Mol Cell Biol 26 8 3319 3326 10.1128/MCB.26.8.3319-3326.2006 1:CAS:528:DC%2BD28Xjs1Sltb0%3D 16581803
42. M Raveendranathan S Chattopadhyay YT Bolon J Haworth DJ Clarke AK Bielinsky 2006 Genome-wide replication profiles of S-phase checkpoint mutants reveal fragile sites in yeast EMBO J 25 15 3627 3639 10.1038/sj.emboj.7601251 1:CAS:528:DC%2BD28XnvVGlsbw%3D 16888628 (Pubitemid 44264873)
43. P Romanowski J Marr MA Madine A Rowles JJ Blow J Gautier RA Laskey 2000 Interaction of Xenopus Cdc2 x cyclin A1 with the origin recognition complex J Biol Chem 275 6 4239 4243 10.1074/jbc.275.6.4239 1:CAS:528:DC%2BD3cXht12gtL8%3D 10660590 (Pubitemid 30094662)
44. D Shechter V Costanzo J Gautier 2004 ATR and ATM regulate the timing of DNA replication origin firing Nat Cell Biol 6 7 648 655 10.1038/ncb1145 1:CAS:528:DC%2BD2cXlt1Ortrk%3D 15220931 (Pubitemid 38960923)
45. Y Shiloh 1997 Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart Annu Rev Genet 31 635 662 10.1146/annurev. genet.31.1.635 1:CAS:528:DyaK1cXhtlGltw%3D%3D 9442910 (Pubitemid 28023722)
46. M Shimada H Niida DH Zineldeen H Tagami M Tanaka H Saito M Nakanishi 2008 Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression Cell 132 2 221 232 10.1016/j.cell.2007.12.013 1:CAS:528:DC%2BD1cXhvVSrtb8%3D 18243098 (Pubitemid 351172429)
47. VA Smits PM Reaper SP Jackson 2006 Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response Curr Biol 16 2 150 159 10.1016/j.cub.2005.11.066 1:CAS:528:DC%2BD28Xosl2msQ%3D%3D 16360315 (Pubitemid 43117429)
48. CS Sorensen RG Syljuasen J Lukas J Bartek 2004 ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage Cell Cycle 3 7 941 945 1:CAS:528:DC%2BD2MXmtlOjug%3D%3D 15190204
49. JA Stamatoyannopoulos I Adzhubei RE Thurman GV Kryukov SM Mirkin SR Sunyaev 2009 Human mutation rate associated with DNA replication timing Nat Genet 41 4 393 395 10.1038/ng.363 1:CAS:528:DC%2BD1MXjtFCis7w%3D 19287383
50. DT Stinchcomb K Struhl RW Davis 1979 Isolation and characterisation of a yeast chromosomal replicator Nature 282 5734 39 43 10.1038/282039a0 1:CAS:528:DyaL3cXhtVOisb4%3D 388229 (Pubitemid 10250104)
51. Y Sun X Jiang S Chen N Fernandes BD Price 2005 A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM Proc Natl Acad Sci U S A 102 37 13182 13187 10.1073/pnas.0504211102 1:CAS:528: DC%2BD2MXhtVejsr7P 16141325 (Pubitemid 41324998)
52. H Takai K Tominaga N Motoyama YA Minamishima H Nagahama T Tsukiyama K Ikeda K Nakayama M Nakanishi 2000 Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice Genes Dev 14 12 1439 1447 1:CAS:528:DC%2BD3cXksVGnt74%3D 10859163
53. H Takai K Naka Y Okada M Watanabe N Harada S Saito CW Anderson E Appella M Nakanishi H Suzuki K Nagashima H Sawa K Ikeda N Motoyama 2002 Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription EMBO J 21 19 5195 5205 10.1093/emboj/cdf506 1:CAS:528:DC%2BD38Xns1Cms7Y%3D 12356735
54. N Willis N Rhind 2009 Regulation of DNA replication by the S-phase DNA damage checkpoint Cell Div 4 13 10.1186/1747-1028-4-13 19575778
55. AM Woodward T Gohler MG Luciani M Oehlmann X Ge A Gartner DA Jackson JJ Blow 2006 Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress J Cell Biol 173 5 673 683 10.1083/jcb.200602108 1:CAS:528:DC%2BD28Xls1Shsro%3D 16754955 (Pubitemid 46165576)
56. J Wuarin V Buck P Nurse JB Millar 2002 Stable association of mitotic cyclin B/Cdc2 to replication origins prevents endoreduplication Cell 111 3 419 431 10.1016/S0092-8674(02)01042-5 1:CAS:528:DC%2BD38XovVaku7g%3D 12419251 (Pubitemid 35341394)
57. L Zou SJ Elledge 2003 Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes Science 300 5625 1542 1548 10.1126/science.1083430 1:CAS:528:DC%2BD3sXktlKrtbk%3D 12791985 (Pubitemid 36682880)
58. L Zou B Stillman 1998 Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin Science 280 5363 593 596 10.1126/science.280.5363.593 1:CAS:528:DyaK1cXjtVahs70%3D 9554851 (Pubitemid 28227763)