ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background

EMBO Journal

Volumn 23, Issue 15, 2004, Pages 3164-3174

  Fang, Yanan ^a   Tsao, Cheng Chung ^b   Goodman, Barbara K ^a   Furumai, Ryohei ^a   Tirado, Carlos A ^a   Abraham, Robert T ^b   Wang, Xiao Fan ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b BURNHAM INSTITUTE   (United States)

Author keywords

ATR; Mismatch repair; MLH1; Tumor suppressor

Indexed keywords

ATR PROTEIN; CHECKPOINT KINASE 1; MMR PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATR GENE; CANCER INHIBITION; CARCINOGENESIS; CELL DEATH; CELL LINE; CHROMOSOME FRAGILITY; CHROMOSOME REARRANGEMENT; COLON CARCINOMA; CONTROLLED STUDY; DNA DAMAGE; EARLY CANCER; EMBRYO; EMBRYO DEATH; GENE; GENE DOSAGE; GENE INACTIVATION; GENE MUTATION; GENOTOXICITY; GENOTYPE; HAPLOTYPE; HETEROZYGOSITY; HUMAN; HUMAN CELL; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; STRESS;

ANIMALS; BASE PAIR MISMATCH; CARRIER PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATIONS; DNA; DNA REPAIR; GENE AMPLIFICATION; GENE DOSAGE; GENOTYPE; HUMANS; KARYOTYPING; MICE; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA;

EID: 4143051517     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600315     Document Type: Article

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