-
2
-
-
0032475878
-
Signaling to p53: Breaking the MDM2-p53 circuit
-
Prives C. Signaling to p53: breaking the MDM2-p53 circuit. Cell 1998;95:5-8.
-
(1998)
Cell
, vol.95
, pp. 5-8
-
-
Prives, C.1
-
3
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 2003;3:155-68.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
4
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist CJ, Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003;421:499-506.
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
5
-
-
4444339751
-
ATM and ataxia telangiectasia
-
McKinnon PJ. ATM and ataxia telangiectasia. EMBO Rep 2004;5:772-6.
-
(2004)
EMBO Rep
, vol.5
, pp. 772-776
-
-
McKinnon, P.J.1
-
6
-
-
0032530486
-
DNA damage activates p53 through a phosphorylation-acetylation cascade
-
Sakaguchi K, Herrera JE, Saito S, et al. DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev 1998;12:2831-41.
-
(1998)
Genes Dev
, vol.12
, pp. 2831-2841
-
-
Sakaguchi, K.1
Herrera, J.E.2
Saito, S.3
-
7
-
-
0033572746
-
Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2
-
Dumaz N, Meek DW. Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2. EMBO J 1999;18:7002-10.
-
(1999)
EMBO J
, vol.18
, pp. 7002-7010
-
-
Dumaz, N.1
Meek, D.W.2
-
8
-
-
0142186242
-
The MRN complex: Coordinating and mediating the response to broken chromosomes
-
van den Bosch M, Bree RT, Lowndes NF. The MRN complex: coordinating and mediating the response to broken chromosomes. EMBO Rep 2003;4:844-9.
-
(2003)
EMBO Rep
, vol.4
, pp. 844-849
-
-
Van Den Bosch, M.1
Bree, R.T.2
Lowndes, N.F.3
-
9
-
-
1842431822
-
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex
-
Lee JH, Paull TT. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science 2004;304:93-6.
-
(2004)
Science
, vol.304
, pp. 93-96
-
-
Lee, J.H.1
Paull, T.T.2
-
10
-
-
0034713466
-
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
-
Wu X, Ranganathan V, Weisman DS, et al. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature 2000;405:477-82.
-
(2000)
Nature
, vol.405
, pp. 477-482
-
-
Wu, X.1
Ranganathan, V.2
Weisman, D.S.3
-
11
-
-
0034713393
-
Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
-
Zhao S, Weng YC, Yuan SS, et al. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature 2000;405:473-7.
-
(2000)
Nature
, vol.405
, pp. 473-477
-
-
Zhao, S.1
Weng, Y.C.2
Yuan, S.S.3
-
12
-
-
0034611728
-
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
-
Lim DS, Kim ST, Xu B, et al. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 2000;404:613-7.
-
(2000)
Nature
, vol.404
, pp. 613-617
-
-
Lim, D.S.1
Kim, S.T.2
Xu, B.3
-
13
-
-
0034106722
-
ATM-dependent phosphorylation of nibrin in response to radiation exposure
-
Gatei M, Young D, Cerosaletti KM, et al. ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat Genet 2000;25:115-9.
-
(2000)
Nat Genet
, vol.25
, pp. 115-119
-
-
Gatei, M.1
Young, D.2
Cerosaletti, K.M.3
-
14
-
-
0037123768
-
Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways
-
Taniguchi T, Garcia-Higuera I, Xu B, et al. Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell 2002;109:459-72.
-
(2002)
Cell
, vol.109
, pp. 459-472
-
-
Taniguchi, T.1
Garcia-Higuera, I.2
Xu, B.3
-
15
-
-
4544280871
-
Interaction of FANCD2 and NBS1 in the DNA damage response
-
Nakanishi K, Taniguchi T, Ranganathan V, et al. Interaction of FANCD2 and NBS1 in the DNA damage response. Nat Cell Biol 2002;4:913-20.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 913-920
-
-
Nakanishi, K.1
Taniguchi, T.2
Ranganathan, V.3
-
16
-
-
0345073699
-
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
-
O'Driscoll M, Ruiz-Perez VL, Woods CG, Jeggo PA, Goodship JA. A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat Genet 2003;33:497-501.
-
(2003)
Nat Genet
, vol.33
, pp. 497-501
-
-
O'Driscoll, M.1
Ruiz-Perez, V.L.2
Woods, C.G.3
Jeggo, P.A.4
Goodship, J.A.5
-
17
-
-
0037364415
-
RecQ helicases: Caretakers of the genome
-
Hickson ID. RecQ helicases: caretakers of the genome. Nat Rev Cancer 2003;3:169-78.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 169-178
-
-
Hickson, I.D.1
-
18
-
-
3142670793
-
BRCA1 in cancer, cell cycle and genomic stability
-
Jhanwar-Uniyal M. BRCA1 in cancer, cell cycle and genomic stability. Front Biosci 2003;8:s1107-17.
-
(2003)
Front Biosci
, vol.8
-
-
Jhanwar-Uniyal, M.1
-
19
-
-
0037335861
-
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance
-
Brown EJ, Baltimore D. Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev 2003;17:615-28.
-
(2003)
Genes Dev
, vol.17
, pp. 615-628
-
-
Brown, E.J.1
Baltimore, D.2
-
20
-
-
18644375649
-
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
-
Takai H, Naka K, Okada Y, et al. Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J 2002;21:5195-205.
-
(2002)
EMBO J
, vol.21
, pp. 5195-5205
-
-
Takai, H.1
Naka, K.2
Okada, Y.3
-
21
-
-
0036724625
-
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner
-
Hirao A, Cheung A, Duncan G, et al. Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol 2002;22:6521-32.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 6521-6532
-
-
Hirao, A.1
Cheung, A.2
Duncan, G.3
-
22
-
-
17644432403
-
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
-
Liu Q, Guntuku S, Cui XS, et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 2000;14:1448-59.
-
(2000)
Genes Dev
, vol.14
, pp. 1448-1459
-
-
Liu, Q.1
Guntuku, S.2
Cui, X.S.3
-
23
-
-
0034659341
-
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
-
Takai H, Tominaga K, Motoyama N, et al. Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev 2000;14:1439-47.
-
(2000)
Genes Dev
, vol.14
, pp. 1439-1447
-
-
Takai, H.1
Tominaga, K.2
Motoyama, N.3
-
24
-
-
0037415735
-
Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects
-
Zachos G, Rainey MD, Gillespie DA. Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects. EMBO J 2003;22:713-23.
-
(2003)
EMBO J
, vol.22
, pp. 713-723
-
-
Zachos, G.1
Rainey, M.D.2
Gillespie, D.A.3
-
25
-
-
0038013782
-
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation
-
Gatei M, Sloper K, Sorensen C, et al. Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J Biol Chem 2003;278:14806-11.
-
(2003)
J Biol Chem
, vol.278
, pp. 14806-14811
-
-
Gatei, M.1
Sloper, K.2
Sorensen, C.3
-
27
-
-
0027486024
-
Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells
-
Khanna KK, Lavin MF. Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells. Oncogene 1993;8:3307-12.
-
(1993)
Oncogene
, vol.8
, pp. 3307-3312
-
-
Khanna, K.K.1
Lavin, M.F.2
-
29
-
-
0033552932
-
p53 inhibits entry into mitosis when DNA synthesis is blocked
-
Taylor WR, Agarwal ML, Agarwal A, Stacey DW, Stark GR. p53 inhibits entry into mitosis when DNA synthesis is blocked. Oncogene 1999;18:283-95.
-
(1999)
Oncogene
, vol.18
, pp. 283-295
-
-
Taylor, W.R.1
Agarwal, M.L.2
Agarwal, A.3
Stacey, D.W.4
Stark, G.R.5
-
30
-
-
85047680162
-
p53 accumulates but is functionally impaired when DNA synthesis is blocked
-
Gottifredi V, Shieh S, Taya Y, Prives C. p53 accumulates but is functionally impaired when DNA synthesis is blocked. Proc Natl Acad Sci USA 2001;98:1036-41.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 1036-1041
-
-
Gottifredi, V.1
Shieh, S.2
Taya, Y.3
Prives, C.4
-
31
-
-
0037126383
-
Stabilization of p53 and transactivation of its target genes in response to replication blockade
-
Nayak BK, Das GM. Stabilization of p53 and transactivation of its target genes in response to replication blockade. Oncogene 2002;21:7226-9.
-
(2002)
Oncogene
, vol.21
, pp. 7226-7229
-
-
Nayak, B.K.1
Das, G.M.2
-
32
-
-
0037197914
-
RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells
-
Yu JY, DeRuiter SL, Turner DL. RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc Natl Acad Sci U S A 2002;99:6047-52.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 6047-6052
-
-
Yu, J.Y.1
DeRuiter, S.L.2
Turner, D.L.3
-
33
-
-
13544251546
-
The relative contribution of CHK1 and CHK2 to Adriamycin-induced checkpoint
-
Ho CC, Siu WY, Chow JP, et al. The relative contribution of CHK1 and CHK2 to Adriamycin-induced checkpoint. Exp Cell Res 2005;304:1-15.
-
(2005)
Exp Cell Res
, vol.304
, pp. 1-15
-
-
Ho, C.C.1
Siu, W.Y.2
Chow, J.P.3
-
34
-
-
0034629072
-
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
-
Hirao A, Kong YY, Matsuoka S, et al. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 2000;287:1824-7.
-
(2000)
Science
, vol.287
, pp. 1824-1827
-
-
Hirao, A.1
Kong, Y.Y.2
Matsuoka, S.3
-
35
-
-
0029145975
-
Redistribution of the CDK inhibitor p27 between different cyclin. CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation
-
Poon RYC, Toyoshima H, Hunter T. Redistribution of the CDK inhibitor p27 between different cyclin. CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. Mol Biol Cell 1995;6:1197-213.
-
(1995)
Mol Biol Cell
, vol.6
, pp. 1197-1213
-
-
Poon, R.Y.C.1
Toyoshima, H.2
Hunter, T.3
-
37
-
-
0142135133
-
Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints
-
Chow JPH, Siu WY, Ho HTB, Ma KHT, Ho CC, Poon RYC. Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints. J Biol Chem 2003;278:40815-28.
-
(2003)
J Biol Chem
, vol.278
, pp. 40815-40828
-
-
Chow, J.P.H.1
Siu, W.Y.2
Ho, H.T.B.3
Ma, K.H.T.4
Ho, C.C.5
Poon, R.Y.C.6
-
38
-
-
0023919963
-
A simple technique for quantitation of low levels of DNA damage in individual cells
-
Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988;175:184-91.
-
(1988)
Exp Cell Res
, vol.175
, pp. 184-191
-
-
Singh, N.P.1
McCoy, M.T.2
Tice, R.R.3
Schneider, E.L.4
-
39
-
-
1542365321
-
Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains
-
Ng CP, Lee HC, Ho CW, et al. Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains. J Biol Chem 2004;279:8808-19.
-
(2004)
J Biol Chem
, vol.279
, pp. 8808-8819
-
-
Ng, C.P.1
Lee, H.C.2
Ho, C.W.3
-
40
-
-
3543112227
-
Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms
-
Siu WY, Lau A, Arooz T, Chow JP, Ho HT, Poon RYC. Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms. Mol Cancer Ther 2004;3:621-32.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 621-632
-
-
Siu, W.Y.1
Lau, A.2
Arooz, T.3
Chow, J.P.4
Ho, H.T.5
Poon, R.Y.C.6
-
41
-
-
0035930537
-
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
-
Ward IM, Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem 2001;276:47759-62.
-
(2001)
J Biol Chem
, vol.276
, pp. 47759-47762
-
-
Ward, I.M.1
Chen, J.2
-
42
-
-
0141740426
-
Focusing on foci: H2AX and the recruitment of DNA-damage response factors
-
Fernandez-Capetillo O, Celeste A, Nussenzweig A. Focusing on foci: H2AX and the recruitment of DNA-damage response factors. Cell Cycle 2003;2:426-7.
-
(2003)
Cell Cycle
, vol.2
, pp. 426-427
-
-
Fernandez-Capetillo, O.1
Celeste, A.2
Nussenzweig, A.3
-
43
-
-
0030871855
-
Apoptosis induced by gliotoxin is preceded by phosphorylation of histone H3 and enhanced sensitivity of chromatin to nuclease digestion
-
Waring P, Khan T, Sjaarda A. Apoptosis induced by gliotoxin is preceded by phosphorylation of histone H3 and enhanced sensitivity of chromatin to nuclease digestion. J Biol Chem 1997;272:17929-36.
-
(1997)
J Biol Chem
, vol.272
, pp. 17929-17936
-
-
Waring, P.1
Khan, T.2
Sjaarda, A.3
-
44
-
-
4544235194
-
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest
-
Sengupta S, Robles AI, Linke SP, et al. Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol 2004;166:801-13.
-
(2004)
J Cell Biol
, vol.166
, pp. 801-813
-
-
Sengupta, S.1
Robles, A.I.2
Linke, S.P.3
-
46
-
-
0033566082
-
Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
-
Chaturvedi P, Eng WK, Zhu Y, et al. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Oncogene 1999;18:4047-54.
-
(1999)
Oncogene
, vol.18
, pp. 4047-4054
-
-
Chaturvedi, P.1
Eng, W.K.2
Zhu, Y.3
-
47
-
-
0032484084
-
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
-
Matsuoka S, Huang M, Elledge SJ. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 1998;282:1893-7.
-
(1998)
Science
, vol.282
, pp. 1893-1897
-
-
Matsuoka, S.1
Huang, M.2
Elledge, S.J.3
-
48
-
-
0141864666
-
Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks
-
Davalos AR, Campisi J. Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks. J Cell Biol 2003;162:1197-209.
-
(2003)
J Cell Biol
, vol.162
, pp. 1197-1209
-
-
Davalos, A.R.1
Campisi, J.2
-
49
-
-
0037416149
-
BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination
-
Sengupta S, Linke SP, Pedeux R, et al. BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination. EMBO J 2003;22:1210-22.
-
(2003)
EMBO J
, vol.22
, pp. 1210-1222
-
-
Sengupta, S.1
Linke, S.P.2
Pedeux, R.3
|