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Volumn 170, Issue , 2017, Pages 80-97

Chitosan oligosaccharide: Biological activities and potential therapeutic applications

Author keywords

Chitin; Chitosan; Chitosan oligosaccharide; Drug discovery; Polymers

Indexed keywords

ANTILIPEMIC AGENT; ANTIOBESITY AGENT; CHITOSAN; CHITOSAN OLIGOSACCHARIDE; NEUROPROTECTIVE AGENT; OLIGOSACCHARIDE; UNCLASSIFIED DRUG; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE;

EID: 85006137671     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2016.10.013     Document Type: Review
Times cited : (420)

References (205)
  • 1
    • 77952965887 scopus 로고    scopus 로고
    • Production of chitooligosaccharides and their potential applications in medicine
    • Aam, B.B., Heggset, E.B., Norberg, A.L., Sorlie, M., Varum, K.M., Eijsink, V.G., Production of chitooligosaccharides and their potential applications in medicine. Mar Drugs 8 (2010), 1482–1517.
    • (2010) Mar Drugs , vol.8 , pp. 1482-1517
    • Aam, B.B.1    Heggset, E.B.2    Norberg, A.L.3    Sorlie, M.4    Varum, K.M.5    Eijsink, V.G.6
  • 2
    • 84886949886 scopus 로고    scopus 로고
    • Polymer gene delivery: overcoming the obstacles
    • Aied, A., Greiser, U., Pandit, A., Wang, W., Polymer gene delivery: overcoming the obstacles. Drug Discov Today 18 (2013), 1090–1098.
    • (2013) Drug Discov Today , vol.18 , pp. 1090-1098
    • Aied, A.1    Greiser, U.2    Pandit, A.3    Wang, W.4
  • 4
    • 77649190619 scopus 로고    scopus 로고
    • Anti-HIV-1 activity of low molecular weight sulfated chitooligosaccharides
    • Artan, M., Karadeniz, F., Karagozlu, M.Z., Kim, M.M., Kim, S.K., Anti-HIV-1 activity of low molecular weight sulfated chitooligosaccharides. Carbohydr Res 345 (2010), 656–662.
    • (2010) Carbohydr Res , vol.345 , pp. 656-662
    • Artan, M.1    Karadeniz, F.2    Karagozlu, M.Z.3    Kim, M.M.4    Kim, S.K.5
  • 5
    • 84922607138 scopus 로고    scopus 로고
    • The biology of innate lymphoid cells
    • Artis, D., Spits, H., The biology of innate lymphoid cells. Nature 517 (2015), 293–301.
    • (2015) Nature , vol.517 , pp. 293-301
    • Artis, D.1    Spits, H.2
  • 6
    • 0018622998 scopus 로고
    • Captopril in the treatment of clinical hypertension and cardiac failure
    • Atkinson, A.B., Robertson, J.I.S., Captopril in the treatment of clinical hypertension and cardiac failure. Lancet 314 (1979), 836–839.
    • (1979) Lancet , vol.314 , pp. 836-839
    • Atkinson, A.B.1    Robertson, J.I.S.2
  • 7
    • 84861225167 scopus 로고    scopus 로고
    • Chitooligosaccharide elicits acute inflammatory cytokine response through AP-1 pathway in human intestinal epithelial-like (Caco-2) cells
    • Bahar, B., O'Doherty, J.V., Maher, S., McMorrow, J., Sweeney, T., Chitooligosaccharide elicits acute inflammatory cytokine response through AP-1 pathway in human intestinal epithelial-like (Caco-2) cells. Mol Immunol 51 (2012), 283–291.
    • (2012) Mol Immunol , vol.51 , pp. 283-291
    • Bahar, B.1    O'Doherty, J.V.2    Maher, S.3    McMorrow, J.4    Sweeney, T.5
  • 8
    • 84875462347 scopus 로고    scopus 로고
    • Chito-oligosaccharide inhibits the de-methylation of a ‘CpG’ island within the leptin (LEP) promoter during adipogenesis of 3T3-L1 cells
    • Bahar, B., O'Doherty, J.V., O'Doherty, A.M., Sweeney, T., Chito-oligosaccharide inhibits the de-methylation of a ‘CpG’ island within the leptin (LEP) promoter during adipogenesis of 3T3-L1 cells. PLoS One, 8, 2013, e60011.
    • (2013) PLoS One , vol.8
    • Bahar, B.1    O'Doherty, J.V.2    O'Doherty, A.M.3    Sweeney, T.4
  • 9
    • 0042809688 scopus 로고    scopus 로고
    • Efficacy of a novel chitosan formulation on fecal fat excretion: a double-blind, crossover, placebo-controlled study
    • Barroso Aranda, J., Contreras, F., Bagchi, D., Preuss, H.G., Efficacy of a novel chitosan formulation on fecal fat excretion: a double-blind, crossover, placebo-controlled study. J Med 33 (2002), 209–225.
    • (2002) J Med , vol.33 , pp. 209-225
    • Barroso Aranda, J.1    Contreras, F.2    Bagchi, D.3    Preuss, H.G.4
  • 10
    • 0032930793 scopus 로고    scopus 로고
    • Nutritional aspects of calcium absorption
    • Bronner, F., Pansu, D., Nutritional aspects of calcium absorption. J Nutr 129 (1999), 9–12.
    • (1999) J Nutr , vol.129 , pp. 9-12
    • Bronner, F.1    Pansu, D.2
  • 11
  • 12
    • 84885658881 scopus 로고    scopus 로고
    • Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation
    • Cader, M.Z., Kaser, A., Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation. Gut 62 (2013), 1653–1664.
    • (2013) Gut , vol.62 , pp. 1653-1664
    • Cader, M.Z.1    Kaser, A.2
  • 13
    • 84897977837 scopus 로고    scopus 로고
    • Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease
    • Cai, Z., Hussain, M.D., Yan, L.J., Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease. Int J Neurosci 124 (2014), 307–321.
    • (2014) Int J Neurosci , vol.124 , pp. 307-321
    • Cai, Z.1    Hussain, M.D.2    Yan, L.J.3
  • 15
    • 11844288271 scopus 로고    scopus 로고
    • Influence of molecular weight on oral absorption of water soluble chitosans
    • Chae, S.Y., Jang, M.K., Nah, J.W., Influence of molecular weight on oral absorption of water soluble chitosans. J Control Release 102 (2005), 383–394.
    • (2005) J Control Release , vol.102 , pp. 383-394
    • Chae, S.Y.1    Jang, M.K.2    Nah, J.W.3
  • 16
    • 84869827815 scopus 로고    scopus 로고
    • Development of chitosan oligosaccharide-modified gold nanorods for in vivo targeted delivery and noninvasive imaging by NIR irradiation
    • Charan, S., Sanjiv, K., Singh, N., Chien, F.C., Chen, Y.F., Nergui, N.N., et al. Development of chitosan oligosaccharide-modified gold nanorods for in vivo targeted delivery and noninvasive imaging by NIR irradiation. Bioconjug Chem 23 (2012), 2173–2182.
    • (2012) Bioconjug Chem , vol.23 , pp. 2173-2182
    • Charan, S.1    Sanjiv, K.2    Singh, N.3    Chien, F.C.4    Chen, Y.F.5    Nergui, N.N.6
  • 18
    • 84859123648 scopus 로고    scopus 로고
    • Chitooligosaccharide ameliorates diet-induced obesity in mice and affects adipose gene expression involved in adipogenesis and inflammation
    • Choi, E.H., Yang, H.P., Chun, H.S., Chitooligosaccharide ameliorates diet-induced obesity in mice and affects adipose gene expression involved in adipogenesis and inflammation. Nutr Res 32 (2012), 218–228.
    • (2012) Nutr Res , vol.32 , pp. 218-228
    • Choi, E.H.1    Yang, H.P.2    Chun, H.S.3
  • 19
    • 84862790027 scopus 로고    scopus 로고
    • Anti-inflammatory effects of low-molecular weight chitosan oligosaccharides in IgE-antigen complex-stimulated RBL-2H3 cells and asthma model mice
    • Chung, M.J., Park, J.K., Park, Y.I., Anti-inflammatory effects of low-molecular weight chitosan oligosaccharides in IgE-antigen complex-stimulated RBL-2H3 cells and asthma model mice. Int Immunopharmacol 12 (2012), 453–459.
    • (2012) Int Immunopharmacol , vol.12 , pp. 453-459
    • Chung, M.J.1    Park, J.K.2    Park, Y.I.3
  • 20
    • 85010841440 scopus 로고    scopus 로고
    • A single oral dose of a polyglucosamine influences the bioavailability of [9-(14)C]-oleic acid in adult female Gottingen minipigs
    • Cnubben, N.H., Tel, S.L., Hemmes, M.A., Langenkamp-Brand, A., Grossouw, D., Jansen, H.T., et al. A single oral dose of a polyglucosamine influences the bioavailability of [9-(14)C]-oleic acid in adult female Gottingen minipigs. BMC Obes, 3, 2016, 18.
    • (2016) BMC Obes , vol.3 , pp. 18
    • Cnubben, N.H.1    Tel, S.L.2    Hemmes, M.A.3    Langenkamp-Brand, A.4    Grossouw, D.5    Jansen, H.T.6
  • 21
    • 79954582437 scopus 로고    scopus 로고
    • Revisiting the cholinergic hypothesis in the development of Alzheimer's disease
    • Craig, L.A., Hong, N.S., McDonald, R.J., Revisiting the cholinergic hypothesis in the development of Alzheimer's disease. Neurosci Biobehav Rev 35 (2011), 1397–1409.
    • (2011) Neurosci Biobehav Rev , vol.35 , pp. 1397-1409
    • Craig, L.A.1    Hong, N.S.2    McDonald, R.J.3
  • 22
    • 0036023644 scopus 로고    scopus 로고
    • Dissecting the role of chymase in angiotensin II formation and heart and blood vessel diseases
    • Dell'Italia, L.J., Husain, A., Dissecting the role of chymase in angiotensin II formation and heart and blood vessel diseases. Curr Opin Cardiol 17 (2002), 374–379.
    • (2002) Curr Opin Cardiol , vol.17 , pp. 374-379
    • Dell'Italia, L.J.1    Husain, A.2
  • 24
    • 77954572037 scopus 로고    scopus 로고
    • Pharmacokinetics and biodegradation mechanisms of a versatile carboxymethyl derivative of chitosan in rats: in vivo and in vitro evaluation
    • Dong, W., Han, B., Feng, Y., Song, F., Chang, J., Jiang, H., et al. Pharmacokinetics and biodegradation mechanisms of a versatile carboxymethyl derivative of chitosan in rats: in vivo and in vitro evaluation. Biomacromolecules 11 (2010), 1527–1533.
    • (2010) Biomacromolecules , vol.11 , pp. 1527-1533
    • Dong, W.1    Han, B.2    Feng, Y.3    Song, F.4    Chang, J.5    Jiang, H.6
  • 25
    • 84871412372 scopus 로고    scopus 로고
    • Effects of molecular weights on the absorption, distribution and urinary excretion of intraperitoneally administrated carboxymethyl chitosan in rats
    • Dong, W., Han, B., Shao, K., Yang, Z., Peng, Y., Yang, Y., et al. Effects of molecular weights on the absorption, distribution and urinary excretion of intraperitoneally administrated carboxymethyl chitosan in rats. J Mater Sci Mater Med 23 (2012), 2945–2952.
    • (2012) J Mater Sci Mater Med , vol.23 , pp. 2945-2952
    • Dong, W.1    Han, B.2    Shao, K.3    Yang, Z.4    Peng, Y.5    Yang, Y.6
  • 26
    • 34247251383 scopus 로고    scopus 로고
    • Effects of chitooligosaccharides on rabbit neutrophils in vitro
    • Dou, J., Tan, C., Du, Y., Bai, X., Wang, K., Ma, X., Effects of chitooligosaccharides on rabbit neutrophils in vitro. Carbohydr Polym 69 (2007), 209–213.
    • (2007) Carbohydr Polym , vol.69 , pp. 209-213
    • Dou, J.1    Tan, C.2    Du, Y.3    Bai, X.4    Wang, K.5    Ma, X.6
  • 27
    • 78650229450 scopus 로고    scopus 로고
    • Quaternary complexes composed of plasmid DNA/protamine/fish sperm DNA/stearic acid grafted chitosan oligosaccharide micelles for gene delivery
    • Du, Y.Z., Lu, P., Yuan, H., Zhou, J.P., Hu, F.Q., Quaternary complexes composed of plasmid DNA/protamine/fish sperm DNA/stearic acid grafted chitosan oligosaccharide micelles for gene delivery. Int J Biol Macromol 48 (2011), 153–159.
    • (2011) Int J Biol Macromol , vol.48 , pp. 153-159
    • Du, Y.Z.1    Lu, P.2    Yuan, H.3    Zhou, J.P.4    Hu, F.Q.5
  • 28
    • 77952888302 scopus 로고    scopus 로고
    • Stearic acid grafted chitosan oligosaccharide micelle as a promising vector for gene delivery system: factors affecting the complexation
    • Du, Y.Z., Lu, P., Zhou, J.P., Yuan, H., Hu, F.Q., Stearic acid grafted chitosan oligosaccharide micelle as a promising vector for gene delivery system: factors affecting the complexation. Int J Pharm 391 (2010), 260–266.
    • (2010) Int J Pharm , vol.391 , pp. 260-266
    • Du, Y.Z.1    Lu, P.2    Zhou, J.P.3    Yuan, H.4    Hu, F.Q.5
  • 29
    • 78650250435 scopus 로고    scopus 로고
    • Linoleic acid-grafted chitosan oligosaccharide micelles for intracellular drug delivery and reverse drug resistance of tumor cells
    • Du, Y.Z., Wang, L., Yuan, H., Hu, F.Q., Linoleic acid-grafted chitosan oligosaccharide micelles for intracellular drug delivery and reverse drug resistance of tumor cells. Int J Biol Macromol 48 (2011), 215–222.
    • (2011) Int J Biol Macromol , vol.48 , pp. 215-222
    • Du, Y.Z.1    Wang, L.2    Yuan, H.3    Hu, F.Q.4
  • 30
    • 60449087425 scopus 로고    scopus 로고
    • Preparation and characteristics of linoleic acid-grafted chitosan oligosaccharide micelles as a carrier for doxorubicin
    • Du, Y.Z., Wang, L., Yuan, H., Wei, X.H., Hu, F.Q., Preparation and characteristics of linoleic acid-grafted chitosan oligosaccharide micelles as a carrier for doxorubicin. Colloids Surf B Biointerfaces 69 (2009), 257–263.
    • (2009) Colloids Surf B Biointerfaces , vol.69 , pp. 257-263
    • Du, Y.Z.1    Wang, L.2    Yuan, H.3    Wei, X.H.4    Hu, F.Q.5
  • 31
    • 77952741119 scopus 로고    scopus 로고
    • Sustained release of ATP encapsulated in chitosan oligosaccharide nanoparticles
    • Du, Y.Z., Ying, X.Y., Wang, L., Zhai, Y., Yuan, H., Yu, R.S., et al. Sustained release of ATP encapsulated in chitosan oligosaccharide nanoparticles. Int J Pharm 392 (2010), 164–169.
    • (2010) Int J Pharm , vol.392 , pp. 164-169
    • Du, Y.Z.1    Ying, X.Y.2    Wang, L.3    Zhai, Y.4    Yuan, H.5    Yu, R.S.6
  • 32
    • 84979010869 scopus 로고    scopus 로고
    • Improved mucoadhesion and cell uptake of chitosan and chitosan oligosaccharide surface-modified polymer nanoparticles for mucosal delivery of proteins
    • Dyawanapelly, S., Koli, U., Dharamdasani, V., Jain, R., Dandekar, P., Improved mucoadhesion and cell uptake of chitosan and chitosan oligosaccharide surface-modified polymer nanoparticles for mucosal delivery of proteins. Drug Deliv Transl Res 6 (2016), 365–379.
    • (2016) Drug Deliv Transl Res , vol.6 , pp. 365-379
    • Dyawanapelly, S.1    Koli, U.2    Dharamdasani, V.3    Jain, R.4    Dandekar, P.5
  • 33
    • 84945309678 scopus 로고    scopus 로고
    • Cytotoxicity, nitric oxide and acetylcholinesterase inhibitory activity of three limonoids isolated from Trichilia welwitschii (Meliaceae)
    • Dzoyem, J.P., Tsamo, A.T., Melong, R., Mkounga, P., Nkengfack, A.E., McGaw, L.J., et al. Cytotoxicity, nitric oxide and acetylcholinesterase inhibitory activity of three limonoids isolated from Trichilia welwitschii (Meliaceae). Biol Res, 48, 2015, 57.
    • (2015) Biol Res , vol.48 , pp. 57
    • Dzoyem, J.P.1    Tsamo, A.T.2    Melong, R.3    Mkounga, P.4    Nkengfack, A.E.5    McGaw, L.J.6
  • 34
    • 0024468449 scopus 로고
    • Interaction of bile acids, phospholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats
    • Ebihara, K., Schneeman, B.O., Interaction of bile acids, phospholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats. J Nutr 119 (1989), 1100–1106.
    • (1989) J Nutr , vol.119 , pp. 1100-1106
    • Ebihara, K.1    Schneeman, B.O.2
  • 35
    • 84960517067 scopus 로고    scopus 로고
    • Prawn shell chitosan exhibits anti-obesogenic potential through alterations to appetite, affecting feeding behaviour and satiety signals in vivo
    • Egan, A.M., O'Doherty, J.V., Vigors, S., Sweeney, T., Prawn shell chitosan exhibits anti-obesogenic potential through alterations to appetite, affecting feeding behaviour and satiety signals in vivo. PLoS One, 11, 2016, e0149820.
    • (2016) PLoS One , vol.11
    • Egan, A.M.1    O'Doherty, J.V.2    Vigors, S.3    Sweeney, T.4
  • 36
    • 84955493761 scopus 로고    scopus 로고
    • Prawn shell chitosan has anti-obesogenic properties, influencing both nutrient digestibility and microbial populations in a pig model
    • Egan, A.M., Sweeney, T., Hayes, M., O'Doherty, J.V., Prawn shell chitosan has anti-obesogenic properties, influencing both nutrient digestibility and microbial populations in a pig model. PLoS One, 10, 2015, e0144127.
    • (2015) PLoS One , vol.10
    • Egan, A.M.1    Sweeney, T.2    Hayes, M.3    O'Doherty, J.V.4
  • 37
    • 34047253783 scopus 로고    scopus 로고
    • Kinetics of hydrolysis of chitin/chitosan oligomers in concentrated hydrochloric acid
    • Einbu, A., Grasdalen, H., Vårum, K.M., Kinetics of hydrolysis of chitin/chitosan oligomers in concentrated hydrochloric acid. Carbohydr Res 342 (2007), 1055–1062.
    • (2007) Carbohydr Res , vol.342 , pp. 1055-1062
    • Einbu, A.1    Grasdalen, H.2    Vårum, K.M.3
  • 38
    • 84962599688 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of chitosan conjugated GGRGDSK peptides as a cancer cell-targeting molecular transporter
    • El-Sayed, N.S., Shirazi, A.N., El-Meligy, M.G., El-Ziaty, A.K., Nagieb, Z.A., Parang, K., et al. Design, synthesis, and evaluation of chitosan conjugated GGRGDSK peptides as a cancer cell-targeting molecular transporter. Int J Biol Macromol 87 (2016), 611–622.
    • (2016) Int J Biol Macromol , vol.87 , pp. 611-622
    • El-Sayed, N.S.1    Shirazi, A.N.2    El-Meligy, M.G.3    El-Ziaty, A.K.4    Nagieb, Z.A.5    Parang, K.6
  • 39
    • 84932635090 scopus 로고    scopus 로고
    • Co-delivery of paclitaxel and alpha-tocopherol succinate by novel chitosan-based polymeric micelles for improving micellar stability and efficacious combination therapy
    • Emami, J., Rezazadeh, M., Rostami, M., Hassanzadeh, F., Sadeghi, H., Mostafavi, A., et al. Co-delivery of paclitaxel and alpha-tocopherol succinate by novel chitosan-based polymeric micelles for improving micellar stability and efficacious combination therapy. Drug Dev Ind Pharm 41 (2015), 1137–1147.
    • (2015) Drug Dev Ind Pharm , vol.41 , pp. 1137-1147
    • Emami, J.1    Rezazadeh, M.2    Rostami, M.3    Hassanzadeh, F.4    Sadeghi, H.5    Mostafavi, A.6
  • 40
    • 84873266593 scopus 로고    scopus 로고
    • Beta-secretase inhibitory activity of phenolic acid conjugated chitooligosaccharides
    • Eom, T.K., Ryu, B., Lee, J.K., Byun, H.G., Park, S.J., Kim, S.K., Beta-secretase inhibitory activity of phenolic acid conjugated chitooligosaccharides. J Enzyme Inhib Med Chem 28 (2013), 214–217.
    • (2013) J Enzyme Inhib Med Chem , vol.28 , pp. 214-217
    • Eom, T.K.1    Ryu, B.2    Lee, J.K.3    Byun, H.G.4    Park, S.J.5    Kim, S.K.6
  • 41
    • 84928639468 scopus 로고    scopus 로고
    • Chitosan oligosaccharides attenuate ocular inflammation in rats with experimental autoimmune anterior uveitis
    • Fang, I.M., Yang, C.H., Yang, C.M., Chitosan oligosaccharides attenuate ocular inflammation in rats with experimental autoimmune anterior uveitis. Mediat Inflamm, 2014, 2014, 827847.
    • (2014) Mediat Inflamm , vol.2014 , pp. 827847
    • Fang, I.M.1    Yang, C.H.2    Yang, C.M.3
  • 42
    • 1842583687 scopus 로고    scopus 로고
    • Receptor-mediated stimulatory effect of oligochitosan in macrophages
    • Feng, J., Zhao, L., Yu, Q., Receptor-mediated stimulatory effect of oligochitosan in macrophages. Biochem Biophys Res Commun 317 (2004), 414–420.
    • (2004) Biochem Biophys Res Commun , vol.317 , pp. 414-420
    • Feng, J.1    Zhao, L.2    Yu, Q.3
  • 44
    • 73649087900 scopus 로고    scopus 로고
    • Antioxidant activity of chitooligosaccharides upon two biological systems: erythrocytes and bacteriophages
    • Fernandes, J.C., Eaton, P., Nascimento, H., Gião, M.S., Ramos, Ó.S., Belo, L., et al. Antioxidant activity of chitooligosaccharides upon two biological systems: erythrocytes and bacteriophages. Carbohydr Polym 79 (2010), 1101–1106.
    • (2010) Carbohydr Polym , vol.79 , pp. 1101-1106
    • Fernandes, J.C.1    Eaton, P.2    Nascimento, H.3    Gião, M.S.4    Ramos, Ó.S.5    Belo, L.6
  • 46
    • 84871733767 scopus 로고    scopus 로고
    • Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis model
    • Fernandes, J.C., Sereno, J., Garrido, P., Parada, B., Cunha, M.F., Reis, F., et al. Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis model. Mar Drugs 10 (2012), 2661–2675.
    • (2012) Mar Drugs , vol.10 , pp. 2661-2675
    • Fernandes, J.C.1    Sereno, J.2    Garrido, P.3    Parada, B.4    Cunha, M.F.5    Reis, F.6
  • 47
    • 49449107853 scopus 로고    scopus 로고
    • Antimicrobial effects of chitosans and chitooligosaccharides, upon Staphylococcus aureus and Escherichia coli, in food model systems
    • Fernandes, J.C., Tavaria, F.K., Soares, J.C., Ramos, O.S., Joao Monteiro, M., Pintado, M.E., et al. Antimicrobial effects of chitosans and chitooligosaccharides, upon Staphylococcus aureus and Escherichia coli, in food model systems. Food Microbiol 25 (2008), 922–928.
    • (2008) Food Microbiol , vol.25 , pp. 922-928
    • Fernandes, J.C.1    Tavaria, F.K.2    Soares, J.C.3    Ramos, O.S.4    Joao Monteiro, M.5    Pintado, M.E.6
  • 48
    • 0036156684 scopus 로고    scopus 로고
    • Chitosan supplementation does not affect fat absorption in healthy males fed a high-fat diet, a pilot study
    • Gades, M.D., Stern, J.S., Chitosan supplementation does not affect fat absorption in healthy males fed a high-fat diet, a pilot study. Int J Obes Relat Metab Disord 26 (2002), 119–122.
    • (2002) Int J Obes Relat Metab Disord , vol.26 , pp. 119-122
    • Gades, M.D.1    Stern, J.S.2
  • 49
    • 4344591236 scopus 로고    scopus 로고
    • Chitosan supplementation and fecal fat excretion in men
    • Gades, M.D., Stern, J.S., Chitosan supplementation and fecal fat excretion in men. Obes Res 11 (2003), 683–688.
    • (2003) Obes Res , vol.11 , pp. 683-688
    • Gades, M.D.1    Stern, J.S.2
  • 50
    • 84957442697 scopus 로고    scopus 로고
    • Gut microbiome in health and disease: linking the microbiome-gut-brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases
    • Ghaisas, S., Maher, J., Kanthasamy, A., Gut microbiome in health and disease: linking the microbiome-gut-brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases. Pharmacol Ther 158 (2016), 52–62.
    • (2016) Pharmacol Ther , vol.158 , pp. 52-62
    • Ghaisas, S.1    Maher, J.2    Kanthasamy, A.3
  • 51
    • 35548955602 scopus 로고    scopus 로고
    • Specific interaction between chitosan and matrix metalloprotease 2 decreases the invasive activity of human melanoma cells
    • Gorzelanny, C., Poppelmann, B., Strozyk, E., Moerschbacher, B.M., Schneider, S.W., Specific interaction between chitosan and matrix metalloprotease 2 decreases the invasive activity of human melanoma cells. Biomacromolecules 8 (2007), 3035–3040.
    • (2007) Biomacromolecules , vol.8 , pp. 3035-3040
    • Gorzelanny, C.1    Poppelmann, B.2    Strozyk, E.3    Moerschbacher, B.M.4    Schneider, S.W.5
  • 52
    • 0742306785 scopus 로고    scopus 로고
    • Preparation of alginate-chitosan hybrid gel beads and adsorption of divalent metal ions
    • Gotoh, T., Matsushima, K., Kikuchi, K., Preparation of alginate-chitosan hybrid gel beads and adsorption of divalent metal ions. Chemosphere 55 (2004), 135–140.
    • (2004) Chemosphere , vol.55 , pp. 135-140
    • Gotoh, T.1    Matsushima, K.2    Kikuchi, K.3
  • 53
    • 0035378704 scopus 로고    scopus 로고
    • Comparative evaluation of fecal fat excretion induced by orlistat and chitosan
    • Guerciolini, R., Radu-Radulescu, L., Boldrin, M., Dallas, J., Moore, R., Comparative evaluation of fecal fat excretion induced by orlistat and chitosan. Obes Res 9 (2001), 364–367.
    • (2001) Obes Res , vol.9 , pp. 364-367
    • Guerciolini, R.1    Radu-Radulescu, L.2    Boldrin, M.3    Dallas, J.4    Moore, R.5
  • 54
    • 84904326840 scopus 로고    scopus 로고
    • Redox-stimuli responsive micelles from DOX-encapsulating polycaprolactone-g-chitosan oligosaccharide
    • Guerry, A., Cottaz, S., Fleury, E., Bernard, J., Halila, S., Redox-stimuli responsive micelles from DOX-encapsulating polycaprolactone-g-chitosan oligosaccharide. Carbohydr Polym 112 (2014), 746–752.
    • (2014) Carbohydr Polym , vol.112 , pp. 746-752
    • Guerry, A.1    Cottaz, S.2    Fleury, E.3    Bernard, J.4    Halila, S.5
  • 55
    • 0030447810 scopus 로고    scopus 로고
    • In vitro inhibitory effect of chitosan and its degradation products on energy metabolism in Ehrlich ascites tumour cells (EAT)
    • Guminska, M., Ignacak, J., Wojcik, E., In vitro inhibitory effect of chitosan and its degradation products on energy metabolism in Ehrlich ascites tumour cells (EAT). Pol J Pharmacol 48 (1996), 495–501.
    • (1996) Pol J Pharmacol , vol.48 , pp. 495-501
    • Guminska, M.1    Ignacak, J.2    Wojcik, E.3
  • 56
    • 84878768244 scopus 로고    scopus 로고
    • Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium
    • Gunther, C., Neumann, H., Neurath, M.F., Becker, C., Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium. Gut 62 (2013), 1062–1071.
    • (2013) Gut , vol.62 , pp. 1062-1071
    • Gunther, C.1    Neumann, H.2    Neurath, M.F.3    Becker, C.4
  • 57
    • 84924065037 scopus 로고    scopus 로고
    • Enzymatic production of defined chitosan oligomers with a specific pattern of acetylation using a combination of chitin oligosaccharide deacetylases
    • Hamer, S.N., Cord-Landwehr, S., Biarnes, X., Planas, A., Waegeman, H., Moerschbacher, B.M., et al. Enzymatic production of defined chitosan oligomers with a specific pattern of acetylation using a combination of chitin oligosaccharide deacetylases. Sci Rep, 5, 2015, 8716.
    • (2015) Sci Rep , vol.5 , pp. 8716
    • Hamer, S.N.1    Cord-Landwehr, S.2    Biarnes, X.3    Planas, A.4    Waegeman, H.5    Moerschbacher, B.M.6
  • 58
    • 22044448235 scopus 로고    scopus 로고
    • Role of mannose receptor in oligochitosan-mediated stimulation of macrophage function
    • Han, Y., Zhao, L., Yu, Z., Feng, J., Yu, Q., Role of mannose receptor in oligochitosan-mediated stimulation of macrophage function. Int Immunopharmacol 5 (2005), 1533–1542.
    • (2005) Int Immunopharmacol , vol.5 , pp. 1533-1542
    • Han, Y.1    Zhao, L.2    Yu, Z.3    Feng, J.4    Yu, Q.5
  • 59
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan, D., Folkman, J., Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86 (1996), 353–364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 60
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan, D., Weinberg, R.A., Hallmarks of cancer: the next generation. Cell 144 (2011), 646–674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 61
    • 0035015074 scopus 로고    scopus 로고
    • Chitosan induces apoptosis via caspase-3 activation in bladder tumor cells
    • Hasegawa, M., Yagi, K., Iwakawa, S., Hirai, M., Chitosan induces apoptosis via caspase-3 activation in bladder tumor cells. Jpn J Cancer Res 92 (2001), 459–466.
    • (2001) Jpn J Cancer Res , vol.92 , pp. 459-466
    • Hasegawa, M.1    Yagi, K.2    Iwakawa, S.3    Hirai, M.4
  • 62
    • 0036480836 scopus 로고    scopus 로고
    • Antidiabetic action of low molecular weight chitosan in genetically obese diabetic KK-Ay mice
    • Hayashi, K., Ito, M., Antidiabetic action of low molecular weight chitosan in genetically obese diabetic KK-Ay mice. Biol Pharm Bull 25 (2002), 188–192.
    • (2002) Biol Pharm Bull , vol.25 , pp. 188-192
    • Hayashi, K.1    Ito, M.2
  • 63
    • 22544476974 scopus 로고    scopus 로고
    • ACE inhibitory and antihypertensive effect of chitosan oligosaccharides in SHR
    • Hong, S.P., Kim, M.H., Oh, S.W., Han, C.K., Kim, Y.H., ACE inhibitory and antihypertensive effect of chitosan oligosaccharides in SHR. Korean J Food Sci Technol 30 (1998), 1476–1479.
    • (1998) Korean J Food Sci Technol , vol.30 , pp. 1476-1479
    • Hong, S.P.1    Kim, M.H.2    Oh, S.W.3    Han, C.K.4    Kim, Y.H.5
  • 64
    • 84860442794 scopus 로고    scopus 로고
    • Chitosan reduces plasma adipocytokines and lipid accumulation in liver and adipose tissues and ameliorates insulin resistance in diabetic rats
    • Hsieh, Y.-L., Yao, H.-T., Cheng, R.-S., Chiang, M.-T., Chitosan reduces plasma adipocytokines and lipid accumulation in liver and adipose tissues and ameliorates insulin resistance in diabetic rats. J Med Food 15 (2012), 453–460.
    • (2012) J Med Food , vol.15 , pp. 453-460
    • Hsieh, Y.-L.1    Yao, H.-T.2    Cheng, R.-S.3    Chiang, M.-T.4
  • 65
    • 69149084679 scopus 로고    scopus 로고
    • Enhanced cellular uptake of chlorine e6 mediated by stearic acid-grafted chitosan oligosaccharide micelles
    • Hu, F.Q., Jiang, X.H., Huang, X., Wu, X.L., Yuan, H., Wei, X.H., et al. Enhanced cellular uptake of chlorine e6 mediated by stearic acid-grafted chitosan oligosaccharide micelles. J Drug Target 17 (2009), 384–391.
    • (2009) J Drug Target , vol.17 , pp. 384-391
    • Hu, F.Q.1    Jiang, X.H.2    Huang, X.3    Wu, X.L.4    Yuan, H.5    Wei, X.H.6
  • 66
    • 70350211845 scopus 로고    scopus 로고
    • Synthesis and antitumor activity of doxorubicin conjugated stearic acid-g-chitosan oligosaccharide polymeric micelles
    • Hu, F.Q., Liu, L.N., Du, Y.Z., Yuan, H., Synthesis and antitumor activity of doxorubicin conjugated stearic acid-g-chitosan oligosaccharide polymeric micelles. Biomaterials 30 (2009), 6955–6963.
    • (2009) Biomaterials , vol.30 , pp. 6955-6963
    • Hu, F.Q.1    Liu, L.N.2    Du, Y.Z.3    Yuan, H.4
  • 67
    • 41549087356 scopus 로고    scopus 로고
    • Cellular uptake and cytotoxicity of shell crosslinked stearic acid-grafted chitosan oligosaccharide micelles encapsulating doxorubicin
    • Hu, F.Q., Wu, X.L., Du, Y.Z., You, J., Yuan, H., Cellular uptake and cytotoxicity of shell crosslinked stearic acid-grafted chitosan oligosaccharide micelles encapsulating doxorubicin. Eur J Pharm Biopharm 69 (2008), 117–125.
    • (2008) Eur J Pharm Biopharm , vol.69 , pp. 117-125
    • Hu, F.Q.1    Wu, X.L.2    Du, Y.Z.3    You, J.4    Yuan, H.5
  • 68
    • 33646349221 scopus 로고    scopus 로고
    • A novel chitosan oligosaccharide-stearic acid micelles for gene delivery: properties and in vitro transfection studies
    • Hu, F.Q., Zhao, M.D., Yuan, H., You, J., Du, Y.Z., Zeng, S., A novel chitosan oligosaccharide-stearic acid micelles for gene delivery: properties and in vitro transfection studies. Int J Pharm 315 (2006), 158–166.
    • (2006) Int J Pharm , vol.315 , pp. 158-166
    • Hu, F.Q.1    Zhao, M.D.2    Yuan, H.3    You, J.4    Du, Y.Z.5    Zeng, S.6
  • 69
    • 84930648307 scopus 로고    scopus 로고
    • Anti-obese effect of glucosamine and chitosan oligosaccharide in high-fat diet-induced obese rats
    • Huang, L., Chen, J., Cao, P., Pan, H., Ding, C., Xiao, T., et al. Anti-obese effect of glucosamine and chitosan oligosaccharide in high-fat diet-induced obese rats. Mar Drugs 13 (2015), 2732–2756.
    • (2015) Mar Drugs , vol.13 , pp. 2732-2756
    • Huang, L.1    Chen, J.2    Cao, P.3    Pan, H.4    Ding, C.5    Xiao, T.6
  • 70
    • 84939962216 scopus 로고    scopus 로고
    • Chitooligosaccharides attenuate Cu2 +-induced cellular oxidative damage and cell apoptosis involving Nrf2 activation
    • Huang, H.C., Hong, L., Chang, P., Zhang, J., Lu, S.Y., Zheng, B.W., et al. Chitooligosaccharides attenuate Cu2 +-induced cellular oxidative damage and cell apoptosis involving Nrf2 activation. Neurotox Res 27 (2015), 411–420.
    • (2015) Neurotox Res , vol.27 , pp. 411-420
    • Huang, H.C.1    Hong, L.2    Chang, P.3    Zhang, J.4    Lu, S.Y.5    Zheng, B.W.6
  • 71
    • 18144429141 scopus 로고    scopus 로고
    • Improvement of ACE inhibitory activity of chitooligosaccharides (COS) by carboxyl modification
    • Huang, R., Mendis, E., Kim, S.-K., Improvement of ACE inhibitory activity of chitooligosaccharides (COS) by carboxyl modification. Bioorg Med Chem 13 (2005), 3649–3655.
    • (2005) Bioorg Med Chem , vol.13 , pp. 3649-3655
    • Huang, R.1    Mendis, E.2    Kim, S.-K.3
  • 72
    • 33645380604 scopus 로고    scopus 로고
    • Strong electronic charge as an important factor for anticancer activity of chitooligosaccharides (COS)
    • Huang, R., Mendis, E., Rajapakse, N., Kim, S.K., Strong electronic charge as an important factor for anticancer activity of chitooligosaccharides (COS). Life Sci 78 (2006), 2399–2408.
    • (2006) Life Sci , vol.78 , pp. 2399-2408
    • Huang, R.1    Mendis, E.2    Rajapakse, N.3    Kim, S.K.4
  • 73
    • 84954328553 scopus 로고    scopus 로고
    • Chitosan oligosaccharide reduces intestinal inflammation that involves calcium-sensing receptor (CaSR) activation in lipopolysaccharide (LPS)-challenged piglets
    • Huang, B., Xiao, D., Tan, B., Xiao, H., Wang, J., Yin, J., et al. Chitosan oligosaccharide reduces intestinal inflammation that involves calcium-sensing receptor (CaSR) activation in lipopolysaccharide (LPS)-challenged piglets. J Agric Food Chem 64 (2016), 245–252.
    • (2016) J Agric Food Chem , vol.64 , pp. 245-252
    • Huang, B.1    Xiao, D.2    Tan, B.3    Xiao, H.4    Wang, J.5    Yin, J.6
  • 74
    • 0033860508 scopus 로고    scopus 로고
    • Classification and antihypertensive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins
    • Iroyukifujita, H., Eiichiyokoyama, K., Yoshikawa, M., Classification and antihypertensive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins. J Food Sci 65 (2000), 564–569.
    • (2000) J Food Sci , vol.65 , pp. 564-569
    • Iroyukifujita, H.1    Eiichiyokoyama, K.2    Yoshikawa, M.3
  • 75
    • 27544467086 scopus 로고    scopus 로고
    • Water-soluble chitosan derivatives as a BACE1 inhibitor
    • Je, J.Y., Kim, S.K., Water-soluble chitosan derivatives as a BACE1 inhibitor. Bioorg Med Chem 13 (2005), 6551–6555.
    • (2005) Bioorg Med Chem , vol.13 , pp. 6551-6555
    • Je, J.Y.1    Kim, S.K.2
  • 76
    • 84863132928 scopus 로고    scopus 로고
    • Chitooligosaccharides as potential nutraceuticals: production and bioactivities
    • Je, J.Y., Kim, S.K., Chitooligosaccharides as potential nutraceuticals: production and bioactivities. Adv Food Nutr Res 65 (2012), 321–336.
    • (2012) Adv Food Nutr Res , vol.65 , pp. 321-336
    • Je, J.Y.1    Kim, S.K.2
  • 77
    • 1042290486 scopus 로고    scopus 로고
    • Free radical scavenging properties of hetero-chitooligosaccharides using an ESR spectroscopy
    • Je, J.-Y., Park, P.-J., Kim, S.-K., Free radical scavenging properties of hetero-chitooligosaccharides using an ESR spectroscopy. Food Chem Toxicol 42 (2004), 381–387.
    • (2004) Food Chem Toxicol , vol.42 , pp. 381-387
    • Je, J.-Y.1    Park, P.-J.2    Kim, S.-K.3
  • 78
    • 33749329099 scopus 로고    scopus 로고
    • Antihypertensive activity of chitin derivatives
    • Je, J.-Y., Park, P.-J., Kim, B., Kim, S.-K., Antihypertensive activity of chitin derivatives. Biopolymers 83 (2006), 250–254.
    • (2006) Biopolymers , vol.83 , pp. 250-254
    • Je, J.-Y.1    Park, P.-J.2    Kim, B.3    Kim, S.-K.4
  • 79
    • 84903826303 scopus 로고    scopus 로고
    • The reduction effect of low molecular weight chitosan oligosaccharide (GO2KA1) on postprandial blood glucose levels in healthy individuals
    • Jo, S.-H., Ha, K.-S., Lee, J.-W., Kim, Y.-C., Apostolidis, E., Kwon, Y.-I., The reduction effect of low molecular weight chitosan oligosaccharide (GO2KA1) on postprandial blood glucose levels in healthy individuals. Food Sci Biotechnol 23 (2014), 971–973.
    • (2014) Food Sci Biotechnol , vol.23 , pp. 971-973
    • Jo, S.-H.1    Ha, K.-S.2    Lee, J.-W.3    Kim, Y.-C.4    Apostolidis, E.5    Kwon, Y.-I.6
  • 80
    • 79955807235 scopus 로고    scopus 로고
    • Chitooligosaccharide-mediated neuroprotection is associated with modulation of Hsps expression and reduction of MAPK phosphorylation
    • Joodi, G., Ansari, N., Khodagholi, F., Chitooligosaccharide-mediated neuroprotection is associated with modulation of Hsps expression and reduction of MAPK phosphorylation. Int J Biol Macromol 48 (2011), 726–735.
    • (2011) Int J Biol Macromol , vol.48 , pp. 726-735
    • Joodi, G.1    Ansari, N.2    Khodagholi, F.3
  • 81
    • 77957595729 scopus 로고    scopus 로고
    • Antidiabetic effect and mechanism of chitooligosaccharides
    • Ju, C., Yue, W., Yang, Z., Zhang, Q., Yang, X., Liu, Z., et al. Antidiabetic effect and mechanism of chitooligosaccharides. Biol Pharm Bull 33 (2010), 1511–1516.
    • (2010) Biol Pharm Bull , vol.33 , pp. 1511-1516
    • Ju, C.1    Yue, W.2    Yang, Z.3    Zhang, Q.4    Yang, X.5    Liu, Z.6
  • 82
    • 30944462739 scopus 로고    scopus 로고
    • Effect of chitooligosaccharides on calcium bioavailability and bone strength in ovariectomized rats
    • Jung, W.K., Moon, S.H., Kim, S.K., Effect of chitooligosaccharides on calcium bioavailability and bone strength in ovariectomized rats. Life Sci 78 (2006), 970–976.
    • (2006) Life Sci , vol.78 , pp. 970-976
    • Jung, W.K.1    Moon, S.H.2    Kim, S.K.3
  • 83
    • 84866382587 scopus 로고    scopus 로고
    • Modulation of lipid metabolism by mixtures of protamine and chitooligosaccharide through pancreatic lipase inhibitory activity in a rat model
    • Kang, N.H., Lee, W.K., Yi, B.R., Park, M.A., Lee, H.R., Park, S.K., et al. Modulation of lipid metabolism by mixtures of protamine and chitooligosaccharide through pancreatic lipase inhibitory activity in a rat model. Lab Anim Res 28 (2012), 31–38.
    • (2012) Lab Anim Res , vol.28 , pp. 31-38
    • Kang, N.H.1    Lee, W.K.2    Yi, B.R.3    Park, M.A.4    Lee, H.R.5    Park, S.K.6
  • 84
    • 84859341657 scopus 로고    scopus 로고
    • Assessment of chitosan-affected metabolic response by peroxisome proliferator-activated receptor bioluminescent imaging-guided transcriptomic analysis
    • Kao, C.H., Hsiang, C.Y., Ho, T.Y., Assessment of chitosan-affected metabolic response by peroxisome proliferator-activated receptor bioluminescent imaging-guided transcriptomic analysis. PLoS One, 7, 2012, e34969.
    • (2012) PLoS One , vol.7
    • Kao, C.H.1    Hsiang, C.Y.2    Ho, T.Y.3
  • 85
    • 77953911676 scopus 로고    scopus 로고
    • Chitooligosaccharides protect pancreatic β-cells from hydrogen peroxide-induced deterioration
    • Karadeniz, F., Artan, M., Kong, C.-S., Kim, S.-K., Chitooligosaccharides protect pancreatic β-cells from hydrogen peroxide-induced deterioration. Carbohydr Polym 82 (2010), 143–147.
    • (2010) Carbohydr Polym , vol.82 , pp. 143-147
    • Karadeniz, F.1    Artan, M.2    Kong, C.-S.3    Kim, S.-K.4
  • 86
    • 84955513503 scopus 로고    scopus 로고
    • Reparative inflammation takes charge of tissue regeneration
    • Karin, M., Clevers, H., Reparative inflammation takes charge of tissue regeneration. Nature 529 (2016), 307–315.
    • (2016) Nature , vol.529 , pp. 307-315
    • Karin, M.1    Clevers, H.2
  • 87
    • 75149147526 scopus 로고    scopus 로고
    • Biodegradation, biodistribution and toxicity of chitosan
    • Kean, T., Thanou, M., Biodegradation, biodistribution and toxicity of chitosan. Adv Drug Deliv Rev 62 (2010), 3–11.
    • (2010) Adv Drug Deliv Rev , vol.62 , pp. 3-11
    • Kean, T.1    Thanou, M.2
  • 88
    • 77949655624 scopus 로고    scopus 로고
    • Chitosan prevents oxidative stress-induced amyloid beta formation and cytotoxicity in NT2 neurons: involvement of transcription factors Nrf2 and NF-kappaB
    • Khodagholi, F., Eftekharzadeh, B., Maghsoudi, N., Rezaei, P.F., Chitosan prevents oxidative stress-induced amyloid beta formation and cytotoxicity in NT2 neurons: involvement of transcription factors Nrf2 and NF-kappaB. Mol Cell Biochem 337 (2010), 39–51.
    • (2010) Mol Cell Biochem , vol.337 , pp. 39-51
    • Khodagholi, F.1    Eftekharzadeh, B.2    Maghsoudi, N.3    Rezaei, P.F.4
  • 89
    • 28544437497 scopus 로고    scopus 로고
    • Enzymatic production and biological activities of chitosan oligosaccharides (COS): a review
    • Kim, S.-K., Rajapakse, N., Enzymatic production and biological activities of chitosan oligosaccharides (COS): a review. Carbohydr Polym 62 (2005), 357–368.
    • (2005) Carbohydr Polym , vol.62 , pp. 357-368
    • Kim, S.-K.1    Rajapakse, N.2
  • 90
    • 0031956120 scopus 로고    scopus 로고
    • Genetically modified mice for the study of apolipoprotein B
    • Kim, E., Young, S.G., Genetically modified mice for the study of apolipoprotein B. J Lipid Res 39 (1998), 703–723.
    • (1998) J Lipid Res , vol.39 , pp. 703-723
    • Kim, E.1    Young, S.G.2
  • 91
    • 84904774170 scopus 로고    scopus 로고
    • Effect of long-term supplementation of low molecular weight chitosan oligosaccharide (GO2KA1) on fasting blood glucose and HbA1c in db/db mice model and elucidation of mechanism of action
    • Kim, J.-G., Jo, S.-H., Ha, K.-S., Kim, S.-C., Kim, Y.-C., Apostolidis, E., et al. Effect of long-term supplementation of low molecular weight chitosan oligosaccharide (GO2KA1) on fasting blood glucose and HbA1c in db/db mice model and elucidation of mechanism of action. BMC Complement Altern Med, 14, 2014, 272.
    • (2014) BMC Complement Altern Med , vol.14 , pp. 272
    • Kim, J.-G.1    Jo, S.-H.2    Ha, K.-S.3    Kim, S.-C.4    Kim, Y.-C.5    Apostolidis, E.6
  • 92
    • 84912535702 scopus 로고    scopus 로고
    • Sulfated chitosan oligosaccharides suppress LPS-induced NO production via JNK and NF-kappaB inactivation
    • Kim, J.H., Kim, Y.S., Hwang, J.W., Han, Y.K., Lee, J.S., Kim, S.K., et al. Sulfated chitosan oligosaccharides suppress LPS-induced NO production via JNK and NF-kappaB inactivation. Molecules 19 (2014), 18232–18247.
    • (2014) Molecules , vol.19 , pp. 18232-18247
    • Kim, J.H.1    Kim, Y.S.2    Hwang, J.W.3    Han, Y.K.4    Lee, J.S.5    Kim, S.K.6
  • 93
    • 84907852136 scopus 로고    scopus 로고
    • The effects of chitosan oligosaccharide (GO2KA1) supplementation on glucose control in subjects with prediabetes
    • Kim, H.J., Ahn, H.Y., Kwak, J.H., Shin, D.Y., Kwon, Y.-I., Oh, C.-G., et al. The effects of chitosan oligosaccharide (GO2KA1) supplementation on glucose control in subjects with prediabetes. Food Funct 5 (2014), 2662–2669.
    • (2014) Food Funct , vol.5 , pp. 2662-2669
    • Kim, H.J.1    Ahn, H.Y.2    Kwak, J.H.3    Shin, D.Y.4    Kwon, Y.-I.5    Oh, C.-G.6
  • 94
    • 79953235486 scopus 로고    scopus 로고
    • Long-term effects of chitosan oligosaccharide in streptozotocin-induced diabetic rats
    • Kim, J.N., Chang, I.Y., Kim, H.I., Yoon, S.P., Long-term effects of chitosan oligosaccharide in streptozotocin-induced diabetic rats. Islets 1 (2009), 111–116.
    • (2009) Islets , vol.1 , pp. 111-116
    • Kim, J.N.1    Chang, I.Y.2    Kim, H.I.3    Yoon, S.P.4
  • 95
    • 33750616879 scopus 로고    scopus 로고
    • Differential effects of chitooligosaccharides on serum cytokine levels in aged subjects
    • Kim, H.M., Hong, S.H., Yoo, S.J., Baek, K.S., Jeon, Y.J., Choung, S.Y., Differential effects of chitooligosaccharides on serum cytokine levels in aged subjects. J Med Food 9 (2006), 427–430.
    • (2006) J Med Food , vol.9 , pp. 427-430
    • Kim, H.M.1    Hong, S.H.2    Yoo, S.J.3    Baek, K.S.4    Jeon, Y.J.5    Choung, S.Y.6
  • 96
    • 0034828774 scopus 로고    scopus 로고
    • Subacute toxicity of chitosan oligosaccharide in Sprague–Dawley rats
    • Kim, S.K., Park, P.J., Yang, H.P., Han, S.S., Subacute toxicity of chitosan oligosaccharide in Sprague–Dawley rats. Arzneimittelforschung 51 (2001), 769–774.
    • (2001) Arzneimittelforschung , vol.51 , pp. 769-774
    • Kim, S.K.1    Park, P.J.2    Yang, H.P.3    Han, S.S.4
  • 97
    • 0037087199 scopus 로고    scopus 로고
    • Water-soluble chitosan inhibits the production of pro-inflammatory cytokine in human astrocytoma cells activated by amyloid beta peptide and interleukin-1beta
    • Kim, M.S., Sung, M.J., Seo, S.B., Yoo, S.J., Lim, W.K., Kim, H.M., Water-soluble chitosan inhibits the production of pro-inflammatory cytokine in human astrocytoma cells activated by amyloid beta peptide and interleukin-1beta. Neurosci Lett 321 (2002), 105–109.
    • (2002) Neurosci Lett , vol.321 , pp. 105-109
    • Kim, M.S.1    Sung, M.J.2    Seo, S.B.3    Yoo, S.J.4    Lim, W.K.5    Kim, H.M.6
  • 98
    • 15944398651 scopus 로고    scopus 로고
    • Chitooligosaccharides—preparation with the aid of pectinase isozyme from Aspergillus niger and their antibacterial activity
    • Kittur, F.S., Vishu Kumar, A.B., Varadaraj, M.C., Tharanathan, R.N., Chitooligosaccharides—preparation with the aid of pectinase isozyme from Aspergillus niger and their antibacterial activity. Carbohydr Res 340 (2005), 1239–1245.
    • (2005) Carbohydr Res , vol.340 , pp. 1239-1245
    • Kittur, F.S.1    Vishu Kumar, A.B.2    Varadaraj, M.C.3    Tharanathan, R.N.4
  • 99
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., Kangawa, K., Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999), 656–660.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 100
    • 84883478686 scopus 로고    scopus 로고
    • Adipose tissue hormones and appetite and body weight regulators in insulin resistance
    • Koleva, D.I., Orbetzova, M.M., Atanassova, P.K., Adipose tissue hormones and appetite and body weight regulators in insulin resistance. Folia Med 55 (2013), 25–32.
    • (2013) Folia Med , vol.55 , pp. 25-32
    • Koleva, D.I.1    Orbetzova, M.M.2    Atanassova, P.K.3
  • 101
    • 0034530476 scopus 로고    scopus 로고
    • Low molecular weight chitosan prevents the progression of low dose streptozotocin-induced slowly progressive diabetes mellitus in mice
    • Kondo, Y., Nakatani, A., Hayashi, K., Ito, M., Low molecular weight chitosan prevents the progression of low dose streptozotocin-induced slowly progressive diabetes mellitus in mice. Biol Pharm Bull 23 (2000), 1458–1464.
    • (2000) Biol Pharm Bull , vol.23 , pp. 1458-1464
    • Kondo, Y.1    Nakatani, A.2    Hayashi, K.3    Ito, M.4
  • 102
    • 65349101598 scopus 로고    scopus 로고
    • Plasma proteome analysis for anti-obesity and anti-diabetic potentials of chitosan oligosaccharides in ob/ob mice
    • Kumar, S.G., Rahman, M.A., Lee, S.H., Hwang, H.S., Kim, H.A., Yun, J.W., Plasma proteome analysis for anti-obesity and anti-diabetic potentials of chitosan oligosaccharides in ob/ob mice. Proteomics 9 (2009), 2149–2162.
    • (2009) Proteomics , vol.9 , pp. 2149-2162
    • Kumar, S.G.1    Rahman, M.A.2    Lee, S.H.3    Hwang, H.S.4    Kim, H.A.5    Yun, J.W.6
  • 103
    • 84988711071 scopus 로고    scopus 로고
    • Chitosan oligosaccharide suppresses synovial inflammation via AMPK activation: an in vitro and in vivo study
    • Kunanusornchai, W., Witoonpanich, B., Pichyangkura, R., Chatsudthipong, V., Muanprasat, C., Chitosan oligosaccharide suppresses synovial inflammation via AMPK activation: an in vitro and in vivo study. Pharmacol Res 113 (2016), 458–467.
    • (2016) Pharmacol Res , vol.113 , pp. 458-467
    • Kunanusornchai, W.1    Witoonpanich, B.2    Pichyangkura, R.3    Chatsudthipong, V.4    Muanprasat, C.5
  • 104
    • 65549109680 scopus 로고    scopus 로고
    • Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss
    • Lavie, C.J., Milani, R.V., Ventura, H.O., Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. J Am Coll Cardiol 53 (2009), 1925–1932.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 1925-1932
    • Lavie, C.J.1    Milani, R.V.2    Ventura, H.O.3
  • 105
    • 58549103282 scopus 로고    scopus 로고
    • Chitooligosaccharides suppress the level of protein expression and acetylcholinesterase activity induced by Aβ25–35 in PC12 cells
    • Lee, S.-H., Park, J.-S., Kim, S.-K., Ahn, C.-B., Je, J.-Y., Chitooligosaccharides suppress the level of protein expression and acetylcholinesterase activity induced by Aβ25–35 in PC12 cells. Bioorg Med Chem Lett 19 (2009), 860–862.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 860-862
    • Lee, S.-H.1    Park, J.-S.2    Kim, S.-K.3    Ahn, C.-B.4    Je, J.-Y.5
  • 106
    • 71749115665 scopus 로고    scopus 로고
    • Factors affecting anti-inflammatory effect of chitooligosaccharides in lipopolysaccharides-induced RAW264.7 macrophage cells
    • Lee, S.H., Senevirathne, M., Ahn, C.B., Kim, S.K., Je, J.Y., Factors affecting anti-inflammatory effect of chitooligosaccharides in lipopolysaccharides-induced RAW264.7 macrophage cells. Bioorg Med Chem Lett 19 (2009), 6655–6658.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 6655-6658
    • Lee, S.H.1    Senevirathne, M.2    Ahn, C.B.3    Kim, S.K.4    Je, J.Y.5
  • 107
    • 70349561461 scopus 로고    scopus 로고
    • In vitro and in vivo antimicrobial activity of water-soluble chitosan oligosaccharides against Vibrio Vulnificus
    • Lee, B.C., Kim, M.S., Choi, S.H., Kim, K.Y., Kim, T.S., In vitro and in vivo antimicrobial activity of water-soluble chitosan oligosaccharides against Vibrio Vulnificus. Int J Mol Med 24 (2009), 327–333.
    • (2009) Int J Mol Med , vol.24 , pp. 327-333
    • Lee, B.C.1    Kim, M.S.2    Choi, S.H.3    Kim, K.Y.4    Kim, T.S.5
  • 108
    • 2142814239 scopus 로고    scopus 로고
    • Antidiabetic effects of chitosan oligosaccharides in neonatal streptozotocin-induced noninsulin-dependent diabetes mellitus in rats
    • Lee, H.-W., Park, Y.-S., Choi, J.-W., Yi, S.-y., Shin, W.-S., Antidiabetic effects of chitosan oligosaccharides in neonatal streptozotocin-induced noninsulin-dependent diabetes mellitus in rats. Biol Pharm Bull 26 (2003), 1100–1103.
    • (2003) Biol Pharm Bull , vol.26 , pp. 1100-1103
    • Lee, H.-W.1    Park, Y.-S.2    Choi, J.-W.3    Yi, S.-Y.4    Shin, W.-S.5
  • 109
    • 84887339940 scopus 로고    scopus 로고
    • Silver nanoparticle/chitosan oligosaccharide/poly(vinyl alcohol) nanofibers as wound dressings: a preclinical study
    • Li, C., Fu, R., Yu, C., Li, Z., Guan, H., Hu, D., et al. Silver nanoparticle/chitosan oligosaccharide/poly(vinyl alcohol) nanofibers as wound dressings: a preclinical study. Int J Nanomedicine 8 (2013), 4131–4145.
    • (2013) Int J Nanomedicine , vol.8 , pp. 4131-4145
    • Li, C.1    Fu, R.2    Yu, C.3    Li, Z.4    Guan, H.5    Hu, D.6
  • 110
    • 84938582901 scopus 로고    scopus 로고
    • Pharmacokinetics and biodegradation of chitosan in rats
    • Li, H., Jiang, Z., Han, B., Niu, S., Dong, W., Liu, W., Pharmacokinetics and biodegradation of chitosan in rats. J Ocean Univ China 14 (2015), 897–904.
    • (2015) J Ocean Univ China , vol.14 , pp. 897-904
    • Li, H.1    Jiang, Z.2    Han, B.3    Niu, S.4    Dong, W.5    Liu, W.6
  • 111
    • 84884332579 scopus 로고    scopus 로고
    • Chitosan oligosaccharides block LPS-induced O-GlcNAcylation of NF-kappaB and endothelial inflammatory response
    • Li, Y., Liu, H., Xu, Q.S., Du, Y.G., Xu, J., Chitosan oligosaccharides block LPS-induced O-GlcNAcylation of NF-kappaB and endothelial inflammatory response. Carbohydr Polym 99 (2014), 568–578.
    • (2014) Carbohydr Polym , vol.99 , pp. 568-578
    • Li, Y.1    Liu, H.2    Xu, Q.S.3    Du, Y.G.4    Xu, J.5
  • 112
    • 84863380563 scopus 로고    scopus 로고
    • Synthesis and assessment of globotriose-chitosan conjugate, a novel inhibitor of Shiga toxins produced by Escherichia coli
    • Li, X., Wu, P., Cheng, S., Lv, X., Synthesis and assessment of globotriose-chitosan conjugate, a novel inhibitor of Shiga toxins produced by Escherichia coli. J Med Chem 55 (2012), 2702–2710.
    • (2012) J Med Chem , vol.55 , pp. 2702-2710
    • Li, X.1    Wu, P.2    Cheng, S.3    Lv, X.4
  • 114
    • 84958981642 scopus 로고    scopus 로고
    • Long-term feeding of chitosan ameliorates glucose and lipid metabolism in a high-fructose-diet-impaired rat model of glucose tolerance
    • Liu, S.-H., Cai, F.-Y., Chiang, M.-T., Long-term feeding of chitosan ameliorates glucose and lipid metabolism in a high-fructose-diet-impaired rat model of glucose tolerance. Mar Drugs 13 (2015), 7302–7313.
    • (2015) Mar Drugs , vol.13 , pp. 7302-7313
    • Liu, S.-H.1    Cai, F.-Y.2    Chiang, M.-T.3
  • 115
    • 77952197534 scopus 로고    scopus 로고
    • Chitosan reduces gluconeogenesis and increases glucose uptake in skeletal muscle in streptozotocin-induced diabetic rats
    • Liu, S.-H., Chang, Y.-H., Chiang, M.-T., Chitosan reduces gluconeogenesis and increases glucose uptake in skeletal muscle in streptozotocin-induced diabetic rats. J Agric Food Chem 58 (2010), 5795–5800.
    • (2010) J Agric Food Chem , vol.58 , pp. 5795-5800
    • Liu, S.-H.1    Chang, Y.-H.2    Chiang, M.-T.3
  • 116
    • 34547959003 scopus 로고    scopus 로고
    • Synthesis, characterization, and evaluation of phosphated cross-linked konjac glucomannan hydrogels for colon-targeted drug delivery
    • Liu, M., Fan, J., Wang, K., He, Z., Synthesis, characterization, and evaluation of phosphated cross-linked konjac glucomannan hydrogels for colon-targeted drug delivery. Drug Deliv 14 (2007), 397–402.
    • (2007) Drug Deliv , vol.14 , pp. 397-402
    • Liu, M.1    Fan, J.2    Wang, K.3    He, Z.4
  • 117
    • 79953800025 scopus 로고    scopus 로고
    • Chitosan oligosaccharides suppress LPS-induced IL-8 expression in human umbilical vein endothelial cells through blockade of p38 and Akt protein kinases
    • Liu, H.T., Huang, P., Ma, P., Liu, Q.S., Yu, C., Du, Y.G., Chitosan oligosaccharides suppress LPS-induced IL-8 expression in human umbilical vein endothelial cells through blockade of p38 and Akt protein kinases. Acta Pharmacol Sin 32 (2011), 478–486.
    • (2011) Acta Pharmacol Sin , vol.32 , pp. 478-486
    • Liu, H.T.1    Huang, P.2    Ma, P.3    Liu, Q.S.4    Yu, C.5    Du, Y.G.6
  • 118
    • 77951043764 scopus 로고    scopus 로고
    • Chitosan oligosaccharides inhibit the expression of interleukin-6 in lipopolysaccharide-induced human umbilical vein endothelial cells through p38 and ERK1/2 protein kinases
    • Liu, H.T., Li, W.M., Li, X.Y., Xu, Q.S., Liu, Q.S., Bai, X.F., et al. Chitosan oligosaccharides inhibit the expression of interleukin-6 in lipopolysaccharide-induced human umbilical vein endothelial cells through p38 and ERK1/2 protein kinases. Basic Clin Pharmacol Toxicol 106 (2010), 362–371.
    • (2010) Basic Clin Pharmacol Toxicol , vol.106 , pp. 362-371
    • Liu, H.T.1    Li, W.M.2    Li, X.Y.3    Xu, Q.S.4    Liu, Q.S.5    Bai, X.F.6
  • 119
    • 59349093746 scopus 로고    scopus 로고
    • Chitosan oligosaccharides attenuate hydrogen peroxide-induced stress injury in human umbilical vein endothelial cells
    • Liu, H.T., Li, W.M., Xu, G., Li, X.Y., Bai, X.F., Wei, P., et al. Chitosan oligosaccharides attenuate hydrogen peroxide-induced stress injury in human umbilical vein endothelial cells. Pharmacol Res 59 (2009), 167–175.
    • (2009) Pharmacol Res , vol.59 , pp. 167-175
    • Liu, H.T.1    Li, W.M.2    Xu, G.3    Li, X.Y.4    Bai, X.F.5    Wei, P.6
  • 120
    • 33847004403 scopus 로고    scopus 로고
    • Antidiabetic effects of chitooligosaccharides on pancreatic islet cells in streptozotocin-induced diabetic rats
    • Liu, B., Liu, W.-S., Han, B.-Q., Sun, Y.-Y., Antidiabetic effects of chitooligosaccharides on pancreatic islet cells in streptozotocin-induced diabetic rats. World J Gastroenterol 13 (2007), 725–731.
    • (2007) World J Gastroenterol , vol.13 , pp. 725-731
    • Liu, B.1    Liu, W.-S.2    Han, B.-Q.3    Sun, Y.-Y.4
  • 121
    • 48249152711 scopus 로고    scopus 로고
    • Growth inhibition and apoptosis of human leukemia K562 cells induced by seleno-short-chain chitosan
    • Liu, A., Song, W., Cao, D., Liu, X., Jia, Y., Growth inhibition and apoptosis of human leukemia K562 cells induced by seleno-short-chain chitosan. Methods Find Exp Clin Pharmacol 30 (2008), 181–186.
    • (2008) Methods Find Exp Clin Pharmacol , vol.30 , pp. 181-186
    • Liu, A.1    Song, W.2    Cao, D.3    Liu, X.4    Jia, Y.5
  • 122
    • 84892167041 scopus 로고    scopus 로고
    • Synthesis, characterization, and antimicrobial activity of kojic acid grafted chitosan oligosaccharide
    • Liu, X., Xia, W., Jiang, Q., Xu, Y., Yu, P., Synthesis, characterization, and antimicrobial activity of kojic acid grafted chitosan oligosaccharide. J Agric Food Chem 62 (2014), 297–303.
    • (2014) J Agric Food Chem , vol.62 , pp. 297-303
    • Liu, X.1    Xia, W.2    Jiang, Q.3    Xu, Y.4    Yu, P.5
  • 123
    • 84897876970 scopus 로고    scopus 로고
    • Chitooligosaccharide and its derivatives: preparation and biological applications
    • Lodhi, G., Kim, Y.S., Hwang, J.W., Kim, S.K., Jeon, Y.J., Je, J.Y., et al. Chitooligosaccharide and its derivatives: preparation and biological applications. Biomed Res Int, 2014, 2014, 654913.
    • (2014) Biomed Res Int , vol.2014 , pp. 654913
    • Lodhi, G.1    Kim, Y.S.2    Hwang, J.W.3    Kim, S.K.4    Jeon, Y.J.5    Je, J.Y.6
  • 124
    • 83555174606 scopus 로고    scopus 로고
    • Protective effects of sulfated chitooligosaccharides against hydrogen peroxide-induced damage in MIN6 cells
    • Lu, X., Guo, H., Zhang, Y., Protective effects of sulfated chitooligosaccharides against hydrogen peroxide-induced damage in MIN6 cells. Int J Biol Macromol 50 (2012), 50–58.
    • (2012) Int J Biol Macromol , vol.50 , pp. 50-58
    • Lu, X.1    Guo, H.2    Zhang, Y.3
  • 125
    • 84890164095 scopus 로고    scopus 로고
    • Nitric oxide-releasing chitosan oligosaccharides as antibacterial agents
    • Lu, Y., Slomberg, D.L., Schoenfisch, M.H., Nitric oxide-releasing chitosan oligosaccharides as antibacterial agents. Biomaterials 35 (2014), 1716–1724.
    • (2014) Biomaterials , vol.35 , pp. 1716-1724
    • Lu, Y.1    Slomberg, D.L.2    Schoenfisch, M.H.3
  • 126
    • 84907288273 scopus 로고    scopus 로고
    • Chitooligosaccharides inhibit ethanol-induced oxidative stress via activation of Nrf2 and reduction of MAPK phosphorylation
    • Luo, Z., Dong, X., Ke, Q., Duan, Q., Shen, L., Chitooligosaccharides inhibit ethanol-induced oxidative stress via activation of Nrf2 and reduction of MAPK phosphorylation. Oncol Rep 32 (2014), 2215–2222.
    • (2014) Oncol Rep , vol.32 , pp. 2215-2222
    • Luo, Z.1    Dong, X.2    Ke, Q.3    Duan, Q.4    Shen, L.5
  • 127
    • 84901197522 scopus 로고    scopus 로고
    • Downregulation of CD147 by chitooligosaccharide inhibits MMP-2 expression and suppresses the metastatic potential of human gastric cancer
    • Luo, Z., Dong, X., Ke, Q., Duan, Q., Shen, L., Downregulation of CD147 by chitooligosaccharide inhibits MMP-2 expression and suppresses the metastatic potential of human gastric cancer. Oncol Lett 8 (2014), 361–366.
    • (2014) Oncol Lett , vol.8 , pp. 361-366
    • Luo, Z.1    Dong, X.2    Ke, Q.3    Duan, Q.4    Shen, L.5
  • 128
    • 78650178421 scopus 로고    scopus 로고
    • Nanostructured lipid carrier (NLC) coated with chitosan oligosaccharides and its potential use in ocular drug delivery system
    • Luo, Q., Zhao, J., Zhang, X., Pan, W., Nanostructured lipid carrier (NLC) coated with chitosan oligosaccharides and its potential use in ocular drug delivery system. Int J Pharm 403 (2011), 185–191.
    • (2011) Int J Pharm , vol.403 , pp. 185-191
    • Luo, Q.1    Zhao, J.2    Zhang, X.3    Pan, W.4
  • 129
    • 1842582833 scopus 로고    scopus 로고
    • Antitumor effects of various low-molecular-weight chitosans are due to increased natural killer activity of intestinal intraepithelial lymphocytes in sarcoma 180-bearing mice
    • Maeda, Y., Kimura, Y., Antitumor effects of various low-molecular-weight chitosans are due to increased natural killer activity of intestinal intraepithelial lymphocytes in sarcoma 180-bearing mice. J Nutr 134 (2004), 945–950.
    • (2004) J Nutr , vol.134 , pp. 945-950
    • Maeda, Y.1    Kimura, Y.2
  • 130
    • 3543051289 scopus 로고    scopus 로고
    • The depolymerization of chitosan: effects on physicochemical and biological properties
    • Mao, S., Shuai, X., Unger, F., Simon, M., Bi, D., Kissel, T., The depolymerization of chitosan: effects on physicochemical and biological properties. Int J Pharm 281 (2004), 45–54.
    • (2004) Int J Pharm , vol.281 , pp. 45-54
    • Mao, S.1    Shuai, X.2    Unger, F.3    Simon, M.4    Bi, D.5    Kissel, T.6
  • 131
    • 84902136814 scopus 로고    scopus 로고
    • Anti-tumor properties of orally administered glucosamine and N-acetyl-D-glucosamine oligomers in a mouse model
    • Masuda, S., Azuma, K., Kurozumi, S., Kiyose, M., Osaki, T., Tsuka, T., et al. Anti-tumor properties of orally administered glucosamine and N-acetyl-D-glucosamine oligomers in a mouse model. Carbohydr Polym 111 (2014), 783–787.
    • (2014) Carbohydr Polym , vol.111 , pp. 783-787
    • Masuda, S.1    Azuma, K.2    Kurozumi, S.3    Kiyose, M.4    Osaki, T.5    Tsuka, T.6
  • 132
    • 84961745266 scopus 로고    scopus 로고
    • Chitosan oligosaccharide suppresses tumor progression in a mouse model of colitis-associated colorectal cancer through AMPK activation and suppression of NF-kappaB and mTOR signaling
    • Mattaveewong, T., Wongkrasant, P., Chanchai, S., Pichyangkura, R., Chatsudthipong, V., Muanprasat, C., Chitosan oligosaccharide suppresses tumor progression in a mouse model of colitis-associated colorectal cancer through AMPK activation and suppression of NF-kappaB and mTOR signaling. Carbohydr Polym 145 (2016), 30–36.
    • (2016) Carbohydr Polym , vol.145 , pp. 30-36
    • Mattaveewong, T.1    Wongkrasant, P.2    Chanchai, S.3    Pichyangkura, R.4    Chatsudthipong, V.5    Muanprasat, C.6
  • 133
    • 34248572357 scopus 로고    scopus 로고
    • An in vitro cellular analysis of the radical scavenging efficacy of chitooligosaccharides
    • Mendis, E., Kim, M.M., Rajapakse, N., Kim, S.K., An in vitro cellular analysis of the radical scavenging efficacy of chitooligosaccharides. Life Sci 80 (2007), 2118–2127.
    • (2007) Life Sci , vol.80 , pp. 2118-2127
    • Mendis, E.1    Kim, M.M.2    Rajapakse, N.3    Kim, S.K.4
  • 134
    • 4344629867 scopus 로고    scopus 로고
    • The effect of the dietary supplement, chitosan, on body weight: a randomised controlled trial in 250 overweight and obese adults
    • Mhurchu, C.N., Poppitt, S.D., McGill, A.T., Leahy, F.E., Bennett, D.A., Lin, R.B., et al. The effect of the dietary supplement, chitosan, on body weight: a randomised controlled trial in 250 overweight and obese adults. Int J Obes Relat Metab Disord 28 (2004), 1149–1156.
    • (2004) Int J Obes Relat Metab Disord , vol.28 , pp. 1149-1156
    • Mhurchu, C.N.1    Poppitt, S.D.2    McGill, A.T.3    Leahy, F.E.4    Bennett, D.A.5    Lin, R.B.6
  • 135
    • 0030981239 scopus 로고    scopus 로고
    • Substrate dependence of angiotensin I-converting enzyme inhibition: captopril displays a partial selectivity for inhibition of N-acetyl-seryl-aspartyl-lysyl-proline hydrolysis compared with that of angiotensin I·
    • Michaud, A., Williams, T.A., Chauvet, M.-T., Corvol, P., Substrate dependence of angiotensin I-converting enzyme inhibition: captopril displays a partial selectivity for inhibition of N-acetyl-seryl-aspartyl-lysyl-proline hydrolysis compared with that of angiotensin I·. Mol Pharmacol 51 (1997), 1070–1076.
    • (1997) Mol Pharmacol , vol.51 , pp. 1070-1076
    • Michaud, A.1    Williams, T.A.2    Chauvet, M.-T.3    Corvol, P.4
  • 136
    • 0028882476 scopus 로고
    • Hypoglycemic and hypolipidemic effect of chitosan in normal and neonatal streptozotocin-induced diabetic mice
    • Miura, T., Usami, M., Tsuura, Y., Ishida, H., Seino, Y., Hypoglycemic and hypolipidemic effect of chitosan in normal and neonatal streptozotocin-induced diabetic mice. Biol Pharm Bull 18 (1995), 1623–1625.
    • (1995) Biol Pharm Bull , vol.18 , pp. 1623-1625
    • Miura, T.1    Usami, M.2    Tsuura, Y.3    Ishida, H.4    Seino, Y.5
  • 137
    • 84973330893 scopus 로고    scopus 로고
    • The role of toll-like receptor 4 in infectious and noninfectious inflammation
    • Molteni, M., Gemma, S., Rossetti, C., The role of toll-like receptor 4 in infectious and noninfectious inflammation. Mediat Inflamm, 2016, 2016, 6978936.
    • (2016) Mediat Inflamm , vol.2016 , pp. 6978936
    • Molteni, M.1    Gemma, S.2    Rossetti, C.3
  • 138
    • 34250650160 scopus 로고    scopus 로고
    • The antibacterial and immunostimulative effect of chitosan-oligosaccharides against infection by Staphylococcus aureus isolated from bovine mastitis
    • Moon, J.S., Kim, H.K., Koo, H.C., Joo, Y.S., Nam, H.M., Park, Y.H., et al. The antibacterial and immunostimulative effect of chitosan-oligosaccharides against infection by Staphylococcus aureus isolated from bovine mastitis. Appl Microbiol Biotechnol 75 (2007), 989–998.
    • (2007) Appl Microbiol Biotechnol , vol.75 , pp. 989-998
    • Moon, J.S.1    Kim, H.K.2    Koo, H.C.3    Joo, Y.S.4    Nam, H.M.5    Park, Y.H.6
  • 139
    • 84934798838 scopus 로고    scopus 로고
    • Activation of AMPK by chitosan oligosaccharide in intestinal epithelial cells: mechanism of action and potential applications in intestinal disorders
    • Muanprasat, C., Wongkrasant, P., Satitsri, S., Moonwiriyakit, A., Pongkorpsakol, P., Mattaveewong, T., et al. Activation of AMPK by chitosan oligosaccharide in intestinal epithelial cells: mechanism of action and potential applications in intestinal disorders. Biochem Pharmacol 96 (2015), 225–236.
    • (2015) Biochem Pharmacol , vol.96 , pp. 225-236
    • Muanprasat, C.1    Wongkrasant, P.2    Satitsri, S.3    Moonwiriyakit, A.4    Pongkorpsakol, P.5    Mattaveewong, T.6
  • 140
    • 84856597241 scopus 로고    scopus 로고
    • Pulmonary delivery of elcatonin using surface-modified liposomes to improve systemic absorption: polyvinyl alcohol with a hydrophobic anchor and chitosan oligosaccharide as effective surface modifiers
    • Murata, M., Nakano, K., Tahara, K., Tozuka, Y., Takeuchi, H., Pulmonary delivery of elcatonin using surface-modified liposomes to improve systemic absorption: polyvinyl alcohol with a hydrophobic anchor and chitosan oligosaccharide as effective surface modifiers. Eur J Pharm Biopharm 80 (2012), 340–346.
    • (2012) Eur J Pharm Biopharm , vol.80 , pp. 340-346
    • Murata, M.1    Nakano, K.2    Tahara, K.3    Tozuka, Y.4    Takeuchi, H.5
  • 141
    • 34547126904 scopus 로고    scopus 로고
    • A 90-day ad libitum administration toxicity study of oligoglucosamine in F344 rats
    • Naito, Y., Tago, K., Nagata, T., Furuya, M., Seki, T., Kato, H., et al. A 90-day ad libitum administration toxicity study of oligoglucosamine in F344 rats. Food Chem Toxicol 45 (2007), 1575–1587.
    • (2007) Food Chem Toxicol , vol.45 , pp. 1575-1587
    • Naito, Y.1    Tago, K.2    Nagata, T.3    Furuya, M.4    Seki, T.5    Kato, H.6
  • 142
    • 68049090666 scopus 로고    scopus 로고
    • Suppression of metastasis of human breast cancer cells by chitosan oligosaccharides
    • Nam, K.S., Shon, Y.H., Suppression of metastasis of human breast cancer cells by chitosan oligosaccharides. J Microbiol Biotechnol 19 (2009), 629–633.
    • (2009) J Microbiol Biotechnol , vol.19 , pp. 629-633
    • Nam, K.S.1    Shon, Y.H.2
  • 143
    • 35348829889 scopus 로고    scopus 로고
    • Chemopreventive effect of chitosan oligosaccharide against colon carcinogenesis
    • Nam, K.S., Kim, M.K., Shon, Y.H., Chemopreventive effect of chitosan oligosaccharide against colon carcinogenesis. J Microbiol Biotechnol 17 (2007), 1546–1549.
    • (2007) J Microbiol Biotechnol , vol.17 , pp. 1546-1549
    • Nam, K.S.1    Kim, M.K.2    Shon, Y.H.3
  • 144
    • 38149083982 scopus 로고    scopus 로고
    • Inhibition of proinflammatory cytokine-induced invasiveness of HT-29 cells by chitosan oligosaccharide
    • Nam, K.S., Kim, M.K., Shon, Y.H., Inhibition of proinflammatory cytokine-induced invasiveness of HT-29 cells by chitosan oligosaccharide. J Microbiol Biotechnol 17 (2007), 2042–2045.
    • (2007) J Microbiol Biotechnol , vol.17 , pp. 2042-2045
    • Nam, K.S.1    Kim, M.K.2    Shon, Y.H.3
  • 145
    • 51249180760 scopus 로고
    • The binding of micellar lipids to chitosan
    • Nauss, J.L., Thompson, J.L., Nagyvary, J., The binding of micellar lipids to chitosan. Lipids 18 (1983), 714–719.
    • (1983) Lipids , vol.18 , pp. 714-719
    • Nauss, J.L.1    Thompson, J.L.2    Nagyvary, J.3
  • 146
    • 37149056322 scopus 로고    scopus 로고
    • Aminoethyl chitooligosaccharides inhibit the activity of angiotensin converting enzyme
    • Ngo, D.-N., Qian, Z.-J., Je, J.-Y., Kim, M.-M., Kim, S.-K., Aminoethyl chitooligosaccharides inhibit the activity of angiotensin converting enzyme. Process Biochem 43 (2008), 119–123.
    • (2008) Process Biochem , vol.43 , pp. 119-123
    • Ngo, D.-N.1    Qian, Z.-J.2    Je, J.-Y.3    Kim, M.-M.4    Kim, S.-K.5
  • 147
    • 79952443181 scopus 로고    scopus 로고
    • Antioxidant activity of gallate-chitooligosaccharides in mouse macrophage RAW264.7 cells
    • Ngo, D.-H., Qian, Z.-J., Vo, T.-S., Ryu, B., Ngo, D.-N., Kim, S.-K., Antioxidant activity of gallate-chitooligosaccharides in mouse macrophage RAW264.7 cells. Carbohydr Polym 84 (2011), 1282–1288.
    • (2011) Carbohydr Polym , vol.84 , pp. 1282-1288
    • Ngo, D.-H.1    Qian, Z.-J.2    Vo, T.-S.3    Ryu, B.4    Ngo, D.-N.5    Kim, S.-K.6
  • 148
    • 0032916739 scopus 로고    scopus 로고
    • Biodegradation and distribution of water-soluble chitosan in mice
    • Onishi, H., Machida, Y., Biodegradation and distribution of water-soluble chitosan in mice. Biomaterials 20 (1999), 175–182.
    • (1999) Biomaterials , vol.20 , pp. 175-182
    • Onishi, H.1    Machida, Y.2
  • 149
    • 80052293126 scopus 로고    scopus 로고
    • Attenuation of pro-inflammatory mediators in LPS-stimulated BV2 microglia by chitooligosaccharides via the MAPK signaling pathway
    • Pangestuti, R., Bak, S.S., Kim, S.K., Attenuation of pro-inflammatory mediators in LPS-stimulated BV2 microglia by chitooligosaccharides via the MAPK signaling pathway. Int J Biol Macromol 49 (2011), 599–606.
    • (2011) Int J Biol Macromol , vol.49 , pp. 599-606
    • Pangestuti, R.1    Bak, S.S.2    Kim, S.K.3
  • 150
  • 151
    • 79251607482 scopus 로고    scopus 로고
    • Effects of the molecular weight and the degree of deacetylation of chitosan oligosaccharides on antitumor activity
    • Park, J.K., Chung, M.J., Choi, H.N., Park, Y.I., Effects of the molecular weight and the degree of deacetylation of chitosan oligosaccharides on antitumor activity. Int J Mol Sci 12 (2011), 266–277.
    • (2011) Int J Mol Sci , vol.12 , pp. 266-277
    • Park, J.K.1    Chung, M.J.2    Choi, H.N.3    Park, Y.I.4
  • 152
    • 0041559915 scopus 로고    scopus 로고
    • Angiotensin I converting enzyme (ACE) inhibitory activity of hetero-chitooligosaccharides prepared from partially different deacetylated chitosans
    • Park, P.-J., Je, J.-Y., Kim, S.-K., Angiotensin I converting enzyme (ACE) inhibitory activity of hetero-chitooligosaccharides prepared from partially different deacetylated chitosans. J Agric Food Chem 51 (2003), 4930–4934.
    • (2003) J Agric Food Chem , vol.51 , pp. 4930-4934
    • Park, P.-J.1    Je, J.-Y.2    Kim, S.-K.3
  • 153
    • 0042303933 scopus 로고    scopus 로고
    • Free radical scavenging activity of chitooligosaccharides by electron spin resonance spectrometry
    • Park, P.J., Je, J.Y., Kim, S.K., Free radical scavenging activity of chitooligosaccharides by electron spin resonance spectrometry. J Agric Food Chem 51 (2003), 4624–4627.
    • (2003) J Agric Food Chem , vol.51 , pp. 4624-4627
    • Park, P.J.1    Je, J.Y.2    Kim, S.K.3
  • 157
    • 0034971296 scopus 로고    scopus 로고
    • Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets
    • Pelletier, J.P., Martel-Pelletier, J., Abramson, S.B., Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. Arthritis Rheum 44 (2001), 1237–1247.
    • (2001) Arthritis Rheum , vol.44 , pp. 1237-1247
    • Pelletier, J.P.1    Martel-Pelletier, J.2    Abramson, S.B.3
  • 158
    • 84969298988 scopus 로고    scopus 로고
    • Efficacy of polyglucosamine for weight loss-confirmed in a randomized double-blind, placebo-controlled clinical investigation
    • Pokhis, K., Bitterlich, N., Cornelli, U., Cassano, G., Efficacy of polyglucosamine for weight loss-confirmed in a randomized double-blind, placebo-controlled clinical investigation. BMC Obes, 2, 2015, 25.
    • (2015) BMC Obes , vol.2 , pp. 25
    • Pokhis, K.1    Bitterlich, N.2    Cornelli, U.3    Cassano, G.4
  • 159
    • 84892991043 scopus 로고    scopus 로고
    • Angiotensin I-converting enzyme inhibitory activity of sulfated chitooligosaccharides with different molecular weights
    • Qian, Z.J., Eom, T.K., Ryu, B., Kim, S.K., Angiotensin I-converting enzyme inhibitory activity of sulfated chitooligosaccharides with different molecular weights. J Chitin Chitosan 15 (2010), 75–79.
    • (2010) J Chitin Chitosan , vol.15 , pp. 75-79
    • Qian, Z.J.1    Eom, T.K.2    Ryu, B.3    Kim, S.K.4
  • 160
    • 78651429880 scopus 로고    scopus 로고
    • Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress
    • Qiao, Y., Bai, X.F., Du, Y.G., Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress. Int Immunopharmacol 11 (2011), 121–127.
    • (2011) Int Immunopharmacol , vol.11 , pp. 121-127
    • Qiao, Y.1    Bai, X.F.2    Du, Y.G.3
  • 161
    • 33645945595 scopus 로고    scopus 로고
    • Safety evaluation of short-term exposure to chitooligomers from enzymic preparation
    • Qin, C., Gao, J., Wang, L., Zeng, L., Liu, Y., Safety evaluation of short-term exposure to chitooligomers from enzymic preparation. Food Chem Toxicol 44 (2006), 855–861.
    • (2006) Food Chem Toxicol , vol.44 , pp. 855-861
    • Qin, C.1    Gao, J.2    Wang, L.3    Zeng, L.4    Liu, Y.5
  • 162
    • 84959018825 scopus 로고    scopus 로고
    • Oxidative stress and metabolic disorders: pathogenesis and therapeutic strategies
    • Rani, V., Deep, G., Singh, R.K., Palle, K., Yadav, U.C., Oxidative stress and metabolic disorders: pathogenesis and therapeutic strategies. Life Sci 148 (2016), 183–193.
    • (2016) Life Sci , vol.148 , pp. 183-193
    • Rani, V.1    Deep, G.2    Singh, R.K.3    Palle, K.4    Yadav, U.C.5
  • 163
    • 84989194896 scopus 로고    scopus 로고
    • The effects of bioactive compounds on biomarkers of obesity
    • Rebecca, C., Danik, M., The effects of bioactive compounds on biomarkers of obesity. Funct Foods Health Dis 5 (2015), 365–380.
    • (2015) Funct Foods Health Dis , vol.5 , pp. 365-380
    • Rebecca, C.1    Danik, M.2
  • 164
    • 0031000552 scopus 로고    scopus 로고
    • Effects of ultrasonic conditions and storage in acidic solutions on changes in molecular weight and polydispersity of treated chitosan
    • Rong Huei, C., Jaan Rong, C., Ju Shii, S., Effects of ultrasonic conditions and storage in acidic solutions on changes in molecular weight and polydispersity of treated chitosan. Carbohydr Res 299 (1997), 287–294.
    • (1997) Carbohydr Res , vol.299 , pp. 287-294
    • Rong Huei, C.1    Jaan Rong, C.2    Ju Shii, S.3
  • 165
    • 84892601165 scopus 로고    scopus 로고
    • Targeted therapy using nanotechnology: focus on cancer
    • Sanna, V., Pala, N., Sechi, M., Targeted therapy using nanotechnology: focus on cancer. Int J Nanomedicine 9 (2014), 467–483.
    • (2014) Int J Nanomedicine , vol.9 , pp. 467-483
    • Sanna, V.1    Pala, N.2    Sechi, M.3
  • 166
    • 84963520567 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease at 25 years
    • Selkoe, D.J., Hardy, J., The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol Med 8 (2016), 595–608.
    • (2016) EMBO Mol Med , vol.8 , pp. 595-608
    • Selkoe, D.J.1    Hardy, J.2
  • 167
    • 0034739705 scopus 로고    scopus 로고
    • Synergistic cooperation between water-soluble chitosan oligomers and interferon-gamma for induction of nitric oxide synthesis and tumoricidal activity in murine peritoneal macrophages
    • Seo, W.G., Pae, H.O., Kim, N.Y., Oh, G.S., Park, I.S., Kim, Y.H., et al. Synergistic cooperation between water-soluble chitosan oligomers and interferon-gamma for induction of nitric oxide synthesis and tumoricidal activity in murine peritoneal macrophages. Cancer Lett 159 (2000), 189–195.
    • (2000) Cancer Lett , vol.159 , pp. 189-195
    • Seo, W.G.1    Pae, H.O.2    Kim, N.Y.3    Oh, G.S.4    Park, I.S.5    Kim, Y.H.6
  • 168
    • 40149099874 scopus 로고    scopus 로고
    • Antifungal effect of high- and low-molecular-weight chitosan hydrochloride, carboxymethyl chitosan, chitosan oligosaccharide and N-acetyl-D-glucosamine against Candida albicans, Candida krusei and Candida glabrata
    • Seyfarth, F., Schliemann, S., Elsner, P., Hipler, U.C., Antifungal effect of high- and low-molecular-weight chitosan hydrochloride, carboxymethyl chitosan, chitosan oligosaccharide and N-acetyl-D-glucosamine against Candida albicans, Candida krusei and Candida glabrata. Int J Pharm 353 (2008), 139–148.
    • (2008) Int J Pharm , vol.353 , pp. 139-148
    • Seyfarth, F.1    Schliemann, S.2    Elsner, P.3    Hipler, U.C.4
  • 169
    • 84938600326 scopus 로고    scopus 로고
    • Pharmacokinetics and biodegradation performance of a hydroxypropyl chitosan derivative
    • Shao, K., Han, B., Dong, W., Song, F., Liu, W., Liu, W., Pharmacokinetics and biodegradation performance of a hydroxypropyl chitosan derivative. J Ocean Univ China 14 (2015), 888–896.
    • (2015) J Ocean Univ China , vol.14 , pp. 888-896
    • Shao, K.1    Han, B.2    Dong, W.3    Song, F.4    Liu, W.5    Liu, W.6
  • 170
    • 68649097772 scopus 로고    scopus 로고
    • Inhibitory effects of chitooligosaccharides on tumor growth and metastasis
    • Shen, K.T., Chen, M.H., Chan, H.Y., Jeng, J.H., Wang, Y.J., Inhibitory effects of chitooligosaccharides on tumor growth and metastasis. Food Chem Toxicol 47 (2009), 1864–1871.
    • (2009) Food Chem Toxicol , vol.47 , pp. 1864-1871
    • Shen, K.T.1    Chen, M.H.2    Chan, H.Y.3    Jeng, J.H.4    Wang, Y.J.5
  • 171
    • 0037680717 scopus 로고    scopus 로고
    • Inhibition of polyamine biosynthesis in Acanthamoeba castellanii and 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity by chitosanoligosaccharide
    • Shon, Y.H., Nam, K.S., Inhibition of polyamine biosynthesis in Acanthamoeba castellanii and 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity by chitosanoligosaccharide. Biotechnol Lett 25 (2003), 701–704.
    • (2003) Biotechnol Lett , vol.25 , pp. 701-704
    • Shon, Y.H.1    Nam, K.S.2
  • 172
    • 84864067073 scopus 로고    scopus 로고
    • The antimicrobial action of chitosan, low molar mass chitosan, and chitooligosaccharides on human colonic bacteria
    • Simunek, J., Brandysova, V., Koppova, I., Simunek, J. Jr., The antimicrobial action of chitosan, low molar mass chitosan, and chitooligosaccharides on human colonic bacteria. Folia Microbiol (Praha) 57 (2012), 341–345.
    • (2012) Folia Microbiol (Praha) , vol.57 , pp. 341-345
    • Simunek, J.1    Brandysova, V.2    Koppova, I.3    Simunek, J.4
  • 174
    • 31544480928 scopus 로고    scopus 로고
    • Low molecular weight chitosan inhibits obesity induced by feeding a high-fat diet long-term in mice
    • Sumiyoshi, M., Kimura, Y., Low molecular weight chitosan inhibits obesity induced by feeding a high-fat diet long-term in mice. J Pharm Pharmacol 58 (2006), 201–207.
    • (2006) J Pharm Pharmacol , vol.58 , pp. 201-207
    • Sumiyoshi, M.1    Kimura, Y.2
  • 175
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi, O., Akira, S., Pattern recognition receptors and inflammation. Cell 140 (2010), 805–820.
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 176
    • 7444237728 scopus 로고    scopus 로고
    • Proapoptotic effect of a dietary supplement: water soluble chitosan activates caspase-8 and modulating death receptor expression
    • Takimoto, H., Hasegawa, M., Yagi, K., Nakamura, T., Sakaeda, T., Hirai, M., Proapoptotic effect of a dietary supplement: water soluble chitosan activates caspase-8 and modulating death receptor expression. Drug Metab Pharmacokinet 19 (2004), 76–82.
    • (2004) Drug Metab Pharmacokinet , vol.19 , pp. 76-82
    • Takimoto, H.1    Hasegawa, M.2    Yagi, K.3    Nakamura, T.4    Sakaeda, T.5    Hirai, M.6
  • 177
    • 84872765812 scopus 로고    scopus 로고
    • Chitosan oligosaccharide-arachidic acid-based nanoparticles for anti-cancer drug delivery
    • Termsarasab, U., Cho, H.J., Kim, D.H., Chong, S., Chung, S.J., Shim, C.K., et al. Chitosan oligosaccharide-arachidic acid-based nanoparticles for anti-cancer drug delivery. Int J Pharm 441 (2013), 373–380.
    • (2013) Int J Pharm , vol.441 , pp. 373-380
    • Termsarasab, U.1    Cho, H.J.2    Kim, D.H.3    Chong, S.4    Chung, S.J.5    Shim, C.K.6
  • 178
    • 0030020046 scopus 로고    scopus 로고
    • The influence of high and low molecular weight chitosan on colonic cell proliferation and aberrant crypt foci development in CF1 mice
    • Torzsas, T.L., Kendall, C.W., Sugano, M., Iwamoto, Y., Rao, A.V., The influence of high and low molecular weight chitosan on colonic cell proliferation and aberrant crypt foci development in CF1 mice. Food Chem Toxicol 34 (1996), 73–77.
    • (1996) Food Chem Toxicol , vol.34 , pp. 73-77
    • Torzsas, T.L.1    Kendall, C.W.2    Sugano, M.3    Iwamoto, Y.4    Rao, A.V.5
  • 179
    • 84954111119 scopus 로고    scopus 로고
    • Single-blind, placebo controlled randomised clinical study of chitosan for body weight reduction
    • Trivedi, V.R., Satia, M.C., Deschamps, A., Maquet, V., Shah, R.B., Zinzuwadia, P.H., et al. Single-blind, placebo controlled randomised clinical study of chitosan for body weight reduction. Nutr J, 15, 2016, 3.
    • (2016) Nutr J , vol.15 , pp. 3
    • Trivedi, V.R.1    Satia, M.C.2    Deschamps, A.3    Maquet, V.4    Shah, R.B.5    Zinzuwadia, P.H.6
  • 180
    • 0033178547 scopus 로고    scopus 로고
    • Accelerating effects of chitosan for healing at early phase of experimental open wound in dogs
    • Ueno, H., Yamada, H., Tanaka, I., Kaba, N., Matsuura, M., Okumura, M., et al. Accelerating effects of chitosan for healing at early phase of experimental open wound in dogs. Biomaterials 20 (1999), 1407–1414.
    • (1999) Biomaterials , vol.20 , pp. 1407-1414
    • Ueno, H.1    Yamada, H.2    Tanaka, I.3    Kaba, N.4    Matsuura, M.5    Okumura, M.6
  • 181
    • 78951488750 scopus 로고    scopus 로고
    • Inhibitory effects of chitooligosaccharides on degranulation and cytokine generation in rat basophilic leukemia RBL-2H3 cells
    • Vo, T.-S., Kong, C.-S., Kim, S.-K., Inhibitory effects of chitooligosaccharides on degranulation and cytokine generation in rat basophilic leukemia RBL-2H3 cells. Carbohydr Polym 84 (2011), 649–655.
    • (2011) Carbohydr Polym , vol.84 , pp. 649-655
    • Vo, T.-S.1    Kong, C.-S.2    Kim, S.-K.3
  • 182
    • 84872358358 scopus 로고    scopus 로고
    • Multi-functional roles of chitosan as a potential protective agent against obesity
    • Walsh, A.M., Sweeney, T., Bahar, B., O'Doherty, J.V., Multi-functional roles of chitosan as a potential protective agent against obesity. PLoS One, 8, 2013, e53828.
    • (2013) PLoS One , vol.8
    • Walsh, A.M.1    Sweeney, T.2    Bahar, B.3    O'Doherty, J.V.4
  • 183
    • 34147138790 scopus 로고    scopus 로고
    • N-acetylchitooligosaccharide is a potent angiogenic inhibitor both in vivo and in vitro
    • Wang, Z., Zheng, L., Yang, S., Niu, R., Chu, E., Lin, X., N-acetylchitooligosaccharide is a potent angiogenic inhibitor both in vivo and in vitro. Biochem Biophys Res Commun 357 (2007), 26–31.
    • (2007) Biochem Biophys Res Commun , vol.357 , pp. 26-31
    • Wang, Z.1    Zheng, L.2    Yang, S.3    Niu, R.4    Chu, E.5    Lin, X.6
  • 184
    • 34047124901 scopus 로고    scopus 로고
    • Antimicrobial effect of chitooligosaccharides produced by chitosanase from Pseudomonas CUY8
    • Wang, Y., Zhou, P., Yu, J., Pan, X., Wang, P., Lan, W., et al. Antimicrobial effect of chitooligosaccharides produced by chitosanase from Pseudomonas CUY8. Asia Pac J Clin Nutr 16:Suppl 1 (2007), 174–177.
    • (2007) Asia Pac J Clin Nutr , vol.16 , pp. 174-177
    • Wang, Y.1    Zhou, P.2    Yu, J.3    Pan, X.4    Wang, P.5    Lan, W.6
  • 185
    • 84952639536 scopus 로고    scopus 로고
    • Preferential tumor accumulation and desirable interstitial penetration of poly(lactic-co-glycolic acid) nanoparticles with dual coating of chitosan oligosaccharide and polyethylene glycol-poly(D,L-lactic acid)
    • Wang, G., Chen, Y., Wang, P., Wang, Y., Hong, H., Li, Y., et al. Preferential tumor accumulation and desirable interstitial penetration of poly(lactic-co-glycolic acid) nanoparticles with dual coating of chitosan oligosaccharide and polyethylene glycol-poly(D,L-lactic acid). Acta Biomater 29 (2016), 248–260.
    • (2016) Acta Biomater , vol.29 , pp. 248-260
    • Wang, G.1    Chen, Y.2    Wang, P.3    Wang, Y.4    Hong, H.5    Li, Y.6
  • 187
    • 84953362584 scopus 로고    scopus 로고
    • Chitosan degradation products promote nerve regeneration by stimulating Schwann cell proliferation via miR-27a/FOXO1 Axis
    • Wang, Y., Zhao, Y., Sun, C., Hu, W., Zhao, J., Li, G., et al. Chitosan degradation products promote nerve regeneration by stimulating Schwann cell proliferation via miR-27a/FOXO1 Axis. Mol Neurobiol 53 (2016), 28–39.
    • (2016) Mol Neurobiol , vol.53 , pp. 28-39
    • Wang, Y.1    Zhao, Y.2    Sun, C.3    Hu, W.4    Zhao, J.5    Li, G.6
  • 188
  • 189
    • 33845224632 scopus 로고    scopus 로고
    • Chitooligosaccharides in combination with interferon-gamma increase nitric oxide production via nuclear factor-kappaB activation in murine RAW264.7 macrophages
    • Wu, G.J., Tsai, G.J., Chitooligosaccharides in combination with interferon-gamma increase nitric oxide production via nuclear factor-kappaB activation in murine RAW264.7 macrophages. Food Chem Toxicol 45 (2007), 250–258.
    • (2007) Food Chem Toxicol , vol.45 , pp. 250-258
    • Wu, G.J.1    Tsai, G.J.2
  • 190
    • 34548238320 scopus 로고    scopus 로고
    • Chitosan as a lipid binder: a langmuir monolayer study of chitosan–lipid interactions
    • Wydro, P., Krajewska, B., Hac-Wydro, K., Chitosan as a lipid binder: a langmuir monolayer study of chitosan–lipid interactions. Biomacromolecules 8 (2007), 2611–2617.
    • (2007) Biomacromolecules , vol.8 , pp. 2611-2617
    • Wydro, P.1    Krajewska, B.2    Hac-Wydro, K.3
  • 191
    • 70349176085 scopus 로고    scopus 로고
    • Potent angiogenic inhibition effects of deacetylated chitohexaose separated from chitooligosaccharides and its mechanism of action in vitro
    • Xiong, C., Wu, H., Wei, P., Pan, M., Tuo, Y., Kusakabe, I., et al. Potent angiogenic inhibition effects of deacetylated chitohexaose separated from chitooligosaccharides and its mechanism of action in vitro. Carbohydr Res 344 (2009), 1975–1983.
    • (2009) Carbohydr Res , vol.344 , pp. 1975-1983
    • Xiong, C.1    Wu, H.2    Wei, P.3    Pan, M.4    Tuo, Y.5    Kusakabe, I.6
  • 192
    • 77952105334 scopus 로고    scopus 로고
    • Chitooligosaccharides protect rat cortical neurons against copper induced damage by attenuating intracellular level of reactive oxygen species
    • Xu, W., Huang, H.C., Lin, C.J., Jiang, Z.F., Chitooligosaccharides protect rat cortical neurons against copper induced damage by attenuating intracellular level of reactive oxygen species. Bioorg Med Chem Lett 20 (2010), 3084–3088.
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 3084-3088
    • Xu, W.1    Huang, H.C.2    Lin, C.J.3    Jiang, Z.F.4
  • 193
    • 77953028633 scopus 로고    scopus 로고
    • Chitooligosaccharides protect human embryonic hepatocytes against oxidative stress induced by hydrogen peroxide
    • Xu, Q., Ma, P., Yu, W., Tan, C., Liu, H., Xiong, C., et al. Chitooligosaccharides protect human embryonic hepatocytes against oxidative stress induced by hydrogen peroxide. Mar Biotechnol (NY) 12 (2010), 292–298.
    • (2010) Mar Biotechnol (NY) , vol.12 , pp. 292-298
    • Xu, Q.1    Ma, P.2    Yu, W.3    Tan, C.4    Liu, H.5    Xiong, C.6
  • 194
    • 84906676003 scopus 로고    scopus 로고
    • Oxidation and pH responsive nanoparticles based on ferrocene-modified chitosan oligosaccharide for 5-fluorouracil delivery
    • Xu, Y., Wang, L., Li, Y.K., Wang, C.Q., Oxidation and pH responsive nanoparticles based on ferrocene-modified chitosan oligosaccharide for 5-fluorouracil delivery. Carbohydr Polym 114 (2014), 27–35.
    • (2014) Carbohydr Polym , vol.114 , pp. 27-35
    • Xu, Y.1    Wang, L.2    Li, Y.K.3    Wang, C.Q.4
  • 195
    • 84891365390 scopus 로고    scopus 로고
    • Effects of chitosan on xenograft models of melanoma in C57BL/6 mice and hepatoma formation in SCID mice
    • Yeh, M.Y., Wu, M.F., Shang, H.S., Chang, J.B., Shih, Y.L., Chen, Y.L., et al. Effects of chitosan on xenograft models of melanoma in C57BL/6 mice and hepatoma formation in SCID mice. Anticancer Res 33 (2013), 4867–4873.
    • (2013) Anticancer Res , vol.33 , pp. 4867-4873
    • Yeh, M.Y.1    Wu, M.F.2    Shang, H.S.3    Chang, J.B.4    Shih, Y.L.5    Chen, Y.L.6
  • 196
    • 34249058349 scopus 로고    scopus 로고
    • Chitosan oligosaccharide (COS) inhibits LPS-induced inflammatory effects in RAW 264.7 macrophage cells
    • Yoon, H.J., Moon, M.E., Park, H.S., Im, S.Y., Kim, Y.H., Chitosan oligosaccharide (COS) inhibits LPS-induced inflammatory effects in RAW 264.7 macrophage cells. Biochem Biophys Res Commun 358 (2007), 954–959.
    • (2007) Biochem Biophys Res Commun , vol.358 , pp. 954-959
    • Yoon, H.J.1    Moon, M.E.2    Park, H.S.3    Im, S.Y.4    Kim, Y.H.5
  • 197
    • 69749111211 scopus 로고    scopus 로고
    • Acetylcholinesterase inhibitory activity of novel chitooligosaccharide derivatives
    • Yoon, N.Y., Ngo, D.-N., Kim, S.-K., Acetylcholinesterase inhibitory activity of novel chitooligosaccharide derivatives. Carbohydr Polym 78 (2009), 869–872.
    • (2009) Carbohydr Polym , vol.78 , pp. 869-872
    • Yoon, N.Y.1    Ngo, D.-N.2    Kim, S.-K.3
  • 198
    • 26444620953 scopus 로고    scopus 로고
    • Chitosan oligosaccharide inhibits 203HgCl2-induced genotoxicity in mice: micronuclei occurrence and chromosomal aberration
    • Yoon, H.J., Park, H.S., Bom, H.S., Roh, Y.B., Kim, J.S., Kim, Y.H., Chitosan oligosaccharide inhibits 203HgCl2-induced genotoxicity in mice: micronuclei occurrence and chromosomal aberration. Arch Pharm Res 28 (2005), 1079–1085.
    • (2005) Arch Pharm Res , vol.28 , pp. 1079-1085
    • Yoon, H.J.1    Park, H.S.2    Bom, H.S.3    Roh, Y.B.4    Kim, J.S.5    Kim, Y.H.6
  • 199
    • 1642299571 scopus 로고    scopus 로고
    • Effects of PVA sponge containing chitooligosaccharide in the early stage of wound healing
    • You, Y., Park, W.H., Ko, B.M., Min, B.M., Effects of PVA sponge containing chitooligosaccharide in the early stage of wound healing. J Mater Sci Mater Med 15 (2004), 297–301.
    • (2004) J Mater Sci Mater Med , vol.15 , pp. 297-301
    • You, Y.1    Park, W.H.2    Ko, B.M.3    Min, B.M.4
  • 200
    • 84860440603 scopus 로고    scopus 로고
    • Chitosan oligosaccharide as potential therapy of inflammatory bowel disease: therapeutic efficacy and possible mechanisms of action
    • Yousef, M., Pichyangkura, R., Soodvilai, S., Chatsudthipong, V., Muanprasat, C., Chitosan oligosaccharide as potential therapy of inflammatory bowel disease: therapeutic efficacy and possible mechanisms of action. Pharmacol Res 66 (2012), 66–79.
    • (2012) Pharmacol Res , vol.66 , pp. 66-79
    • Yousef, M.1    Pichyangkura, R.2    Soodvilai, S.3    Chatsudthipong, V.4    Muanprasat, C.5
  • 201
    • 80053469514 scopus 로고    scopus 로고
    • The two faces of interferon-gamma in cancer
    • Zaidi, M.R., Merlino, G., The two faces of interferon-gamma in cancer. Clin Cancer Res 17 (2011), 6118–6124.
    • (2011) Clin Cancer Res , vol.17 , pp. 6118-6124
    • Zaidi, M.R.1    Merlino, G.2
  • 202
    • 36549013188 scopus 로고    scopus 로고
    • Absorption and distribution of chitosan in mice after oral administration
    • Zeng, L., Qin, C., Wang, W., Chi, W., Li, W., Absorption and distribution of chitosan in mice after oral administration. Carbohydr Polym 71 (2008), 435–440.
    • (2008) Carbohydr Polym , vol.71 , pp. 435-440
    • Zeng, L.1    Qin, C.2    Wang, W.3    Chi, W.4    Li, W.5
  • 203
    • 33644975021 scopus 로고    scopus 로고
    • Prehypertension, diabetes, and cardiovascular disease risk in a population-based sample: the strong heart study
    • Zhang, Y., Lee, E.T., Devereux, R.B., Yeh, J., Best, L.G., Fabsitz, R.R., et al. Prehypertension, diabetes, and cardiovascular disease risk in a population-based sample: the strong heart study. Hypertension 47 (2006), 410–414.
    • (2006) Hypertension , vol.47 , pp. 410-414
    • Zhang, Y.1    Lee, E.T.2    Devereux, R.B.3    Yeh, J.4    Best, L.G.5    Fabsitz, R.R.6
  • 204
    • 84907456205 scopus 로고    scopus 로고
    • Toll like receptor 4 (TLR4) mediates the stimulating activities of chitosan oligosaccharide on macrophages
    • Zhang, P., Liu, W., Peng, Y., Han, B., Yang, Y., Toll like receptor 4 (TLR4) mediates the stimulating activities of chitosan oligosaccharide on macrophages. Int Immunopharmacol 23 (2014), 254–261.
    • (2014) Int Immunopharmacol , vol.23 , pp. 254-261
    • Zhang, P.1    Liu, W.2    Peng, Y.3    Han, B.4    Yang, Y.5
  • 205
    • 84881156379 scopus 로고    scopus 로고
    • Galactosylated chitosan oligosaccharide nanoparticles for hepatocellular carcinoma cell-targeted delivery of adenosine triphosphate
    • Zhu, X.L., Du, Y.Z., Yu, R.S., Liu, P., Shi, D., Chen, Y., et al. Galactosylated chitosan oligosaccharide nanoparticles for hepatocellular carcinoma cell-targeted delivery of adenosine triphosphate. Int J Mol Sci 14 (2013), 15755–15766.
    • (2013) Int J Mol Sci , vol.14 , pp. 15755-15766
    • Zhu, X.L.1    Du, Y.Z.2    Yu, R.S.3    Liu, P.4    Shi, D.5    Chen, Y.6


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