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Volumn 35, Issue 6, 2011, Pages 1397-1409

Revisiting the cholinergic hypothesis in the development of Alzheimer's disease

Author keywords

Acetylcholine; Aging; Alzheimer's disease; Co factors; Hippocampus; Memory

Indexed keywords

ACETYLCHOLINE; BRAIN DERIVED NEUROTROPHIC FACTOR; CHOLINE; CHOLINERGIC RECEPTOR STIMULATING AGENT; CHOLINESTERASE INHIBITOR; DONEPEZIL; ESTRADIOL; ESTROGEN; NEUROTROPHIN; NICOTINE; PHOSPHATIDYLCHOLINE; PLACEBO;

EID: 79954582437     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2011.03.001     Document Type: Review
Times cited : (390)

References (171)
  • 1
    • 2442475297 scopus 로고    scopus 로고
    • The time-course of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise
    • Adlard P.A., Perreau V.M., Engesser-Cesar C., Cotman C.W. The time-course of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise. Neurosci. Lett. 2004, 363:43-48.
    • (2004) Neurosci. Lett. , vol.363 , pp. 43-48
    • Adlard, P.A.1    Perreau, V.M.2    Engesser-Cesar, C.3    Cotman, C.W.4
  • 2
    • 0028278717 scopus 로고
    • Nicotine-induced protection of cultured cortical neurons against N-methyl-d-aspartate receptor-mediated glutamate cytotoxicity
    • Akaike A., Tamura Y., Yokota T., Shimohama S., Kimura J. Nicotine-induced protection of cultured cortical neurons against N-methyl-d-aspartate receptor-mediated glutamate cytotoxicity. Brain Res. 1994, 644:181-187.
    • (1994) Brain Res. , vol.644 , pp. 181-187
    • Akaike, A.1    Tamura, Y.2    Yokota, T.3    Shimohama, S.4    Kimura, J.5
  • 4
    • 0028856460 scopus 로고
    • An English translation of Alzheimer's 1907 paper, " Uber eine eigenartige Erkankung der Hirnrinde"
    • Alzheimer A., Stelzmann R.A., Schnitzlein H.N., Murtagh F.R. An English translation of Alzheimer's 1907 paper, " Uber eine eigenartige Erkankung der Hirnrinde" Clin. Anat. 1995, 8:429-431.
    • (1995) Clin. Anat. , vol.8 , pp. 429-431
    • Alzheimer, A.1    Stelzmann, R.A.2    Schnitzlein, H.N.3    Murtagh, F.R.4
  • 6
    • 0002503154 scopus 로고    scopus 로고
    • Beta-amyloid peptides as direct cholinergic neuromodulators: a missing link?
    • Auld D.S., Kar S., Quirion R. Beta-amyloid peptides as direct cholinergic neuromodulators: a missing link?. TINS 1998, 21(1):43-49.
    • (1998) TINS , vol.21 , Issue.1 , pp. 43-49
    • Auld, D.S.1    Kar, S.2    Quirion, R.3
  • 7
    • 0036810329 scopus 로고    scopus 로고
    • Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies
    • Auld D.S., Kornecook T.J., Bastianetto S., Quirion R. Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies. Prog. Neurobiol. 2002, 68(3):209-245.
    • (2002) Prog. Neurobiol. , vol.68 , Issue.3 , pp. 209-245
    • Auld, D.S.1    Kornecook, T.J.2    Bastianetto, S.3    Quirion, R.4
  • 8
    • 15944383855 scopus 로고    scopus 로고
    • Lesion evolution in cerebral ischemia
    • Back T., Hemmen T., Schuler O.G. Lesion evolution in cerebral ischemia. J. Neurol. 2004, 251:388-397.
    • (2004) J. Neurol. , vol.251 , pp. 388-397
    • Back, T.1    Hemmen, T.2    Schuler, O.G.3
  • 11
    • 0034125843 scopus 로고    scopus 로고
    • On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis
    • Bartus R.T. On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp. Neurol. 2000, 163:495-529.
    • (2000) Exp. Neurol. , vol.163 , pp. 495-529
    • Bartus, R.T.1
  • 12
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus R.T., Dean R.L., Beer B., Lippa A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982, 217:408-414.
    • (1982) Science , vol.217 , pp. 408-414
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3    Lippa, A.S.4
  • 13
    • 0019310943 scopus 로고
    • Age-related changes in passive avoidance retention: modulation with dietary choline
    • Bartus R.T., Dean R.L., Goas J.A., Lippa A.S. Age-related changes in passive avoidance retention: modulation with dietary choline. Science 1980, 209:301-303.
    • (1980) Science , vol.209 , pp. 301-303
    • Bartus, R.T.1    Dean, R.L.2    Goas, J.A.3    Lippa, A.S.4
  • 14
    • 0018256391 scopus 로고
    • Evidence for a direct cholinergic involvement in the scopolamine-induced amnesia in monkeys: effects of concurrent administration of physostigmine and methylphenidate with scopolamine
    • Bartus R.T. Evidence for a direct cholinergic involvement in the scopolamine-induced amnesia in monkeys: effects of concurrent administration of physostigmine and methylphenidate with scopolamine. Pharmacol. Biochem. Behav. 1978, 9:833-836.
    • (1978) Pharmacol. Biochem. Behav. , vol.9 , pp. 833-836
    • Bartus, R.T.1
  • 15
    • 33845600453 scopus 로고    scopus 로고
    • Aging causes partial loss of basal forebrain but no loss of pontine reticular cholinergic neurons
    • Baskerville K.A., Kent C., Nicolle M.N., Gallagher M., McKinney M. Aging causes partial loss of basal forebrain but no loss of pontine reticular cholinergic neurons. Neuroreport 2006, 17:1819-1823.
    • (2006) Neuroreport , vol.17 , pp. 1819-1823
    • Baskerville, K.A.1    Kent, C.2    Nicolle, M.N.3    Gallagher, M.4    McKinney, M.5
  • 16
    • 0030747603 scopus 로고    scopus 로고
    • Effects of cholinergic depletion on experience-dependent plasticity in the cortex of the rat
    • Baskerville K.A., Schweitzer J.B., Herron P. Effects of cholinergic depletion on experience-dependent plasticity in the cortex of the rat. Neuroscience 1997, 80:1159-1169.
    • (1997) Neuroscience , vol.80 , pp. 1159-1169
    • Baskerville, K.A.1    Schweitzer, J.B.2    Herron, P.3
  • 17
    • 0032484494 scopus 로고    scopus 로고
    • Acute intermittent nicotine treatment produces regional increases of basic fibroblast growth factor messenger RNA and protein in the tel- and diencephalon of the rat
    • Belluardo N., Blum M., Mudo G., Andbjer B., Fuxe K. Acute intermittent nicotine treatment produces regional increases of basic fibroblast growth factor messenger RNA and protein in the tel- and diencephalon of the rat. Neuroscience 1998, 83:723-740.
    • (1998) Neuroscience , vol.83 , pp. 723-740
    • Belluardo, N.1    Blum, M.2    Mudo, G.3    Andbjer, B.4    Fuxe, K.5
  • 18
    • 0036605368 scopus 로고    scopus 로고
    • Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum
    • Berchtold N.C., Kesslak J.P., Cotman C.W. Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum. J. Neurosci. Res. 2002, 68(5):511-521.
    • (2002) J. Neurosci. Res. , vol.68 , Issue.5 , pp. 511-521
    • Berchtold, N.C.1    Kesslak, J.P.2    Cotman, C.W.3
  • 21
    • 0020424541 scopus 로고
    • Choline acetyltransferase activity and histopathology of frontal neocortex from biopsies of demented patients
    • Bowen D.M., Benton J.S., Spillane J.A., Smith C.C.T., Allen S.J. Choline acetyltransferase activity and histopathology of frontal neocortex from biopsies of demented patients. J. Neurol. Sci. 1982, 57:191-202.
    • (1982) J. Neurol. Sci. , vol.57 , pp. 191-202
    • Bowen, D.M.1    Benton, J.S.2    Spillane, J.A.3    Smith, C.C.T.4    Allen, S.J.5
  • 22
    • 0029584771 scopus 로고
    • Risk of dementia in patients with Parkinson's disease, epilepsy, and severe head trauma: a register-based follow-up study
    • Breteler M.M., de Groot R.R., van Romunde L.K., Hofman A. Risk of dementia in patients with Parkinson's disease, epilepsy, and severe head trauma: a register-based follow-up study. Am. J. Epidemiol. 1995, 142:1300-1305.
    • (1995) Am. J. Epidemiol. , vol.142 , pp. 1300-1305
    • Breteler, M.M.1    de Groot, R.R.2    van Romunde, L.K.3    Hofman, A.4
  • 23
    • 0345042214 scopus 로고
    • Silent brain infarcts
    • Caplan L.R. Silent brain infarcts. Cerebrovasc. Dis. 1994, 4:32-39.
    • (1994) Cerebrovasc. Dis. , vol.4 , pp. 32-39
    • Caplan, L.R.1
  • 24
    • 0027104098 scopus 로고
    • Memory deficits in Alzheimer's patients: a comprehensive review
    • Carlesimo G.A., Oscar-Berman M. Memory deficits in Alzheimer's patients: a comprehensive review. Neuropsychol. Rev. 1992, 3:119-169.
    • (1992) Neuropsychol. Rev. , vol.3 , pp. 119-169
    • Carlesimo, G.A.1    Oscar-Berman, M.2
  • 26
    • 14544280149 scopus 로고    scopus 로고
    • Predicting the outcome of cholinesterase inhibitor treatment in Alzheimer's disease
    • Connelly P.J., Prentice N.P., Fowler K.G. Predicting the outcome of cholinesterase inhibitor treatment in Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 2005, 76(3):320-324.
    • (2005) J. Neurol. Neurosurg. Psychiatry , vol.76 , Issue.3 , pp. 320-324
    • Connelly, P.J.1    Prentice, N.P.2    Fowler, K.G.3
  • 27
    • 0038386024 scopus 로고    scopus 로고
    • Lesions of the basal forebrain system impair task acquisition and abolish cortical plasticity associated with motor skill learning
    • Conner J.M., Culberson A., Packowski C., Chiba A.A., Tuszynski M.H. Lesions of the basal forebrain system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Neuron 2003, 38:819-829.
    • (2003) Neuron , vol.38 , pp. 819-829
    • Conner, J.M.1    Culberson, A.2    Packowski, C.3    Chiba, A.A.4    Tuszynski, M.H.5
  • 28
    • 3042760266 scopus 로고    scopus 로고
    • Decreased neurogenesis after cholinergic forebrain lesion in the adult rat
    • Cooper-Kuhn C.M., Winkler J., Kuhn H.G. Decreased neurogenesis after cholinergic forebrain lesion in the adult rat. J. Neurosci. Res. 2004, 77:155-165.
    • (2004) J. Neurosci. Res. , vol.77 , pp. 155-165
    • Cooper-Kuhn, C.M.1    Winkler, J.2    Kuhn, H.G.3
  • 30
    • 0035847204 scopus 로고    scopus 로고
    • Nicotine prevents striatal dopamine loss produced by 6-hydroxydopamine lesion in the substantia nigra
    • Costa G., Abin-Carriquiry J.A., Dajas F. Nicotine prevents striatal dopamine loss produced by 6-hydroxydopamine lesion in the substantia nigra. Brain Res. 2001, 888(2):336-342.
    • (2001) Brain Res. , vol.888 , Issue.2 , pp. 336-342
    • Costa, G.1    Abin-Carriquiry, J.A.2    Dajas, F.3
  • 32
    • 59449102287 scopus 로고    scopus 로고
    • Selective lesion of medial septal cholinergic neurons followed by a mini-stroke impairs spatial learning in rats
    • Craig L.A., Hong N.S., Kopp J., McDonald R.J. Selective lesion of medial septal cholinergic neurons followed by a mini-stroke impairs spatial learning in rats. Exp. Brain Res. 2009, 193(1):29-42.
    • (2009) Exp. Brain Res. , vol.193 , Issue.1 , pp. 29-42
    • Craig, L.A.1    Hong, N.S.2    Kopp, J.3    McDonald, R.J.4
  • 33
    • 60249102594 scopus 로고    scopus 로고
    • Cholinergic depletion of the medial septum followed by phase shifting does not impair memory or rest-activity rhythms measured under standard light/dark conditions in rats
    • Craig L.A., Hong N.S., Kopp J., McDonald R.J. Cholinergic depletion of the medial septum followed by phase shifting does not impair memory or rest-activity rhythms measured under standard light/dark conditions in rats. Brain Res. Bull. 2009, 79(1):53-62.
    • (2009) Brain Res. Bull. , vol.79 , Issue.1 , pp. 53-62
    • Craig, L.A.1    Hong, N.S.2    Kopp, J.3    McDonald, R.J.4
  • 34
    • 55549083891 scopus 로고    scopus 로고
    • Reduced cholinergic status in hippocampus produces spatial memory deficits when combined with kainic acid induced seizures
    • Craig L.A., Hong N.S., Kopp J., McDonald R.J. Reduced cholinergic status in hippocampus produces spatial memory deficits when combined with kainic acid induced seizures. Hippocampus 2008, 18(11):1112-1121.
    • (2008) Hippocampus , vol.18 , Issue.11 , pp. 1112-1121
    • Craig, L.A.1    Hong, N.S.2    Kopp, J.3    McDonald, R.J.4
  • 35
    • 42549100781 scopus 로고    scopus 로고
    • Emergence of spatial impairment in rats following specific cholinergic depletion of the medial septum combined with chronic stress
    • Craig L.A., Hong N.S., Kopp J., McDonald R.J. Emergence of spatial impairment in rats following specific cholinergic depletion of the medial septum combined with chronic stress. Eur. J. Neurosci. 2008, 27:2262-2271.
    • (2008) Eur. J. Neurosci. , vol.27 , pp. 2262-2271
    • Craig, L.A.1    Hong, N.S.2    Kopp, J.3    McDonald, R.J.4
  • 36
    • 41449117426 scopus 로고    scopus 로고
    • Chronic disruption of circadian rhythms impairs hippocampal memory in the rat
    • 141,151
    • Craig L.A., McDonald R.J. Chronic disruption of circadian rhythms impairs hippocampal memory in the rat. Brain Res. Bull. 2008, 76(1-2). 141,151.
    • (2008) Brain Res. Bull. , vol.76 , Issue.1-2
    • Craig, L.A.1    McDonald, R.J.2
  • 39
    • 0011162190 scopus 로고
    • Selective loss of central cholinergic neurons in Alzheimer's disease
    • Davies P., Maloney A.J. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 1976, 8000:1403.
    • (1976) Lancet , vol.8000 , pp. 1403
    • Davies, P.1    Maloney, A.J.2
  • 41
    • 0036218738 scopus 로고    scopus 로고
    • Alzheimer disease as a vascular disorder: nosological evidence
    • de la Torre J.C. Alzheimer disease as a vascular disorder: nosological evidence. Stroke 2002, 33(4):1152-1162.
    • (2002) Stroke , vol.33 , Issue.4 , pp. 1152-1162
    • de la Torre, J.C.1
  • 44
    • 0015965912 scopus 로고
    • Human memory and the cholinergic system. A relationship to aging?
    • Drachman D.A., Leavitt J. Human memory and the cholinergic system. A relationship to aging?. Arch. Neurol. 1974, 30:113-121.
    • (1974) Arch. Neurol. , vol.30 , pp. 113-121
    • Drachman, D.A.1    Leavitt, J.2
  • 45
    • 0017652462 scopus 로고
    • Memory and cognitive function in man: does the cholinergic system have a specific role?
    • Drachman D.A. Memory and cognitive function in man: does the cholinergic system have a specific role?. Neurology 1977, 27:783-790.
    • (1977) Neurology , vol.27 , pp. 783-790
    • Drachman, D.A.1
  • 46
    • 53649089109 scopus 로고    scopus 로고
    • Enhanced cell death and learning deficits after a mini-stroke in aged hippocampus
    • Driscoll I., Hong N.S., Craig L.A., Sutherland R.J., McDonald R.J. Enhanced cell death and learning deficits after a mini-stroke in aged hippocampus. Neurobiol. Aging 2008, 29:1847-1858.
    • (2008) Neurobiol. Aging , vol.29 , pp. 1847-1858
    • Driscoll, I.1    Hong, N.S.2    Craig, L.A.3    Sutherland, R.J.4    McDonald, R.J.5
  • 49
    • 76549126343 scopus 로고    scopus 로고
    • Use of drugs with anticholinergic effect and impact on cognition in Parkinson's disease: a cohort study
    • Ehrt U., Broich K., Larsen J.P., Ballard C., Aarsland D. Use of drugs with anticholinergic effect and impact on cognition in Parkinson's disease: a cohort study. J. Neurol. Neurosurg. Psychiatry 2010, 81:160-165.
    • (2010) J. Neurol. Neurosurg. Psychiatry , vol.81 , pp. 160-165
    • Ehrt, U.1    Broich, K.2    Larsen, J.P.3    Ballard, C.4    Aarsland, D.5
  • 50
    • 0037436416 scopus 로고    scopus 로고
    • A Golgi-Cox morphological analysis of neuronal changes induced by environmental enrichment
    • Faherty C.J., Kerley D., Smeyne R.J. A Golgi-Cox morphological analysis of neuronal changes induced by environmental enrichment. Dev. Brain Res. 2003, 14:55-61.
    • (2003) Dev. Brain Res. , vol.14 , pp. 55-61
    • Faherty, C.J.1    Kerley, D.2    Smeyne, R.J.3
  • 52
    • 0030844888 scopus 로고    scopus 로고
    • Effects of cholinergic denervation on seizure development and neurotrophin messenger RNA regulation in rapid hippocampal kindling
    • Ferencz I., Kokaia M., Keep M., Elmer E., Metsis M., Kokaia Z., Lindvall O. Effects of cholinergic denervation on seizure development and neurotrophin messenger RNA regulation in rapid hippocampal kindling. Neuroscience 1997, 80:389-399.
    • (1997) Neuroscience , vol.80 , pp. 389-399
    • Ferencz, I.1    Kokaia, M.2    Keep, M.3    Elmer, E.4    Metsis, M.5    Kokaia, Z.6    Lindvall, O.7
  • 53
    • 0035109207 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat
    • Ferrer I., Krupinski J., Goutan E., Martí E., Ambrosio S., Arenas E. Brain-derived neurotrophic factor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat. Acta Neuropathol. 2001, 101:229-238.
    • (2001) Acta Neuropathol. , vol.101 , pp. 229-238
    • Ferrer, I.1    Krupinski, J.2    Goutan, E.3    Martí, E.4    Ambrosio, S.5    Arenas, E.6
  • 54
    • 0030713963 scopus 로고    scopus 로고
    • Genetics of aging
    • Finch T.E., Tanzi R.E. Genetics of aging. Science 1997, 278:407-411.
    • (1997) Science , vol.278 , pp. 407-411
    • Finch, T.E.1    Tanzi, R.E.2
  • 55
    • 0026567917 scopus 로고
    • Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging
    • Fischer W., Chen K.S., Gage F.H., Bjorklund A. Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging. Neurobiol. Aging 1991, 13:9-23.
    • (1991) Neurobiol. Aging , vol.13 , pp. 9-23
    • Fischer, W.1    Chen, K.S.2    Gage, F.H.3    Bjorklund, A.4
  • 56
    • 0033758338 scopus 로고    scopus 로고
    • Therapeutic strategies in Alzheimer's disease: M1 muscarinic agonists
    • Fisher A. Therapeutic strategies in Alzheimer's disease: M1 muscarinic agonists. Jpn. J. Pharm. 2000, 84(2):101-212.
    • (2000) Jpn. J. Pharm. , vol.84 , Issue.2 , pp. 101-212
    • Fisher, A.1
  • 58
    • 0035896367 scopus 로고    scopus 로고
    • Acute and chronic nicotine exposure reverse age-related declines in the induction of long-term potentiation in the rat hippocampus
    • Fujii S., Sumikawa K. Acute and chronic nicotine exposure reverse age-related declines in the induction of long-term potentiation in the rat hippocampus. Brain Res. 2001, 894:347-353.
    • (2001) Brain Res. , vol.894 , pp. 347-353
    • Fujii, S.1    Sumikawa, K.2
  • 59
    • 18044372996 scopus 로고    scopus 로고
    • Neuroprotective effect of donepezil, a nicotinic acetylcholine-receptor activator, on cerebral infarction in rats
    • Fujiki M., Kobayashi H., Uchida S., Inoue R., Ishii K. Neuroprotective effect of donepezil, a nicotinic acetylcholine-receptor activator, on cerebral infarction in rats. Brain Res. 2005, 1043:236-241.
    • (2005) Brain Res. , vol.1043 , pp. 236-241
    • Fujiki, M.1    Kobayashi, H.2    Uchida, S.3    Inoue, R.4    Ishii, K.5
  • 60
    • 41949104908 scopus 로고    scopus 로고
    • Cholinergic neuronal and axonal abnormalities are present early in aging and in Alzheimer disease
    • Geula C., Nagykery N., Nicholas A., Wu C.K. Cholinergic neuronal and axonal abnormalities are present early in aging and in Alzheimer disease. J. Neuropathol. Exp. Neurol. 2008, 67:309-318.
    • (2008) J. Neuropathol. Exp. Neurol. , vol.67 , pp. 309-318
    • Geula, C.1    Nagykery, N.2    Nicholas, A.3    Wu, C.K.4
  • 61
    • 0012871793 scopus 로고    scopus 로고
    • Effects of aging, ovariectomy, and long-term hormone replacement on cholinergic neurons in the medial septum and nucleus basalis magnocellularis
    • Gibbs R.B. Effects of aging, ovariectomy, and long-term hormone replacement on cholinergic neurons in the medial septum and nucleus basalis magnocellularis. J. Neuroendocrinol. 2003, 15:477-485.
    • (2003) J. Neuroendocrinol. , vol.15 , pp. 477-485
    • Gibbs, R.B.1
  • 62
    • 33947620292 scopus 로고    scopus 로고
    • Preclinical data relating to estrogen's effects on cognitive performance
    • University Press, Baltimore, N.L. Rasgon (Ed.)
    • Gibbs R. Preclinical data relating to estrogen's effects on cognitive performance. The Effects of Estrogen on Brain Function. The Johns Hopkins 2006, 9-45. University Press, Baltimore. N.L. Rasgon (Ed.).
    • (2006) The Effects of Estrogen on Brain Function. The Johns Hopkins , pp. 9-45
    • Gibbs, R.1
  • 63
    • 34547935982 scopus 로고    scopus 로고
    • Estradiol enhances DMP acquisition via a mechanism not mediated by turning strategy but which requires intact basal forebrain cholinergic projections
    • Gibbs R.B. Estradiol enhances DMP acquisition via a mechanism not mediated by turning strategy but which requires intact basal forebrain cholinergic projections. Horm. Behav. 2007, 52:352-359.
    • (2007) Horm. Behav. , vol.52 , pp. 352-359
    • Gibbs, R.B.1
  • 64
    • 67349142096 scopus 로고    scopus 로고
    • Donepezil treatment restores the ability of estradiol to enhance cognitive performance in aged rats: evidence for the cholinergic basis of the critical period hypothesis
    • Gibbs R.B., Gibbs R.B., Mauk R., Nelson D., Johnson D.A. Donepezil treatment restores the ability of estradiol to enhance cognitive performance in aged rats: evidence for the cholinergic basis of the critical period hypothesis. Horm. Behav. 2009, 56:73-83.
    • (2009) Horm. Behav. , vol.56 , pp. 73-83
    • Gibbs, R.B.1    Gibbs, R.B.2    Mauk, R.3    Nelson, D.4    Johnson, D.A.5
  • 65
    • 0033530073 scopus 로고    scopus 로고
    • Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease
    • Gilmore M.L., Erickson J.D., Varoqui H., Hersh L.B., Bennett D.A., Cochran E.J., Mufson E.J., Levey A.I. Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease. J. Comp. Neurol. 1999, 411(4):693-704.
    • (1999) J. Comp. Neurol. , vol.411 , Issue.4 , pp. 693-704
    • Gilmore, M.L.1    Erickson, J.D.2    Varoqui, H.3    Hersh, L.B.4    Bennett, D.A.5    Cochran, E.J.6    Mufson, E.J.7    Levey, A.I.8
  • 66
    • 33646707541 scopus 로고    scopus 로고
    • Chronic low-dose administration of nicotine facilitates recovery and synaptic change after focal ischemia in rats
    • Gonzalez C.L.R., Gharbawie O.A., Kolb B. Chronic low-dose administration of nicotine facilitates recovery and synaptic change after focal ischemia in rats. Neuropharmacology 2006, 50:777-787.
    • (2006) Neuropharmacology , vol.50 , pp. 777-787
    • Gonzalez, C.L.R.1    Gharbawie, O.A.2    Kolb, B.3
  • 67
    • 0032189954 scopus 로고    scopus 로고
    • Responses in the aged rat brain after total immunolesion
    • Gu Z., Yu J., Perez-Polo J.R. Responses in the aged rat brain after total immunolesion. J. Neurosci. Res. 1998, 54:7-16.
    • (1998) J. Neurosci. Res. , vol.54 , pp. 7-16
    • Gu, Z.1    Yu, J.2    Perez-Polo, J.R.3
  • 68
    • 0242384620 scopus 로고    scopus 로고
    • Differential effects of cholinergic lesions on dendritic spines in frontal cortex of young adult and aging rats
    • Harmon K.M., Wellman C.L. Differential effects of cholinergic lesions on dendritic spines in frontal cortex of young adult and aging rats. Brain Res. 2003, 992:60-68.
    • (2003) Brain Res. , vol.992 , pp. 60-68
    • Harmon, K.M.1    Wellman, C.L.2
  • 69
    • 2442502760 scopus 로고    scopus 로고
    • Disrupted daily activity/rest sessions in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementia
    • Hatfield C.F., Herbert J., van Someren E.J.W., Hodges J.R., Hastings M.H. Disrupted daily activity/rest sessions in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementia. Brain 2004, 127:1061-1074.
    • (2004) Brain , vol.127 , pp. 1061-1074
    • Hatfield, C.F.1    Herbert, J.2    van Someren, E.J.W.3    Hodges, J.R.4    Hastings, M.H.5
  • 70
    • 0022531202 scopus 로고
    • Seizures and myoclonus in patients with Alzheimer's disease
    • Hauser W.A., Morris M.L., Heston L.L., Anderson V.E. Seizures and myoclonus in patients with Alzheimer's disease. Neurology 1986, 36:1226-1230.
    • (1986) Neurology , vol.36 , pp. 1226-1230
    • Hauser, W.A.1    Morris, M.L.2    Heston, L.L.3    Anderson, V.E.4
  • 73
    • 0021145680 scopus 로고
    • Alzheimer's disease: cell-specific pathology isolates the hippocampal formation
    • Hyman B.T., Van Hoesen G.W., Damasio A.R., Barnes C.L. Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science 1984, 225:1168-1170.
    • (1984) Science , vol.225 , pp. 1168-1170
    • Hyman, B.T.1    Van Hoesen, G.W.2    Damasio, A.R.3    Barnes, C.L.4
  • 74
    • 0033914032 scopus 로고    scopus 로고
    • Long-term environmental enrichment leads to regional increases in neurotrophin levels in rat brain
    • Ickes B.R., Pham T.M., Sanders L.A., Albeck D.S., Mohammed A.H., Granholm A.C. Long-term environmental enrichment leads to regional increases in neurotrophin levels in rat brain. Exp. Neurol. 2000, 164:45-52.
    • (2000) Exp. Neurol. , vol.164 , pp. 45-52
    • Ickes, B.R.1    Pham, T.M.2    Sanders, L.A.3    Albeck, D.S.4    Mohammed, A.H.5    Granholm, A.C.6
  • 76
    • 0025064423 scopus 로고
    • Spatial learning is affected by transient occlusion of common carotid arteries (2VO): comparison of behavioural and histopathological changes after '2VO' and 'four-vessel-occlusion' in rats
    • Jaspers R.M.A., Block F., Heim C., Sontag K.H. Spatial learning is affected by transient occlusion of common carotid arteries (2VO): comparison of behavioural and histopathological changes after '2VO' and 'four-vessel-occlusion' in rats. Neurosci. Lett. 1990, 117:149-153.
    • (1990) Neurosci. Lett. , vol.117 , pp. 149-153
    • Jaspers, R.M.A.1    Block, F.2    Heim, C.3    Sontag, K.H.4
  • 77
    • 0034879826 scopus 로고    scopus 로고
    • Timing and location of nicotinic activity enhances or depresses hippocampal synaptic plasticity
    • Ji D., Lape R., Dani J.A. Timing and location of nicotinic activity enhances or depresses hippocampal synaptic plasticity. Neuron 2001, 31:131-141.
    • (2001) Neuron , vol.31 , pp. 131-141
    • Ji, D.1    Lape, R.2    Dani, J.A.3
  • 79
    • 0029937475 scopus 로고    scopus 로고
    • Persistence of CA1 hippocampal LTP after selective cholinergic denervation
    • Jouvenceau A., Billard J.M., Lamour Y., Dutar P. Persistence of CA1 hippocampal LTP after selective cholinergic denervation. Neuroreport 1996, 7:948-952.
    • (1996) Neuroreport , vol.7 , pp. 948-952
    • Jouvenceau, A.1    Billard, J.M.2    Lamour, Y.3    Dutar, P.4
  • 80
    • 0030961529 scopus 로고    scopus 로고
    • Potentiation of glutamatergic EPSPs in rat CA1 hippocampal neurons after selective cholinergic denervation by 192 IgG-Saporin
    • Jouvenceau A., Billard J.-M., Lamour Y., Dutar P. Potentiation of glutamatergic EPSPs in rat CA1 hippocampal neurons after selective cholinergic denervation by 192 IgG-Saporin. Synapse 1997, 26:292-300.
    • (1997) Synapse , vol.26 , pp. 292-300
    • Jouvenceau, A.1    Billard, J.-M.2    Lamour, Y.3    Dutar, P.4
  • 81
    • 0034727894 scopus 로고    scopus 로고
    • Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus
    • Kenny P.J., File S.E., Rattray M. Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus. Brain Res. Mol. Brain Res. 2000, 85:234-238.
    • (2000) Brain Res. Mol. Brain Res. , vol.85 , pp. 234-238
    • Kenny, P.J.1    File, S.E.2    Rattray, M.3
  • 82
    • 0032513387 scopus 로고    scopus 로고
    • Cortical map reorganization enabled by nucleus basalis activity
    • Kilgard M.P., Merzenich M.M. Cortical map reorganization enabled by nucleus basalis activity. Science 1998, 279:1714-1718.
    • (1998) Science , vol.279 , pp. 1714-1718
    • Kilgard, M.P.1    Merzenich, M.M.2
  • 83
    • 0026034172 scopus 로고
    • Relationship between brain damage and memory impairment in rats exposed to transient forebrain ischemia
    • Kiyota Y., Miyamoto M., Nagaoka A. Relationship between brain damage and memory impairment in rats exposed to transient forebrain ischemia. Brain. Res. 1991, 538:295-302.
    • (1991) Brain. Res. , vol.538 , pp. 295-302
    • Kiyota, Y.1    Miyamoto, M.2    Nagaoka, A.3
  • 84
    • 0029655587 scopus 로고    scopus 로고
    • Immunolesioning of basal forebrain cholinergic neurons facilitates hippocampal kindling and perturbs neurotrophin messenger RNA regulation
    • Kokaia M., Ferencz I., Leanza G., Elmer E., Metsis M., Kokaia Z., Wiley R.G., Lindvall O. Immunolesioning of basal forebrain cholinergic neurons facilitates hippocampal kindling and perturbs neurotrophin messenger RNA regulation. Neuroscience 1996, 70:313-327.
    • (1996) Neuroscience , vol.70 , pp. 313-327
    • Kokaia, M.1    Ferencz, I.2    Leanza, G.3    Elmer, E.4    Metsis, M.5    Kokaia, Z.6    Wiley, R.G.7    Lindvall, O.8
  • 86
    • 0026115614 scopus 로고
    • Environmental enrichment and cortical injury: behavioural and anatomical consequences of frontal cortex lesions
    • Kolb B., Gibb R. Environmental enrichment and cortical injury: behavioural and anatomical consequences of frontal cortex lesions. Cereb. Cortex 1991, 1:189-198.
    • (1991) Cereb. Cortex , vol.1 , pp. 189-198
    • Kolb, B.1    Gibb, R.2
  • 88
    • 0038472369 scopus 로고    scopus 로고
    • Role of the medial septum diagonal band of Broca cholinergic neurons in oestrogen-induced spine synapse formation on hippocampal CA1 pyramidal cells of female rats
    • Lam T.T, Leranth C. Role of the medial septum diagonal band of Broca cholinergic neurons in oestrogen-induced spine synapse formation on hippocampal CA1 pyramidal cells of female rats. Eur. J. Neurosci. 2003, 17:1997-2005.
    • (2003) Eur. J. Neurosci. , vol.17 , pp. 1997-2005
    • Lam, T.T.1    Leranth, C.2
  • 89
    • 33644800309 scopus 로고    scopus 로고
    • Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older
    • Larson E.B., Wang L., Bowen J.D., McCormick W.C., Teri L., Crane P., Kukull W. Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Ann. Intern. Med. 2006, 144:73-81.
    • (2006) Ann. Intern. Med. , vol.144 , pp. 73-81
    • Larson, E.B.1    Wang, L.2    Bowen, J.D.3    McCormick, W.C.4    Teri, L.5    Crane, P.6    Kukull, W.7
  • 90
    • 37149055595 scopus 로고    scopus 로고
    • Cholinesterase inhibitors in dementia: yes, no, or maybe?
    • Lemstra A.W., Richard E., van Gool W.A. Cholinesterase inhibitors in dementia: yes, no, or maybe?. Age Aging 2007, 36:625-627.
    • (2007) Age Aging , vol.36 , pp. 625-627
    • Lemstra, A.W.1    Richard, E.2    van Gool, W.A.3
  • 93
    • 0031741246 scopus 로고    scopus 로고
    • Nicotine prevents experimental parkinsonism in rodents and induces striatal increase of neurotrophic factors
    • Maggio R., Riva M., Vaglini F., Fornai F., Molteni R., Armogida M., Racagni G., Corsini G.U. Nicotine prevents experimental parkinsonism in rodents and induces striatal increase of neurotrophic factors. J. Neurochem. 1998, 71:2439-2446.
    • (1998) J. Neurochem. , vol.71 , pp. 2439-2446
    • Maggio, R.1    Riva, M.2    Vaglini, F.3    Fornai, F.4    Molteni, R.5    Armogida, M.6    Racagni, G.7    Corsini, G.U.8
  • 94
    • 0034671366 scopus 로고    scopus 로고
    • Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
    • Malberg J.E., Eisch A.J., Nestler E.J., Duman R.S. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci. 2000, 20:9104-9110.
    • (2000) J. Neurosci. , vol.20 , pp. 9104-9110
    • Malberg, J.E.1    Eisch, A.J.2    Nestler, E.J.3    Duman, R.S.4
  • 95
    • 0034042406 scopus 로고    scopus 로고
    • Synaptic plasticity and memory: An evaluation of the hypothesis
    • Martin S.J., Grimwood P.D., Morris R.G.M. Synaptic plasticity and memory: An evaluation of the hypothesis. Ann. Rev. Neurosci. 2000, 23:649-711.
    • (2000) Ann. Rev. Neurosci. , vol.23 , pp. 649-711
    • Martin, S.J.1    Grimwood, P.D.2    Morris, R.G.M.3
  • 97
    • 0033784185 scopus 로고    scopus 로고
    • Activation of nicotinic acetylcholine receptors induces long-term potentiation in vivo in the intact mouse dentate gyrus
    • Matsuyama S., Matsumoto A., Enomoto T., Nishizaki T. Activation of nicotinic acetylcholine receptors induces long-term potentiation in vivo in the intact mouse dentate gyrus. Eur. J. Neurosci. 2000, 12:3741-3747.
    • (2000) Eur. J. Neurosci. , vol.12 , pp. 3741-3747
    • Matsuyama, S.1    Matsumoto, A.2    Enomoto, T.3    Nishizaki, T.4
  • 98
    • 42049086996 scopus 로고    scopus 로고
    • Enhanced cell death in hippocampus and emergence of cognitive impairments following a localized mini-stroke in hippocampus if preceded by a previous episode of acute stress
    • McDonald R.J., Craig L.A., Hong N.S. Enhanced cell death in hippocampus and emergence of cognitive impairments following a localized mini-stroke in hippocampus if preceded by a previous episode of acute stress. Eur. J. Neurosci. 2008, 27:2197-2209.
    • (2008) Eur. J. Neurosci. , vol.27 , pp. 2197-2209
    • McDonald, R.J.1    Craig, L.A.2    Hong, N.S.3
  • 99
    • 0036729424 scopus 로고    scopus 로고
    • Multiple combinations of co-factors produce variants of age-related cognitive decline: a theory
    • McDonald R.J. Multiple combinations of co-factors produce variants of age-related cognitive decline: a theory. Can. J. Exp. Psychol. 2002, 56:221-339.
    • (2002) Can. J. Exp. Psychol. , vol.56 , pp. 221-339
    • McDonald, R.J.1
  • 100
    • 77955056492 scopus 로고    scopus 로고
    • The etiology of Alzheimer's disease is more complicated than we think
    • McDonald R.J., Craig L.A., Hong N.S. The etiology of Alzheimer's disease is more complicated than we think. Behav. Brain Res. 2010, 214:3-11.
    • (2010) Behav. Brain Res. , vol.214 , pp. 3-11
    • McDonald, R.J.1    Craig, L.A.2    Hong, N.S.3
  • 101
    • 0033796385 scopus 로고    scopus 로고
    • The role of cortical cholinergic afferent projections in cognition: impact of new selective immunotoxins
    • McGaughy J., Everitt B.J., Robbins T.W., Sarter M. The role of cortical cholinergic afferent projections in cognition: impact of new selective immunotoxins. Behav. Brain Res. 2000, 115:251-263.
    • (2000) Behav. Brain Res. , vol.115 , pp. 251-263
    • McGaughy, J.1    Everitt, B.J.2    Robbins, T.W.3    Sarter, M.4
  • 102
    • 0021246085 scopus 로고
    • Aging, Alzheimer's disease, and the cholinergic system of the basal forebrain
    • McGeer P.L., McGeer E.G., Suzuki J., Dolman C.E., Nagai T. Aging, Alzheimer's disease, and the cholinergic system of the basal forebrain. Neurology 1984, 34:741-746.
    • (1984) Neurology , vol.34 , pp. 741-746
    • McGeer, P.L.1    McGeer, E.G.2    Suzuki, J.3    Dolman, C.E.4    Nagai, T.5
  • 103
    • 0036543201 scopus 로고    scopus 로고
    • Nicotinic receptors and hippocampal synaptic plasticity... it's all in the timing
    • McGehee D.S. Nicotinic receptors and hippocampal synaptic plasticity... it's all in the timing. TINS 2002, 25:171-172.
    • (2002) TINS , vol.25 , pp. 171-172
    • McGehee, D.S.1
  • 104
    • 0033230623 scopus 로고    scopus 로고
    • Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles
    • Mesulam M. Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles. Neuron 1999, 24:521-529.
    • (1999) Neuron , vol.24 , pp. 521-529
    • Mesulam, M.1
  • 105
    • 0842304284 scopus 로고    scopus 로고
    • The cholinergic lesion of Alzheimer's disease: pivotal factor or side show?
    • Mesulam M. The cholinergic lesion of Alzheimer's disease: pivotal factor or side show?. Learn. Mem. 2004, 11:43-49.
    • (2004) Learn. Mem. , vol.11 , pp. 43-49
    • Mesulam, M.1
  • 106
    • 13844296729 scopus 로고    scopus 로고
    • Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning
    • Mohapel P., Leanza G., Kokaia M., Lindvall O. Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning. Neurobiol. Aging 2005, 26:939-946.
    • (2005) Neurobiol. Aging , vol.26 , pp. 939-946
    • Mohapel, P.1    Leanza, G.2    Kokaia, M.3    Lindvall, O.4
  • 107
    • 0035859851 scopus 로고    scopus 로고
    • A 1-year, placebo-controlled preservation of function survival study of donepezil in AD patients
    • " 312" Study Group
    • Mohs R.C., Doody R.S., Morris J.C., Ieni J.R., Rogers S.L., Perdomo C.A., Pratt R.D. A 1-year, placebo-controlled preservation of function survival study of donepezil in AD patients. Neurology 2001, 57:481-488. " 312" Study Group.
    • (2001) Neurology , vol.57 , pp. 481-488
    • Mohs, R.C.1    Doody, R.S.2    Morris, J.C.3    Ieni, J.R.4    Rogers, S.L.5    Perdomo, C.A.6    Pratt, R.D.7
  • 109
    • 34548801253 scopus 로고    scopus 로고
    • Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain
    • Mora F., Segovia G., del Arco A. Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain. Brain Res. Rev. 2007, 55:78-88.
    • (2007) Brain Res. Rev. , vol.55 , pp. 78-88
    • Mora, F.1    Segovia, G.2    del Arco, A.3
  • 110
    • 0035939099 scopus 로고    scopus 로고
    • Selective cholinergic denervation inhibits expression of long-term potentiation in the adult but not infant rat hippocampus
    • Motooka Y., Kondoh T., Nomura T., Tamaki N., Tozaki H., Kanno T., Nishizaki T. Selective cholinergic denervation inhibits expression of long-term potentiation in the adult but not infant rat hippocampus. Brain Res. Dev. Brain Res. 2001, 129:119-123.
    • (2001) Brain Res. Dev. Brain Res. , vol.129 , pp. 119-123
    • Motooka, Y.1    Kondoh, T.2    Nomura, T.3    Tamaki, N.4    Tozaki, H.5    Kanno, T.6    Nishizaki, T.7
  • 111
    • 33847376090 scopus 로고    scopus 로고
    • Acute intermittent nicotine treatment induces fibroblast growth factor-2 in the subventricular zone of the adult rat brain and enhances neuronal precursor cell proliferation
    • Mudo G., Belluardo N., Mauro A., Fuxe K. Acute intermittent nicotine treatment induces fibroblast growth factor-2 in the subventricular zone of the adult rat brain and enhances neuronal precursor cell proliferation. Neuroscience 2007, 145:470-483.
    • (2007) Neuroscience , vol.145 , pp. 470-483
    • Mudo, G.1    Belluardo, N.2    Mauro, A.3    Fuxe, K.4
  • 112
    • 34548672350 scopus 로고    scopus 로고
    • Cholinotrophic molecular substrates of mild cognitive impairment in the elderly
    • Mufson E.J., Counts S.E., Fahnestock M., Ginsberg S.D. Cholinotrophic molecular substrates of mild cognitive impairment in the elderly. Curr. Alzheimer Res. 2007, 4:340-350.
    • (2007) Curr. Alzheimer Res. , vol.4 , pp. 340-350
    • Mufson, E.J.1    Counts, S.E.2    Fahnestock, M.3    Ginsberg, S.D.4
  • 113
    • 0031938318 scopus 로고    scopus 로고
    • Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils
    • Nanri M., Yamamoto J., Miyake H., Watanabe H. Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils. Jpn. J. Pharm. 1998, 76(1):23-29.
    • (1998) Jpn. J. Pharm. , vol.76 , Issue.1 , pp. 23-29
    • Nanri, M.1    Yamamoto, J.2    Miyake, H.3    Watanabe, H.4
  • 115
    • 0033564083 scopus 로고    scopus 로고
    • Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory
    • Nilsson M., Perfilieva E., Johansson U., Orwar O., Eriksson P.S. Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory. J. Neurobiol. 1999, 39:569-578.
    • (1999) J. Neurobiol. , vol.39 , pp. 569-578
    • Nilsson, M.1    Perfilieva, E.2    Johansson, U.3    Orwar, O.4    Eriksson, P.S.5
  • 116
    • 0035251677 scopus 로고    scopus 로고
    • Nicotinic receptor abnormalities of Alzheimer's disease: therapeutic implications
    • Nordberg A. Nicotinic receptor abnormalities of Alzheimer's disease: therapeutic implications. Biol. Psychiatry 2001, 49(3):200-210.
    • (2001) Biol. Psychiatry , vol.49 , Issue.3 , pp. 200-210
    • Nordberg, A.1
  • 117
    • 0842347486 scopus 로고    scopus 로고
    • Septohippocampal acetylcholine: involved in but not necessary for learning and memory?
    • Parent M.B., Baxter M.G. Septohippocampal acetylcholine: involved in but not necessary for learning and memory?. Learn. Mem. 2004, 11:9-20.
    • (2004) Learn. Mem. , vol.11 , pp. 9-20
    • Parent, M.B.1    Baxter, M.G.2
  • 118
    • 0028834799 scopus 로고
    • Genetic susceptibility to Alzheimer's disease
    • Pericak-Vance M.A., Haines J.L. Genetic susceptibility to Alzheimer's disease. Trends Genet. 1995, 11:504-508.
    • (1995) Trends Genet. , vol.11 , pp. 504-508
    • Pericak-Vance, M.A.1    Haines, J.L.2
  • 119
  • 121
    • 0026635574 scopus 로고
    • Differential contributions of amygdala and hippocampus to cued and contextual fear conditioning
    • Phillips R.G., Ledoux J.E. Differential contributions of amygdala and hippocampus to cued and contextual fear conditioning. Behav. Neurosci. 1992, 106:274-285.
    • (1992) Behav. Neurosci. , vol.106 , pp. 274-285
    • Phillips, R.G.1    Ledoux, J.E.2
  • 122
    • 77954845470 scopus 로고    scopus 로고
    • Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines
    • Pop V., Head E., Hill M.A., Gillen D., Bechtold N.C., Muggenburg B.A., Milgram N.W., Murphy M.P., Cotman C.W. Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines. J. Neurosci. 2010, 30:9831-9839.
    • (2010) J. Neurosci. , vol.30 , pp. 9831-9839
    • Pop, V.1    Head, E.2    Hill, M.A.3    Gillen, D.4    Bechtold, N.C.5    Muggenburg, B.A.6    Milgram, N.W.7    Murphy, M.P.8    Cotman, C.W.9
  • 123
    • 0026355073 scopus 로고
    • Sleep problems and institutionalization of the elderly
    • Pollak C.P., Perlick D. Sleep problems and institutionalization of the elderly. J. Geriat. Psychiatry Neurol. 1991, 4:204-210.
    • (1991) J. Geriat. Psychiatry Neurol. , vol.4 , pp. 204-210
    • Pollak, C.P.1    Perlick, D.2
  • 124
    • 0037707696 scopus 로고    scopus 로고
    • Cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys
    • Resnick, S.M., Henderson
    • Rapp P.R., Morrison J.H., Roberts J.A. Cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys. J. Neurosci. 2003, 23(13):5708-5714. Resnick, S.M., Henderson.
    • (2003) J. Neurosci. , vol.23 , Issue.13 , pp. 5708-5714
    • Rapp, P.R.1    Morrison, J.H.2    Roberts, J.A.3
  • 125
    • 0029055175 scopus 로고
    • Oxidative processes and antioxidative defense mechanisms in the aging brain
    • Reiter R.J. Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB 1995, 9:526-533.
    • (1995) FASEB , vol.9 , pp. 526-533
    • Reiter, R.J.1
  • 126
    • 0037032405 scopus 로고    scopus 로고
    • Hormone therapy and risk of Alzheimer disease: a critical time
    • Resnick S.M., Henderson V.W. Hormone therapy and risk of Alzheimer disease: a critical time. JAMA 2002, 288(17):2170-2172.
    • (2002) JAMA , vol.288 , Issue.17 , pp. 2170-2172
    • Resnick, S.M.1    Henderson, V.W.2
  • 127
    • 17344364726 scopus 로고    scopus 로고
    • Neonatal treatment with 192 IgG SAPorin produces long-term forebrain cholinergic deficits and reduces branching and spine density of neocortical pyramidal neurons
    • Robertson R.T., Gallardo K.A., Clayton K.J., Ha D.H., Ku K.-H., Yu B.P., Lauterborn J.C., Wiley R.G., Yu J., Gall C.M., Leslie F.M. Neonatal treatment with 192 IgG SAPorin produces long-term forebrain cholinergic deficits and reduces branching and spine density of neocortical pyramidal neurons. Cereb. Cort. 1998, 8:142-155.
    • (1998) Cereb. Cort. , vol.8 , pp. 142-155
    • Robertson, R.T.1    Gallardo, K.A.2    Clayton, K.J.3    Ha, D.H.4    Ku, K.-H.5    Yu, B.P.6    Lauterborn, J.C.7    Wiley, R.G.8    Yu, J.9    Gall, C.M.10    Leslie, F.M.11
  • 128
    • 33846201154 scopus 로고    scopus 로고
    • Education and Alzheimer disease without dementia: support for the cognitive reserve hypothesis
    • Roe C.M., Xiong C., Miller J.P., Morris J.C. Education and Alzheimer disease without dementia: support for the cognitive reserve hypothesis. Neurology 2007, 68:223-228.
    • (2007) Neurology , vol.68 , pp. 223-228
    • Roe, C.M.1    Xiong, C.2    Miller, J.P.3    Morris, J.C.4
  • 129
    • 0024996068 scopus 로고
    • Advanced Alzheimer's disease is a risk factor for late-onset seizures
    • Romanelli M.F., Morris J.C., Ashkin K., Coben L.A. Advanced Alzheimer's disease is a risk factor for late-onset seizures. Arch. Neurol. 1990, 47:847-850.
    • (1990) Arch. Neurol. , vol.47 , pp. 847-850
    • Romanelli, M.F.1    Morris, J.C.2    Ashkin, K.3    Coben, L.A.4
  • 130
    • 0032871472 scopus 로고    scopus 로고
    • Glucocorticoids, stress, and their adverse neurological effects: relevance to aging
    • Sapolsky R.M. Glucocorticoids, stress, and their adverse neurological effects: relevance to aging. Exp. Gerontol. 1999, 34:721-732.
    • (1999) Exp. Gerontol. , vol.34 , pp. 721-732
    • Sapolsky, R.M.1
  • 131
    • 0033922730 scopus 로고    scopus 로고
    • Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert
    • Sassin I., Schultz C., Thal D.R., Rub U., Arai K., Braak E., Braak H. Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert. Acta Neuropathol. 2000, 100:259-269.
    • (2000) Acta Neuropathol. , vol.100 , pp. 259-269
    • Sassin, I.1    Schultz, C.2    Thal, D.R.3    Rub, U.4    Arai, K.5    Braak, E.6    Braak, H.7
  • 132
    • 1842575785 scopus 로고    scopus 로고
    • Effect of brain-derived neurotrophic factor treatment and forced arm use on functional motor recovery after small cortical ischemia
    • Schäbitz W.R., Berger C., Kollmar R., Seitz M., Tanay E., Kiessling M., Schwab S., Sommer C. Effect of brain-derived neurotrophic factor treatment and forced arm use on functional motor recovery after small cortical ischemia. Stroke 2004, 35:992-997.
    • (2004) Stroke , vol.35 , pp. 992-997
    • Schäbitz, W.R.1    Berger, C.2    Kollmar, R.3    Seitz, M.4    Tanay, E.5    Kiessling, M.6    Schwab, S.7    Sommer, C.8
  • 133
    • 35748959415 scopus 로고    scopus 로고
    • Mixed brain pathologies account for most dementia cases in community-dwelling older persons
    • Schneider J.A., Arvanitakis Z., Bang W., Bennett D.A. Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 2007, 69:2197-2204.
    • (2007) Neurology , vol.69 , pp. 2197-2204
    • Schneider, J.A.1    Arvanitakis, Z.2    Bang, W.3    Bennett, D.A.4
  • 134
    • 27744446263 scopus 로고    scopus 로고
    • Selective acetylcholine and dopamine lesions in neonatal rats produce distinct patterns of cortical dendritic atrophy in adulthood
    • Sherren N., Pappas B.A. Selective acetylcholine and dopamine lesions in neonatal rats produce distinct patterns of cortical dendritic atrophy in adulthood. Neuroscience 2005, 136:445-456.
    • (2005) Neuroscience , vol.136 , pp. 445-456
    • Sherren, N.1    Pappas, B.A.2
  • 135
    • 37549022692 scopus 로고    scopus 로고
    • Brain aging modulates the neuroprotective effects of estrogen on selective aspects of cognition in women: a critical review
    • Sherwin B.B., Henry J.F. Brain aging modulates the neuroprotective effects of estrogen on selective aspects of cognition in women: a critical review. Front. Neuroendocrinol. 2008, 29(1):88-113.
    • (2008) Front. Neuroendocrinol. , vol.29 , Issue.1 , pp. 88-113
    • Sherwin, B.B.1    Henry, J.F.2
  • 136
    • 33847189602 scopus 로고    scopus 로고
    • Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the alpha7 nicotinic acetylcholine receptor
    • Shin E.J., Chae J.S., Jung M.E., Bing G., Ko K.H., Kim W.K., Wie M.B., Cheon M.A., Nah S.Y., Kim H.C. Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the alpha7 nicotinic acetylcholine receptor. Epilepsy Res. 2007, 73:292-298.
    • (2007) Epilepsy Res. , vol.73 , pp. 292-298
    • Shin, E.J.1    Chae, J.S.2    Jung, M.E.3    Bing, G.4    Ko, K.H.5    Kim, W.K.6    Wie, M.B.7    Cheon, M.A.8    Nah, S.Y.9    Kim, H.C.10
  • 137
    • 0035868717 scopus 로고    scopus 로고
    • Neurogenesis in the adult is involved in the formation of trace memories
    • Shors T.J., Miesegaes G., Beylin A., Zhao M., Rydel T., Gould E. Neurogenesis in the adult is involved in the formation of trace memories. Nature 2001, 410:372-376.
    • (2001) Nature , vol.410 , pp. 372-376
    • Shors, T.J.1    Miesegaes, G.2    Beylin, A.3    Zhao, M.4    Rydel, T.5    Gould, E.6
  • 138
    • 0034730687 scopus 로고    scopus 로고
    • Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats
    • Silveira D.C., Holmes G.L., Schachter S.C., Geula C., Schomer D.L. Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats. Brain Res. 2000, 878:223-227.
    • (2000) Brain Res. , vol.878 , pp. 223-227
    • Silveira, D.C.1    Holmes, G.L.2    Schachter, S.C.3    Geula, C.4    Schomer, D.L.5
  • 141
    • 34250170146 scopus 로고    scopus 로고
    • Clinical significance of silent cerebral infarctions in patients with Alzheimer's disease
    • Song I.U., Kim J.S., Kim Y.I., Eah K.Y., Lee K.S. Clinical significance of silent cerebral infarctions in patients with Alzheimer's disease. Cogn. Behav. Neurol. 2007, 20:93-98.
    • (2007) Cogn. Behav. Neurol. , vol.20 , pp. 93-98
    • Song, I.U.1    Kim, J.S.2    Kim, Y.I.3    Eah, K.Y.4    Lee, K.S.5
  • 142
    • 33847666058 scopus 로고    scopus 로고
    • Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or Fluoxetine
    • Spanswick S.C., Epp J.R., Keith J.R., Sutherland R.J. Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or Fluoxetine. Hippocampus 2007, 17:137-146.
    • (2007) Hippocampus , vol.17 , pp. 137-146
    • Spanswick, S.C.1    Epp, J.R.2    Keith, J.R.3    Sutherland, R.J.4
  • 144
    • 33748096584 scopus 로고    scopus 로고
    • Cognitive reserve and Alzheimer's disease
    • Stern Y. Cognitive reserve and Alzheimer's disease. Alzheimer. Dis. Assoc. Disord. 2006, 20:112-117.
    • (2006) Alzheimer. Dis. Assoc. Disord. , vol.20 , pp. 112-117
    • Stern, Y.1
  • 145
    • 0031884981 scopus 로고    scopus 로고
    • A million dollar question: Does LTP=memory?
    • Stevens C.F. A million dollar question: Does LTP=memory?. Neuron 1998, 20:1-2.
    • (1998) Neuron , vol.20 , pp. 1-2
    • Stevens, C.F.1
  • 146
    • 0032707190 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus, cognitive impairment and dementia
    • Stewart R., Liolitsa D. Type 2 diabetes mellitus, cognitive impairment and dementia. Diabetic Med. 1999, 16:93-112.
    • (1999) Diabetic Med. , vol.16 , pp. 93-112
    • Stewart, R.1    Liolitsa, D.2
  • 147
    • 0020674881 scopus 로고
    • A behavioural analysis of spatial localization following electrolytic, kainate-or colchicine-induced damage to the hippocampal formation in the rat
    • Sutherland R.J., Whishaw I.Q., Kolb B. A behavioural analysis of spatial localization following electrolytic, kainate-or colchicine-induced damage to the hippocampal formation in the rat. Behav. Brain Res. 1983, 7:133-153.
    • (1983) Behav. Brain Res. , vol.7 , pp. 133-153
    • Sutherland, R.J.1    Whishaw, I.Q.2    Kolb, B.3
  • 148
    • 0029041350 scopus 로고
    • Effect of YM796, a novel muscarinic agonist, on the impairment of passive avoidance response in senescence-accelerated mice
    • Suzuki M., Yamaguchi T., Ozawa Y., Iwai A., Yamamoto M. Effect of YM796, a novel muscarinic agonist, on the impairment of passive avoidance response in senescence-accelerated mice. Pharmacol. Biochem. Behav. 1995, 51:623-626.
    • (1995) Pharmacol. Biochem. Behav. , vol.51 , pp. 623-626
    • Suzuki, M.1    Yamaguchi, T.2    Ozawa, Y.3    Iwai, A.4    Yamamoto, M.5
  • 149
    • 0029562079 scopus 로고
    • Effects of (-)-S-2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4,5]decane l-tartrate monohydrate (YM796), a novel muscarinic agonist, on disturbance of passive avoidance learning behaviour in drug-treated and senescence-accelerated mice
    • Suzuki M., Yamaguchi T., Ozawa Y., Ohyama M., Yamamoto M. Effects of (-)-S-2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4,5]decane l-tartrate monohydrate (YM796), a novel muscarinic agonist, on disturbance of passive avoidance learning behaviour in drug-treated and senescence-accelerated mice. J. Pharmacol. Exp. Ther. 1995, 275:728-736.
    • (1995) J. Pharmacol. Exp. Ther. , vol.275 , pp. 728-736
    • Suzuki, M.1    Yamaguchi, T.2    Ozawa, Y.3    Ohyama, M.4    Yamamoto, M.5
  • 150
    • 33746216297 scopus 로고    scopus 로고
    • Mechanisms of neuroprotection by estrogen
    • Suzuki S., Brown C.M., Wise P.M. Mechanisms of neuroprotection by estrogen. Endocrine 2006, 29:209-215.
    • (2006) Endocrine , vol.29 , pp. 209-215
    • Suzuki, S.1    Brown, C.M.2    Wise, P.M.3
  • 151
    • 0037622682 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons
    • Takada Y., Yonezawa A., Kume T., Katsuki H., Kaneko S., Sugimoto H., Akaike A. Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons. J. Pharmacol. Exp. Ther. 2003, 306:772-777.
    • (2003) J. Pharmacol. Exp. Ther. , vol.306 , pp. 772-777
    • Takada, Y.1    Yonezawa, A.2    Kume, T.3    Katsuki, H.4    Kaneko, S.5    Sugimoto, H.6    Akaike, A.7
  • 152
    • 24044490937 scopus 로고    scopus 로고
    • Neuroprotective effect of nicotine against 3-nitropropionic acid (3-NP)-induced experimental Huntington's disease in rats
    • Tariq M., Khan H.A., Elfaki I., Al Deeb S., Al Moutaery K. Neuroprotective effect of nicotine against 3-nitropropionic acid (3-NP)-induced experimental Huntington's disease in rats. Brain Res. Bull. 2005, 67:161-168.
    • (2005) Brain Res. Bull. , vol.67 , pp. 161-168
    • Tariq, M.1    Khan, H.A.2    Elfaki, I.3    Al Deeb, S.4    Al Moutaery, K.5
  • 153
    • 33644621626 scopus 로고    scopus 로고
    • Cognitive decline in severe intractable epilepsy
    • Thompson P.J., Duncan J.S. Cognitive decline in severe intractable epilepsy. Epilepsia 2005, 46:1780-1787.
    • (2005) Epilepsia , vol.46 , pp. 1780-1787
    • Thompson, P.J.1    Duncan, J.S.2
  • 154
    • 30644465969 scopus 로고    scopus 로고
    • Vascular remodeling versus beta-amyloid induced oxidative stress in the cerebrovascular dysfunctions associated with Alzheimer's disease
    • Tong X.K., Nicolakakis N., Kocharyan A., Hamel E. Vascular remodeling versus beta-amyloid induced oxidative stress in the cerebrovascular dysfunctions associated with Alzheimer's disease. J. Neurosci. 2005, 25:11165-11174.
    • (2005) J. Neurosci. , vol.25 , pp. 11165-11174
    • Tong, X.K.1    Nicolakakis, N.2    Kocharyan, A.3    Hamel, E.4
  • 155
    • 0023243990 scopus 로고
    • Age-related changes in circadian sleep-wakefulness rhythms in male rats isolated from time cues
    • van Gool W.A., Witting W., Mirmiran M. Age-related changes in circadian sleep-wakefulness rhythms in male rats isolated from time cues. Brain. Res. 1987, 413:384-387.
    • (1987) Brain. Res. , vol.413 , pp. 384-387
    • van Gool, W.A.1    Witting, W.2    Mirmiran, M.3
  • 156
    • 0033360314 scopus 로고    scopus 로고
    • Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
    • van Praag H., Kempermann G., Gage F.H. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci. 1999, 2:266-270.
    • (1999) Nat. Neurosci. , vol.2 , pp. 266-270
    • van Praag, H.1    Kempermann, G.2    Gage, F.H.3
  • 157
    • 9644270414 scopus 로고    scopus 로고
    • Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
    • Vaynman S., Ying Z., Gomez-Pinilla F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur. J. Neurosci. 2004, 20:2580-2590.
    • (2004) Eur. J. Neurosci. , vol.20 , pp. 2580-2590
    • Vaynman, S.1    Ying, Z.2    Gomez-Pinilla, F.3
  • 158
    • 0037756814 scopus 로고    scopus 로고
    • Chronic intermittent nicotine administration attenuates traumatic brain injury-induced cognitive dysfunction
    • Verbois S.L., Hopkins D.M., Scheff S.W., Pauly J.R. Chronic intermittent nicotine administration attenuates traumatic brain injury-induced cognitive dysfunction. Neuroscience 2003, 119:1199-1208.
    • (2003) Neuroscience , vol.119 , pp. 1199-1208
    • Verbois, S.L.1    Hopkins, D.M.2    Scheff, S.W.3    Pauly, J.R.4
  • 159
    • 0026510932 scopus 로고
    • Neurological and behavioural outcomes of focal ischemia in rats
    • Wahl F., Allix M., Plotkine M., Boulu R.G. Neurological and behavioural outcomes of focal ischemia in rats. Stroke 1992, 23:267-272.
    • (1992) Stroke , vol.23 , pp. 267-272
    • Wahl, F.1    Allix, M.2    Plotkine, M.3    Boulu, R.G.4
  • 160
    • 0028062912 scopus 로고
    • Characterization of a novel muscarinic receptor agonist, YM796: comparison with cholinesterase inhibitors in in vivo pharmacological studies
    • Wanibuchi F., Nishida T., Yamashita H., Hidaka K., Koshiya K., Tsukamoto S., Usuda S. Characterization of a novel muscarinic receptor agonist, YM796: comparison with cholinesterase inhibitors in in vivo pharmacological studies. Eur. J. Pharmacol. 1994, 265:151-158.
    • (1994) Eur. J. Pharmacol. , vol.265 , pp. 151-158
    • Wanibuchi, F.1    Nishida, T.2    Yamashita, H.3    Hidaka, K.4    Koshiya, K.5    Tsukamoto, S.6    Usuda, S.7
  • 161
    • 11144247377 scopus 로고    scopus 로고
    • Interaction between a rat model of cerebral ischemia and beta-amyloid toxicity: inflammatory responses
    • Whitehead S.N., Hachinski V.C., Cechetto D.F. Interaction between a rat model of cerebral ischemia and beta-amyloid toxicity: inflammatory responses. Stroke 2005, 36:107-112.
    • (2005) Stroke , vol.36 , pp. 107-112
    • Whitehead, S.N.1    Hachinski, V.C.2    Cechetto, D.F.3
  • 164
    • 33847032838 scopus 로고    scopus 로고
    • Acute effects of estrogen on neuronal physiology
    • Woolley C.S. Acute effects of estrogen on neuronal physiology. Annu. Rev. Pharmacol. Toxicol. 2007, 47:657-680.
    • (2007) Annu. Rev. Pharmacol. Toxicol. , vol.47 , pp. 657-680
    • Woolley, C.S.1
  • 165
    • 3042605164 scopus 로고    scopus 로고
    • Age-dependent effect of cholinergic lesion on dendritic morphology in rat frontal cortex
    • Works S.J., Wilson R.E., Wellman C.L. Age-dependent effect of cholinergic lesion on dendritic morphology in rat frontal cortex. Neurobiol. Aging 2004, 25:963-974.
    • (2004) Neurobiol. Aging , vol.25 , pp. 963-974
    • Works, S.J.1    Wilson, R.E.2    Wellman, C.L.3
  • 167
    • 0028887364 scopus 로고
    • YM796, a novel muscarinic agonist, improves the impairment of learning behaviour in a rat model of chronic focal cerebral ischemia
    • Yamaguchi T., Suzuki M., Yamamoto M. YM796, a novel muscarinic agonist, improves the impairment of learning behaviour in a rat model of chronic focal cerebral ischemia. Brain Res. 1995, 669:107-114.
    • (1995) Brain Res. , vol.669 , pp. 107-114
    • Yamaguchi, T.1    Suzuki, M.2    Yamamoto, M.3
  • 168
    • 0029563699 scopus 로고
    • Role of the cholinergic system in the regulation of neurotrophin synthesis
    • Yu J., Pizzo D.P., Hutton L.A., Perez-Polo J.R. Role of the cholinergic system in the regulation of neurotrophin synthesis. Brain Res. 1995, 705:247-252.
    • (1995) Brain Res. , vol.705 , pp. 247-252
    • Yu, J.1    Pizzo, D.P.2    Hutton, L.A.3    Perez-Polo, J.R.4
  • 169
    • 0030937773 scopus 로고    scopus 로고
    • Nicotine modulates the neurotoxic effect of beta-amyloid protein(25-35) in hippocampal cultures
    • Zamani M.R., Allen Y.S., Owen G.P., Gray J.A. Nicotine modulates the neurotoxic effect of beta-amyloid protein(25-35) in hippocampal cultures. Neuroreport 2001, 8:513-517.
    • (2001) Neuroreport , vol.8 , pp. 513-517
    • Zamani, M.R.1    Allen, Y.S.2    Owen, G.P.3    Gray, J.A.4
  • 170
    • 0037337815 scopus 로고    scopus 로고
    • Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases
    • Zarow C., Lyness S.A., Mortimer J.A., Chui H.C. Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases. Arch. Neurol. 2003, 60:337-341.
    • (2003) Arch. Neurol. , vol.60 , pp. 337-341
    • Zarow, C.1    Lyness, S.A.2    Mortimer, J.A.3    Chui, H.C.4
  • 171
    • 0031594779 scopus 로고    scopus 로고
    • Cholinergic depletion reduces plasticity of barrel field cortex
    • Zhu X.O., Waite P.M.E. Cholinergic depletion reduces plasticity of barrel field cortex. Cereb. Cort. 1998, 8:63-72.
    • (1998) Cereb. Cort. , vol.8 , pp. 63-72
    • Zhu, X.O.1    Waite, P.M.E.2


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