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Volumn 62, Issue 11, 2013, Pages 1653-1664

Recent advances in inflammatory bowel disease: Mucosal immune cells in intestinal inflammation

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; ANRUKINZUMAB; BASILIXIMAB; BRIAKINUMAB; BRODALUMAB; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CD14 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CERTOLIZUMAB PEGOL; CHEMOKINE RECEPTOR CX3CR1; DACLIZUMAB; ETROLIZUMAB; FONTOLIZUMAB; INFLIXIMAB; INTERLEUKIN 17; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 23 RECEPTOR; NATALIZUMAB; SECUKINUMAB; SOTRASTAURIN; TOCILIZUMAB; TRALOKINUMAB; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; USTEKINUMAB; VEDOLIZUMAB; VIDOFLUDIMUS; VISILIZUMAB;

EID: 84885658881     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2012-303955     Document Type: Article
Times cited : (288)

References (146)
  • 1
    • 79959271087 scopus 로고    scopus 로고
    • Intestinal homeostasis and its breakdown in inflammatory bowel disease
    • Maloy KJ, Powrie F. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature 2011;474:298-306.
    • (2011) Nature , vol.474 , pp. 298-306
    • Maloy, K.J.1    Powrie, F.2
  • 2
    • 1642463846 scopus 로고    scopus 로고
    • Evolution of the innate immune system: The worm perspective
    • DOI 10.1111/j.0105-2896.2004.0125.x
    • Schulenburg H, Kurz CL, Ewbank JJ. Evolution of the innate immune system: the worm perspective. Immunol Rev 2004;198:36-58. (Pubitemid 38406934)
    • (2004) Immunological Reviews , vol.198 , pp. 36-58
    • Schulenburg, H.1    Kurz, C.L.2    Ewbank, J.J.3
  • 3
    • 84862276328 scopus 로고    scopus 로고
    • Structure, function and diversity of the healthy human microbiome
    • The Human Microbiome Project Consortium
    • The Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 2012;486:207-14.
    • (2012) Nature , vol.486 , pp. 207-14
  • 4
    • 0030218844 scopus 로고    scopus 로고
    • Costimulation of the CD3 pathway by CD28 ligation in human intestinal lymphocytes
    • DOI 10.1006/cimm.1996.0195
    • Ebert EC, Roberts AI. Costimulation of the CD3 pathway by CD28 ligation in human intestinal lymphocytes. Cellular Immunol 1996;171:211-16. (Pubitemid 26268476)
    • (1996) Cellular Immunology , vol.171 , Issue.2 , pp. 211-216
    • Ebert, E.C.1    Roberts, A.I.2
  • 7
    • 84862748792 scopus 로고    scopus 로고
    • Dead on arrival: Understanding the failure of CTLA4-immunoglobulin therapy in inflammatory bowel disease
    • Mayer L, Kaser A, Blumberg RS. Dead on arrival: understanding the failure of CTLA4-immunoglobulin therapy in inflammatory bowel disease. Gastroenterology 2012;143:13-17.
    • (2012) Gastroenterology , vol.143 , pp. 13-17
    • Mayer, L.1    Kaser, A.2    Blumberg, R.S.3
  • 9
    • 32944466887 scopus 로고    scopus 로고
    • Ecological and evolutionary forces shaping microbial diversity in the human intestine
    • DOI 10.1016/j.cell.2006.02.017, PII S0092867406001929
    • Ley RE, Peterson DA, Gordon JI. Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 2006;124:837-48. (Pubitemid 43261456)
    • (2006) Cell , vol.124 , Issue.4 , pp. 837-848
    • Ley, R.E.1    Peterson, D.A.2    Gordon, J.I.3
  • 10
    • 11444258288 scopus 로고
    • Morphological and physiological characterization of germfree life
    • Gordon HA. Morphological and physiological characterization of germfree life. Ann N Y Acad Sci 1959;78:208-20.
    • (1959) Ann N y Acad Sci , vol.78 , pp. 208-20
    • Gordon, H.A.1
  • 11
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • Ivanov II, Atarashi K, Manel N, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009;139:485-98.
    • (2009) Cell , vol.139 , pp. 485-98
    • Ivanov, I.I.1    Atarashi, K.2    Manel, N.3
  • 12
    • 70349742524 scopus 로고    scopus 로고
    • The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses
    • Gaboriau-Routhiau V, Rakotobe S, Lecuyer E, et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 2009;31:677-89.
    • (2009) Immunity , vol.31 , pp. 677-89
    • Gaboriau-Routhiau, V.1    Rakotobe, S.2    Lecuyer, E.3
  • 13
    • 79952986650 scopus 로고    scopus 로고
    • RORgammat+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota
    • Sawa S, Lochner M, Satoh-Takayama N, et al. RORgammat+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota. Nat Immunol 2011;12:320-6.
    • (2011) Nat Immunol , vol.12 , pp. 320-6
    • Sawa, S.1    Lochner, M.2    Satoh-Takayama, N.3
  • 14
    • 84873691650 scopus 로고    scopus 로고
    • The Th17 Pathway and inflammatory diseases of the intestines, lungs, and skin
    • Weaver CT, Elson III CO, Fouser LA, et al. The Th17 Pathway and inflammatory diseases of the intestines, lungs, and skin. Annu Rev Pathol 2012;8:477-512.
    • (2012) Annu Rev Pathol , vol.8 , pp. 477-512
    • Weaver, C.T.1    Elson III, C.O.2    Fouser, L.A.3
  • 15
    • 84862637797 scopus 로고    scopus 로고
    • Gut immune maturation depends on colonization with a host-specific microbiota
    • Chung H, Pamp SJ, Hill JA, et al. Gut immune maturation depends on colonization with a host-specific microbiota. Cell 2012;149:1578-93.
    • (2012) Cell , vol.149 , pp. 1578-93
    • Chung, H.1    Pamp, S.J.2    Hill, J.A.3
  • 16
    • 84866146940 scopus 로고    scopus 로고
    • Diversity, stability and resilience of the human gut microbiota
    • Lozupone CA, Stombaugh JI, Gordon JI, et al. Diversity, stability and resilience of the human gut microbiota. Nature 2012;489:220-30.
    • (2012) Nature , vol.489 , pp. 220-30
    • Lozupone, C.A.1    Stombaugh, J.I.2    Gordon, J.I.3
  • 17
    • 78649270889 scopus 로고    scopus 로고
    • Environmental risk factors in inflammatory bowel diseases. Investigating the hygiene hypothesis: A Spanish case-control study
    • Lopez-Serrano P, Perez-Calle JL, Perez-Fernandez MT, et al. Environmental risk factors in inflammatory bowel diseases. Investigating the hygiene hypothesis: a Spanish case-control study. Scand J Gastroenterol 2010;45:1464-71.
    • (2010) Scand J Gastroenterol , vol.45 , pp. 1464-71
    • Lopez-Serrano, P.1    Perez-Calle, J.L.2    Perez-Fernandez, M.T.3
  • 18
    • 0037136537 scopus 로고    scopus 로고
    • The effect of infections on susceptibility to autoimmune and allergic diseases
    • Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 2002;347:911-20.
    • (2002) N Engl J Med , vol.347 , pp. 911-20
    • Bach, J.F.1
  • 19
    • 84860216630 scopus 로고    scopus 로고
    • Microbial exposure during early life has persistent effects on natural killer T cell function
    • Olszak T, An D, Zeissig S, et al. Microbial exposure during early life has persistent effects on natural killer T cell function. Science 2012;336:489-93.
    • (2012) Science , vol.336 , pp. 489-93
    • Olszak, T.1    An, D.2    Zeissig, S.3
  • 20
    • 84864739900 scopus 로고    scopus 로고
    • Turned on by danger: Activation of CD1d-restricted invariant natural killer T cells
    • Lawson V. Turned on by danger: activation of CD1d-restricted invariant natural killer T cells. Immunology 2012;137:20-7.
    • (2012) Immunology , vol.137 , pp. 20-7
    • Lawson, V.1
  • 22
    • 0036850908 scopus 로고    scopus 로고
    • Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells
    • DOI 10.1016/S1074-7613(02)00453-3
    • Heller F, Fuss IJ, Nieuwenhuis EE, et al. Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity 2002;17:629-38. (Pubitemid 35351508)
    • (2002) Immunity , vol.17 , Issue.5 , pp. 629-638
    • Heller, F.1    Fuss, I.J.2    Nieuwenhuis, E.E.3    Blumberg, R.S.4    Strober, W.5
  • 23
    • 79954486763 scopus 로고    scopus 로고
    • Regulatory T cells and Foxp3
    • Rudensky AY. Regulatory T cells and Foxp3. Immunol Rev 2011;241:260-8.
    • (2011) Immunol Rev , vol.241 , pp. 260-8
    • Rudensky, A.Y.1
  • 24
    • 85027947787 scopus 로고    scopus 로고
    • Induction of colonic regulatory T cells by indigenous Clostridium species
    • Atarashi K, Tanoue T, Shima T, et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 2011;331:337-41.
    • (2011) Science , vol.331 , pp. 337-41
    • Atarashi, K.1    Tanoue, T.2    Shima, T.3
  • 25
    • 83555163699 scopus 로고    scopus 로고
    • Consumption of probiotics increases the effect of regulatory T cells in transfer colitis
    • Petersen ER, Claesson MH, Schmidt EG, et al. Consumption of probiotics increases the effect of regulatory T cells in transfer colitis. Inflamm Bowel Dis 2012;18:131-42.
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 131-42
    • Petersen, E.R.1    Claesson, M.H.2    Schmidt, E.G.3
  • 26
    • 14844349149 scopus 로고    scopus 로고
    • Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-β-bearing regulatory cells
    • Di, Giacinto, Marinaro C, Sanchez M, et al. Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells. J Immunol 2005;174:3237-46. (Pubitemid 40354026)
    • (2005) Journal of Immunology , vol.174 , Issue.6 , pp. 3237-3246
    • Di Giacinto, C.1    Marinaro, M.2    Sanchez, M.3    Strober, W.4    Boirivant, M.5
  • 28
    • 55949124035 scopus 로고    scopus 로고
    • Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
    • Sokol H, Pigneur B, Watterlot L, et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci USA 2008;105:16731-6.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 16731-6
    • Sokol, H.1    Pigneur, B.2    Watterlot, L.3
  • 29
    • 80155164160 scopus 로고    scopus 로고
    • Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation
    • Li Y, Innocentin S, Withers DR, et al. Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. Cell 2011; 147:629-40.
    • (2011) Cell , vol.147 , pp. 629-40
    • Li, Y.1    Innocentin, S.2    Withers, D.R.3
  • 30
    • 83855160821 scopus 로고    scopus 로고
    • Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles
    • Kiss EA, Vonarbourg C, Kopfmann S, et al. Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science 2011;334:1561-5.
    • (2011) Science , vol.334 , pp. 1561-5
    • Kiss, E.A.1    Vonarbourg, C.2    Kopfmann, S.3
  • 31
    • 0025109036 scopus 로고
    • Developmentally regulated fetal thymic and extrathymic T-cell receptor gamma delta gene expression
    • Carding SR, Kyes S, Jenkinson EJ, et al. Developmentally regulated fetal thymic and extrathymic T-cell receptor gamma delta gene expression. Genes Dev 1990;4:1304-15.
    • (1990) Genes Dev , vol.4 , pp. 1304-15
    • Carding, S.R.1    Kyes, S.2    Jenkinson, E.J.3
  • 32
    • 84863436944 scopus 로고    scopus 로고
    • Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
    • Devkota S, Wang Y, Musch MW, et al. Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice. Nature 2012;487:104-8.
    • (2012) Nature , vol.487 , pp. 104-8
    • Devkota, S.1    Wang, Y.2    Musch, M.W.3
  • 33
    • 84864270714 scopus 로고    scopus 로고
    • ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
    • Hashimoto T, Perlot T, Rehman A, et al. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature 2012; 487:477-81.
    • (2012) Nature , vol.487 , pp. 477-81
    • Hashimoto, T.1    Perlot, T.2    Rehman, A.3
  • 35
    • 67651159312 scopus 로고    scopus 로고
    • Stem cells, self-renewal, and differentiation in the intestinal epithelium
    • van der Flier LG, Clevers H. Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol 2009;71:241-60.
    • (2009) Annu Rev Physiol , vol.71 , pp. 241-60
    • Van Der Flier, L.G.1    Clevers, H.2
  • 36
    • 82155175676 scopus 로고    scopus 로고
    • Composition and functional role of the mucus layers in the intestine
    • Johansson ME, Ambort D, Pelaseyed T, et al. Composition and functional role of the mucus layers in the intestine. Cell Mol Life Sci 2011;68:3635-41.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 3635-41
    • Johansson, M.E.1    Ambort, D.2    Pelaseyed, T.3
  • 37
    • 79952748335 scopus 로고    scopus 로고
    • The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions
    • Johansson ME, Larsson JM, Hansson GC. The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions. Proc Natl Acad Sci USA 2011;108(Suppl 1):4659-65.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.SUPPL. 1 , pp. 4659-65
    • Johansson, M.E.1    Larsson, J.M.2    Hansson, G.C.3
  • 39
    • 80054122238 scopus 로고    scopus 로고
    • The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine
    • Vaishnava S, Yamamoto M, Severson KM, et al. The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science 2011;334:255-8.
    • (2011) Science , vol.334 , pp. 255-8
    • Vaishnava, S.1    Yamamoto, M.2    Severson, K.M.3
  • 40
    • 0035527332 scopus 로고    scopus 로고
    • Altered mucin expression in the gastrointestinal tract: A review
    • Jass JR, Walsh MD. Altered mucin expression in the gastrointestinal tract: a review. J Cell Mol Med 2001;5:327-51.
    • (2001) J Cell Mol Med , vol.5 , pp. 327-51
    • Jass, J.R.1    Walsh, M.D.2
  • 41
  • 43
    • 41549092745 scopus 로고    scopus 로고
    • Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
    • Heazlewood CK, Cook MC, Eri R, et al. Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med 2008;5:e54.
    • (2008) PLoS Med , vol.5
    • Heazlewood, C.K.1    Cook, M.C.2    Eri, R.3
  • 45
    • 73949086150 scopus 로고    scopus 로고
    • Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection
    • Herbert DR, Yang JQ, Hogan SP, et al. Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. J Exp Med 2009; 206:2947-57.
    • (2009) J Exp Med , vol.206 , pp. 2947-57
    • Herbert, D.R.1    Yang, J.Q.2    Hogan, S.P.3
  • 46
    • 84863230541 scopus 로고    scopus 로고
    • Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine
    • McDole JR, Wheeler LW, McDonald KG, et al. Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature 2012;483:345-9.
    • (2012) Nature , vol.483 , pp. 345-9
    • McDole, J.R.1    Wheeler, L.W.2    McDonald, K.G.3
  • 48
    • 79954915318 scopus 로고    scopus 로고
    • Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
    • Bevins CL, Salzman NH. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat Rev Microbiol 2011;9:356-68.
    • (2011) Nat Rev Microbiol , vol.9 , pp. 356-68
    • Bevins, C.L.1    Salzman, N.H.2
  • 51
    • 35348932070 scopus 로고    scopus 로고
    • Intracellular NOD-like Receptors in Host Defense and Disease
    • DOI 10.1016/j.immuni.2007.10.002, PII S1074761307004554
    • Kanneganti TD, Lamkanfi M, Nunez G. Intracellular NOD-like receptors in host defense and disease. Immunity 2007;27:549-59. (Pubitemid 47615512)
    • (2007) Immunity , vol.27 , Issue.4 , pp. 549-559
    • Kanneganti, T.-D.1    Lamkanfi, M.2    Nunez, G.3
  • 52
    • 80052641505 scopus 로고    scopus 로고
    • Crohn's disease: NOD2, autophagy and ER stress converge
    • Fritz T, Niederreiter L, Adolph T, et al. Crohn's disease: NOD2, autophagy and ER stress converge. Gut 2011;60:1580-8.
    • (2011) Gut , vol.60 , pp. 1580-8
    • Fritz, T.1    Niederreiter, L.2    Adolph, T.3
  • 55
    • 77957047689 scopus 로고    scopus 로고
    • Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum
    • Biswas A, Liu YJ, Hao L, et al. Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum. Proc Natl Acad Sci USA 2010;107:14739-44.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 14739-44
    • Biswas, A.1    Liu, Y.J.2    Hao, L.3
  • 58
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008;132:27-42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 59
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell K, Liu JY, Brown SL, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008;456:259-63.
    • (2008) Nature , vol.456 , pp. 259-63
    • Cadwell, K.1    Liu, J.Y.2    Brown, S.L.3
  • 60
    • 77953904042 scopus 로고    scopus 로고
    • Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine
    • Cadwell K, Patel KK, Maloney NS, et al. Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell 2010;141:1135-45.
    • (2010) Cell , vol.141 , pp. 1135-45
    • Cadwell, K.1    Patel, K.K.2    Maloney, N.S.3
  • 61
    • 56249090667 scopus 로고    scopus 로고
    • Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
    • Saitoh T, Fujita N, Jang MH, et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 2008;456:264-8.
    • (2008) Nature , vol.456 , pp. 264-8
    • Saitoh, T.1    Fujita, N.2    Jang, M.H.3
  • 62
    • 73849121209 scopus 로고    scopus 로고
    • Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
    • Travassos LH, Carneiro LA, Ramjeet M, et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol 2010;11:55-62.
    • (2010) Nat Immunol , vol.11 , pp. 55-62
    • Travassos, L.H.1    Carneiro, L.A.2    Ramjeet, M.3
  • 63
    • 73849151394 scopus 로고    scopus 로고
    • NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
    • Cooney R, Baker J, Brain O, et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med 2010;16:90-7.
    • (2010) Nat Med , vol.16 , pp. 90-7
    • Cooney, R.1    Baker, J.2    Brain, O.3
  • 64
    • 79955555098 scopus 로고    scopus 로고
    • Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease
    • Kaser A, Blumberg RS. Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease. Gastroenterology 2011;140:1738-47.
    • (2011) Gastroenterology , vol.140 , pp. 1738-47
    • Kaser, A.1    Blumberg, R.S.2
  • 65
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • Barrett JC, Hansoul S, Nicolae DL, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008;40:955-62.
    • (2008) Nat Genet , vol.40 , pp. 955-62
    • Barrett, J.C.1    Hansoul, S.2    Nicolae, D.L.3
  • 66
    • 50249086073 scopus 로고    scopus 로고
    • XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
    • Kaser A, Lee AH, Franke A, et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 2008;134:743-56.
    • (2008) Cell , vol.134 , pp. 743-56
    • Kaser, A.1    Lee, A.H.2    Franke, A.3
  • 67
    • 33645140228 scopus 로고    scopus 로고
    • Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease
    • Zheng W, Rosenstiel P, Huse K, et al. Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease. Genes Immun 2006;7:11-8.
    • (2006) Genes Immun , vol.7 , pp. 11-8
    • Zheng, W.1    Rosenstiel, P.2    Huse, K.3
  • 68
    • 80052110662 scopus 로고    scopus 로고
    • Altered endoplasmic reticulum stress affects translation in inactive colon tissue from patients with ulcerative colitis
    • Treton X, Pedruzzi E, Cazals-Hatem D, et al. Altered endoplasmic reticulum stress affects translation in inactive colon tissue from patients with ulcerative colitis. Gastroenterology 2011;141:1024-35.
    • (2011) Gastroenterology , vol.141 , pp. 1024-35
    • Treton, X.1    Pedruzzi, E.2    Cazals-Hatem, D.3
  • 69
    • 74749103667 scopus 로고    scopus 로고
    • Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice
    • Zhao F, Edwards R, Dizon D, et al. Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice. Dev Biol 2010;338:270-9.
    • (2010) Dev Biol , vol.338 , pp. 270-9
    • Zhao, F.1    Edwards, R.2    Dizon, D.3
  • 70
    • 77952887297 scopus 로고    scopus 로고
    • Unravelling mononuclear phagocyte heterogeneity
    • Geissmann F, Gordon S, Hume DA, et al. Unravelling mononuclear phagocyte heterogeneity. Nat Rev Immunol 2010;10:453-60.
    • (2010) Nat Rev Immunol , vol.10 , pp. 453-60
    • Geissmann, F.1    Gordon, S.2    Hume, D.A.3
  • 73
    • 77949911050 scopus 로고    scopus 로고
    • Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions
    • Niess JH, Adler G. Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions. J Immunol 2010;184:2026-37.
    • (2010) J Immunol , vol.184 , pp. 2026-37
    • Niess, J.H.1    Adler, G.2
  • 74
    • 84055200171 scopus 로고    scopus 로고
    • CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice
    • Medina-Contreras O, Geem D, Laur O, et al. CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice. J Clin Invest 2011;121:4787-95.
    • (2011) J Clin Invest , vol.121 , pp. 4787-95
    • Medina-Contreras, O.1    Geem, D.2    Laur, O.3
  • 75
    • 84870900504 scopus 로고    scopus 로고
    • Ly6C(hi) monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells
    • Zigmond E, Varol C, Farache J, et al. Ly6C(hi) monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. Immunity 2012;37:1076-90.
    • (2012) Immunity , vol.37 , pp. 1076-90
    • Zigmond, E.1    Varol, C.2    Farache, J.3
  • 78
    • 34548764423 scopus 로고    scopus 로고
    • Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses
    • DOI 10.1038/ni1511, PII NI1511
    • Denning TL, Wang YC, Patel SR, et al. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 2007;8:1086-94. (Pubitemid 47423756)
    • (2007) Nature Immunology , vol.8 , Issue.10 , pp. 1086-1094
    • Denning, T.L.1    Wang, Y.-C.2    Patel, S.R.3    Williams, I.R.4    Pulendran, B.5
  • 80
    • 62949219864 scopus 로고    scopus 로고
    • Biological therapies for inflammatory bowel diseases
    • Rutgeerts P, Vermeire S, Van Assche G. Biological therapies for inflammatory bowel diseases. Gastroenterology 2009;136:1182-97.
    • (2009) Gastroenterology , vol.136 , pp. 1182-97
    • Rutgeerts, P.1    Vermeire, S.2    Van Assche, G.3
  • 81
    • 78650459480 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor-alpha antibodies induce regulatory macrophages in an Fc region-dependent manner
    • Vos AC, Wildenberg ME, Duijvestein M, et al. Anti-tumor necrosis factor-alpha antibodies induce regulatory macrophages in an Fc region-dependent manner. Gastroenterology 2011;140:221-30.
    • (2011) Gastroenterology , vol.140 , pp. 221-30
    • Vos, A.C.1    Wildenberg, M.E.2    Duijvestein, M.3
  • 84
    • 69449105914 scopus 로고    scopus 로고
    • Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease
    • Smith AM, Rahman FZ, Hayee B, et al. Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J Exp Med 2009;206:1883-97.
    • (2009) J Exp Med , vol.206 , pp. 1883-97
    • Smith, A.M.1    Rahman, F.Z.2    Hayee, B.3
  • 86
    • 33747089041 scopus 로고    scopus 로고
    • Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology
    • Uhlig HH, McKenzie BS, Hue S, et al. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 2006;25:309-18.
    • (2006) Immunity , vol.25 , pp. 309-18
    • Uhlig, H.H.1    McKenzie, B.S.2    Hue, S.3
  • 89
    • 81255160601 scopus 로고    scopus 로고
    • Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis
    • Hammer GE, Turer EE, Taylor KE, et al. Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol 2011;12:1184-93.
    • (2011) Nat Immunol , vol.12 , pp. 1184-93
    • Hammer, G.E.1    Turer, E.E.2    Taylor, K.E.3
  • 90
    • 77951934151 scopus 로고    scopus 로고
    • E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis
    • Siddiqui KR, Laffont S, Powrie F. E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. Immunity 2010;32:557-67.
    • (2010) Immunity , vol.32 , pp. 557-67
    • Siddiqui, K.R.1    Laffont, S.2    Powrie, F.3
  • 92
    • 84867856710 scopus 로고    scopus 로고
    • The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells
    • Powell N, Walker AW, Stolarczyk E, et al. The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells. Immunity 2012;37:674-84.
    • (2012) Immunity , vol.37 , pp. 674-84
    • Powell, N.1    Walker, A.W.2    Stolarczyk, E.3
  • 93
    • 77951878587 scopus 로고    scopus 로고
    • Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
    • Buonocore S, Ahern PP, Uhlig HH, et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 2010;464: 1371-5.
    • (2010) Nature , vol.464 , pp. 1371-5
    • Buonocore, S.1    Ahern, P.P.2    Uhlig, H.H.3
  • 94
    • 78751706261 scopus 로고    scopus 로고
    • CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut
    • Sonnenberg GF, Monticelli LA, Elloso MM, et al. CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity 2011;34:122-34.
    • (2011) Immunity , vol.34 , pp. 122-34
    • Sonnenberg, G.F.1    Monticelli, L.A.2    Elloso, M.M.3
  • 95
    • 84872977452 scopus 로고    scopus 로고
    • Innate lymphoid cells-A proposal for uniform nomenclature
    • Spits H, Artis D, Colonna M, et al. Innate lymphoid cells-a proposal for uniform nomenclature. Nat Rev Immunol 2013;13:145-9.
    • (2013) Nat Rev Immunol , vol.13 , pp. 145-9
    • Spits, H.1    Artis, D.2    Colonna, M.3
  • 97
    • 84859384082 scopus 로고    scopus 로고
    • Innate lymphoid cells: Emerging insights in development, lineage relationships, and function
    • Spits H, Cupedo T. Innate lymphoid cells: emerging insights in development, lineage relationships, and function. Annu Rev Immunol 2012;30:647-75.
    • (2012) Annu Rev Immunol , vol.30 , pp. 647-75
    • Spits, H.1    Cupedo, T.2
  • 98
    • 84873729246 scopus 로고    scopus 로고
    • A T-bet gradient controls the fate and function of CCR6-ROR[ggr]t+ innate lymphoid cells
    • Klose CSN, Kiss EA, Schwierzeck V, et al. A T-bet gradient controls the fate and function of CCR6-ROR[ggr]t+ innate lymphoid cells. Nature 2013;494:261-5.
    • (2013) Nature , vol.494 , pp. 261-5
    • Klose, C.S.N.1    Kiss, E.A.2    Schwierzeck, V.3
  • 99
    • 0346496018 scopus 로고    scopus 로고
    • An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells
    • DOI 10.1038/ni1022
    • Eberl G, Marmon S, Sunshine MJ, et al. An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol 2004;5:64-73. (Pubitemid 38081470)
    • (2004) Nature Immunology , vol.5 , Issue.1 , pp. 64-73
    • Eberl, G.1    Marmon, S.2    Sunshine, M.-J.3    Rennert, P.D.4    Choi, Y.5    Littmann, D.R.6
  • 101
    • 57849145994 scopus 로고    scopus 로고
    • Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin
    • Luci C, Reynders A, Ivanov II, et al. Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin. Nat Immunol 2009;10:75-82.
    • (2009) Nat Immunol , vol.10 , pp. 75-82
    • Luci, C.1    Reynders, A.2    Ivanov, I.I.3
  • 102
    • 57849117363 scopus 로고    scopus 로고
    • RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells
    • Sanos SL, Bui VL, Mortha A, et al. RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells. Nat Immunol 2009;10:83-91.
    • (2009) Nat Immunol , vol.10 , pp. 83-91
    • Sanos, S.L.1    Bui, V.L.2    Mortha, A.3
  • 103
    • 57449118239 scopus 로고    scopus 로고
    • Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense
    • Satoh-Takayama N, Vosshenrich CA, Lesjean-Pottier S, et al. Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity 2008;29:958-70.
    • (2008) Immunity , vol.29 , pp. 958-70
    • Satoh-Takayama, N.1    Vosshenrich, C.A.2    Lesjean-Pottier, S.3
  • 104
    • 79955030498 scopus 로고    scopus 로고
    • Border patrol: Regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22
    • Sonnenberg GF, Fouser LA, Artis D. Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nat Immunol 2011;12:383-90.
    • (2011) Nat Immunol , vol.12 , pp. 383-90
    • Sonnenberg, G.F.1    Fouser, L.A.2    Artis, D.3
  • 105
    • 57449090428 scopus 로고    scopus 로고
    • Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
    • Zenewicz LA, Yancopoulos GD, Valenzuela DM, et al. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 2008;29:947-57.
    • (2008) Immunity , vol.29 , pp. 947-57
    • Zenewicz, L.A.1    Yancopoulos, G.D.2    Valenzuela, D.M.3
  • 106
    • 78049385155 scopus 로고    scopus 로고
    • Lineage relationship analysis of RORgammat + innate lymphoid cells
    • Sawa S, Cherrier M, Lochner M, et al. Lineage relationship analysis of RORgammat + innate lymphoid cells. Science 2010;330:665-9.
    • (2010) Science , vol.330 , pp. 665-9
    • Sawa, S.1    Cherrier, M.2    Lochner, M.3
  • 107
    • 84861989207 scopus 로고    scopus 로고
    • Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria
    • Sonnenberg GF, Monticelli LA, Alenghat T, et al. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science 2012;336:1321-5.
    • (2012) Science , vol.336 , pp. 1321-5
    • Sonnenberg, G.F.1    Monticelli, L.A.2    Alenghat, T.3
  • 108
    • 78649360369 scopus 로고    scopus 로고
    • Regulated expression of nuclear receptor RORgammat confers distinct functional fates to NK cell receptor-expressing RORgammat(+) innate lymphocytes
    • Vonarbourg C, Mortha A, Bui VL, et al. Regulated expression of nuclear receptor RORgammat confers distinct functional fates to NK cell receptor-expressing RORgammat(+) innate lymphocytes. Immunity 2010;33:736-51.
    • (2010) Immunity , vol.33 , pp. 736-51
    • Vonarbourg, C.1    Mortha, A.2    Bui, V.L.3
  • 109
    • 79958277385 scopus 로고    scopus 로고
    • IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease
    • Geremia A, Arancibia-Carcamo CV, Fleming MP, et al. IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease. J Exp Med 2011;208:1127-33.
    • (2011) J Exp Med , vol.208 , pp. 1127-33
    • Geremia, A.1    Arancibia-Carcamo, C.V.2    Fleming, M.P.3
  • 110
    • 77956190936 scopus 로고    scopus 로고
    • Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease
    • 92e1-3
    • Takayama T, Kamada N, Chinen H, et al. Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease. Gastroenterology 2010;139:882-92, 92e1-3.
    • (2010) Gastroenterology , vol.139 , pp. 882-92
    • Takayama, T.1    Kamada, N.2    Chinen, H.3
  • 112
    • 84868336049 scopus 로고    scopus 로고
    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • Jostins L, Ripke S, Weersma RK, et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 2012;491:119-24.
    • (2012) Nature , vol.491 , pp. 119-24
    • Jostins, L.1    Ripke, S.2    Weersma, R.K.3
  • 113
    • 79959335758 scopus 로고    scopus 로고
    • Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses
    • Sarin R, Wu X, Abraham C. Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses. Proc Natl Acad Sci USA 2011;108:9560-5.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 9560-5
    • Sarin, R.1    Wu, X.2    Abraham, C.3
  • 114
    • 77957831207 scopus 로고    scopus 로고
    • Innate lymphocytes induce inflammatory bowel disease
    • Diefenbach A, Vonarbourg C. Innate lymphocytes induce inflammatory bowel disease. Immunol Cell Biol 2010;88:694-6.
    • (2010) Immunol Cell Biol , vol.88 , pp. 694-6
    • Diefenbach, A.1    Vonarbourg, C.2
  • 115
    • 18844455031 scopus 로고    scopus 로고
    • Inducible lymphoid tissues in the adult gut: Recapitulation of a fetal developmental pathway?
    • DOI 10.1038/nri1600
    • Eberl G. Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway? Nat Rev Immunol 2005;5:413-20. (Pubitemid 40685990)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.5 , pp. 413-420
    • Eberl, G.1
  • 116
    • 75749122181 scopus 로고    scopus 로고
    • Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    • Moro K, Yamada T, Tanabe M, et al. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature 2010;463:540-4.
    • (2010) Nature , vol.463 , pp. 540-4
    • Moro, K.1    Yamada, T.2    Tanabe, M.3
  • 117
    • 77951817855 scopus 로고    scopus 로고
    • Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
    • Neill DR, Wong SH, Bellosi A, et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 2010;464:1367-70.
    • (2010) Nature , vol.464 , pp. 1367-70
    • Neill, D.R.1    Wong, S.H.2    Bellosi, A.3
  • 118
    • 77954926597 scopus 로고    scopus 로고
    • Systemically dispersed innate IL-13-expressing cells in type 2 immunity
    • Price AE, Liang HE, Sullivan BM, et al. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci USA 2010;107:11489-94.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 11489-94
    • Price, A.E.1    Liang, H.E.2    Sullivan, B.M.3
  • 119
    • 33748059226 scopus 로고    scopus 로고
    • Immunology. Unraveling gut inflammation
    • Strober W. Immunology. Unraveling gut inflammation. Science 2006;313:1052-4.
    • (2006) Science , vol.313 , pp. 1052-4
    • Strober, W.1
  • 120
    • 84866436436 scopus 로고    scopus 로고
    • Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses
    • Hand TW, Dos Santos, Bouladoux LM, et al. Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses. Science 2012;337:1553-6.
    • (2012) Science , vol.337 , pp. 1553-6
    • Hand, T.W.1    Santos, D.2    Bouladoux, L.M.3
  • 121
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • Neurath MF, Fuss I, Kelsall BL, et al. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 1995;182:1281-90.
    • (1995) J Exp Med , vol.182 , pp. 1281-90
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3
  • 122
    • 84871701834 scopus 로고    scopus 로고
    • Ustekinumab induction and maintenance therapy in refractory Crohn's disease
    • Sandborn WJ, Gasink C, Gao LL, et al. Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N Engl J Med 2012;367:1519-28.
    • (2012) N Engl J Med , vol.367 , pp. 1519-28
    • Sandborn, W.J.1    Gasink, C.2    Gao, L.L.3
  • 124
    • 73949092345 scopus 로고    scopus 로고
    • Fontolizumab in moderate to severe Crohn's disease: A phase 2, randomized, double-blind, placebo-controlled, multiple-dose study
    • Reinisch W, de Villiers W, Bene L, et al. Fontolizumab in moderate to severe Crohn's disease: a phase 2, randomized, double-blind, placebo-controlled, multiple-dose study. Inflamm Bowel Dis 2010;16:233-42.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 233-42
    • Reinisch, W.1    De Villiers, W.2    Bene, L.3
  • 126
    • 77955890952 scopus 로고    scopus 로고
    • Interleukin-23 drives intestinal inflammation through direct activity on T cells
    • Ahern PP, Schiering C, Buonocore S, et al. Interleukin-23 drives intestinal inflammation through direct activity on T cells. Immunity 2010;33:279-88.
    • (2010) Immunity , vol.33 , pp. 279-88
    • Ahern, P.P.1    Schiering, C.2    Buonocore, S.3
  • 127
    • 63449133361 scopus 로고    scopus 로고
    • Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation
    • Kleinschek MA, Boniface K, Sadekova S, et al. Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation. J Exp Med 2009;206:525-34.
    • (2009) J Exp Med , vol.206 , pp. 525-34
    • Kleinschek, M.A.1    Boniface, K.2    Sadekova, S.3
  • 128
    • 0842324613 scopus 로고    scopus 로고
    • Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
    • DOI 10.1016/j.clim.2003.09.013
    • Ogawa A, Andoh A, Araki Y, et al. Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clin Immunol 2004;110:55-62. (Pubitemid 38177420)
    • (2004) Clinical Immunology , vol.110 , Issue.1 , pp. 55-62
    • Ogawa, A.1    Andoh, A.2    Araki, Y.3    Bamba, T.4    Fujiyama, Y.5
  • 130
    • 65749091607 scopus 로고    scopus 로고
    • A protective function for interleukin 17A in T cell-mediated intestinal inflammation
    • O'Connor W Jr, Kamanaka M, Booth CJ, et al. A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol 2009;10:603-9.
    • (2009) Nat Immunol , vol.10 , pp. 603-9
    • O'Connor Jr., W.1    Kamanaka, M.2    Booth, C.J.3
  • 131
    • 84868680312 scopus 로고    scopus 로고
    • Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: Unexpected results of a randomised, double-blind placebo-controlled trial
    • Hueber W, Sands BE, Lewitzky S, et al. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut 2012;61:1693-700.
    • (2012) Gut , vol.61 , pp. 1693-700
    • Hueber, W.1    Sands, B.E.2    Lewitzky, S.3
  • 132
    • 77958072084 scopus 로고    scopus 로고
    • Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis
    • Hueber W, Patel DD, Dryja T, et al. Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis. Sci Transl Med 2010;2:52ra72.
    • (2010) Sci Transl Med , vol.2
    • Hueber, W.1    Patel, D.D.2    Dryja, T.3
  • 133
    • 84859073115 scopus 로고    scopus 로고
    • Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis
    • Leonardi C, Matheson R, Zachariae C, et al. Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N Engl J Med 2012;366:1190-9.
    • (2012) N Engl J Med , vol.366 , pp. 1190-9
    • Leonardi, C.1    Matheson, R.2    Zachariae, C.3
  • 134
    • 41549169557 scopus 로고    scopus 로고
    • Contextual regulation of inflammation: A duet by transforming growth factor-β and interleukin-10
    • DOI 10.1016/j.immuni.2008.03.003, PII S1074761308001180
    • Li MO, Flavell RA. Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10. Immunity 2008;28:468-76. (Pubitemid 351467045)
    • (2008) Immunity , vol.28 , Issue.4 , pp. 468-476
    • Li, M.O.1    Flavell, R.A.2
  • 135
    • 62949223226 scopus 로고    scopus 로고
    • Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression
    • e1-3
    • Fantini MC, Rizzo A, Fina D, et al. Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression. Gastroenterology 2009;136:1308-16, e1-3.
    • (2009) Gastroenterology , vol.136 , pp. 1308-16
    • Fantini, M.C.1    Rizzo, A.2    Fina, D.3
  • 136
    • 77950349016 scopus 로고    scopus 로고
    • Th17 and regulatory T cells in mediating and restraining inflammation
    • Littman DR, Rudensky AY. Th17 and regulatory T cells in mediating and restraining inflammation. Cell 2010;140:845-58.
    • (2010) Cell , vol.140 , pp. 845-58
    • Littman, D.R.1    Rudensky, A.Y.2
  • 138
    • 84862741210 scopus 로고    scopus 로고
    • Basiliximab does not increase efficacy of corticosteroids in patients with steroid-refractory ulcerative colitis
    • Sands BE, Sandborn WJ, Creed TJ, et al. Basiliximab does not increase efficacy of corticosteroids in patients with steroid-refractory ulcerative colitis. Gastroenterology 2012;143:356-64.
    • (2012) Gastroenterology , vol.143 , pp. 356-64
    • Sands, B.E.1    Sandborn, W.J.2    Creed, T.J.3
  • 142
    • 84866754490 scopus 로고    scopus 로고
    • 943b Induction therapy for ulcerative colitis: Results of GEMINI I, a randomized, placebo-controlled, double-blind, multicenter Phase 3 trial
    • Feagan BG, Rutgeerts PJ, Sands BE, et al. 943b Induction therapy for ulcerative colitis: results of GEMINI I, a randomized, placebo-controlled, double-blind, multicenter Phase 3 trial. Gastroenterology 2012;142:S-160-S-1.
    • (2012) Gastroenterology , vol.142 , pp. 160-1
    • Feagan, B.G.1    Rutgeerts, P.J.2    Sands, B.E.3
  • 143
    • 77957867461 scopus 로고    scopus 로고
    • Genes and environment: How will our concepts on the pathophysiology of IBD develop in the future?
    • Kaser A, Zeissig S, Blumberg RS. Genes and environment: how will our concepts on the pathophysiology of IBD develop in the future? Dig Dis 2010;28: 395-405.
    • (2010) Dig Dis , vol.28 , pp. 395-405
    • Kaser, A.1    Zeissig, S.2    Blumberg, R.S.3
  • 144
    • 70949087383 scopus 로고    scopus 로고
    • Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
    • Glocker EO, Kotlarz D, Boztug K, et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med 2009;361:2033-45.
    • (2009) N Engl J Med , vol.361 , pp. 2033-45
    • Glocker, E.O.1    Kotlarz, D.2    Boztug, K.3
  • 145
    • 84865013186 scopus 로고    scopus 로고
    • Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis
    • Sandborn WJ, Ghosh S, Panes J, et al. Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis. N Engl J Med 2012;367:616-24.
    • (2012) N Engl J Med , vol.367 , pp. 616-24
    • Sandborn, W.J.1    Ghosh, S.2    Panes, J.3
  • 146
    • 84868689685 scopus 로고    scopus 로고
    • Seventeen in Crohn's disease: Less prime than we thought?
    • Raine T, Kaser A. Seventeen in Crohn's disease: less prime than we thought? Gut 2012;61:1653-4.
    • (2012) Gut , vol.61 , pp. 1653-4
    • Raine, T.1    Kaser, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.