Chitosan oligosaccharide as potential therapy of inflammatory bowel disease: Therapeutic efficacy and possible mechanisms of action

Pharmacological Research

Volumn 66, Issue 1, 2012, Pages 66-79

  Yousef, Mohammad ^a   Pichyangkura, Rath ^b   Soodvilai, Sunhapas ^a   Chatsudthipong, Varanuj ^a   Muanprasat, Chatchai ^a  

^a Mahidol University ^*  (Thailand)

^b CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

Apoptosis; Chitosan oligosaccharide; Inflammatory bowel disease; Intestinal epithelial cell; NF B

Indexed keywords

ACETIC ACID; ANTIINFLAMMATORY AGENT; CHITOSAN OLIGOSACCHARIDE; DEXTRAN SULFATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MYELOPEROXIDASE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACUTE DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL VIABILITY; CHRONIC DISEASE; COLITIS; COLON; COLON MUCOSA; CONTROLLED STUDY; DISEASE SEVERITY; DNA BINDING; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; ENZYME ACTIVITY; EPITHELIUM CELL; FLOW CYTOMETRY; LOW DRUG DOSE; MALE; MORTALITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

ACETIC ACID; ACUTE DISEASE; ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; CELL LINE; CHITOSAN; CHRONIC DISEASE; COLITIS; COLON; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GASTROINTESTINAL AGENTS; HUMANS; INFLAMMATION MEDIATORS; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-6; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED ICR; NF-KAPPA B; OXIDATIVE STRESS; PERMEABILITY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84860440603     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2012.03.013     Document Type: Article

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