Downregulation of CD147 by chitooligosaccharide inhibits MMP-2 expression and suppresses the metastatic potential of human gastric cancer

Oncology Letters

Volumn 8, Issue 1, 2014, Pages 361-366

  Luo, Zhiguo ^a   Dong, Xiaoxia ^a   Ke, Qing ^a   Duan, Qiwen ^a   Shen, Li ^a  

^a HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

CD147; Chitooligosaccharide; Gastric cancer; Metastasis; MMP 2

Indexed keywords

CD147 ANTIGEN; CHITOSE OLIGOSACCHARIDE; GELATINASE A; MESSENGER RNA; OLIGOSACCHARIDE; UNCLASSIFIED DRUG;

ARTICLE; BIOASSAY; CELL CULTURE; CELL INVASION; CELL MIGRATION ASSAY; CELL PROLIFERATION; DOWN REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; METASTASIS; METASTASIS INHIBITION; MTT ASSAY; PLASMID; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; STOMACH CANCER; WESTERN BLOTTING; WOUND HEALING ASSAY; ZYMOGRAPHY;

EID: 84901197522     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2014.2115     Document Type: Article

References (25)

1. Zheng L, Qi T, Yang D, et al: microRNA-9 suppresses the proliferation, invasion and metastasis of gastric cancer cells through targeting cyclin D1 and Ets1. PLoS One 8: e55719, 2013.
2. Mehlen P and Puisieux A: Metastasis: a question of life or death. Nat Rev Cancer 6: 449-458, 2006.
3. Nagase H, Visse R and Murphy G: Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res 69: 562-573, 2006.
4. Murray G, Duncan M, Arbuckle E, Melvin W and Fothergill J: Matrix metalloproteinases and their inhibitors in gastric cancer. Gut 43: 791-797, 1998.
5. Partyka R, Gonciarz M, Jalowiecki P, Kokocinska D and Byrczek T: VEGF and metalloproteinase 2 (MMP 2) expression in gastric cancer tissue. Med Sci Monit 18: BR130-BR134, 2012.
6. Zhou J, Zhu P, Jiang JL, et al: Involvement of CD147 in overexpression of MMP-2 and MMP-9 and enhancement of invasive potential of PMA-differentiated THP-1. BMC Cell Biol 6: 25, 2005.
7. Tang W, Chang SB and Hemler ME: Links between CD147 function, glycosylation, and caveolin-1. Mol Biol Cell 15: 4043-4050, 2004.
8. Jiang JL, Chan HC, Zhou Q, et al: HAb18G/CD147-mediated calcium mobilization and hepatoma metastasis require both C-terminal and N-terminal domains. Cell Mol Life Sci 61: 2083-2091, 2004.
9. Voigt H, Vetter-Kauczok CS, Schrama D, Hofmann UB, Becker JC and Houben R: CD147 impacts angiogenesis and metastasis formation. Cancer Invest 27: 329-333, 2009.
10. Zheng HC, Takahashi H, Murai Y, et al: Upregulated EMMPRIN/CD147 might contribute to growth and angiogenesis of gastric carcinoma: a good marker for local invasion and prognosis. Br J Cancer 95: 1371-1378, 2006.
11. Wang B, Xu YF, He BS, et al: RNAi-mediated silencing of CD147 inhibits tumor cell proliferation, invasion and increases chemosensitivity to cisplatin in SGC7901 cells in vitro. J Exp Clin Cancer Res 29: 61, 2010.
12. Li J, He J and Yu C: Chitosan oligosaccharide inhibits LPS-induced apoptosis of vascular endothelial cells through the BKCa channel and the p38 signaling pathway. Int J Mol Med 30: 157-164, 2012.
13. Lee JK, Lim HS and Kim JH: Cytotoxic activity of aminoderivatized cationic chitosan derivatives. Bioorg Med Chem Lett 12: 2949-2951, 2002.
14. Chen D, Wang Y, Zhang K, Jiao X, Yan B and Liang J: Antisense oligonucleotide against clusterin regulates human hepatocellular carcinoma invasion through transcriptional regulation of matrix metalloproteinase-2 and e-cadherin. Int J Mol Sci 13: 10594-10607, 2012.
15. Nam KS and Shon YH: Suppression of metastasis of human breast cancer cells by chitosan oligosaccharides. J Microbiol Biotechnol 19: 629-633, 2009.
16. Shen KT, Chen MH, Chan HY, Jeng JH and Wang YJ: Inhibitory effects of chitooligosaccharides on tumor growth and metastasis. Food Chem Toxicol 47: 1864-1871, 2009.
17. Karagozlu MZ, Kim JA, Karadeniz F, Kong CS and Kim SK: Anti-proliferative effect of aminoderivatized chitooligosaccharides on AGS human gastric cancer cells. Process Biochem 45: 1523-1528, 2010.
18. Rundhaug JE: Matrix metalloproteinases, angiogenesis, and cancer: commentary re: A. C. Lockhart et al., Reduction of wound angiogenesis in patients treated with BMS-275291, a broad spectrum matrix metalloproteinase inhibitor. Clin. Cancer Res., 9: 00-00, 2003. Clin Cancer Res 9: 551-554, 2003.
19. Kim MM and Kim SK: Chitooligosaccharides inhibit activation and expression of matrix metalloproteinase-2 in human dermal fibroblasts. FEBS Lett 580: 2661-2666, 2006.
20. Van Ta Q, Kim MM and Kim SK: Inhibitory effect of chitooligosaccharides on matrix metalloproteinase-9 in human fibrosarcoma cells (HT1080). Mar Biotechnol (NY) 8: 593-599, 2006.
21. Rajapakse N, Kim MM, Mendis E, Huang R and Kim SK: Carboxylated chitooligosaccharides (CCOS) inhibit MMP-9 expression in human fibrosarcoma cells via down-regulation of AP-1. Biochim Biophys Acta 1760: 1780-1788, 2006.
22. Omi Y, Shibata N, Okamoto T, Obara T and Kobayashi M: The role of CD147 in the invasiveness of follicular thyroid carcinoma cells. Thyroid 22: 383-394, 2012.
23. Huang W, Luo WJ, Zhu P, et al: Modulation of CD147-induced matrix metalloproteinase activity: role of CD147 N-glycosylation. Biochem J 449: 437-448, 2013.
24. Li R, Pan Y, He B, et al: Downregulation of CD147 expression by RNA interference inhibits HT29 cell proliferation, invasion and tumorigenicity in vitro and in vivo. Int J Oncol 43: 1885-1894, 2013.
25. Chen L, Pan Y, Gu L, et al: ERK1/2 signalling pathway is involved in CD147-mediated gastric cancer cell line SGC7901 proliferation and invasion. Exp Biol Med (Maywood) 238: 903-912, 2013.