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Volumn 2016, Issue , 2016, Pages

The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation

Author keywords

[No Author keywords available]

Indexed keywords

TOLL LIKE RECEPTOR 4; PATTERN RECOGNITION RECEPTOR;

EID: 84973330893     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2016/6978936     Document Type: Review
Times cited : (331)

References (102)
  • 1
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signaling
    • S. Akira and K. Takeda, "Toll-like receptor signaling," Nature Reviews Immunology, vol. 4, no. 7, pp. 1-16, 2004.
    • (2004) Nature Reviews Immunology , vol.4 , Issue.7 , pp. 1-16
    • Akira, S.1    Takeda, K.2
  • 2
    • 78649696296 scopus 로고    scopus 로고
    • Endogenous toll-like receptor ligands and their biological significance
    • L. Yu, L. Wang, and S. Chen, "Endogenous toll-like receptor ligands and their biological significance," Journal of Cellular and Molecular Medicine, vol. 14, no. 11, pp. 2592-2603, 2010.
    • (2010) Journal of Cellular and Molecular Medicine , vol.14 , Issue.11 , pp. 2592-2603
    • Yu, L.1    Wang, L.2    Chen, S.3
  • 4
    • 0032701642 scopus 로고    scopus 로고
    • Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium
    • S. Frantz, L. Kobzik, Y.-D. Kim et al., "Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium," The Journal of Clinical Investigation, vol. 104, no. 3,pp. 271-280, 1999.
    • (1999) The Journal of Clinical Investigation , vol.104 , Issue.3 , pp. 271-280
    • Frantz, S.1    Kobzik, L.2    Kim, Y.-D.3
  • 5
    • 33645322938 scopus 로고    scopus 로고
    • Toll-like receptors in CNS glial inflammation and homeostasis
    • T. Kielian, "Toll-like receptors in CNS glial inflammation and homeostasis," Journal of Neuroscience Research, vol. 83, no. 5, pp. 711-730, 2006.
    • (2006) Journal of Neuroscience Research , vol.83 , Issue.5 , pp. 711-730
    • Kielian, T.1
  • 6
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila toll protein signals activation of adaptive immunity
    • R. Medzhitov, P. Preston-Hurlburt, and C. A. Janeway Jr., "A human homologue of the Drosophila toll protein signals activation of adaptive immunity," Nature, vol. 388, no. 6640, pp. 394-397, 1997.
    • (1997) Nature , vol.388 , Issue.6640 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway, C.A.3
  • 7
    • 0036301797 scopus 로고    scopus 로고
    • Essential role of MD-2 in LPS responsiveness and TLR4 distribution
    • Y. Nagai, S. Akashi, M. Nagafuku et al., "Essential role of MD-2 in LPS responsiveness and TLR4 distribution," Nature Immunology, vol. 3, no. 7, pp. 667-672, 2002.
    • (2002) Nature Immunology , vol.3 , Issue.7 , pp. 667-672
    • Nagai, Y.1    Akashi, S.2    Nagafuku, M.3
  • 8
    • 0035796406 scopus 로고    scopus 로고
    • Molecular genetic analysis of an endotoxin nonresponder mutant cell line: A point mutation in a conserved region of MD-2 abolishes endotoxininduced signaling
    • A. B. Schromm, E. Lien, P. Henneke et al., "Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxininduced signaling," The Journal of Experimental Medicine, vol. 194, no. 1, pp. 79-88, 2001.
    • (2001) The Journal of Experimental Medicine , vol.194 , Issue.1 , pp. 79-88
    • Schromm, A.B.1    Lien, E.2    Henneke, P.3
  • 9
    • 0033532629 scopus 로고    scopus 로고
    • MD-2, a molecule that confers lipopolysaccharide responsiveness on toll-like receptor 4
    • R. Shimazu, S. Akashi, H. Ogata et al., "MD-2, a molecule that confers lipopolysaccharide responsiveness on toll-like receptor 4," Journal of Experimental Medicine, vol. 189, no. 11, pp. 1777-1782, 1999.
    • (1999) Journal of Experimental Medicine , vol.189 , Issue.11 , pp. 1777-1782
    • Shimazu, R.1    Akashi, S.2    Ogata, H.3
  • 11
    • 34548222514 scopus 로고    scopus 로고
    • Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist eritoran
    • H. M. Kim, B. S. Park, J.-I. Kim et al., "Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist eritoran," Cell, vol. 130, no. 5, pp. 906-917, 2007.
    • (2007) Cell , vol.130 , Issue.5 , pp. 906-917
    • Kim, H.M.1    Park, B.S.2    Kim, J.-I.3
  • 12
    • 67349182481 scopus 로고    scopus 로고
    • The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
    • B. S. Park, D. H. Song, H. M. Kim, B.-S. Choi, H. Lee, and J.-O. Lee, "The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex," Nature, vol. 458, no. 7242, pp. 1191-1195, 2009.
    • (2009) Nature , vol.458 , Issue.7242 , pp. 1191-1195
    • Park, B.S.1    Song, D.H.2    Kim, H.M.3    Choi, B.-S.4    Lee, H.5    Lee, J.-O.6
  • 14
    • 81055129630 scopus 로고    scopus 로고
    • CD14 controls the LPSinduced endocytosis of toll-like receptor 4
    • I.Zanoni, R. Ostuni, L. R. Marek et al., "CD14 controls the LPSinduced endocytosis of toll-like receptor 4," Cell, vol. 147, no. 4, pp. 868-880, 2011.
    • (2011) Cell , vol.147 , Issue.4 , pp. 868-880
    • Zanoni, I.1    Ostuni, R.2    Marek, L.R.3
  • 15
    • 0038242875 scopus 로고    scopus 로고
    • Toll-like receptor signaling pathways
    • G. M. Barton and R. Medzhitov, "Toll-like receptor signaling pathways," Science, vol. 300, no. 5625, pp. 1524-1525, 2003.
    • (2003) Science , vol.300 , Issue.5625 , pp. 1524-1525
    • Barton, G.M.1    Medzhitov, R.2
  • 17
    • 71749096218 scopus 로고    scopus 로고
    • MIR-146a is critical for endotoxin-induced tolerance: Implication in innate immunity
    • M. A. Nahid, K. M. Pauley, M. Satoh, and E. K. L. Chan, "miR-146a is critical for endotoxin-induced tolerance: implication in innate immunity," The Journal of Biological Chemistry, vol. 284, no. 50, pp. 34590-34599, 2009.
    • (2009) The Journal of Biological Chemistry , vol.284 , Issue.50 , pp. 34590-34599
    • Nahid, M.A.1    Pauley, K.M.2    Satoh, M.3    Chan, E.K.L.4
  • 18
    • 79952186298 scopus 로고    scopus 로고
    • MicroRNAs: The fine-tuners of Toll-like receptor signalling
    • L. A. O'Neill, F. J. Sheedy, and C. E. McCoy, "MicroRNAs: the fine-tuners of Toll-like receptor signalling," Nature Reviews Immunology, vol. 11, no. 3, pp. 163-175, 2011.
    • (2011) Nature Reviews Immunology , vol.11 , Issue.3 , pp. 163-175
    • O'Neill, L.A.1    Sheedy, F.J.2    McCoy, C.E.3
  • 19
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
    • A. Poltorak, X. He, I. Smirnova et al., "Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene," Science, vol. 282, no. 5396, pp. 2085-2088, 1998.
    • (1998) Science , vol.282 , Issue.5396 , pp. 2085-2088
    • Poltorak, A.1    He, X.2    Smirnova, I.3
  • 20
    • 0345561540 scopus 로고    scopus 로고
    • Endotoxintolerant mice have mutations in toll-like receptor 4 (Tlr4)
    • S. T. Qureshi, L. Larivière, G. Leveque et al., "Endotoxintolerant mice have mutations in toll-like receptor 4 (Tlr4)," Journal of Experimental Medicine, vol. 189, no. 4, pp. 615-625, 1999.
    • (1999) Journal of Experimental Medicine , vol.189 , Issue.4 , pp. 615-625
    • Qureshi, S.T.1    Larivière, L.2    Leveque, G.3
  • 21
    • 5944261457 scopus 로고    scopus 로고
    • Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
    • E. A.Kurt-Jones, L. Popova, L.Kwinn et al., "Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus," Nature Immunology, vol. 1, no. 5, pp. 398-401, 2000.
    • (2000) Nature Immunology , vol.1 , Issue.5 , pp. 398-401
    • Kurt-Jones, E.A.1    Popova, L.2    Kwinn, L.3
  • 22
    • 0037144610 scopus 로고    scopus 로고
    • Involvement of Toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers
    • T. H. Flo, L. Ryan, E. Latz et al., "Involvement of Toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers,"The Journal of Biological Chemistry, vol. 277, no. 38, pp. 35489-35495, 2002.
    • (2002) The Journal of Biological Chemistry , vol.277 , Issue.38 , pp. 35489-35495
    • Flo, T.H.1    Ryan, L.2    Latz, E.3
  • 23
    • 0035077556 scopus 로고    scopus 로고
    • Micrococcus luteus teichuronic acids activate human andmurinemonocytic cells in a CD14-and toll-like receptor 4-dependent manner
    • S. Yang, S. Sugawara, T. Monodane et al., "Micrococcus luteus teichuronic acids activate human andmurinemonocytic cells in a CD14-and toll-like receptor 4-dependent manner," Infection and Immunity, vol. 69, no. 4, pp. 2025-2030, 2001.
    • (2001) Infection and Immunity , vol.69 , Issue.4 , pp. 2025-2030
    • Yang, S.1    Sugawara, S.2    Monodane, T.3
  • 24
    • 33745305542 scopus 로고    scopus 로고
    • Analysis of TLR4 polymorphic variants: New insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling
    • P. Rallabhandi, J. Bell, M. S. Boukhvalova et al., "Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling," The Journal of Immunology, vol. 177, no. 1, pp. 322-332, 2006.
    • (2006) The Journal of Immunology , vol.177 , Issue.1 , pp. 322-332
    • Rallabhandi, P.1    Bell, J.2    Boukhvalova, M.S.3
  • 25
    • 0037087255 scopus 로고    scopus 로고
    • Toll-like receptor 4-MD-2 complex mediates the signal transduction induced by flavolipin, an amino acid-containing lipid unique to Flavobacterium meningosepticum
    • K. Gomi, K. Kawasaki, Y. Kawai, M. Shiozaki, and M. Nishijima, "Toll-like receptor 4-MD-2 complex mediates the signal transduction induced by flavolipin, an amino acid-containing lipid unique to Flavobacterium meningosepticum," The Journal of Immunology, vol. 168, no. 6, pp. 2939-2943, 2002.
    • (2002) The Journal of Immunology , vol.168 , Issue.6 , pp. 2939-2943
    • Gomi, K.1    Kawasaki, K.2    Kawai, Y.3    Shiozaki, M.4    Nishijima, M.5
  • 26
    • 79953163170 scopus 로고    scopus 로고
    • Immunity to fungal infections
    • L. Romani, "Immunity to fungal infections," Nature Reviews Immunology, vol. 11, no. 4, pp. 275-288, 2011.
    • (2011) Nature Reviews Immunology , vol.11 , Issue.4 , pp. 275-288
    • Romani, L.1
  • 27
    • 84941247956 scopus 로고    scopus 로고
    • Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cellmonolayer integrity
    • N. Modhiran, D. Watterson, D. A. Muller et al., "Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cellmonolayer integrity," Science Translational Medicine, vol. 7, no. 304,Article ID 304ra142, 2015.
    • (2015) Science Translational Medicine , vol.7 , Issue.304
    • Modhiran, N.1    Watterson, D.2    Muller, D.A.3
  • 28
    • 0034723186 scopus 로고    scopus 로고
    • Mouse toll-like receptor 4·MD-2 complex mediates lipopolysaccharide - Mimetic signal transduction by Taxol
    • K. Kawasaki, S. Akashi, R. Shimazu, T. Yoshida, K. Miyake, and M. Nishijima, "Mouse toll-like receptor 4·MD-2 complex mediates lipopolysaccharide - mimetic signal transduction by Taxol," The Journal of Biological Chemistry, vol. 275, no. 4, pp. 2251-2254, 2000.
    • (2000) The Journal of Biological Chemistry , vol.275 , Issue.4 , pp. 2251-2254
    • Kawasaki, K.1    Akashi, S.2    Shimazu, R.3    Yoshida, T.4    Miyake, K.5    Nishijima, M.6
  • 29
    • 0035399615 scopus 로고    scopus 로고
    • Diphosphoryl lipid A fromRhodobacter sphaeroides blocks the binding and internalization of lipopolysaccharide inRAW264.7 cells
    • G.D.Kutuzova, R.M. Albrecht,C.M.Erickson, andN.Qureshi, "Diphosphoryl lipid A fromRhodobacter sphaeroides blocks the binding and internalization of lipopolysaccharide inRAW264.7 cells," The Journal of Immunology, vol. 167, no. 1, pp. 482-489, 2001.
    • (2001) The Journal of Immunology , vol.167 , Issue.1 , pp. 482-489
    • Kutuzova, G.D.1    Albrecht, R.M.2    Erickson, C.M.3    Qureshi, N.4
  • 30
    • 33745041451 scopus 로고    scopus 로고
    • A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression
    • A. Macagno, M. Molteni, A. Rinaldi et al., "A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression," Journal of Experimental Medicine, vol. 203, no. 6, pp. 1481-1492, 2006.
    • (2006) Journal of Experimental Medicine , vol.203 , Issue.6 , pp. 1481-1492
    • Macagno, A.1    Molteni, M.2    Rinaldi, A.3
  • 31
    • 0037033364 scopus 로고    scopus 로고
    • Oligosaccharides of hyaluronan activate dendritic cells via toll-like receptor 4
    • C. Termeer, F. Benedix, J. Sleeman et al., "Oligosaccharides of hyaluronan activate dendritic cells via toll-like receptor 4," The Journal of Experimental Medicine, vol. 195, no. 1, pp. 99-111, 2002.
    • (2002) The Journal of Experimental Medicine , vol.195 , Issue.1 , pp. 99-111
    • Termeer, C.1    Benedix, F.2    Sleeman, J.3
  • 32
    • 23644456849 scopus 로고    scopus 로고
    • The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages
    • L. Schaefer, A. Babelova, E. Kiss et al., "The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages," The Journal of Clinical Investigation, vol. 115, no. 8, pp. 2223-2233, 2005.
    • (2005) The Journal of Clinical Investigation , vol.115 , Issue.8 , pp. 2223-2233
    • Schaefer, L.1    Babelova, A.2    Kiss, E.3
  • 33
    • 34548434800 scopus 로고    scopus 로고
    • The extra domain A of fibronectin stimulates murine mast cells via tolllike receptor 4
    • S. P. Gondokaryono, H. Ushio, F. Niyonsaba et al., "The extra domain A of fibronectin stimulates murine mast cells via tolllike receptor 4," Journal of Leukocyte Biology, vol. 82, no. 3, pp. 657-665, 2007.
    • (2007) Journal of Leukocyte Biology , vol.82 , Issue.3 , pp. 657-665
    • Gondokaryono, S.P.1    Ushio, H.2    Niyonsaba, F.3
  • 34
    • 0037094084 scopus 로고    scopus 로고
    • Receptormediated monitoring of tissue well-being via detection of soluble heparan sulfate by toll-like receptor 4
    • G. B. Johnson, G. J. Brunn, Y. Kodaira, and J. L. Platt, "Receptormediated monitoring of tissue well-being via detection of soluble heparan sulfate by toll-like receptor 4," Journal of Immunology, vol. 168, no. 10, pp. 5233-5239, 2002.
    • (2002) Journal of Immunology , vol.168 , Issue.10 , pp. 5233-5239
    • Johnson, G.B.1    Brunn, G.J.2    Kodaira, Y.3    Platt, J.L.4
  • 35
    • 67650502739 scopus 로고    scopus 로고
    • Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease
    • K. Midwood, S. Sacre, A. M. Piccinini et al., "Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease," Nature Medicine, vol. 15, no. 7, pp. 774-780, 2009.
    • (2009) Nature Medicine , vol.15 , Issue.7 , pp. 774-780
    • Midwood, K.1    Sacre, S.2    Piccinini, A.M.3
  • 36
    • 17144376810 scopus 로고    scopus 로고
    • High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal
    • M. T. Lotze and K. J. Tracey, "High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal," Nature Reviews Immunology, vol. 5, no. 4, pp. 331-342, 2005.
    • (2005) Nature Reviews Immunology , vol.5 , Issue.4 , pp. 331-342
    • Lotze, M.T.1    Tracey, K.J.2
  • 37
    • 33646882893 scopus 로고    scopus 로고
    • Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis
    • M. F. Roelofs, W. C. Boelens, L. A. B. Joosten et al., "Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis," Journal of Immunology, vol. 176, no. 11,pp. 7021-7027, 2006.
    • (2006) Journal of Immunology , vol.176 , Issue.11 , pp. 7021-7027
    • Roelofs, M.F.1    Boelens, W.C.2    Joosten, L.A.B.3
  • 38
    • 0034650427 scopus 로고    scopus 로고
    • Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
    • K. Ohashi, V. Burkart, S. Flohé, andH. Kolb, "Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex," The Journal of Immunology, vol. 164, no. 2, pp. 558-561, 2000.
    • (2000) The Journal of Immunology , vol.164 , Issue.2 , pp. 558-561
    • Ohashi, K.1    Burkart, V.2    Flohé, S.3    Kolb, H.4
  • 39
    • 0037177825 scopus 로고    scopus 로고
    • Novel signal transduction pathway utilized by extracellular HSP70: Role of toll-like receptor (TLR) 2 and TLR4
    • A.Asea, M. Rehli, E. Kabingu et al., "Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4," Journal of Biological Chemistry, vol. 277, no. 17, pp. 15028-15034, 2002.
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.17 , pp. 15028-15034
    • Asea, A.1    Rehli, M.2    Kabingu, E.3
  • 40
    • 38449110130 scopus 로고    scopus 로고
    • Hsp72 induces inflammation and regulates cytokine production in airway epithelium through a TLR4-and NF-κB-dependentmechanism
    • M. A. Chase, D. S. Wheeler, K. M. Lierl, V. S. Hughes, H. R. Wong, and K. Page, "Hsp72 induces inflammation and regulates cytokine production in airway epithelium through a TLR4-and NF-κB-dependentmechanism,"TheJournal of Immunology, vol. 179, no. 9, pp. 6318-6324, 2007.
    • (2007) TheJournal of Immunology , vol.179 , Issue.9 , pp. 6318-6324
    • Chase, M.A.1    Wheeler, D.S.2    Lierl, K.M.3    Hughes, V.S.4    Wong, H.R.5    Page, K.6
  • 41
    • 80052209288 scopus 로고    scopus 로고
    • Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response
    • H. Fang, Y. Wu, X. Huang et al., "Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response," The Journal of Biological Chemistry, vol. 286, no. 35, pp. 30393-30400, 2011.
    • (2011) The Journal of Biological Chemistry , vol.286 , Issue.35 , pp. 30393-30400
    • Fang, H.1    Wu, Y.2    Huang, X.3
  • 42
    • 0037036369 scopus 로고    scopus 로고
    • The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the toll-like receptor 2/4 pathway
    • R. M. Vabulas, S. Braedel, N. Hilf et al., "The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the toll-like receptor 2/4 pathway," Journal of Biological Chemistry, vol. 277, no. 23, pp. 20847-20853, 2002.
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.23 , pp. 20847-20853
    • Vabulas, R.M.1    Braedel, S.2    Hilf, N.3
  • 43
    • 84961159478 scopus 로고    scopus 로고
    • Calcineurin B stimulates cytokine production through a CD14-independent Toll-like receptor 4 pathway
    • W. Wu, Q. Chen, F. Geng et al., "Calcineurin B stimulates cytokine production through a CD14-independent Toll-like receptor 4 pathway," Immunology and Cell Biology, vol. 94, no. 3, pp. 285-292, 2015.
    • (2015) Immunology and Cell Biology , vol.94 , Issue.3 , pp. 285-292
    • Wu, W.1    Chen, Q.2    Geng, F.3
  • 44
    • 0036829687 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2
    • A. Biragyn, P. A. Ruffini, C. A. Leifer et al., "Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2," Science, vol. 298, no. 5595, pp. 1025-1029, 2002.
    • (2002) Science , vol.298 , Issue.5595 , pp. 1025-1029
    • Biragyn, A.1    Ruffini, P.A.2    Leifer, C.A.3
  • 45
    • 34948900275 scopus 로고    scopus 로고
    • Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
    • T. Vogl, K. Tenbrock, S. Ludwig et al., "Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock," Nature Medicine, vol. 13, no. 9, pp. 1042-1049, 2007.
    • (2007) Nature Medicine , vol.13 , Issue.9 , pp. 1042-1049
    • Vogl, T.1    Tenbrock, K.2    Ludwig, S.3
  • 46
    • 0037097672 scopus 로고    scopus 로고
    • Cutting edge: The immunostimulatory activity of the lung surfactant protein-A involves Tolllike receptor 4
    • L. Guillot, V. Balloy, F. X. McCormack, D. T. Golenbock, M. Chignard, and M. Si-Tahar, "Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Tolllike receptor 4,"The Journal of Immunology, vol. 168, no. 12, pp. 5989-5992, 2002.
    • (2002) The Journal of Immunology , vol.168 , Issue.12 , pp. 5989-5992
    • Guillot, L.1    Balloy, V.2    McCormack, F.X.3    Golenbock, D.T.4    Chignard, M.5    Si-Tahar, M.6
  • 48
    • 0035451118 scopus 로고    scopus 로고
    • Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4
    • S. T. Smiley, J. A. King, and W. W. Hancock, "Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4," Journal of Immunology, vol. 167, no. 5, pp. 2887-2894, 2001.
    • (2001) Journal of Immunology , vol.167 , Issue.5 , pp. 2887-2894
    • Smiley, S.T.1    King, J.A.2    Hancock, W.W.3
  • 49
    • 75649087741 scopus 로고    scopus 로고
    • CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
    • C. R. Stewart, L. M. Stuart, K. Wilkinson et al., "CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer," Nature Immunology, vol. 11, no. 2, pp. 155-161, 2010.
    • (2010) Nature Immunology , vol.11 , Issue.2 , pp. 155-161
    • Stewart, C.R.1    Stuart, L.M.2    Wilkinson, K.3
  • 50
    • 77954005130 scopus 로고    scopus 로고
    • Endogenous ligands of TLR2 and TLR4: Agonists or assistants?
    • C. Erridge, "Endogenous ligands of TLR2 and TLR4: agonists or assistants?" Journal of Leukocyte Biology, vol. 87, no. 6, pp. 989-999, 2010.
    • (2010) Journal of Leukocyte Biology , vol.87 , Issue.6 , pp. 989-999
    • Erridge, C.1
  • 51
    • 30744462300 scopus 로고    scopus 로고
    • Regulation of lung injury and repair by Toll-like receptors and hyaluronan
    • D. Jiang, J. Liang, J. Fan et al., "Regulation of lung injury and repair by Toll-like receptors and hyaluronan," Nature Medicine, vol. 11, no. 11, pp. 1173-1179, 2005.
    • (2005) Nature Medicine , vol.11 , Issue.11 , pp. 1173-1179
    • Jiang, D.1    Liang, J.2    Fan, J.3
  • 52
    • 40449097556 scopus 로고    scopus 로고
    • A vicious cycle involving release of heat shock protein 60 frominjured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS
    • S. Lehnardt, E. Schott, T. Trimbuch et al., "A vicious cycle involving release of heat shock protein 60 frominjured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS," The Journal of Neuroscience, vol. 28, no. 10, pp. 2320-2331, 2008.
    • (2008) The Journal of Neuroscience , vol.28 , Issue.10 , pp. 2320-2331
    • Lehnardt, S.1    Schott, E.2    Trimbuch, T.3
  • 54
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Tolllike receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
    • K. Hoshino, O. Takeuchi, T. Kawai et al., "Cutting edge: tolllike receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product," The Journal of Immunology, vol. 162, no. 7, pp. 3749-3752, 1999.
    • (1999) The Journal of Immunology , vol.162 , Issue.7 , pp. 3749-3752
    • Hoshino, K.1    Takeuchi, O.2    Kawai, T.3
  • 56
    • 0023690962 scopus 로고
    • Mouse genetic locus Lps influences susceptibility to Neisseria meningitidis infection
    • J. P. Woods, J. A. Frelinger, G. Warrack, and J. G. Cannon, "Mouse genetic locus Lps influences susceptibility to Neisseria meningitidis infection," Infection and Immunity, vol. 56, no. 8, pp. 1950-1955, 1988.
    • (1988) Infection and Immunity , vol.56 , Issue.8 , pp. 1950-1955
    • Woods, J.P.1    Frelinger, J.A.2    Warrack, G.3    Cannon, J.G.4
  • 58
    • 84862068459 scopus 로고    scopus 로고
    • Genetic variation in Toll-like receptors and disease susceptibility
    • M. G. Netea, C. Wijmenga, and L. A. J. O'Neill, "Genetic variation in Toll-like receptors and disease susceptibility," Nature Immunology, vol. 13, no. 6, pp. 535-542, 2012.
    • (2012) Nature Immunology , vol.13 , Issue.6 , pp. 535-542
    • Netea, M.G.1    Wijmenga, C.2    O'Neill, L.A.J.3
  • 59
    • 44649115688 scopus 로고    scopus 로고
    • Functional consequences of toll-like receptor 4 polymorphisms
    • B. Ferwerda, M. B. B. McCall, K. Verheijen et al., "Functional consequences of toll-like receptor 4 polymorphisms,"Molecular Medicine, vol. 14, no. 5-6, pp. 346-352, 2008.
    • (2008) Molecular Medicine , vol.14 , Issue.5-6 , pp. 346-352
    • Ferwerda, B.1    McCall, M.B.B.2    Verheijen, K.3
  • 60
    • 35349024974 scopus 로고    scopus 로고
    • Evidence for association between a Toll-like receptor 4 gene polymorphism and moderate/severe periodontitis in the Japanese population
    • T. Fukusaki, N. Ohara, Y. Hara,A. Yoshimura, and K. Yoshiura, "Evidence for association between a Toll-like receptor 4 gene polymorphism and moderate/severe periodontitis in the Japanese population," Journal of Periodontal Research, vol. 42, no. 6, pp. 541-545, 2007.
    • (2007) Journal of Periodontal Research , vol.42 , Issue.6 , pp. 541-545
    • Fukusaki, T.1    Ohara, N.2    Hara, Y.3    Yoshimura, A.4    Yoshiura, K.5
  • 61
    • 84902690881 scopus 로고    scopus 로고
    • The regulatory toll-like receptor 4 genetic polymorphism rs11536889 is associated with renal, coagulation and hepatic organ failure in sepsis patients
    • A. Mansur, L. von Gruben, A. F. Popov et al., "The regulatory toll-like receptor 4 genetic polymorphism rs11536889 is associated with renal, coagulation and hepatic organ failure in sepsis patients," Journal of Translational Medicine, vol. 12, no. 1, pp. 177-185, 2014.
    • (2014) Journal of Translational Medicine , vol.12 , Issue.1 , pp. 177-185
    • Mansur, A.1    Von Gruben, L.2    Popov, A.F.3
  • 62
    • 84864083454 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in 3'-untranslated region contributes to the regulation of toll-like receptor 4 translation
    • K. Sato, A. Yoshimura, T. Kaneko et al., "A single nucleotide polymorphism in 3'-untranslated region contributes to the regulation of toll-like receptor 4 translation," Journal of Biological Chemistry, vol. 287, no. 30, pp. 25163-25172, 2012.
    • (2012) Journal of Biological Chemistry , vol.287 , Issue.30 , pp. 25163-25172
    • Sato, K.1    Yoshimura, A.2    Kaneko, T.3
  • 63
    • 84875124740 scopus 로고    scopus 로고
    • Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: The ACCESS randomized trial
    • S.M.Opal, P. F. Laterre, B. Francois et al., "Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial," Journal of the American Medical Association, vol. 309, no. 11, pp. 1154-1162, 2013.
    • (2013) Journal of the American Medical Association , vol.309 , Issue.11 , pp. 1154-1162
    • Opal, S.M.1    Laterre, P.F.2    Francois, B.3
  • 64
    • 84897378109 scopus 로고    scopus 로고
    • The newnormal: Immunomodulatory agents against sepsis immune suppression
    • N. A. Hutchins, J. Unsinger, R. S. Hotchkiss, and A. Ayala, "The newnormal: immunomodulatory agents against sepsis immune suppression," Trends in Molecular Medicine, vol. 20, no. 4, pp. 224-233, 2014.
    • (2014) Trends in Molecular Medicine , vol.20 , Issue.4 , pp. 224-233
    • Hutchins, N.A.1    Unsinger, J.2    Hotchkiss, R.S.3    Ayala, A.4
  • 65
    • 51649111202 scopus 로고    scopus 로고
    • High-mobility group box-1 in ischemia-reperfusion injury of the heart
    • M. Andrassy, H. C. Volz, J. C. Igwe et al., "High-mobility group box-1 in ischemia-reperfusion injury of the heart," Circulation, vol. 117, no. 25, pp. 3216-3226, 2008.
    • (2008) Circulation , vol.117 , Issue.25 , pp. 3216-3226
    • Andrassy, M.1    Volz, H.C.2    Igwe, J.C.3
  • 66
    • 84861661391 scopus 로고    scopus 로고
    • The sterile immune response during hepatic ischemia/reperfusion
    • R. F. van Golen, T. M. van Gulik, and M. Heger, "The sterile immune response during hepatic ischemia/reperfusion," Cytokine and Growth Factor Reviews, vol. 23, no. 3, pp. 69-84, 2012.
    • (2012) Cytokine and Growth Factor Reviews , vol.23 , Issue.3 , pp. 69-84
    • Van Golen, R.F.1    Van Gulik, T.M.2    Heger, M.3
  • 68
    • 84896720425 scopus 로고    scopus 로고
    • Role of tolllike receptors in liver transplantation
    • J. Howell, P. Gow, P. Angus, and K. Visvanathan, "Role of tolllike receptors in liver transplantation," Liver Transplantation, vol. 20, no. 3, pp. 270-280, 2014.
    • (2014) Liver Transplantation , vol.20 , Issue.3 , pp. 270-280
    • Howell, J.1    Gow, P.2    Angus, P.3    Visvanathan, K.4
  • 69
    • 1242336786 scopus 로고    scopus 로고
    • Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice
    • J.-I. Oyama, C. Blais Jr., X. Liu et al., "Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice," Circulation, vol. 109, no. 6, pp. 784-789, 2004.
    • (2004) Circulation , vol.109 , Issue.6 , pp. 784-789
    • Oyama, J.-I.1    Blais, C.2    Liu, X.3
  • 70
    • 67649613033 scopus 로고    scopus 로고
    • Mechanisms of Toll-like receptor 4 (TLR4)-mediated inflammation after cold ischemia/reperfusion in the heart
    • D. J. Kaczorowski, A. Nakao, R. Vallabhaneni et al., "Mechanisms of Toll-like receptor 4 (TLR4)-mediated inflammation after cold ischemia/reperfusion in the heart," Transplantation, vol. 87, no. 10, pp. 1455-1463, 2009.
    • (2009) Transplantation , vol.87 , Issue.10 , pp. 1455-1463
    • Kaczorowski, D.J.1    Nakao, A.2    Vallabhaneni, R.3
  • 71
    • 20244373939 scopus 로고    scopus 로고
    • The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemiareperfusion
    • A. Tsung, R. Sahai, H. Tanaka et al., "The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemiareperfusion," Journal of Experimental Medicine, vol. 201, no. 7, pp. 1135-1143, 2005.
    • (2005) Journal of Experimental Medicine , vol.201 , Issue.7 , pp. 1135-1143
    • Tsung, A.1    Sahai, R.2    Tanaka, H.3
  • 72
    • 34247545017 scopus 로고    scopus 로고
    • Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke
    • J. R. Caso, J. M. Pradillo, O. Hurtado, P. Lorenzo, M. A. Moro, and I. Lizasoain, "Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke," Circulation, vol. 115, no. 12, pp. 1599-1608, 2007.
    • (2007) Circulation , vol.115 , Issue.12 , pp. 1599-1608
    • Caso, J.R.1    Pradillo, J.M.2    Hurtado, O.3    Lorenzo, P.4    Moro, M.A.5    Lizasoain, I.6
  • 73
    • 34948835806 scopus 로고    scopus 로고
    • TLR4 activationmediates kidney ischemia/reperfusion injury
    • H.Wu,G. Chen, K. R.Wyburn et al., "TLR4 activationmediates kidney ischemia/reperfusion injury," Journal of Clinical Investigation, vol. 117, no. 10, pp. 2847-2859, 2007.
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.10 , pp. 2847-2859
    • Wu, H.1    Chen, G.2    Wyburn, K.R.3
  • 74
    • 35448993875 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion
    • F. Hua, J. Ma, T. Ha et al., "Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion," Journal of Neuroimmunology, vol. 190, no. 1-2, pp. 101-111, 2007.
    • (2007) Journal of Neuroimmunology , vol.190 , Issue.1-2 , pp. 101-111
    • Hua, F.1    Ma, J.2    Ha, T.3
  • 76
    • 38449109334 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates the early inflammatory response after cold ischemia/reperfusion
    • D. J. Kaczorowski, A. Nakao, K. P. Mollen et al., "Toll-like receptor 4 mediates the early inflammatory response after cold ischemia/reperfusion," Transplantation, vol. 84,no. 10,pp. 1279-1287, 2007.
    • (2007) Transplantation , vol.84 , Issue.10 , pp. 1279-1287
    • Kaczorowski, D.J.1    Nakao, A.2    Mollen, K.P.3
  • 77
    • 33747178729 scopus 로고    scopus 로고
    • Inhibition of tolllike receptor 4 with eritoran attenuates myocardial ischemiareperfusion injury
    • A. Shimamoto, A. J. Chong, M. Yada et al., "Inhibition of tolllike receptor 4 with eritoran attenuates myocardial ischemiareperfusion injury," Circulation, vol. 114, no. 1, pp. I270-I274, 2006.
    • (2006) Circulation , vol.114 , Issue.1 , pp. I270-I274
    • Shimamoto, A.1    Chong, A.J.2    Yada, M.3
  • 78
    • 84973379697 scopus 로고    scopus 로고
    • CYP, a toll-like receptor 4 antagonist, protects the heart from ischemia/reperfusion injury
    • A. Soldo, M.Molteni, C. Rossetti et al., "CyP, a toll-like receptor 4 antagonist, protects the heart from ischemia/reperfusion injury," European Heart Journal, vol. 32, supplement 1, p. 690, 2011.
    • (2011) European Heart Journal , vol.32 , pp. 690
    • Soldo, A.1    Molteni, M.2    Rossetti, C.3
  • 79
    • 84965089938 scopus 로고    scopus 로고
    • Toll-like receptor 4 (TLR4) antagonist eritoran tetrasodium attenuates liver ischemia and reperfusion injury through inhibition of highmobility group box protein B1 (HMGB1) signaling
    • K. A. Mcdonald, H. Huang, S. Tohme et al., "Toll-like receptor 4 (TLR4) antagonist eritoran tetrasodium attenuates liver ischemia and reperfusion injury through inhibition of highmobility group box protein B1 (HMGB1) signaling," Molecular Medicine, vol. 20, pp. 639-648, 2015.
    • (2015) Molecular Medicine , vol.20 , pp. 639-648
    • Mcdonald, K.A.1    Huang, H.2    Tohme, S.3
  • 80
    • 84926370173 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimer's disease
    • M. T. Heneka, M. J. Carson, J. El. Khoury et al., "Neuroinflammation in Alzheimer's disease," The Lancet Neurology, vol. 14, no. 4, pp. 388-405, 2015.
    • (2015) The Lancet Neurology , vol.14 , Issue.4 , pp. 388-405
    • Heneka, M.T.1    Carson, M.J.2    Khoury, J.E.3
  • 81
    • 84897933220 scopus 로고    scopus 로고
    • Epilepsy and inflammation in the brain: Overview and pathophysiology
    • A. Vezzani, "Epilepsy and inflammation in the brain: overview and pathophysiology," Epilepsy Currents, vol. 14, no. 1, pp. 3-7, 2014.
    • (2014) Epilepsy Currents , vol.14 , Issue.1 , pp. 3-7
    • Vezzani, A.1
  • 83
    • 4644232615 scopus 로고    scopus 로고
    • Microglia initiate central nervous systeminnate and adaptiveimmune responses throughmultiple TLRs
    • J. K. Olson and S. D. Miller, "Microglia initiate central nervous systeminnate and adaptiveimmune responses throughmultiple TLRs,"TheJournal of Immunology, vol. 173, no. 6,pp. 3916-3924, 2004.
    • (2004) TheJournal of Immunology , vol.173 , Issue.6 , pp. 3916-3924
    • Olson, J.K.1    Miller, S.D.2
  • 84
    • 78650420511 scopus 로고    scopus 로고
    • The effects of age on lipopolysaccharide-induced cognitive deficits and interleukin-1β expression
    • A. J. Tarr, K. A. McLinden, D. Kranjac, R. A. Kohman, W. Amaral, and G. W. Boehm, "The effects of age on lipopolysaccharide-induced cognitive deficits and interleukin-1β expression," Behavioural Brain Research, vol. 217, no. 2, pp. 481-485, 2011.
    • (2011) Behavioural Brain Research , vol.217 , Issue.2 , pp. 481-485
    • Tarr, A.J.1    McLinden, K.A.2    Kranjac, D.3    Kohman, R.A.4    Amaral, W.5    Boehm, G.W.6
  • 85
    • 77952026719 scopus 로고    scopus 로고
    • The impact of IL-1 modulation on the development of lipopolysaccharideinduced cognitive dysfunction
    • N. Terrando, A. R. Fidalgo, M. Vizcaychipi et al., "The impact of IL-1 modulation on the development of lipopolysaccharideinduced cognitive dysfunction," Critical Care, vol. 14, article R88, 2010.
    • (2010) Critical Care , vol.14
    • Terrando, N.1    Fidalgo, A.R.2    Vizcaychipi, M.3
  • 86
    • 80055009332 scopus 로고    scopus 로고
    • High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and receptor for advanced glycation end products
    • A. Mazarati, M. Maroso, V. Iori, A. Vezzani, and M. Carli, "High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and receptor for advanced glycation end products," Experimental Neurology, vol. 232, no. 2, pp. 143-148, 2011.
    • (2011) Experimental Neurology , vol.232 , Issue.2 , pp. 143-148
    • Mazarati, A.1    Maroso, M.2    Iori, V.3    Vezzani, A.4    Carli, M.5
  • 87
    • 49349097868 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal
    • S.-C. Tang, J. D. Lathia, P. K. Selvaraj et al., "Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal," Experimental Neurology, vol. 213, no. 1, pp. 114-121, 2008.
    • (2008) Experimental Neurology , vol.213 , Issue.1 , pp. 114-121
    • Tang, S.-C.1    Lathia, J.D.2    Selvaraj, P.K.3
  • 88
    • 35848963223 scopus 로고    scopus 로고
    • Role of the tolllike receptor 4 in neuroinflammation in Alzheimer's disease
    • S. Walter, M. Letiembre, Y. Liu et al., "Role of the tolllike receptor 4 in neuroinflammation in Alzheimer's disease," Cellular Physiology and Biochemistry, vol. 20,no. 6, pp. 247-256, 2007.
    • (2007) Cellular Physiology and Biochemistry , vol.20 , Issue.6 , pp. 247-256
    • Walter, S.1    Letiembre, M.2    Liu, Y.3
  • 89
    • 60949108812 scopus 로고    scopus 로고
    • Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice
    • S. Frank, E. Copanaki, G. J. Burbach,U. C.Müller, and T.Deller, "Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice," Neuroscience Letters, vol. 453, no. 1, pp. 41-44, 2009.
    • (2009) Neuroscience Letters , vol.453 , Issue.1 , pp. 41-44
    • Frank, S.1    Copanaki, E.2    Burbach, G.J.3    Müller, U.C.4    Deller, T.5
  • 90
    • 54949139241 scopus 로고    scopus 로고
    • Expression of TLR4 and CD14 in the central nervous system (CNS) in a MPTP mouse model of Parkinson's-like disease
    • M. A. Panaro,D.D. Lofrumento, C. Saponaro et al., "Expression of TLR4 and CD14 in the central nervous system (CNS) in a MPTP mouse model of Parkinson's-like disease," Immunopharmacology and Immunotoxicology, vol. 30, no. 4, pp. 729-740, 2008.
    • (2008) Immunopharmacology and Immunotoxicology , vol.30 , Issue.4 , pp. 729-740
    • Panaro, M.A.1    Lofrumento, D.D.2    Saponaro, C.3
  • 91
    • 79952619563 scopus 로고    scopus 로고
    • Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue
    • M. Casula, A. M. Iyer,W. G. M. Spliet et al., "Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue," Neuroscience, vol. 179, pp. 233-243, 2011.
    • (2011) Neuroscience , vol.179 , pp. 233-243
    • Casula, M.1    Iyer, A.M.2    Spliet, W.G.M.3
  • 92
    • 84865214998 scopus 로고    scopus 로고
    • Neuroprotective effects of toll-like receptor 4 antagonism in spinal cord cultures and in a mouse model of motor neuron degeneration
    • M.De Paola, A.Mariani, P. Bigini et al., "Neuroprotective effects of toll-like receptor 4 antagonism in spinal cord cultures and in a mouse model of motor neuron degeneration," Molecular Medicine, vol. 18, no. 6, pp. 971-981, 2012.
    • (2012) Molecular Medicine , vol.18 , Issue.6 , pp. 971-981
    • De Paola, M.1    Mariani, A.2    Bigini, P.3
  • 93
    • 84955401857 scopus 로고    scopus 로고
    • The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease
    • M. R.Minter, J. M. Taylor, and P. J. Crack, "The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease," Journal of Neurochemistry, vol. 136, no. 3, pp. 457-474, 2016.
    • (2016) Journal of Neurochemistry , vol.136 , Issue.3 , pp. 457-474
    • Minter, M.R.1    Taylor, J.M.2    Crack, P.J.3
  • 94
    • 79961134149 scopus 로고    scopus 로고
    • TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease
    • M. Song, J. Jin, J.-E. Lim et al., "TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease," Journal of Neuroinflammation, vol. 8, pp. 92-106, 2011.
    • (2011) Journal of Neuroinflammation , vol.8 , pp. 92-106
    • Song, M.1    Jin, J.2    Lim, J.-E.3
  • 95
    • 78650678688 scopus 로고    scopus 로고
    • Decreased clearance of CNS β-amyloid in Alzheimer's disease
    • K. G. Mawuenyega, W. Sigurdson, V. Ovod et al., "Decreased clearance of CNS β-amyloid in Alzheimer's disease," Science, vol. 330, no. 6012, pp. 1774-1776, 2010.
    • (2010) Science , vol.330 , Issue.6012 , pp. 1774-1776
    • Mawuenyega, K.G.1    Sigurdson, W.2    Ovod, V.3
  • 96
    • 51149120624 scopus 로고    scopus 로고
    • Microglial dysfunction and defective β-amyloid clearance pathways in aging Alzheimer's disease mice
    • S. E. Hickman, E. K. Allison, and J. El Khoury, "Microglial dysfunction and defective β-amyloid clearance pathways in aging alzheimer's disease mice," Journal of Neuroscience, vol. 28, no. 33, pp. 8354-8360, 2008.
    • (2008) Journal of Neuroscience , vol.28 , Issue.33 , pp. 8354-8360
    • Hickman, S.E.1    Allison, E.K.2    El Khoury, J.3
  • 97
    • 84873111294 scopus 로고    scopus 로고
    • Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology
    • J.-P.Michaud,M. Hallé, A. Lampron et al., "Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology," Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 5, pp. 1941-1946, 2013.
    • (2013) Proceedings of the National Academy of Sciences of the United States of America , vol.110 , Issue.5 , pp. 1941-1946
    • Michaud, J.-P.1    Hallé, M.2    Lampron, A.3
  • 98
    • 84875123349 scopus 로고    scopus 로고
    • Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease
    • C. Noelker, L. Morel, T. Lescot et al., "Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease," Scientific Reports, vol. 3, article 1393, 2013.
    • (2013) Scientific Reports , vol.3
    • Noelker, C.1    Morel, L.2    Lescot, T.3
  • 99
    • 80052473816 scopus 로고    scopus 로고
    • Toll-like receptor 4 promotes α-synuclein clearance and survival of nigral dopaminergic neurons
    • N. Stefanova,L.Fellner,M.Reindl, E.Masliah,W. Poewe, andG. K. Wenning, "Toll-like receptor 4 promotes α-synuclein clearance and survival of nigral dopaminergic neurons," American Journal of Pathology, vol. 179, no. 2, pp. 954-963, 2011.
    • (2011) American Journal of Pathology , vol.179 , Issue.2 , pp. 954-963
    • Stefanova, N.1    Fellner, L.2    Reindl, M.3    Masliah, E.4    Poewe, W.5    Wenning, G.K.6
  • 100
    • 84872595532 scopus 로고    scopus 로고
    • Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
    • L. Fellner, R. Irschick, K. Schanda et al., "Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia," Glia, vol. 61, no. 3, pp. 349-360, 2013.
    • (2013) Glia , vol.61 , Issue.3 , pp. 349-360
    • Fellner, L.1    Irschick, R.2    Schanda, K.3
  • 101
    • 1242336763 scopus 로고    scopus 로고
    • Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis
    • M. D. Nguyen, T.D'Aigle,G.Gowing, J.-P. Julien, and S. Rivest, "Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis," The Journal of Neuroscience, vol. 24, no. 6, pp. 1340-1349, 2004.
    • (2004) The Journal of Neuroscience , vol.24 , Issue.6 , pp. 1340-1349
    • Nguyen, M.D.1    D'Aigle, T.2    Gowing, G.3    Julien, J.-P.4    Rivest, S.5
  • 102
    • 77950539231 scopus 로고    scopus 로고
    • Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures
    • M.Maroso, S. Balosso, T. Ravizza et al., "Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures," Nature Medicine, vol. 16, no. 4, pp. 413-419, 2010.
    • (2010) Nature Medicine , vol.16 , Issue.4 , pp. 413-419
    • Maroso, M.1    Balosso, S.2    Ravizza, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.