Chitooligosaccharides inhibit ethanol-induced oxidative stress via activation of Nrf2 and reduction of MAPK phosphorylation

Oncology Reports

Volumn 32, Issue 5, 2014, Pages 2215-2222

  Luo, Zhiguo ^a   Dong, Xiaoxia ^a   Ke, Qing ^a   Duan, Qiwen ^a   Shen, Li ^a  

^a HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

Chitooligosaccharide; Hepatoprotective; MAPK; Nrf2; Oxidative stress

Indexed keywords

ALCOHOL; CHITOOLIGOSACCHARIDE DERIVATIVE; GLUTATHIONE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEME OXYGENASE 1; MITOGEN ACTIVATED PROTEIN KINASE; OLIGOSACCHARIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (QUINONE); STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTIOXIDANT; CHITOSAN; NFE2L2 PROTEIN, HUMAN;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG EXPOSURE; ENZYME INHIBITION; GENE; GENE ACTIVATION; GENE LOCATION; GENE SILENCING; HO 1 GENE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID PEROXIDATION; LIVER CELL; LIVER PROTECTION; LIVER TOXICITY; NQO1 GENE; OXIDATIVE STRESS; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SOD GENE; TOXICITY TESTING; TRANSCRIPTION INITIATION; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; LIVER; LIVER DISEASES, ALCOHOLIC; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

ANTIOXIDANTS; CELL LINE; CHITOSAN; ETHANOL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER; LIVER DISEASES, ALCOHOLIC; MITOGEN-ACTIVATED PROTEIN KINASES; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES;

EID: 84907288273     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3463     Document Type: Article

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