Chitosan oligosaccharide inhibits 203HgCl2-induced genotoxicity in mice: Micronuclei occurrence and chromosomal aberration

Archives of Pharmacal Research

Volumn 28, Issue 9, 2005, Pages 1079-1085

  Yoon, Hyun Joong ^a   Haeng, Soon Park ^a   Bom, Hee Seung ^b   Young, Bok Roh ^c   Jong, Se Kim ^c   Young, Ho Kim ^a  

^a Chonnam National University   (South Korea)

^b Chonnam National University Medical School   (South Korea)

^c Chosun University   (South Korea)

Author keywords

Chitosan oligosaccharide; Chromosomal aberration; Mercury; Micronucleus

Indexed keywords

EID: 26444620953     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02977405     Document Type: Article

References (37)

1. Bala, K. V. C. and Rao, K. P., Inhibition of methyl mercury chloride-induced chromosomal damage by gamma-linonelic acid. Fd. Chem. Toxic, 31, 431-434 (1993).
2. Darina, C. and Jozef, S., Effect of carboxymethyl-chitin-glucan on cyclophosphamide induced mutagenicity. Mutation Research, 346, 43-48 (1995).
3. Fenench, M. and Morley, A. A., Measurement of micronuclei in lymphocyte. Mutation Research, 147, 29-36 (1985).
4. Garcia, C. L., Darroudi, F., Tates, A. D., and Natarajan, A. T., Induction and presistence of micronuclei, sister-chromatid exchanges and chromosomal aberrations in splenocytes and bone-marrow cells of rats exposed to ethylene oxide. Mutation Research, 492, 59-67 (2001).
5. Goncharova, R., Zabrejko, S., Dalivelya, O., and Kuzhir, T., Anticlastogenecity of two derivatives of 1,4-dihydroisonicotinic acid in mouse micronucleus test. Mutation Research, 496, 129-135 (2001).
6. Guadano, A., Coloma, A. G., and Pena, E., Genotoxicity of the insecticide rotenone in cultured human lympocytes. Mutation Research, 414, 1-7 (1998).
7. Heddle, J. A., A rapid in vivo test for chromosome damage. Mutation Research, 18, 187-190 (1973).
8. Hirano, S. M., Iwata, K., Nakayama, H., and Toda, H., Enhancement of serum lysozyme activity by injecting a mixture of chitosan oligosaccharides intravenously in rabbit. Agric. Biol. Chem., 55, 2623-2625 (1991).
9. Jagetia, G. C. and Aruna, R., Effects of various concentration of acyclovir on cell survival and micronuclei induction on cultured HeLa cells. Mutation Res., 446, 155-165 (1999).
10. Kim, J. H., Yoo, K. J., Song, H. C., and Kim, H. K., Antiparasitic effects of chitosan oligosaccharide against scuticociliatids collected from japanese flounder, Paralichtys olivaceus. Kor. J. Chitin Chitosan, 6, 47-52 (2001).
11. Kim, Y. H., Bom, H. S., Kim, K. Y., Kim, H. K., and Kim, J. Y., Inhibitory effect of chitosan on the milk transfer of radiostrontium from contaminated mice to their sucklers. Kor. J. Chitin Chitosan, 4, 15-18 (1999).
12. Kim, Y. H., Bom, H. S., Kim, J. Y., and Roh, Y. B., The effect of calcium and chitosan metabolism to the excretion of radiostrontium in mice. J. Kor. Asso. Radiat. Prot., 22, 9-14 (1997).
13. Koga, D., Induction of chitinase for plant self-defense. Chitin/Chitosan symposium, in Japan Chitin/Chitosan Res., 4-26 (1993).
14. Lawrence, J. N. and Benford, D. J., Detection of chemical-induced unscheduled DNA synthesis in cultures of normal adult human keratinoctes. Toxic. In Vitro, 5, 377-381 (1991).
15. Ledebur, M. V. and Schmid, W., The micronucleus test methodological aspects. Mutation Res., 19, 109-117 (1973).
16. Lin, W., Xue, H., Liu, S., He, Y., Fu, J., and Zhou, Z., Genotoxicity of nitric oxide produced from sodium nitroprusside. Mutation Res., 413, 121-127 (1998).
17. Natarajan, A. T. and Obe, G., Molecular mechanisms involved in the production of chromosomal aberrations. Chromosome, 90, 120-127 (1984).
18. Nishimura, Y., Kim, S. H., Ikota, N., Arima, H., Bom, H. S., Kim, Y. H., Watanabe, Y., Yukawa, M., and Ozawa, T., Radioprotective effect of chitosan in sub-lethally X-ray irradiated mice. J. Radiat. Res., 44, 53-58 (2003).
19. Okamoto, Y., Ohmi, H., Minami, S., Muhashi, A., Shigemasa, Y., Okumura, M., and Fujinaga, T., Anti-tumor effect of chitin and chitosan on canine transmissible sarcoma. Chitin/Chitosan symposium, in Japan Chitin/Chitosan Res., 1, 76-77 (1995).
20. Padovani, L., Tronati, L., Mauro, F., Testa, A., Appolloni, M., Azzidei, P., Caporossi, D., Tedeschi, B., and Vernole, P., Cytogenetic effects in lymphocytes from children exposed to radiation fall-out after the chernobyl accident. Mutation Res., 395, 249-254 (1997).
21. Ramalho, A., Sunjevaric, I., and Natarajan, A. T., Use of the frequencies of micronuclei as quantitative indicators of X-ray-induced chromosomal aberration in human peripheral blood lymphocytes: Comparison of the method. Mutation Res., 207, 141-146 (1988).
22. Rauscher, R., Edenharber, R., and Platt, K. L., In vitro antimutagenic and in vivo anticlastogenic effects of carotenoids and solvent extracts from fruits and vegetables rich in carotenoids. Mutation Res., 41, 129-142 (1998).
23. Robbiano, R., Mereto, E., Morando, A. M., and Brambilla, G., Increased frequency of micronucleated kidney cells in rats exposed to halogenated anaesthetic. Mutation Res., 413, 1-6 (1998).
24. Romm, H. and Stwphan, G., Chromosome analysis-a routine method for quantitative radiation dose assessment. Kerntechnik, 55(4), 219-225 (1990).
25. Schmid, M., The micronucleus test. Mutation Res., 31, 9-15 (1975).
26. Skjak, G., Anthonsen, T., and Sandford, P., The use of chitosan in cosmetics. In Chitin and chitosan: Sources, chemistry, biochemistry, physical properties and application. Elsevier, Applied science, pp. 139-147, (1998).
27. Stacher, A., Ruzicka, H., and Schuhfried, G., Chromosomal aberration due to cytostatic agents. Int. J. Clin. Pharmacol., 9, 250-257 (1974).
28. Stoiber, T., Bonacker, D., Boöhm, K. J., Bolt, H. M., Their, R., Degen, G. H., and Unger, E., Disturbed microtubule function and induction of micronuclei by chelate complexes of mercury(II). Mutation Res., 563, 97-106 (2004).
29. Sudharsan, A. and Heddle, J. A., Simultaneous detection of chromosomal aberration and sister-chromatid exchanges: Experience with DNA intercalating agents. Mutation Res., 78, 253-260 (1980).
30. Thier, R., Bonacker, D., Stoiber, T., Böhm, K. J., Wang, M., Unger, E., Bolt, H. M., and Degen, G., Interaction of metal salts with cytoskeletal motor protein systems. Toxicol. Lett., 140-141, 75-81 (2003).
31. Tokura, S., Miura, Y., Kaneda, Y., and Uraki, Y., Drug delivery system using biodegradable carrier. Annual Report, Chitin/Chitosan Res., pp. 314-324, (1992).
32. Tsurutani, R., Yoshimura, M., Tanimoto, N., Hasegawa, A., and Kifune, K., Clinical application of chitin materials to ulcers. Chitin/Chitosan symposium, in Japan Chitin/Chitosan Res., 1, 78-79 (1995).
33. Wakata, A. and Sasaki, M. S., Measurement of micronuclei by cytochalasin-block method in cultured chinese hamster cells: Comparison with types and rates of chromosome aberration. Mutation Res., 190, 51-57 (1987).
34. Wolff, S., Biological dosimetry with cytogenetic endpoints. New Horizons in Biological Dosimetry, 351-362 (1991).
35. Yoon, H. J., Kim, Y. H., Park, S. W., Lee, H. B., and Park, H. S., Chitosan increases the release of renal dipeptidase from porcine renal proximal tubule cells. Korean J. Biol. Sci., 7, 309-315 (2003).
36. Yoon, H. J., Kim, Y. H., Lee, H. B., Lee, J. H., and Park, H. S., Study of chitosan on fibroblast growth factor 2 (bFGF) from the renal proximal tubular cells. J. Chitin Chitosan, 9(3), 114-118 (2004).
37. 2) in mice. J. Chitin Chitosan, 10(2), 61-66 (2005).