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Volumn 174, Issue , 2017, Pages 73-83

Allergies – A T cells perspective in the era beyond the TH1/TH2 paradigm

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 9; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IL9 PROTEIN, HUMAN;

EID: 85002412583     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2016.11.001     Document Type: Review
Times cited : (48)

References (186)
  • 1
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • [1] Mosmann, T.R., Cherwinski, H., Bond, M.W., Giedlin, M.A., Coffman, R.L., Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. Baltim. Md 1950 136 (1986), 2348–2357.
    • (1986) J. Immunol. Baltim. Md 1950 , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 2
    • 0031172781 scopus 로고    scopus 로고
    • The Th1/Th2 paradigm
    • [2] Romagnani, S., The Th1/Th2 paradigm. Immunol. Today 18 (1997), 263–266, 10.1016/S0167-5699(97)80019-9.
    • (1997) Immunol. Today , vol.18 , pp. 263-266
    • Romagnani, S.1
  • 3
    • 0025245434 scopus 로고
    • Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse
    • [3] Sher, A., Coffman, R.L., Hieny, S., Cheever, A.W., Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse. J. Immunol. Baltim. Md 1950 145 (1990), 3911–3916.
    • (1990) J. Immunol. Baltim. Md 1950 , vol.145 , pp. 3911-3916
    • Sher, A.1    Coffman, R.L.2    Hieny, S.3    Cheever, A.W.4
  • 4
    • 84947420101 scopus 로고    scopus 로고
    • New developments providing mechanistic insight into the impact of the microbiota on allergic disease
    • [4] McCoy, K.D., Köller, Y., New developments providing mechanistic insight into the impact of the microbiota on allergic disease. Clin. Immunol. 159 (2015), 170–176, 10.1016/j.clim.2015.05.007.
    • (2015) Clin. Immunol. , vol.159 , pp. 170-176
    • McCoy, K.D.1    Köller, Y.2
  • 7
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • [7] Zheng, W., Flavell, R.A., The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89 (1997), 587–596.
    • (1997) Cell , vol.89 , pp. 587-596
    • Zheng, W.1    Flavell, R.A.2
  • 8
    • 0033427612 scopus 로고    scopus 로고
    • Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells
    • [8] Kurata, H., Lee, H.J., O'Garra, A., Arai, N., Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells. Immunity 11 (1999), 677–688.
    • (1999) Immunity , vol.11 , pp. 677-688
    • Kurata, H.1    Lee, H.J.2    O'Garra, A.3    Arai, N.4
  • 9
    • 0025279825 scopus 로고
    • Human P40/IL-9. Expression in activated CD4 + T cells, genomic organization, and comparison with the mouse gene
    • [9] Renauld, J.C., Goethals, A., Houssiau, F., Merz, H., Van Roost, E., Van Snick, J., Human P40/IL-9. Expression in activated CD4 + T cells, genomic organization, and comparison with the mouse gene. J. Immunol. Baltim. Md 1950 144 (1990), 4235–4241.
    • (1990) J. Immunol. Baltim. Md 1950 , vol.144 , pp. 4235-4241
    • Renauld, J.C.1    Goethals, A.2    Houssiau, F.3    Merz, H.4    Van Roost, E.5    Van Snick, J.6
  • 10
    • 0024408824 scopus 로고
    • Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    • [10] Fiorentino, D.F., Bond, M.W., Mosmann, T.R., Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 170 (1989), 2081–2095.
    • (1989) J. Exp. Med. , vol.170 , pp. 2081-2095
    • Fiorentino, D.F.1    Bond, M.W.2    Mosmann, T.R.3
  • 11
    • 14244254463 scopus 로고    scopus 로고
    • Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarization
    • [11] Traidl-Hoffmann, C., Mariani, V., Hochrein, H., Karg, K., Wagner, H., Ring, J., Mueller, M.J., Jakob, T., Behrendt, H., Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarization. J. Exp. Med. 201 (2005), 627–636, 10.1084/jem.20041065.
    • (2005) J. Exp. Med. , vol.201 , pp. 627-636
    • Traidl-Hoffmann, C.1    Mariani, V.2    Hochrein, H.3    Karg, K.4    Wagner, H.5    Ring, J.6    Mueller, M.J.7    Jakob, T.8    Behrendt, H.9
  • 12
    • 64149087970 scopus 로고    scopus 로고
    • House dust mite allergen induces asthma via toll-like receptor 4 triggering of airway structural cells
    • [12] Hammad, H., Chieppa, M., Perros, F., Willart, M.A., Germain, R.N., Lambrecht, B.N., House dust mite allergen induces asthma via toll-like receptor 4 triggering of airway structural cells. Nat. Med. 15 (2009), 410–416, 10.1038/nm.1946.
    • (2009) Nat. Med. , vol.15 , pp. 410-416
    • Hammad, H.1    Chieppa, M.2    Perros, F.3    Willart, M.A.4    Germain, R.N.5    Lambrecht, B.N.6
  • 14
    • 42449157214 scopus 로고    scopus 로고
    • Upregulation of the release of granulocyte-macrophage colony-stimulating factor from keratinocytes stimulated with cysteine protease activity of recombinant major mite allergens, Der f 1 and Der p 1
    • [14] Ogawa, T., Takai, T., Kato, T., Kikuchi, Y., Niyonsaba, F., Ikeda, S., Okumura, K., Ogawa, H., Upregulation of the release of granulocyte-macrophage colony-stimulating factor from keratinocytes stimulated with cysteine protease activity of recombinant major mite allergens, Der f 1 and Der p 1. Int. Arch. Allergy Immunol. 146 (2008), 27–35, 10.1159/000112500.
    • (2008) Int. Arch. Allergy Immunol. , vol.146 , pp. 27-35
    • Ogawa, T.1    Takai, T.2    Kato, T.3    Kikuchi, Y.4    Niyonsaba, F.5    Ikeda, S.6    Okumura, K.7    Ogawa, H.8
  • 16
    • 0034283943 scopus 로고    scopus 로고
    • C8/119S mutation of major mite allergen Derf-2 leads to degenerate secondary structure and molecular polymerization and induces potent and exclusive Th1 cell differentiation
    • [16] Korematsu, S., Tanaka, Y., Hosoi, S., Koyanagi, S., Yokota, T., Mikami, B., Minato, N., C8/119S mutation of major mite allergen Derf-2 leads to degenerate secondary structure and molecular polymerization and induces potent and exclusive Th1 cell differentiation. J. Immunol. Baltim. Md 1950 165 (2000), 2895–2902.
    • (2000) J. Immunol. Baltim. Md 1950 , vol.165 , pp. 2895-2902
    • Korematsu, S.1    Tanaka, Y.2    Hosoi, S.3    Koyanagi, S.4    Yokota, T.5    Mikami, B.6    Minato, N.7
  • 19
    • 27744510433 scopus 로고    scopus 로고
    • TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand
    • [19] Ito, T., TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J. Exp. Med. 202 (2005), 1213–1223, 10.1084/jem.20051135.
    • (2005) J. Exp. Med. , vol.202 , pp. 1213-1223
    • Ito, T.1
  • 21
    • 77957745031 scopus 로고    scopus 로고
    • Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen
    • [21] Hammad, H., Plantinga, M., Deswarte, K., Pouliot, P., Willart, M.A.M., Kool, M., Muskens, F., Lambrecht, B.N., Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. J. Exp. Med. 207 (2010), 2097–2111, 10.1084/jem.20101563.
    • (2010) J. Exp. Med. , vol.207 , pp. 2097-2111
    • Hammad, H.1    Plantinga, M.2    Deswarte, K.3    Pouliot, P.4    Willart, M.A.M.5    Kool, M.6    Muskens, F.7    Lambrecht, B.N.8
  • 22
    • 67649216604 scopus 로고    scopus 로고
    • Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response
    • [22] Sokol, C.L., Chu, N.-Q., Yu, S., Nish, S.A., Laufer, T.M., Medzhitov, R., Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat. Immunol. 10 (2009), 713–720, 10.1038/ni.1738.
    • (2009) Nat. Immunol. , vol.10 , pp. 713-720
    • Sokol, C.L.1    Chu, N.-Q.2    Yu, S.3    Nish, S.A.4    Laufer, T.M.5    Medzhitov, R.6
  • 24
    • 84975127155 scopus 로고    scopus 로고
    • IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function
    • [24] Noval Rivas, M., Burton, O.T., Oettgen, H.C., Chatila, T., IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function. J. Allergy Clin. Immunol, 2016, 10.1016/j.jaci.2016.02.030.
    • (2016) J. Allergy Clin. Immunol
    • Noval Rivas, M.1    Burton, O.T.2    Oettgen, H.C.3    Chatila, T.4
  • 28
    • 84959571948 scopus 로고    scopus 로고
    • IL-33 mediates reactive eosinophilopoiesis in response to airborne allergen exposure
    • [28] Anderson, E.L., Kobayashi, T., Iijima, K., Bartemes, K.R., Chen, C.-C., Kita, H., IL-33 mediates reactive eosinophilopoiesis in response to airborne allergen exposure. Allergy, 2016, 10.1111/all.12861.
    • (2016) Allergy
    • Anderson, E.L.1    Kobayashi, T.2    Iijima, K.3    Bartemes, K.R.4    Chen, C.-C.5    Kita, H.6
  • 31
    • 33947244350 scopus 로고    scopus 로고
    • Cutting edge: proinflammatory and Th2 cytokines synergize to induce thymic stromal lymphopoietin production by human skin keratinocytes
    • [31] Bogiatzi, S.I., Fernandez, I., Bichet, J.-C., Marloie-Provost, M.-A., Volpe, E., Sastre, X., Soumelis, V., Cutting edge: proinflammatory and Th2 cytokines synergize to induce thymic stromal lymphopoietin production by human skin keratinocytes. J. Immunol. Baltim. Md 1950 178 (2007), 3373–3377.
    • (2007) J. Immunol. Baltim. Md 1950 , vol.178 , pp. 3373-3377
    • Bogiatzi, S.I.1    Fernandez, I.2    Bichet, J.-C.3    Marloie-Provost, M.-A.4    Volpe, E.5    Sastre, X.6    Soumelis, V.7
  • 32
    • 33847134006 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells
    • [32] Allakhverdi, Z., Comeau, M.R., Jessup, H.K., Yoon, B.-R.P., Brewer, A., Chartier, S., Paquette, N., Ziegler, S.F., Sarfati, M., Delespesse, G., Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J. Exp. Med. 204 (2007), 253–258, 10.1084/jem.20062211.
    • (2007) J. Exp. Med. , vol.204 , pp. 253-258
    • Allakhverdi, Z.1    Comeau, M.R.2    Jessup, H.K.3    Yoon, B.-R.P.4    Brewer, A.5    Chartier, S.6    Paquette, N.7    Ziegler, S.F.8    Sarfati, M.9    Delespesse, G.10
  • 34
    • 33644908476 scopus 로고    scopus 로고
    • Pen ch 13 allergen induces secretion of mediators and degradation of occludin protein of human lung epithelial cells
    • [34] Tai, H.-Y., Tam, M.F., Chou, H., Peng, H.-J., Su, S.-N., Perng, D.-W., Shen, H.-D., Pen ch 13 allergen induces secretion of mediators and degradation of occludin protein of human lung epithelial cells. Allergy 61 (2006), 382–388, 10.1111/j.1398-9995.2005.00958.x.
    • (2006) Allergy , vol.61 , pp. 382-388
    • Tai, H.-Y.1    Tam, M.F.2    Chou, H.3    Peng, H.-J.4    Su, S.-N.5    Perng, D.-W.6    Shen, H.-D.7
  • 35
    • 85027938991 scopus 로고    scopus 로고
    • Signaling through FcRγ-associated receptors on dendritic cells drives IL-33–dependent TH2-type responses
    • e8
    • [35] Tjota, M.Y., Hrusch, C.L., Blaine, K.M., Williams, J.W., Barrett, N.A., Sperling, A.I., Signaling through FcRγ-associated receptors on dendritic cells drives IL-33–dependent TH2-type responses. J. Allergy Clin. Immunol. 134 (2014), 706–713, e8, 10.1016/j.jaci.2014.06.013.
    • (2014) J. Allergy Clin. Immunol. , vol.134 , pp. 706-713
    • Tjota, M.Y.1    Hrusch, C.L.2    Blaine, K.M.3    Williams, J.W.4    Barrett, N.A.5    Sperling, A.I.6
  • 36
    • 23044493539 scopus 로고    scopus 로고
    • Recombinant Der p 1 and Der f 1 with in vitro enzymatic activity to cleave human CD23, CD25 and alpha1-antitrypsin, and in vivo IgE-eliciting activity in mice
    • [36] Takai, T., Kato, T., Ota, M., Yasueda, H., Kuhara, T., Okumura, K., Ogawa, H., Recombinant Der p 1 and Der f 1 with in vitro enzymatic activity to cleave human CD23, CD25 and alpha1-antitrypsin, and in vivo IgE-eliciting activity in mice. Int. Arch. Allergy Immunol. 137 (2005), 194–200, 10.1159/000086331.
    • (2005) Int. Arch. Allergy Immunol. , vol.137 , pp. 194-200
    • Takai, T.1    Kato, T.2    Ota, M.3    Yasueda, H.4    Kuhara, T.5    Okumura, K.6    Ogawa, H.7
  • 37
    • 0035723069 scopus 로고    scopus 로고
    • Th2 cytokines and asthma: an introduction
    • [37] Barnes, P.J., Th2 cytokines and asthma: an introduction. Respir. Res. 2:2 (2001), 64–65, 10.1186/rr39.
    • (2001) Respir. Res. , vol.2 , Issue.2 , pp. 64-65
    • Barnes, P.J.1
  • 38
    • 84864345639 scopus 로고    scopus 로고
    • New paradigms in type 2 immunity
    • [38] Pulendran, B., Artis, D., New paradigms in type 2 immunity. Science 337 (2012), 431–435, 10.1126/science.1221064.
    • (2012) Science , vol.337 , pp. 431-435
    • Pulendran, B.1    Artis, D.2
  • 40
    • 77953465584 scopus 로고    scopus 로고
    • Role played by Th2 type cytokines in IgE mediated allergy and asthma
    • [40] Deo, S., Mistry, K., Kakade, A., Niphadkar, P., Role played by Th2 type cytokines in IgE mediated allergy and asthma. Lung India, 27, 2010, 66, 10.4103/0970-2113.63609.
    • (2010) Lung India , vol.27 , pp. 66
    • Deo, S.1    Mistry, K.2    Kakade, A.3    Niphadkar, P.4
  • 41
    • 0038459267 scopus 로고    scopus 로고
    • Effects of histamine on Th1/Th2 cytokine balance
    • [41] Packard, K.A., Khan, M.M., Effects of histamine on Th1/Th2 cytokine balance. Int. Immunopharmacol. 3 (2003), 909–920, 10.1016/S1567-5769(02)00235-7.
    • (2003) Int. Immunopharmacol. , vol.3 , pp. 909-920
    • Packard, K.A.1    Khan, M.M.2
  • 42
    • 0034283675 scopus 로고    scopus 로고
    • T cells from human allergen-induced late asthmatic responses express IL-12 receptor 2 subunit mRNA and respond to IL-12 in vitro
    • [42] Varga, E.M., Wachholz, P., Nouri-Aria, K.T., Verhoef, A., Corrigan, C.J., Till, S.J., Durham, S.R., T cells from human allergen-induced late asthmatic responses express IL-12 receptor 2 subunit mRNA and respond to IL-12 in vitro. J. Immunol. 165 (2000), 2877–2885, 10.4049/jimmunol.165.5.2877.
    • (2000) J. Immunol. , vol.165 , pp. 2877-2885
    • Varga, E.M.1    Wachholz, P.2    Nouri-Aria, K.T.3    Verhoef, A.4    Corrigan, C.J.5    Till, S.J.6    Durham, S.R.7
  • 44
    • 84878261946 scopus 로고    scopus 로고
    • TH2, allergy and group 2 innate lymphoid cells
    • [44] Licona-Limón, P., Kim, L.K., Palm, N.W., Flavell, R.A., TH2, allergy and group 2 innate lymphoid cells. Nat. Immunol. 14 (2013), 536–542, 10.1038/ni.2617.
    • (2013) Nat. Immunol. , vol.14 , pp. 536-542
    • Licona-Limón, P.1    Kim, L.K.2    Palm, N.W.3    Flavell, R.A.4
  • 45
    • 9644281044 scopus 로고    scopus 로고
    • Interleukin-13 in asthma pathogenesis
    • [45] Wills-Karp, M., Interleukin-13 in asthma pathogenesis. Immunol. Rev. 202 (2004), 175–190, 10.1111/j.0105-2896.2004.00215.x.
    • (2004) Immunol. Rev. , vol.202 , pp. 175-190
    • Wills-Karp, M.1
  • 46
    • 84927618165 scopus 로고    scopus 로고
    • Anti-interleukin 4 and 13 for asthma treatment in the era of endotypes
    • [46] Kau, A.L., Korenblat, P.E., Anti-interleukin 4 and 13 for asthma treatment in the era of endotypes. Curr. Opin. Allergy Clin. Immunol. 14 (2014), 570–575, 10.1097/ACI.0000000000000108.
    • (2014) Curr. Opin. Allergy Clin. Immunol. , vol.14 , pp. 570-575
    • Kau, A.L.1    Korenblat, P.E.2
  • 48
    • 84964573673 scopus 로고    scopus 로고
    • Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial
    • [48] Wenzel, S., Castro, M., Corren, J., Maspero, J., Wang, L., Zhang, B., Pirozzi, G., Sutherland, E.R., Evans, R.R., Joish, V.N., Eckert, L., Graham, N.M.H., Stahl, N., Yancopoulos, G.D., Louis-Tisserand, M., Teper, A., Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial. Lancet Lond. Engl. 388 (2016), 31–44, 10.1016/S0140-6736(16)30307-5.
    • (2016) Lancet Lond. Engl. , vol.388 , pp. 31-44
    • Wenzel, S.1    Castro, M.2    Corren, J.3    Maspero, J.4    Wang, L.5    Zhang, B.6    Pirozzi, G.7    Sutherland, E.R.8    Evans, R.R.9    Joish, V.N.10    Eckert, L.11    Graham, N.M.H.12    Stahl, N.13    Yancopoulos, G.D.14    Louis-Tisserand, M.15    Teper, A.16
  • 49
    • 84884674979 scopus 로고    scopus 로고
    • Critical role of interleukin-5 in the development of a mite antigen-induced chronic bronchial asthma model
    • [49] Shimizu, H., Obase, Y., Katoh, S., Mouri, K., Kobashi, Y., Oka, M., Critical role of interleukin-5 in the development of a mite antigen-induced chronic bronchial asthma model. Inflamm. Res. 62 (2013), 911–917, 10.1007/s00011-013-0651-y.
    • (2013) Inflamm. Res. , vol.62 , pp. 911-917
    • Shimizu, H.1    Obase, Y.2    Katoh, S.3    Mouri, K.4    Kobashi, Y.5    Oka, M.6
  • 53
    • 84862837437 scopus 로고    scopus 로고
    • Th2 cytokines and atopic dermatitis
    • [53] Brandt, E.B., Th2 cytokines and atopic dermatitis. J. Clin. Cell. Immunol., 02, 2011, 10.4172/2155-9899.1000110.
    • (2011) J. Clin. Cell. Immunol. , vol.2
    • Brandt, E.B.1
  • 55
    • 0034677646 scopus 로고    scopus 로고
    • A novel transcription factor, T-bet, directs Th1 lineage commitment
    • [55] Szabo, S.J., Kim, S.T., Costa, G.L., Zhang, X., Fathman, C.G., Glimcher, L.H., A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100 (2000), 655–669.
    • (2000) Cell , vol.100 , pp. 655-669
    • Szabo, S.J.1    Kim, S.T.2    Costa, G.L.3    Zhang, X.4    Fathman, C.G.5    Glimcher, L.H.6
  • 56
    • 0038195719 scopus 로고    scopus 로고
    • Molecular mechanisms regulating Th1 immune responses
    • [56] Szabo, S.J., Sullivan, B.M., Peng, S.L., Glimcher, L.H., Molecular mechanisms regulating Th1 immune responses. Annu. Rev. Immunol. 21 (2003), 713–758, 10.1146/annurev.immunol.21.120601.140942.
    • (2003) Annu. Rev. Immunol. , vol.21 , pp. 713-758
    • Szabo, S.J.1    Sullivan, B.M.2    Peng, S.L.3    Glimcher, L.H.4
  • 58
    • 0033230302 scopus 로고    scopus 로고
    • T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production
    • [58] Cohn, L., Homer, R.J., Niu, N., Bottomly, K., T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production. J. Exp. Med. 190 (1999), 1309–1318.
    • (1999) J. Exp. Med. , vol.190 , pp. 1309-1318
    • Cohn, L.1    Homer, R.J.2    Niu, N.3    Bottomly, K.4
  • 59
    • 80053478421 scopus 로고    scopus 로고
    • IFN-γ acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease
    • [59] Mitchell, C., Provost, K., Niu, N., Homer, R., Cohn, L., IFN-γ acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease. J. Immunol. 187 (2011), 3815–3820.
    • (2011) J. Immunol. , vol.187 , pp. 3815-3820
    • Mitchell, C.1    Provost, K.2    Niu, N.3    Homer, R.4    Cohn, L.5
  • 60
    • 0027409773 scopus 로고
    • Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4 + T cells
    • [60] Iwamoto, I., Nakajima, H., Endo, H., Yoshida, S., Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4 + T cells. J. Exp. Med. 177 (1993), 573–576.
    • (1993) J. Exp. Med. , vol.177 , pp. 573-576
    • Iwamoto, I.1    Nakajima, H.2    Endo, H.3    Yoshida, S.4
  • 61
    • 79957443439 scopus 로고    scopus 로고
    • Altered expressions of helper T cell (Th) 1, Th2, and Th17 cytokines in CD8 + and γδ T cells in patients with allergic asthma
    • [61] Zhao, Y., Yang, J., Gao, Y.-D., Altered expressions of helper T cell (Th) 1, Th2, and Th17 cytokines in CD8 + and γδ T cells in patients with allergic asthma. J. Asthma 48 (2011), 429–436.
    • (2011) J. Asthma , vol.48 , pp. 429-436
    • Zhao, Y.1    Yang, J.2    Gao, Y.-D.3
  • 62
    • 0023794030 scopus 로고
    • Immunoglobulin E and immunoglobulin G subclass distribution in vivo and relationship to in vitro generation of interferon-gamma and neopterin in patients with severe atopic dermatitis
    • [62] Reinhold, U., Pawelec, G., Wehrmann, W., Herold, M., Wernet, P., Kreysel, H.W., Immunoglobulin E and immunoglobulin G subclass distribution in vivo and relationship to in vitro generation of interferon-gamma and neopterin in patients with severe atopic dermatitis. Int. Arch. Allergy Immunol. 87 (1988), 120–126.
    • (1988) Int. Arch. Allergy Immunol. , vol.87 , pp. 120-126
    • Reinhold, U.1    Pawelec, G.2    Wehrmann, W.3    Herold, M.4    Wernet, P.5    Kreysel, H.W.6
  • 63
    • 0028981432 scopus 로고
    • Allergen-stimulated interleukin-4 and interferon-gamma production in primary culture: responses of subjects with allergic rhinitis and normal controls
    • [63] Imada, M., Simons, F.E., Jay, F.T., Hayglass, K.T., Allergen-stimulated interleukin-4 and interferon-gamma production in primary culture: responses of subjects with allergic rhinitis and normal controls. Immunology, 85, 1995, 373.
    • (1995) Immunology , vol.85 , pp. 373
    • Imada, M.1    Simons, F.E.2    Jay, F.T.3    Hayglass, K.T.4
  • 65
  • 66
    • 0028176866 scopus 로고
    • Lesional expression of interferon-γ in atopic eczema
    • [66] Grewe, M., Gyufko, K., Schöpf, E., Krutmann, J., Lesional expression of interferon-γ in atopic eczema. Lancet 343 (1994), 25–26.
    • (1994) Lancet , vol.343 , pp. 25-26
    • Grewe, M.1    Gyufko, K.2    Schöpf, E.3    Krutmann, J.4
  • 67
    • 9644302965 scopus 로고    scopus 로고
    • Early up-regulation of Th2 cytokines and late surge of Th1 cytokines in an atopic dermatitis model
    • [67] Chen, L., Martinez, O., Overbergh, L., Mathieu, C., Prabhakar, B.S., Chan, L.S., Early up-regulation of Th2 cytokines and late surge of Th1 cytokines in an atopic dermatitis model. Clin. Exp. Immunol. 138 (2004), 375–387.
    • (2004) Clin. Exp. Immunol. , vol.138 , pp. 375-387
    • Chen, L.1    Martinez, O.2    Overbergh, L.3    Mathieu, C.4    Prabhakar, B.S.5    Chan, L.S.6
  • 68
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • [68] Harrington, L.E., Hatton, R.D., Mangan, P.R., Turner, H., Murphy, T.L., Murphy, K.M., Weaver, C.T., Interleukin 17-producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6 (2005), 1123–1132, 10.1038/ni1254.
    • (2005) Nat. Immunol. , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6    Weaver, C.T.7
  • 69
    • 1542674589 scopus 로고    scopus 로고
    • Immunity to fungal infections
    • [69] Romani, L., Immunity to fungal infections. Nat. Rev. Immunol. 4 (2004), 11–24, 10.1038/nri1255.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 11-24
    • Romani, L.1
  • 70
    • 44049104564 scopus 로고    scopus 로고
    • The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
    • [70] Manel, N., Unutmaz, D., Littman, D.R., The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt. Nat. Immunol. 9 (2008), 641–649, 10.1038/ni.1610.
    • (2008) Nat. Immunol. , vol.9 , pp. 641-649
    • Manel, N.1    Unutmaz, D.2    Littman, D.R.3
  • 72
    • 85108124451 scopus 로고    scopus 로고
    • Two types of human Th17 cells with pro- and anti-inflammatory properties and distinct roles in autoinflammation
    • [72] Noster, R., de Koning, H., Sallusto, F., Zielinski, C., Two types of human Th17 cells with pro- and anti-inflammatory properties and distinct roles in autoinflammation. Pediatr. Rheumatol. Online J., 13, 2015, O49, 10.1186/1546-0096-13-S1-O49.
    • (2015) Pediatr. Rheumatol. Online J. , vol.13 , pp. O49
    • Noster, R.1    de Koning, H.2    Sallusto, F.3    Zielinski, C.4
  • 73
    • 0037841704 scopus 로고    scopus 로고
    • Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression
    • [73] Chakir, J., Shannon, J., Molet, S., Fukakusa, M., Elias, J., Laviolette, M., Boulet, L.-P., Hamid, Q., Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression. J. Allergy Clin. Immunol. 111 (2003), 1293–1298, 10.1067/mai.2003.1557.
    • (2003) J. Allergy Clin. Immunol. , vol.111 , pp. 1293-1298
    • Chakir, J.1    Shannon, J.2    Molet, S.3    Fukakusa, M.4    Elias, J.5    Laviolette, M.6    Boulet, L.-P.7    Hamid, Q.8
  • 75
    • 84973138132 scopus 로고    scopus 로고
    • Endotypes of allergic diseases and asthma: an important step in building blocks for the future of precision medicine
    • [75] Agache, I., Akdis, C.A., Endotypes of allergic diseases and asthma: an important step in building blocks for the future of precision medicine. Allergol. Int. 65 (2016), 243–252, 10.1016/j.alit.2016.04.011.
    • (2016) Allergol. Int. , vol.65 , pp. 243-252
    • Agache, I.1    Akdis, C.A.2
  • 76
    • 84926299974 scopus 로고    scopus 로고
    • Mode of dendritic cell activation: the decisive hand in Th2/Th17 cell differentiation. Implications in asthma severity?
    • [76] Vroman, H., van den Blink, B., Kool, M., Mode of dendritic cell activation: the decisive hand in Th2/Th17 cell differentiation. Implications in asthma severity?. Immunobiology 220 (2015), 254–261, 10.1016/j.imbio.2014.09.016.
    • (2015) Immunobiology , vol.220 , pp. 254-261
    • Vroman, H.1    van den Blink, B.2    Kool, M.3
  • 77
    • 84889092877 scopus 로고    scopus 로고
    • Th17-mediated inflammation in asthma
    • [77] Newcomb, D.C., Peebles, R.S. Jr., Th17-mediated inflammation in asthma. Curr. Opin. Immunol. 25 (2013), 755–760, 10.1016/j.coi.2013.08.002.
    • (2013) Curr. Opin. Immunol. , vol.25 , pp. 755-760
    • Newcomb, D.C.1    Peebles, R.S.2
  • 78
    • 11144232876 scopus 로고    scopus 로고
    • Interleukin-17F induces pulmonary neutrophilia and amplifies antigen-induced allergic response
    • [78] Oda, N., Canelos, P.B., Essayan, D.M., Plunkett, B.A., Myers, A.C., Huang, S.-K., Interleukin-17F induces pulmonary neutrophilia and amplifies antigen-induced allergic response. Am. J. Respir. Crit. Care Med. 171 (2005), 12–18, 10.1164/rccm.200406-778OC.
    • (2005) Am. J. Respir. Crit. Care Med. , vol.171 , pp. 12-18
    • Oda, N.1    Canelos, P.B.2    Essayan, D.M.3    Plunkett, B.A.4    Myers, A.C.5    Huang, S.-K.6
  • 82
    • 84862785630 scopus 로고    scopus 로고
    • Contribution of interleukin 17A to the development and regulation of allergic inflammation in a murine allergic rhinitis model
    • [82] Quan, S.-H., Zhang, Y.-L., Han, D.H., Iwakura, Y., Rhee, C.-S., Contribution of interleukin 17A to the development and regulation of allergic inflammation in a murine allergic rhinitis model. Ann. Allergy Asthma Immunol. 108 (2012), 342–350, 10.1016/j.anai.2012.02.014.
    • (2012) Ann. Allergy Asthma Immunol. , vol.108 , pp. 342-350
    • Quan, S.-H.1    Zhang, Y.-L.2    Han, D.H.3    Iwakura, Y.4    Rhee, C.-S.5
  • 83
    • 84869761470 scopus 로고    scopus 로고
    • FOXP3-marked IL-17a-producing regulatory T cells are increased in patients with allergic rhinitis
    • [83] Cheng, X., Lou, W., Wang, C., Zhang, W., Han, D., Zhang, L., FOXP3-marked IL-17a-producing regulatory T cells are increased in patients with allergic rhinitis. Acta Otolaryngol. (Stockh.) 132 (2012), 1311–1317, 10.3109/00016489.2012.709320.
    • (2012) Acta Otolaryngol. (Stockh.) , vol.132 , pp. 1311-1317
    • Cheng, X.1    Lou, W.2    Wang, C.3    Zhang, W.4    Han, D.5    Zhang, L.6
  • 84
    • 74749091686 scopus 로고    scopus 로고
    • Peripheral Th-17 cells in allergic rhinitis: new evidence, Int. Immunopharmacol. (n.d.) 226–229.
    • [84] G. Ciprandi, G. Filaci, F. Battaglia, D. Fenoglio, Peripheral Th-17 cells in allergic rhinitis: new evidence, Int. Immunopharmacol. 2010 (n.d.) 226–229.
    • (2010)
    • Ciprandi, G.1    Filaci, G.2    Battaglia, F.3    Fenoglio, D.4
  • 85
    • 84883433362 scopus 로고    scopus 로고
    • Comparison of the nasal release of IL-4, IL-10, IL-17, CCL13/MCP-4, and CCL26/eotaxin-3 in allergic rhinitis during season and after allergen challenge
    • [85] Baumann, R., Rabaszowski, M., Stenin, I., Tilgner, L., Scheckenbach, K., Wiltfang, J., Schipper, J., Chaker, A., Wagenmann, M., Comparison of the nasal release of IL-4, IL-10, IL-17, CCL13/MCP-4, and CCL26/eotaxin-3 in allergic rhinitis during season and after allergen challenge. Am. J. Rhinol. Allergy 27 (2013), 266–272, 10.2500/ajra.2013.27.3913.
    • (2013) Am. J. Rhinol. Allergy , vol.27 , pp. 266-272
    • Baumann, R.1    Rabaszowski, M.2    Stenin, I.3    Tilgner, L.4    Scheckenbach, K.5    Wiltfang, J.6    Schipper, J.7    Chaker, A.8    Wagenmann, M.9
  • 86
    • 68949217323 scopus 로고    scopus 로고
    • Serum interleukin-17 levels are related to clinical severity in allergic rhinitis
    • [86] Ciprandi, G., De Amici, M., Murdaca, G., Fenoglio, D., Ricciardolo, F., Marseglia, G., Tosca, M., Serum interleukin-17 levels are related to clinical severity in allergic rhinitis. Allergy 64 (2009), 1375–1378, 10.1111/j.1398-9995.2009.02010.x.
    • (2009) Allergy , vol.64 , pp. 1375-1378
    • Ciprandi, G.1    De Amici, M.2    Murdaca, G.3    Fenoglio, D.4    Ricciardolo, F.5    Marseglia, G.6    Tosca, M.7
  • 87
    • 84904410851 scopus 로고    scopus 로고
    • A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis
    • [87] Dhingra, N., Guttman-Yassky, E., A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis. J. Invest. Dermatol. 134 (2014), 2071–2074, 10.1038/jid.2014.141.
    • (2014) J. Invest. Dermatol. , vol.134 , pp. 2071-2074
    • Dhingra, N.1    Guttman-Yassky, E.2
  • 89
    • 84920670523 scopus 로고    scopus 로고
    • The microbiota is important for IL-17A expression and neutrophil infiltration in lesional skin of Flgft/ft mice
    • [89] Hoff, S., Oyoshi, M.K., Macpherson, A., Geha, R.S., The microbiota is important for IL-17A expression and neutrophil infiltration in lesional skin of Flgft/ft mice. Clin. Immunol. 156 (2015), 128–130, 10.1016/j.clim.2014.12.001.
    • (2015) Clin. Immunol. , vol.156 , pp. 128-130
    • Hoff, S.1    Oyoshi, M.K.2    Macpherson, A.3    Geha, R.S.4
  • 91
    • 69349088601 scopus 로고    scopus 로고
    • Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen
    • e1
    • [91] Oyoshi, M.K., Murphy, G.F., Geha, R.S., Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen. J. Allergy Clin. Immunol. 124 (2009), 485–493, e1, 10.1016/j.jaci.2009.05.042.
    • (2009) J. Allergy Clin. Immunol. , vol.124 , pp. 485-493
    • Oyoshi, M.K.1    Murphy, G.F.2    Geha, R.S.3
  • 92
    • 0036604122 scopus 로고    scopus 로고
    • Cutting edge: immune cells as sources and targets of the IL-10 family members?
    • [92] Wolk, K., Kunz, S., Asadullah, K., Sabat, R., Cutting edge: immune cells as sources and targets of the IL-10 family members?. J. Immunol. Baltim. Md 1950 168 (2002), 5397–5402.
    • (2002) J. Immunol. Baltim. Md 1950 , vol.168 , pp. 5397-5402
    • Wolk, K.1    Kunz, S.2    Asadullah, K.3    Sabat, R.4
  • 93
    • 70449479858 scopus 로고    scopus 로고
    • Multiparametric analysis of cytokine-driven human Th17 differentiation reveals a differential regulation of IL-17 and IL-22 production
    • [93] Volpe, E., Touzot, M., Servant, N., Marloie-Provost, M.-A., Hupé, P., Barillot, E., Soumelis, V., Multiparametric analysis of cytokine-driven human Th17 differentiation reveals a differential regulation of IL-17 and IL-22 production. Blood 114 (2009), 3610–3614, 10.1182/blood-2009-05-223768.
    • (2009) Blood , vol.114 , pp. 3610-3614
    • Volpe, E.1    Touzot, M.2    Servant, N.3    Marloie-Provost, M.-A.4    Hupé, P.5    Barillot, E.6    Soumelis, V.7
  • 94
    • 84873688049 scopus 로고    scopus 로고
    • IL-22, not simply a Th17 cytokine
    • [94] Rutz, S., Eidenschenk, C., Ouyang, W., IL-22, not simply a Th17 cytokine. Immunol. Rev. 252 (2013), 116–132, 10.1111/imr.12027.
    • (2013) Immunol. Rev. , vol.252 , pp. 116-132
    • Rutz, S.1    Eidenschenk, C.2    Ouyang, W.3
  • 96
    • 67651154105 scopus 로고    scopus 로고
    • Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
    • [96] Duhen, T., Geiger, R., Jarrossay, D., Lanzavecchia, A., Sallusto, F., Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat. Immunol. 10 (2009), 857–863, 10.1038/ni.1767.
    • (2009) Nat. Immunol. , vol.10 , pp. 857-863
    • Duhen, T.1    Geiger, R.2    Jarrossay, D.3    Lanzavecchia, A.4    Sallusto, F.5
  • 97
    • 39049165088 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history
    • [97] Fitzgerald-Bocarsly, P., Dai, J., Singh, S., Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history. Cytokine Growth Factor Rev. 19 (2008), 3–19, 10.1016/j.cytogfr.2007.10.006.
    • (2008) Cytokine Growth Factor Rev. , vol.19 , pp. 3-19
    • Fitzgerald-Bocarsly, P.1    Dai, J.2    Singh, S.3
  • 99
    • 77953495368 scopus 로고    scopus 로고
    • Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A
    • [99] Sonnenberg, G.F., Nair, M.G., Kirn, T.J., Zaph, C., Fouser, L.A., Artis, D., Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A. J. Exp. Med. 207 (2010), 1293–1305, 10.1084/jem.20092054.
    • (2010) J. Exp. Med. , vol.207 , pp. 1293-1305
    • Sonnenberg, G.F.1    Nair, M.G.2    Kirn, T.J.3    Zaph, C.4    Fouser, L.A.5    Artis, D.6
  • 101
    • 33646552450 scopus 로고    scopus 로고
    • IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis
    • [101] Wolk, K., Witte, E., Wallace, E., Döcke, W.-D., Kunz, S., Asadullah, K., Volk, H.-D., Sterry, W., Sabat, R., IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur. J. Immunol. 36 (2006), 1309–1323, 10.1002/eji.200535503.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 1309-1323
    • Wolk, K.1    Witte, E.2    Wallace, E.3    Döcke, W.-D.4    Kunz, S.5    Asadullah, K.6    Volk, H.-D.7    Sterry, W.8    Sabat, R.9
  • 102
    • 58649110860 scopus 로고    scopus 로고
    • The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds
    • [102] Li, W., Danilenko, D.M., Bunting, S., Ganesan, R., Sa, S., Ferrando, R., Wu, T.D., Kolumam, G.A., Ouyang, W., Kirchhofer, D., The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds. J. Biol. Chem. 284 (2009), 218–228, 10.1074/jbc.M806267200.
    • (2009) J. Biol. Chem. , vol.284 , pp. 218-228
    • Li, W.1    Danilenko, D.M.2    Bunting, S.3    Ganesan, R.4    Sa, S.5    Ferrando, R.6    Wu, T.D.7    Kolumam, G.A.8    Ouyang, W.9    Kirchhofer, D.10
  • 103
    • 33846906224 scopus 로고    scopus 로고
    • Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    • [103] Zheng, Y., Danilenko, D.M., Valdez, P., Kasman, I., Eastham-Anderson, J., Wu, J., Ouyang, W., Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445 (2007), 648–651, 10.1038/nature05505.
    • (2007) Nature , vol.445 , pp. 648-651
    • Zheng, Y.1    Danilenko, D.M.2    Valdez, P.3    Kasman, I.4    Eastham-Anderson, J.5    Wu, J.6    Ouyang, W.7
  • 104
    • 4143095716 scopus 로고    scopus 로고
    • IL-22 increases the innate immunity of tissues
    • [104] Wolk, K., Kunz, S., Witte, E., Friedrich, M., Asadullah, K., Sabat, R., IL-22 increases the innate immunity of tissues. Immunity 21 (2004), 241–254, 10.1016/j.immuni.2004.07.007.
    • (2004) Immunity , vol.21 , pp. 241-254
    • Wolk, K.1    Kunz, S.2    Witte, E.3    Friedrich, M.4    Asadullah, K.5    Sabat, R.6
  • 107
    • 70350041508 scopus 로고    scopus 로고
    • Th17 immunity in patients with allergic asthma
    • [107] Zhao, Y., Yang, J., Gao, Y.-D., Guo, W., Th17 immunity in patients with allergic asthma. Int. Arch. Allergy Immunol. 151 (2010), 297–307, 10.1159/000250438.
    • (2010) Int. Arch. Allergy Immunol. , vol.151 , pp. 297-307
    • Zhao, Y.1    Yang, J.2    Gao, Y.-D.3    Guo, W.4
  • 112
    • 56349154943 scopus 로고    scopus 로고
    • Transforming growth factor-beta “reprograms” the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    • [112] Veldhoen, M., Uyttenhove, C., van Snick, J., Helmby, H., Westendorf, A., Buer, J., Martin, B., Wilhelm, C., Stockinger, B., Transforming growth factor-beta “reprograms” the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat. Immunol. 9 (2008), 1341–1346, 10.1038/ni.1659.
    • (2008) Nat. Immunol. , vol.9 , pp. 1341-1346
    • Veldhoen, M.1    Uyttenhove, C.2    van Snick, J.3    Helmby, H.4    Westendorf, A.5    Buer, J.6    Martin, B.7    Wilhelm, C.8    Stockinger, B.9
  • 113
    • 0028077321 scopus 로고
    • IL-9 production of naive CD4 + T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by IFN-gamma
    • [113] Schmitt, E., Germann, T., Goedert, S., Hoehn, P., Huels, C., Koelsch, S., Kühn, R., Müller, W., Palm, N., Rüde, E., IL-9 production of naive CD4 + T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by IFN-gamma. J. Immunol. Baltim. Md 1950 153 (1994), 3989–3996.
    • (1994) J. Immunol. Baltim. Md 1950 , vol.153 , pp. 3989-3996
    • Schmitt, E.1    Germann, T.2    Goedert, S.3    Hoehn, P.4    Huels, C.5    Koelsch, S.6    Kühn, R.7    Müller, W.8    Palm, N.9    Rüde, E.10
  • 115
    • 56349154943 scopus 로고    scopus 로고
    • Transforming growth factor-b “reprograms” the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset
    • [115] Veldhoen, et al. Transforming growth factor-b “reprograms” the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset. Nat. Immunol. 9 (2008), 1341–1346, 10.1038/ni.1659.
    • (2008) Nat. Immunol. , vol.9 , pp. 1341-1346
    • Veldhoen1
  • 116
    • 77955862776 scopus 로고    scopus 로고
    • Interferon regulatory factor 4: combinational control of lymphocyte differentiation
    • [116] Veldhoen, M., Interferon regulatory factor 4: combinational control of lymphocyte differentiation. Immunity 33 (2010), 141–143, 10.1016/j.immuni.2010.08.007.
    • (2010) Immunity , vol.33 , pp. 141-143
    • Veldhoen, M.1
  • 117
    • 0033696860 scopus 로고    scopus 로고
    • IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development
    • [117] Townsend, J.M., Fallon, G.P., Matthews, J.D., Smith, P., Jolin, E.H., McKenzie, N.A., IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development. Immunity 13 (2000), 573–583.
    • (2000) Immunity , vol.13 , pp. 573-583
    • Townsend, J.M.1    Fallon, G.P.2    Matthews, J.D.3    Smith, P.4    Jolin, E.H.5    McKenzie, N.A.6
  • 118
    • 0036141448 scopus 로고    scopus 로고
    • Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology
    • [118] Temann, U.-A., Ray, P., Flavell, R.A., Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology. J. Clin. Invest. 109 (2002), 29–39, 10.1172/JCI13696.
    • (2002) J. Clin. Invest. , vol.109 , pp. 29-39
    • Temann, U.-A.1    Ray, P.2    Flavell, R.A.3
  • 119
    • 84874241774 scopus 로고    scopus 로고
    • Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP
    • [119] Yao, W., Zhang, Y., Jabeen, R., Nguyen, E.T., Wilkes, D.S., Tepper, R.S., Kaplan, M.H., Zhou, B., Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP. Immunity 38 (2013), 360–372, 10.1016/j.immuni.2013.01.007.
    • (2013) Immunity , vol.38 , pp. 360-372
    • Yao, W.1    Zhang, Y.2    Jabeen, R.3    Nguyen, E.T.4    Wilkes, D.S.5    Tepper, R.S.6    Kaplan, M.H.7    Zhou, B.8
  • 123
    • 84928584195 scopus 로고    scopus 로고
    • The development and in vivo function of T helper 9 cells
    • [123] Kaplan, M.H., Hufford, M.M., Olson, M.R., The development and in vivo function of T helper 9 cells. Nat. Rev. Immunol. 15 (2015), 295–307, 10.1038/nri3824.
    • (2015) Nat. Rev. Immunol. , vol.15 , pp. 295-307
    • Kaplan, M.H.1    Hufford, M.M.2    Olson, M.R.3
  • 124
  • 127
    • 84888875666 scopus 로고    scopus 로고
    • Possible pathogenic role of T helper type 9 cells and interleukin (IL)-9 in atopic dermatitis
    • [127] Ma, L., Xue, H.-B., Guan, X.-H., Shu, C.-M., Zhang, J.-H., Yu, J., Possible pathogenic role of T helper type 9 cells and interleukin (IL)-9 in atopic dermatitis. Clin. Exp. Immunol. 175 (2014), 25–31, 10.1111/cei.12198.
    • (2014) Clin. Exp. Immunol. , vol.175 , pp. 25-31
    • Ma, L.1    Xue, H.-B.2    Guan, X.-H.3    Shu, C.-M.4    Zhang, J.-H.5    Yu, J.6
  • 128
    • 79956116032 scopus 로고    scopus 로고
    • RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
    • [128] Codarri, L., Gyülvészi, G., Tosevski, V., Hesske, L., Fontana, A., Magnenat, L., Suter, T., Becher, B., RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat. Immunol. 12 (2011), 560–567, 10.1038/ni.2027.
    • (2011) Nat. Immunol. , vol.12 , pp. 560-567
    • Codarri, L.1    Gyülvészi, G.2    Tosevski, V.3    Hesske, L.4    Fontana, A.5    Magnenat, L.6    Suter, T.7    Becher, B.8
  • 129
    • 79956152607 scopus 로고    scopus 로고
    • The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF
    • [129] El-Behi, M., Ciric, B., Dai, H., Yan, Y., Cullimore, M., Safavi, F., Zhang, G.-X., Dittel, B.N., Rostami, A., The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat. Immunol. 12 (2011), 568–575, 10.1038/ni.2031.
    • (2011) Nat. Immunol. , vol.12 , pp. 568-575
    • El-Behi, M.1    Ciric, B.2    Dai, H.3    Yan, Y.4    Cullimore, M.5    Safavi, F.6    Zhang, G.-X.7    Dittel, B.N.8    Rostami, A.9
  • 131
    • 84927580933 scopus 로고    scopus 로고
    • STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation
    • [131] Sheng, W., Yang, F., Zhou, Y., Yang, H., Low, P.Y., Kemeny, D.M., Tan, P., Moh, A., Kaplan, M.H., Zhang, Y., Fu, X.-Y., STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation. Cell Res. 24 (2014), 1387–1402, 10.1038/cr.2014.154.
    • (2014) Cell Res. , vol.24 , pp. 1387-1402
    • Sheng, W.1    Yang, F.2    Zhou, Y.3    Yang, H.4    Low, P.Y.5    Kemeny, D.M.6    Tan, P.7    Moh, A.8    Kaplan, M.H.9    Zhang, Y.10    Fu, X.-Y.11
  • 133
    • 84955569946 scopus 로고    scopus 로고
    • Epidermal growth factor receptor signalling regulates granulocyte-macrophage colony-stimulating factor production by airway epithelial cells and established allergic airway disease
    • [133] Acciani, T.H., Suzuki, T., Trapnell, B.C., Le Cras, T.D., Epidermal growth factor receptor signalling regulates granulocyte-macrophage colony-stimulating factor production by airway epithelial cells and established allergic airway disease. Clin. Exp. Allergy J. Br. Soc. Allergy Clin. Immunol. 46 (2016), 317–328, 10.1111/cea.12612.
    • (2016) Clin. Exp. Allergy J. Br. Soc. Allergy Clin. Immunol. , vol.46 , pp. 317-328
    • Acciani, T.H.1    Suzuki, T.2    Trapnell, B.C.3    Le Cras, T.D.4
  • 134
    • 0031878814 scopus 로고    scopus 로고
    • Compartmentalized transgene expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in mouse lung enhances allergic airways inflammation
    • [134] Lei, X.F., Ohkawara, Y., Stämpfli, M.R., Gauldie, J., Croitoru, K., Jordana, M., Xing, Z., Compartmentalized transgene expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in mouse lung enhances allergic airways inflammation. Clin. Exp. Immunol. 113 (1998), 157–165.
    • (1998) Clin. Exp. Immunol. , vol.113 , pp. 157-165
    • Lei, X.F.1    Ohkawara, Y.2    Stämpfli, M.R.3    Gauldie, J.4    Croitoru, K.5    Jordana, M.6    Xing, Z.7
  • 136
    • 0033006613 scopus 로고    scopus 로고
    • Circulating eosinophil/basophil progenitors and nasal mucosal cytokines in seasonal allergic rhinitis
    • [136] Linden, M., Svensson, C., Andersson, M., Greiff, L., Andersson, E., Denburg, J.A., Persson, C.G., Circulating eosinophil/basophil progenitors and nasal mucosal cytokines in seasonal allergic rhinitis. Allergy 54 (1999), 212–219.
    • (1999) Allergy , vol.54 , pp. 212-219
    • Linden, M.1    Svensson, C.2    Andersson, M.3    Greiff, L.4    Andersson, E.5    Denburg, J.A.6    Persson, C.G.7
  • 137
    • 0034923389 scopus 로고    scopus 로고
    • The role of keratinocytes in the pathogenesis of atopic dermatitis
    • [137] Girolomoni, G., Pastore, S., The role of keratinocytes in the pathogenesis of atopic dermatitis. J. Am. Acad. Dermatol. 45 (2001), S25–S28.
    • (2001) J. Am. Acad. Dermatol. , vol.45 , pp. S25-S28
    • Girolomoni, G.1    Pastore, S.2
  • 138
    • 33645581525 scopus 로고    scopus 로고
    • The contribution of keratinocytes to the pathogenesis of atopic dermatitis
    • [138] Pastore, S., Mascia, F., Girolomoni, G., The contribution of keratinocytes to the pathogenesis of atopic dermatitis. Eur. J. Dermatol. 16 (2006), 125–131.
    • (2006) Eur. J. Dermatol. , vol.16 , pp. 125-131
    • Pastore, S.1    Mascia, F.2    Girolomoni, G.3
  • 142
    • 4644227859 scopus 로고    scopus 로고
    • Regulatory CD4 + CD25 + T lymphocytes in peripheral blood from patients with atopic asthma
    • [142] Shi, H.-Z., Li, S., Xie, Z.-F., Qin, X.-J., Qin, X., Zhong, X.-N., Regulatory CD4 + CD25 + T lymphocytes in peripheral blood from patients with atopic asthma. Clin. Immunol. 113 (2004), 172–178, 10.1016/j.clim.2004.06.009.
    • (2004) Clin. Immunol. , vol.113 , pp. 172-178
    • Shi, H.-Z.1    Li, S.2    Xie, Z.-F.3    Qin, X.-J.4    Qin, X.5    Zhong, X.-N.6
  • 143
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: mechanisms of differentiation and function
    • [143] Josefowicz, S.Z., Lu, L.-F., Rudensky, A.Y., Regulatory T cells: mechanisms of differentiation and function. Annu. Rev. Immunol. 30 (2012), 531–564, 10.1146/annurev.immunol.25.022106.141623.
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.-F.2    Rudensky, A.Y.3
  • 144
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4 + CD25- naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • [144] Chen, W., Jin, W., Hardegen, N., Lei, K.-J., Li, L., Marinos, N., McGrady, G., Wahl, S.M., Conversion of peripheral CD4 + CD25- naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198 (2003), 1875–1886, 10.1084/jem.20030152.
    • (2003) J. Exp. Med. , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.-J.4    Li, L.5    Marinos, N.6    McGrady, G.7    Wahl, S.M.8
  • 149
    • 84867742980 scopus 로고    scopus 로고
    • Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: a paradigm of immunodeficiency with autoimmunity
    • [149] Barzaghi, F., Passerini, L., Bacchetta, R., Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: a paradigm of immunodeficiency with autoimmunity. Front. Immunol., 3, 2012, 10.3389/fimmu.2012.00211.
    • (2012) Front. Immunol. , vol.3
    • Barzaghi, F.1    Passerini, L.2    Bacchetta, R.3
  • 150
    • 84455208146 scopus 로고    scopus 로고
    • Changes in thymic regulatory T-cell maturation from birth to puberty: differences in atopic children
    • e4
    • [150] Tulic, M.K., Andrews, D., Crook, M.L., Charles, A., Tourigny, M.R., Moqbel, R., Prescott, S.L., Changes in thymic regulatory T-cell maturation from birth to puberty: differences in atopic children. J. Allergy Clin. Immunol. 129 (2012), 199–206, e4, 10.1016/j.jaci.2011.10.016.
    • (2012) J. Allergy Clin. Immunol. , vol.129 , pp. 199-206
    • Tulic, M.K.1    Andrews, D.2    Crook, M.L.3    Charles, A.4    Tourigny, M.R.5    Moqbel, R.6    Prescott, S.L.7
  • 151
    • 63449090874 scopus 로고    scopus 로고
    • Mechanisms and treatment of allergic disease in the big picture of regulatory T cells
    • [151] Akdis, C.A., Akdis, M., Mechanisms and treatment of allergic disease in the big picture of regulatory T cells. J. Allergy Clin. Immunol. 123 (2009), 735–746, 10.1016/j.jaci.2009.02.030.
    • (2009) J. Allergy Clin. Immunol. , vol.123 , pp. 735-746
    • Akdis, C.A.1    Akdis, M.2
  • 152
    • 58149337013 scopus 로고    scopus 로고
    • Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-β
    • [152] Satoguina, J.S., Adjobimey, T., Arndts, K., Hoch, J., Oldenburg, J., Layland, L.E., Hoerauf, A., Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-β. Eur. J. Immunol. 38 (2008), 3101–3113, 10.1002/eji.200838193.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 3101-3113
    • Satoguina, J.S.1    Adjobimey, T.2    Arndts, K.3    Hoch, J.4    Oldenburg, J.5    Layland, L.E.6    Hoerauf, A.7
  • 155
    • 84887446273 scopus 로고    scopus 로고
    • Regulatory T cells use “itch” to control asthma
    • [155] Chen, W., Regulatory T cells use “itch” to control asthma. J. Clin. Invest. 123 (2013), 4576–4578, 10.1172/JCI72477.
    • (2013) J. Clin. Invest. , vol.123 , pp. 4576-4578
    • Chen, W.1
  • 156
    • 78650667201 scopus 로고    scopus 로고
    • An intrinsic mechanism predisposes Foxp3-expressing regulatory T cells to Th2 conversion in vivo
    • [156] Wang, Y., Souabni, A., Flavell, R.A., Wan, Y.Y., An intrinsic mechanism predisposes Foxp3-expressing regulatory T cells to Th2 conversion in vivo. J. Immunol. Baltim. Md 1950 185 (2010), 5983–5992, 10.4049/jimmunol.1001255.
    • (2010) J. Immunol. Baltim. Md 1950 , vol.185 , pp. 5983-5992
    • Wang, Y.1    Souabni, A.2    Flavell, R.A.3    Wan, Y.Y.4
  • 157
    • 68949103932 scopus 로고    scopus 로고
    • STAT6 activation confers upon T helper cells resistance to suppression by regulatory T cells
    • [157] Pillemer, B.B.L., Qi, Z., Melgert, B., Oriss, T.B., Ray, P., Ray, A., STAT6 activation confers upon T helper cells resistance to suppression by regulatory T cells. J. Immunol. Baltim. Md 1950 183 (2009), 155–163, 10.4049/jimmunol.0803733.
    • (2009) J. Immunol. Baltim. Md 1950 , vol.183 , pp. 155-163
    • Pillemer, B.B.L.1    Qi, Z.2    Melgert, B.3    Oriss, T.B.4    Ray, P.5    Ray, A.6
  • 158
    • 77951467736 scopus 로고    scopus 로고
    • Regulatory T cells in many flavors control asthma
    • [158] Ray, A., Khare, A., Krishnamoorthy, N., Qi, Z., Ray, P., Regulatory T cells in many flavors control asthma. Mucosal Immunol. 3 (2010), 216–229, 10.1038/mi.2010.4.
    • (2010) Mucosal Immunol. , vol.3 , pp. 216-229
    • Ray, A.1    Khare, A.2    Krishnamoorthy, N.3    Qi, Z.4    Ray, P.5
  • 160
    • 84885437985 scopus 로고    scopus 로고
    • Pneumococcal components induce regulatory T cells that attenuate the development of allergic airways disease by deviating and suppressing the immune response to allergen
    • [160] Thorburn, A.N., Brown, A.C., Nair, P.M., Chevalier, N., Foster, P.S., Gibson, P.G., Hansbro, P.M., Pneumococcal components induce regulatory T cells that attenuate the development of allergic airways disease by deviating and suppressing the immune response to allergen. J. Immunol. Baltim. Md 1950 191 (2013), 4112–4120, 10.4049/jimmunol.1201232.
    • (2013) J. Immunol. Baltim. Md 1950 , vol.191 , pp. 4112-4120
    • Thorburn, A.N.1    Brown, A.C.2    Nair, P.M.3    Chevalier, N.4    Foster, P.S.5    Gibson, P.G.6    Hansbro, P.M.7
  • 163
    • 0023726937 scopus 로고
    • Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones
    • [163] Gajewski, T.F., Fitch, F.W., Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J. Immunol. Baltim. Md 1950 140 (1988), 4245–4252.
    • (1988) J. Immunol. Baltim. Md 1950 , vol.140 , pp. 4245-4252
    • Gajewski, T.F.1    Fitch, F.W.2
  • 165
    • 74549179138 scopus 로고    scopus 로고
    • Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions
    • [165] Hegazy, A.N., Peine, M., Helmstetter, C., Panse, I., Fröhlich, A., Bergthaler, A., Flatz, L., Pinschewer, D.D., Radbruch, A., Löhning, M., Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions. Immunity 32 (2010), 116–128, 10.1016/j.immuni.2009.12.004.
    • (2010) Immunity , vol.32 , pp. 116-128
    • Hegazy, A.N.1    Peine, M.2    Helmstetter, C.3    Panse, I.4    Fröhlich, A.5    Bergthaler, A.6    Flatz, L.7    Pinschewer, D.D.8    Radbruch, A.9    Löhning, M.10
  • 166
    • 84880949850 scopus 로고    scopus 로고
    • Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation
    • e1001633
    • [166] Peine, M., Rausch, S., Helmstetter, C., Fröhlich, A., Hegazy, A.N., Kühl, A.A., Grevelding, C.G., Höfer, T., Hartmann, S., Löhning, M., Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation. PLoS Biol., 11, 2013, e1001633, 10.1371/journal.pbio.1001633.
    • (2013) PLoS Biol. , vol.11
    • Peine, M.1    Rausch, S.2    Helmstetter, C.3    Fröhlich, A.4    Hegazy, A.N.5    Kühl, A.A.6    Grevelding, C.G.7    Höfer, T.8    Hartmann, S.9    Löhning, M.10
  • 167
    • 78149326083 scopus 로고    scopus 로고
    • A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma
    • [167] Wang, Y.-H., Voo, K.S., Liu, B., Chen, C.-Y., Uygungil, B., Spoede, W., Bernstein, J.A., Huston, D.P., Liu, Y.-J., A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma. J. Exp. Med. 207 (2010), 2479–2491, 10.1084/jem.20101376.
    • (2010) J. Exp. Med. , vol.207 , pp. 2479-2491
    • Wang, Y.-H.1    Voo, K.S.2    Liu, B.3    Chen, C.-Y.4    Uygungil, B.5    Spoede, W.6    Bernstein, J.A.7    Huston, D.P.8    Liu, Y.-J.9
  • 168
    • 84913530341 scopus 로고    scopus 로고
    • Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma
    • e7
    • [168] Irvin, C., Zafar, I., Good, J., Rollins, D., Christianson, C., Gorska, M.M., Martin, R.J., Alam, R., Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma. J. Allergy Clin. Immunol. 134 (2014), 1175–1186, e7, 10.1016/j.jaci.2014.05.038.
    • (2014) J. Allergy Clin. Immunol. , vol.134 , pp. 1175-1186
    • Irvin, C.1    Zafar, I.2    Good, J.3    Rollins, D.4    Christianson, C.5    Gorska, M.M.6    Martin, R.J.7    Alam, R.8
  • 169
    • 84856022450 scopus 로고    scopus 로고
    • Rapid in vivo conversion of effector T cells into Th2 cells during helminth infection
    • [169] Panzer, M., Sitte, S., Wirth, S., Drexler, I., Sparwasser, T., Voehringer, D., Rapid in vivo conversion of effector T cells into Th2 cells during helminth infection. J. Immunol. Baltim. Md 1950 188 (2012), 615–623, 10.4049/jimmunol.1101164.
    • (2012) J. Immunol. Baltim. Md 1950 , vol.188 , pp. 615-623
    • Panzer, M.1    Sitte, S.2    Wirth, S.3    Drexler, I.4    Sparwasser, T.5    Voehringer, D.6
  • 170
    • 74549179138 scopus 로고    scopus 로고
    • Interferons direct Th2 cell reprogramming to generate a stable GATA-3 + T-bet + cell subset with combined Th2 and Th1 cell functions
    • [170] Hegazy, A.N., Peine, M., Helmstetter, C., Panse, I., Fröhlich, A., Bergthaler, A., Flatz, L., Pinschewer, D.D., Radbruch, A., Löhning, M., Interferons direct Th2 cell reprogramming to generate a stable GATA-3 + T-bet + cell subset with combined Th2 and Th1 cell functions. Immunity 32 (2010), 116–128, 10.1016/j.immuni.2009.12.004.
    • (2010) Immunity , vol.32 , pp. 116-128
    • Hegazy, A.N.1    Peine, M.2    Helmstetter, C.3    Panse, I.4    Fröhlich, A.5    Bergthaler, A.6    Flatz, L.7    Pinschewer, D.D.8    Radbruch, A.9    Löhning, M.10
  • 171
    • 33947619418 scopus 로고    scopus 로고
    • Functional plasticity in memory T helper cell responses
    • [171] Krawczyk, C.M., Shen, H., Pearce, E.J., Functional plasticity in memory T helper cell responses. J. Immunol. Baltim. Md 1950 178 (2007), 4080–4088.
    • (2007) J. Immunol. Baltim. Md 1950 , vol.178 , pp. 4080-4088
    • Krawczyk, C.M.1    Shen, H.2    Pearce, E.J.3
  • 172
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • [172] Koch, M.A., Tucker-Heard, G.'s., Perdue, N.R., Killebrew, J.R., Urdahl, K.B., Campbell, D.J., The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat. Immunol. 10 (2009), 595–602, 10.1038/ni.1731.
    • (2009) Nat. Immunol. , vol.10 , pp. 595-602
    • Koch, M.A.1    Tucker-Heard, G.S.2    Perdue, N.R.3    Killebrew, J.R.4    Urdahl, K.B.5    Campbell, D.J.6
  • 176
    • 84925038493 scopus 로고    scopus 로고
    • Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy
    • [176] Noval Rivas, M., Burton, O.T., Wise, P., Charbonnier, L.-M., Georgiev, P., Oettgen, H.C., Rachid, R., Chatila, T.A., Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy. Immunity 42 (2015), 512–523, 10.1016/j.immuni.2015.02.004.
    • (2015) Immunity , vol.42 , pp. 512-523
    • Noval Rivas, M.1    Burton, O.T.2    Wise, P.3    Charbonnier, L.-M.4    Georgiev, P.5    Oettgen, H.C.6    Rachid, R.7    Chatila, T.A.8
  • 177
    • 84978698951 scopus 로고    scopus 로고
    • Balancing inflammation: the link between Th17 and regulatory T cells
    • [177] Diller, M.L., Kudchadkar, R.R., Delman, K.A., Lawson, D.H., Ford, M.L., Balancing inflammation: the link between Th17 and regulatory T cells. Mediat. Inflamm., 2016, 2016, 6309219, 10.1155/2016/6309219.
    • (2016) Mediat. Inflamm. , vol.2016 , pp. 6309219
    • Diller, M.L.1    Kudchadkar, R.R.2    Delman, K.A.3    Lawson, D.H.4    Ford, M.L.5
  • 181
    • 84856022450 scopus 로고    scopus 로고
    • Rapid in vivo conversion of effector T cells into Th2 cells during helminth infection
    • [181] Panzer, M., Sitte, S., Wirth, S., Drexler, I., Sparwasser, T., Voehringer, D., Rapid in vivo conversion of effector T cells into Th2 cells during helminth infection. J. Immunol. Baltim. Md 1950 188 (2012), 615–623, 10.4049/jimmunol.1101164.
    • (2012) J. Immunol. Baltim. Md 1950 , vol.188 , pp. 615-623
    • Panzer, M.1    Sitte, S.2    Wirth, S.3    Drexler, I.4    Sparwasser, T.5    Voehringer, D.6
  • 183
    • 84961382219 scopus 로고    scopus 로고
    • Biomarkers in the clinical development of asthma therapies
    • [183] Staton, T.L., Choy, D.F., Arron, J.R., Biomarkers in the clinical development of asthma therapies. Biomark. Med 10 (2016), 165–176, 10.2217/bmm.15.116.
    • (2016) Biomark. Med , vol.10 , pp. 165-176
    • Staton, T.L.1    Choy, D.F.2    Arron, J.R.3
  • 184
    • 36849031788 scopus 로고    scopus 로고
    • Epithelium dysfunction in asthma
    • [184] Holgate, S.T., Epithelium dysfunction in asthma. J. Allergy Clin. Immunol. 120 (2007), 1233–1244, 10.1016/j.jaci.2007.10.025.
    • (2007) J. Allergy Clin. Immunol. , vol.120 , pp. 1233-1244
    • Holgate, S.T.1
  • 185
    • 84920876065 scopus 로고    scopus 로고
    • Recent advances in epithelium-derived cytokines (IL-33, IL-25, and thymic stromal lymphopoietin) and allergic inflammation
    • [185] Divekar, R., Kita, H., Recent advances in epithelium-derived cytokines (IL-33, IL-25, and thymic stromal lymphopoietin) and allergic inflammation. Curr. Opin. Allergy Clin. Immunol. 15 (2015), 98–103, 10.1097/ACI.0000000000000133.
    • (2015) Curr. Opin. Allergy Clin. Immunol. , vol.15 , pp. 98-103
    • Divekar, R.1    Kita, H.2
  • 186
    • 84855765388 scopus 로고    scopus 로고
    • Anti-IL-33 antibody has a therapeutic effect in a murine model of allergic rhinitis
    • [186] Kim, Y.H., Yang, T.Y., Park, C.-S., Ahn, S.-H., Son, B.K., Kim, J.H., Lim, D.H., Jang, T.Y., Anti-IL-33 antibody has a therapeutic effect in a murine model of allergic rhinitis. Allergy 67 (2012), 183–190, 10.1111/j.1398-9995.2011.02735.x.
    • (2012) Allergy , vol.67 , pp. 183-190
    • Kim, Y.H.1    Yang, T.Y.2    Park, C.-S.3    Ahn, S.-H.4    Son, B.K.5    Kim, J.H.6    Lim, D.H.7    Jang, T.Y.8


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