The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen der p 1: An innovative approach to the treatment of allergic asthma

Journal of Medicinal Chemistry

Volumn 57, Issue 22, 2014, Pages 9447-9462

  Newton, Gary K ^a   Perrior, Trevor R ^a   Jenkins, Kerry ^a   Major, Meriel R ^a   Key, Rebekah E ^a   Stewart, Mark R ^a   Firth Clark, Stuart ^a   Lloyd, Steven M ^a   Zhang, Jihui ^b   Francis Newton, Nicola J ^b   Richardson, Jonathan P ^b   Chen, Jie ^b   Lai, Pei ^b   Garrod, David R ^c   Robinson, Clive ^b  

^a Domainex Ltd   (United Kingdom)

^b ST GEORGE S HOSPITAL   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PEPTIDASE; DER P 1 INHIBITOR; HOUSE DUST ALLERGEN; PEPTIDASE; PEPTIDE HYDROLASE INHIBITOR; UNCLASSIFIED DRUG; ALLERGEN; ARTHROPOD PROTEIN; CYSTEINE PROTEINASE; DERMATOPHAGOIDES PTERONYSSINUS ANTIGEN P 1; PEPTIDE; PROTEIN BINDING;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATTENUATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DERMATOPHAGOIDES; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG POTENCY; DRUG POTENTIATION; DRUG SELECTIVITY; ENZYME BINDING; IC50; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PHYSICAL CHEMISTRY; PROTEIN DEGRADATION; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; ASTHMA; CHEMISTRY; HUMAN; HYPERSENSITIVITY; IMMUNOLOGY; MEDICINAL CHEMISTRY; MOLECULAR WEIGHT; ORAL DRUG ADMINISTRATION; PROCEDURES; PROTEIN MOTIF; PYROGLYPHIDAE;

ADMINISTRATION, ORAL; ALLERGENS; AMINO ACID MOTIFS; ANIMALS; ANTIGENS, DERMATOPHAGOIDES; ARTHROPOD PROTEINS; ASTHMA; CHEMISTRY, PHARMACEUTICAL; CYSTEINE ENDOPEPTIDASES; DRUG DESIGN; HUMANS; HYPERSENSITIVITY; INHIBITORY CONCENTRATION 50; MOLECULAR WEIGHT; PEPTIDES; PROTEIN BINDING; PYROGLYPHIDAE;

EID: 84913588033     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501102h     Document Type: Article

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