Th9 cell development requires a BATF-regulated transcriptional network

Journal of Clinical Investigation

Volumn 123, Issue 11, 2013, Pages 4641-4653

  Jabeen, Rukhsana ^a   Goswami, Ritobrata ^a   Awe, Olufolakemi ^a   Kulkarni, Aishwarya ^a   Nguyen, Evelyn T ^a   Attenasio, Andrea ^a   Walsh, Daniel ^a   Olson, Matthew R ^a   Kim, Myung H ^b   Tepper, Robert S ^a   Sun, Jie ^a   Kim, Chang H ^b   Taparowsky, Elizabeth J ^c   Zhou, Baohua ^a   Kaplan, Mark H ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PURDUE UNIVERSITY   (United States)

^c PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BATF PROTEIN; INTERFERON REGULATORY FACTOR 4; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 4; INTERLEUKIN 9; STAT PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR GATA 3; UNCLASSIFIED DRUG;

ALLERGY; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HELPER CELL; HUMAN; HUMAN CELL; INFLAMMATION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; TH17 CELL; TH2 CELL; TH9 CELL;

EID: 84887493396     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI69489     Document Type: Article

References (47)

1. Zhu J, Yamane H, Paul WE. Differentiation of effector CD4 T cell populations. Annu Rev Immunol. 2010;28:445-489.
2. - effector T cells. Nat Immunol. 2008;9(12):1347-1355.
3. Goswami R, et al. STAT6-dependent regulation of Th9 development. J Immunol. 2012;188(3):968-975.
4. Veldhoen M, et al. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol. 2008;9(12):1341-1346.
5. Jabeen R, Kaplan MH. The symphony of the ninth: the development and function of Th9 cells. Curr Opin Immunol. 2012;24(3):303-307.
6. Kaplan MH. Th9 cells: differentiation and disease. Immunol Rev. 2013;252(1):104-115.
7. Staudt V, et al. Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity. 2010;33(2):192-202.
8. Chang HC, Han L, Jabeen R, Carotta S, Nutt SL, Kaplan MH. PU.1 regulates TCR expression by modulating GATA-3 activity. J Immunol. 2009; 183(8):4887-4894.
9. Chang HC, et al. The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol. 2010;11(6):527-534.
10. Chang HC, et al. PU.1 expression delineates heterogeneity in primary Th2 cells. Immunity. 2005; 22(6):693-703.
11. Goswami R, Kaplan MH. Gcn5 is required for PU.1-dependent Interleukin-9 (IL-9) induction in Th9 cells. J Immunol. 2012;189(6):3026-3033.
12. Echlin DR, Tae HJ, Mitin N, Taparowsky EJ. B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos. Oncogene. 2000;19(14):1752-1763.
13. Betz BC, et al. Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J Exp Med. 2010;207(5):933-942.
14. Ise W, et al. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol. 2011;12(6):536-543.
15. Schraml BU, et al. The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature. 2009;460(7253):405-409.
16. Ciofani M, et al. A validated regulatory network for th17 cell specification. Cell. 2012;151(2):289-303.
17. Glasmacher E, et al. A genomic regulatory element that directs assembly and function of immunespecific AP-1-IRF complexes. Science. 2012; 338(6109):975-980.
18. Li P, et al. BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature. 2012; 490(7421):543-546.
19. Kaplan MH, et al. STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis. Blood. 2011; 117(23):6198-6201.
20. Durant L, et al. Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity. 2010;32(5):605-615.
21. Stritesky GL, et al. The transcription factor STAT3 is required for Th2 cell development. Immunity. 2011;34(1):39-49.
22. Yao W, Tepper RS, Kaplan MH. Predisposition to the development of IL-9-secreting T cells in atopic infants. J Allergy Clin Immunol. 2011;128(6):1357-1360.e5.
23. Ramming A, Druzd D, Leipe J, Schulze-Koops H, Skapenko A. Maturation-related histone modifications in the PU.1 promoter regulate Th9-cell development. Blood. 2012;119(20):4665-4674.
24. Tussiwand R, et al. Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature. 2012;490(7421):502-507.
25. Yao W, et al. Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP. Immunity. 2013;38(2):360-372.
26. + T cells. Science. 2010;327(5969):1098-1102.
27. Zhou L, Chong MM, Littman DR. Plasticity of CD4+ T cell lineage differentiation. Immunity. 2009;30(5):646-655.
28. + T cell transcription factors. Nat Rev Immunol. 2012; 12(11):799-804.
29. Thieu VT, et al. Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination. Immunity. 2008;29(5):679-690.
30. Ouyang W, et al. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity. 2000;12(1):27-37.
31. Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000; 100(6):655-669.
32. Brustle A, et al. The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat Immunol. 2007;8(9):958-966.
33. Lohoff M, et al. Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4. Proc Natl Acad Sci U S A. 2002;99(18):11808-11812.
34. Eisenbeis CF, Singh H, Storb U. Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev. 1995;9(11):1377-1387.
35. Ahyi AN, Chang HC, Dent AL, Nutt SL, Kaplan MH. IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines. J Immunol. 2009; 183(3):1598-1606.
36. Jones CP, Gregory LG, Causton B, Campbell GA, Lloyd CM. Activin A and TGF-β promote T(H)9 cell-mediated pulmonary allergic pathology. J Allergy Clin Immunol. 2012;129(4):1000-1010.e3.
37. Zhang Y, Zhou B. Functions of thymic stromal lymphopoietin in immunity and disease. Immunol Res. 2012;52(3):211-223.
38. Elyaman W, et al. Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells. Immunity. 2012;36(4):623-634.
39. Elyaman W, et al. IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells. Proc Natl Acad Sci U S A. 2009;106(31):12885-12890.
40. Kato A, Xiao H, Chustz RT, Liu MC, Schleimer RP. Local release of B cell-activating factor of the TNF family after segmental allergen challenge of allergic subjects. J Allergy Clin Immunol. 2009;123(2):369-375.
41. Dakic A, Metcalf D, Di Rago L, Mifsud S, Wu L, Nutt SL. PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J Exp Med. 2005;201(9):1487-1502.
42. Kaplan MH, Schindler U, Smiley ST, Grusby MJ. Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity. 1996;4(3):313-319.
43. Thornton TM, Zullo AJ, Williams KL, Taparowsky EJ. Direct manipulation of activator protein-1 controls thymocyte proliferation in vitro. Eur J Immunol. 2006;36(1):160-169.
44. Wang C, et al. BATF is required for normal expression of gut-homing receptors by T helper cells in response to retinoic acid. J Exp Med. 2013;210(3):475-489.
45. Yao W, et al. Evaluation of airway reactivity and immune characteristics as risk factors for wheezing early in life. J Allergy Clin Immunol. 2010; 126(3):483-488.e1.
46. Liao J, Humphrey SE, Poston S, Taparowsky EJ. Batf promotes growth arrest and terminal differentiation of mouse myeloid leukemia cells. Mol Cancer Res. 2011;9(3):350-363.
47. Lei L, Zhang Y, Yao W, Kaplan MH, Zhou B. Thymic stromal lymphopoietin interferes with airway tolerance by suppressing the generation of antigen-specific regulatory T cells. J Immunol. 2011;186(4):2254-2261.