Redirection of allergen-specific T H2 responses by a modified adenine through Toll-like receptor 7 interaction and IL-12/IFN release

Journal of Allergy and Clinical Immunology

Volumn 118, Issue 2, 2006, Pages 511-517

  Filì, Lucia ^a   Ferri, Simona ^a   Guarna, Francesco ^b   Sampognaro, Salvatore ^a   Manuelli, Cinzia ^c   Liotta, Francesco ^a   Cosmi, Lorenzo ^a   Matucci, Andrea ^a   Vultaggio, Alessandra ^a   Annunziato, Francesco ^a   Maggi, Enrico ^a   Guarna, Antonio ^b   Romagnani, Sergio ^a   Parronchi, Paola ^a  

^a Excellence Centre for Research Transfer and High Education   (Italy)

^b Department of Organic Chemistry Ugo Schiff ^*

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Adjuvants; allergy; GATA 3; heterocycles; immunotherapy; nuclear factor B; T box expressed in T cells; T H1 T H2 lymphocytes; Toll like receptors

Indexed keywords

9 BENZYL 2 BUTOXY 8 HYDROXYADENINE; 9 BENZYLADENINE; ADENINE DERIVATIVE; ALLERGEN; ANTIGEN; BLOOD DENDRITIC CELL ANTIGEN 4; CD14 ANTIGEN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HAPTEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; T BOX TRANSCRIPTION FACTOR; TOLL LIKE RECEPTOR 7; TRANSCRIPTION FACTOR GATA 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIGEN PRESENTING CELL; ARTICLE; CELL STRAIN HEK293; DENDRITIC CELL; DERMATOPHAGOIDES PTERONYSSINUS; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TH2 CELL; UPREGULATION;

ADENINE; ADJUVANTS, IMMUNOLOGIC; ALLERGENS; AMOXICILLIN; ANTIGENS, DERMATOPHAGOIDES; CELL LINE; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; GENE EXPRESSION REGULATION; HUMANS; HYPERSENSITIVITY; LEUKOCYTES, MONONUCLEAR; RNA, MESSENGER; TH2 CELLS; TOLL-LIKE RECEPTOR 7;

EID: 33746762226     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2006.05.027     Document Type: Article

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