The microbiota is important for IL-17A expression and neutrophil infiltration in lesional skin of Flgft/ft mice

Clinical Immunology

Volumn 156, Issue 2, 2015, Pages 128-130

  Hoff, Sabine ^a   Oyoshi, Michiko K ^a   Macpherson, Andrew ^b   Geha, Raif S ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

Atopic dermatitis; Filaggrin deficiency; Microbiota; Skin inflammation; TH17

Indexed keywords

FILAGGRIN; GAMMA INTERFERON; INTERLEUKIN 17; MESSENGER RNA; FGFR1 PROTEIN, MOUSE; FIBROBLAST GROWTH FACTOR RECEPTOR 1;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; BACTERIAL COLONIZATION; CELL INFILTRATION; DERMATITIS; DISEASE PREDISPOSITION; DRY SKIN; ECZEMA; EOSINOPHIL; EXTRAVASATION; GENE MUTATION; HISTOLOGY; HYGIENE; ICHTHYOSIS VULGARIS; INFLAMMATORY CELL; LETTER; LOSS OF FUNCTION MUTATION; MICROFLORA; MOUSE; NEUTROPHIL; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN DEFECT; STANDARD; STAPHYLOCOCCUS AUREUS; ANIMAL; ATOPIC DERMATITIS; BAGG ALBINO MOUSE; BIOSYNTHESIS; GENETICS; IMMUNOLOGY; MICROBIOLOGY; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; SKIN; TRANSGENIC MOUSE;

ANIMALS; DERMATITIS, ATOPIC; EOSINOPHILS; INTERLEUKIN-17; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MICROBIOTA; NEUTROPHIL INFILTRATION; NEUTROPHILS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; SKIN;

EID: 84920670523     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2014.12.001     Document Type: Letter

References (10)

1. Barker J.N., Palmer C.N., Zhao Y., Liao H., Hull P.R., Lee S.P., Allen M.H., Meggitt S.J., Reynolds N.J., Trembath R.C., McLean W.H. Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood. J. Invest. Dermatol 2007, 127:564-567.
2. Fallon P., Sasaki T., Sandilands A., Campbell L., Saunders S., Mangan N., Callanan J., Kawasaki H., Shiohama A., Kubo A., McLean W. A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming. Nat. Genet. 2009, 41:602-608.
3. Presland R.B., Boggess D., Lewis S.P., Hull C., Fleckmann P., Sundberg J.P. Loss of normal profilaggrin and filaggrin in flaky tail (ft/ft) mice: an animal model for the filaggrin-deficient skin disease ichthyosis vulgaris. J. Invest. Dermatol. 2000, 115:1072-1081.
4. Kawasaki H., Nagao K., Kubo A., Hata T., Shimizu A., Mizuno H., Yamada T., Amagai M. Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice. J. Allergy Clin. Immunol. 2012, 129:1538-1546. (e1536).
5. Oyoshi M.K., Murphy G.F., Geha R.S. Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen. J. Allergy Clin. Immunol. 2009, 124:485-493.
6. Leisten S., Oyoshi M.K., Galand C., Hornick J.L., Gurish M.F., Geha R.S. Development of skin lesions in filaggrin-deficient mice is dependent on adaptive immunity. J. Allergy Clin. Immunol. 2013, 131:1247-1250.
7. Kong H.H., Oh J., Deming C., Conlan S., Grice E.A., Beatson M.A., Nomicos E., Polley E.C., Komarow H.D., Murray P.R., Turner M.L., Segre J.A. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res. 2012, 22:850-859.
8. Kemeny L., Szabo K. Toll-like receptors link atopic march to the hygiene hypothesis. J. Invest. Dermatol. 2013, 133:874-878.
9. Murdock B.J., Falkowski N.R., Shreiner A.B., Sadighi Akha A.A., McDonald R.A., White E.S., Toews G.B., Huffnagle G.B. Interleukin-17 drives pulmonary eosinophilia following repeated exposure to Aspergillus fumigatus conidia. Infect. Immun. 2012, 80:1424-1436.
10. Saunders S.P., Goh C.S., Brown S.J., Palmer C.N., Porter R.M., Cole C., Campbell L.E., Gierlinski M., Barton G.J., Schneider G., Balmain A., Prescott A.R., Weidinger S., Baurecht H., Kabesch M., Gieger C., Lee Y.A., Tavendale R., Mukhopadhyay S., Turner S.W., Madhok V.B., Sullivan F.M., Relton C., Burn J., Meggitt S., Smith C.H., Allen M.A., Barker J.N., Reynolds N.J., Cordell H.J., Irvine A.D., McLean W.H., Sandilands A., Fallon P.G. Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. J. Allergy Clin. Immunol. 2013, 132:1121-1129.