Mechanical Force-Triggered Drug Delivery

Chemical Reviews

Volumn 116, Issue 19, 2016, Pages 12536-12563

  Zhang, Yuqi ^a,b,c   Yu, Jicheng ^a,b   Bomba, Hunter N ^a   Zhu, Yong ^a,c   Gu, Zhen ^a,b,d  

^a Biomedical Research Imaging Center   (United States)

^b UNC Hamner Institute for Drug Safety Sciences   (United States)

^c North Carolina State University   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DOSAGE;

CLINICAL TRANSLATION; COMPRESSIVE FORCES; CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; MECHANICAL FORCE; MECHANICAL STIMULUS; STIMULI-RESPONSIVE; TENSILE FORCES;

CONTROLLED DRUG DELIVERY;

DRUG CARRIER; LIPOSOME; NANOPARTICLE;

ANIMAL; CHEMISTRY; DRUG DELIVERY SYSTEM; MAGNETISM; MECHANICS; MICROBUBBLE; PROCEDURES; ULTRASOUND;

ANIMALS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; LIPOSOMES; MAGNETIC PHENOMENA; MECHANICAL PHENOMENA; MICROBUBBLES; NANOPARTICLES; ULTRASONIC WAVES;

EID: 84991688546     PISSN: 00092665     EISSN: 15206890     Source Type: Journal    
DOI: 10.1021/acs.chemrev.6b00369     Document Type: Review

References (273)

1. Mitragotri, S.; Lahann, J. Materials for Drug Delivery: Innovative Solutions to Address Complex Biological Hurdles Adv. Mater. 2012, 24 (28) 3717-3723 10.1002/adma.201202080
2. Chow, E. K.-H.; Ho, D. Cancer Nanomedicine: from Drug Delivery to Imaging Sci. Transl. Med. 2013, 5 (216) 216rv4 10.1126/scitranslmed.3005872
3. Wilhelm, S.; Tavares, A. J.; Dai, Q.; Ohta, S.; Audet, J.; Dvorak, H. F.; Chan, W. C. Analysis of Nanoparticle Delivery to Tumours Nat. Rev. Mater. 2016, 1, 16014 10.1038/natrevmats.2016.14
4. Tibbitt, M. W.; Dahlman, J. E.; Langer, R. Emerging Frontiers in Drug Delivery J. Am. Chem. Soc. 2016, 138 (3) 704-717 10.1021/jacs.5b09974
5. Allen, T. M.; Cullis, P. R. Drug Delivery Systems: Entering the Mainstream Science 2004, 303 (5665) 1818-1822 10.1126/science.1095833
6. Rosen, H.; Abribat, T. The Rise and Rise of Drug Delivery Nat. Rev. Drug Discovery 2005, 4 (5) 381-385 10.1038/nrd1721
7. Peer, D.; Karp, J. M.; Hong, S.; Farokhzad, O. C.; Margalit, R.; Langer, R. Nanocarriers as an Emerging Platform for Cancer Therapy Nat. Nanotechnol. 2007, 2 (12) 751-760 10.1038/nnano.2007.387
8. Farokhzad, O. C.; Langer, R. Impact of Nanotechnology on Drug Delivery ACS Nano 2009, 3 (1) 16-20 10.1021/nn900002m
9. Hu, Q.; Sun, W.; Wang, C.; Gu, Z. Recent Advances of Cocktail Chemotherapy by Combination drug Delivery Systems Adv. Drug Delivery Rev. 2016, 98, 19-34 10.1016/j.addr.2015.10.022
10. Anselmo, A. C.; Mitragotri, S. Impact of Particle Elasticity on Particle-Based Drug Delivery Systems Adv. Drug Delivery Rev. 2016, 10.1016/j.addr.2016.01.007
11. Nishiyama, N.; Kataoka, K. Current State, Achievements, and Future Prospects of Polymeric Micelles as Nanocarriers for Drug and Gene Delivery Pharmacol. Ther. 2006, 112 (3) 630-648 10.1016/j.pharmthera.2006.05.006
12. de las Heras Alarcón, C.; Pennadam, S.; Alexander, C. Stimuli Responsive Polymers for Biomedical Applications Chem. Soc. Rev. 2005, 34 (3) 276-285 10.1039/B406727D
13. Rapoport, N. Physical Stimuli-Responsive Polymeric Micelles for Anti-Cancer Drug Delivery Prog. Polym. Sci. 2007, 32 (8) 962-990 10.1016/j.progpolymsci.2007.05.009
14. Fleige, E.; Quadir, M. A.; Haag, R. Stimuli-Responsive Polymeric Nanocarriers for the Controlled Transport of Active Compounds: Concepts and Applications Adv. Drug Delivery Rev. 2012, 64 (9) 866-884 10.1016/j.addr.2012.01.020
15. Qiu, Y.; Park, K. Environment-Sensitive Hydrogels for Drug Delivery Adv. Drug Delivery Rev. 2012, 64, 49-60 10.1016/j.addr.2012.09.024
16. Mura, S.; Nicolas, J.; Couvreur, P. Stimuli-Responsive Nanocarriers for Drug Delivery Nat. Mater. 2013, 12 (11) 991-1003 10.1038/nmat3776
17. Lu, Y.; Sun, W.; Gu, Z. Stimuli-Responsive Nanomaterials for Therapeutic Protein Delivery J. Controlled Release 2014, 194, 1-19 10.1016/j.jconrel.2014.08.015
18. Brudno, Y.; Mooney, D. J. On-Demand Drug Delivery from Local Depots J. Controlled Release 2015, 219, 8-17 10.1016/j.jconrel.2015.09.011
19. Torchilin, V. P. Multifunctional, Stimuli-Sensitive Nanoparticulate Systems for Drug Delivery Nat. Rev. Drug Discovery 2014, 13 (11) 813-827 10.1038/nrd4333
20. Karimi, M.; Ghasemi, A.; Zangabad, P. S.; Rahighi, R.; Basri, S. M. M.; Mirshekari, H.; Amiri, M.; Pishabad, Z. S.; Aslani, A.; Bozorgomid, M. et al. Smart Micro/Nanoparticles in Stimulus-Responsive Drug/Gene Delivery Systems Chem. Soc. Rev. 2016, 45 (5) 1457-1501 10.1039/C5CS00798D
21. Caldorera-Moore, M.; Peppas, N. A. Micro- and Nanotechnologies for Intelligent and Responsive Biomaterial-Based Medical Systems Adv. Drug Delivery Rev. 2009, 61 (15) 1391-1401 10.1016/j.addr.2009.09.002
22. Park, K. Controlled Drug Delivery Systems: Past Forward and Future Back J. Controlled Release 2014, 190, 3-8 10.1016/j.jconrel.2014.03.054
23. Felber, A. E.; Dufresne, M.-H.; Leroux, J.-C. pH-Sensitive Vesicles, Polymeric Micelles, and Nanospheres Prepared with Polycarboxylates Adv. Drug Delivery Rev. 2012, 64 (11) 979-992 10.1016/j.addr.2011.09.006
24. Gao, W.; Chan, J. M.; Farokhzad, O. C. pH-Responsive Nanoparticles for Drug Delivery Mol. Pharmaceutics 2010, 7 (6) 1913-1920 10.1021/mp100253e
25. Liu, J.; Huang, Y.; Kumar, A.; Tan, A.; Jin, S.; Mozhi, A.; Liang, X. J. pH-Sensitive Nano-Systems for Drug Delivery in Cancer Therapy Biotechnol. Adv. 2014, 32 (4) 693-710 10.1016/j.biotechadv.2013.11.009
26. Pillai, P. P.; Huda, S.; Kowalczyk, B.; Grzybowski, B. A. Controlled pH Stability and Adjustable Cellular Uptake of Mixed-Charge Nanoparticles J. Am. Chem. Soc. 2013, 135 (17) 6392-6395 10.1021/ja4001272
27. Zhang, S.; Bellinger, A. M.; Glettig, D. L.; Barman, R.; Lee, Y.-A. L.; Zhu, J.; Cleveland, C.; Montgomery, V. A.; Gu, L.; Nash, L. D. et al. A pH-Responsive Supramolecular Polymer Gel as an Enteric Elastomer for Use in Gastric Devices Nat. Mater. 2015, 14 (10) 1065-1071 10.1038/nmat4355
28. Liu, J.; Huang, Y.; Kumar, A.; Tan, A.; Jin, S.; Mozhi, A.; Liang, X.-J. pH-Sensitive Nano-Systems for Drug Delivery in Cancer Therapy Biotechnol. Adv. 2014, 32 (4) 693-710 10.1016/j.biotechadv.2013.11.009
29. McCarley, R. L. Redox-Responsive Delivery Systems Annu. Rev. Anal. Chem. 2012, 5, 391-411 10.1146/annurev-anchem-062011-143157
30. Phillips, D. J.; Gibson, M. I. Redox-Sensitive Materials for Drug Delivery: Targeting the Correct Intracellular Environment, Tuning Release Rates, and Appropriate Predictive Systems Antioxid. Redox Signaling 2014, 21 (5) 786-803 10.1089/ars.2013.5728
31. Wang, M.; Sun, S.; Neufeld, C. I.; Perez-Ramirez, B.; Xu, Q. Reactive Oxygen Species-Responsive Protein Modification and Its Intracellular Delivery for Targeted Cancer Therapy Angew. Chem., Int. Ed. 2014, 53 (49) 13444-13448 10.1002/anie.201407234
32. Ong, W.; Yang, Y.; Cruciano, A. C.; McCarley, R. L. Redox-Triggered Contents Release from Liposomes J. Am. Chem. Soc. 2008, 130 (44) 14739-14744 10.1021/ja8050469
33. Yu, J.; Zhang, Y.; Hu, X.; Wright, G.; Gu, Z. Hypoxia-Sensitive Materials for Biomedical Applications Ann. Biomed. Eng. 2016, 44 (6) 1931-1945 10.1007/s10439-016-1578-6
34. Perche, F.; Biswas, S.; Wang, T.; Zhu, L.; Torchilin, V. P. Hypoxia-Targeted siRNA Delivery Angew. Chem., Int. Ed. 2014, 53 (13) 3362-3366 10.1002/anie.201308368
35. Yu, J.; Zhang, Y.; Ye, Y.; DiSanto, R.; Sun, W.; Ranson, D.; Ligler, F. S.; Buse, J. B.; Gu, Z. Microneedle-Array Patches Loaded with Hypoxia-Sensitive Vesicles Provide Fast Glucose-Responsive Insulin Delivery Proc. Natl. Acad. Sci. U. S. A. 2015, 112 (27) 8260-8265 10.1073/pnas.1505405112
36. Sun, W.; Gu, Z. ATP-Responsive Drug Delivery Systems Expert Opin. Drug Delivery 2016, 13, 311-314 10.1517/17425247.2016.1140147
37. Mo, R.; Jiang, T.; DiSanto, R.; Tai, W.; Gu, Z. ATP-Triggered Anticancer Drug Delivery Nat. Commun. 2014, 5 3364 10.1038/ncomms4364
38. Lai, J.; Shah, B. P.; Zhang, Y.; Yang, L.; Lee, K.-B. Real-Time Monitoring of ATP-Responsive Drug Release Using Mesoporous-Silica-Coated Multicolor Upconversion Nanoparticles ACS Nano 2015, 9 (5) 5234-5245 10.1021/acsnano.5b00641
39. Liao, W.-C.; Lu, C.-H.; Hartmann, R.; Wang, F.; Sohn, Y. S.; Parak, W. J.; Willner, I. Adenosine Triphosphate-Triggered Release of Macromolecular and Nanoparticle Loads from Aptamer/DNA-Cross-Linked Microcapsules ACS Nano 2015, 9 (9) 9078-9086 10.1021/acsnano.5b03223
40. Mo, R.; Jiang, T.; Di, J.; Tai, W.; Gu, Z. Emerging micro- and Nanotechnology Based Synthetic Approaches for Insulin Delivery Chem. Soc. Rev. 2014, 43 (10) 3595-3629 10.1039/c3cs60436e
41. Veiseh, O.; Tang, B. C.; Whitehead, K. A.; Anderson, D. G.; Langer, R. Managing Diabetes with Nanomedicine: Challenges and Opportunities Nat. Rev. Drug Discovery 2015, 14 (1) 45-57 10.1038/nrd4477
42. Wu, Q.; Wang, L.; Yu, H.; Wang, J.; Chen, Z. Organization of Glucose-Responsive Systems and Their Properties Chem. Rev. 2011, 111 (12) 7855-7875 10.1021/cr200027j
43. Webber, M. J.; Anderson, D. G.; Langer, R. Engineering Synthetically Modified Insulin for Glucose-Responsive Diabetes Therapy Expert Rev. Endocrinol. Metab. 2015, 10 (5) 483-489 10.1586/17446651.2015.1071187
44. Rooseboom, M.; Commandeur, J. N. M.; Vermeulen, N. P. E. Enzyme-Catalyzed Activation of Anticancer Prodrugs Pharmacol. Rev. 2004, 56 (1) 53-102 10.1124/pr.56.1.3
45. Hu, J.; Zhang, G.; Liu, S. Enzyme-Responsive Polymeric Assemblies, Nanoparticles and Hydrogels Chem. Soc. Rev. 2012, 41 (18) 5933-5949 10.1039/c2cs35103j
46. Hu, Q.; Katti, P. S.; Gu, Z. Enzyme-Responsive Nanomaterials for Controlled Drug Delivery Nanoscale 2014, 6 (21) 12273-12286 10.1039/C4NR04249B
47. Gu, Z.; Dang, T. T.; Ma, M.; Tang, B. C.; Cheng, H.; Jiang, S.; Dong, Y.; Zhang, Y.; Anderson, D. G. Glucose-Responsive Microgels Integrated with Enzyme Nanocapsules for Closed-Loop Insulin Delivery ACS Nano 2013, 7 (8) 6758-6766 10.1021/nn401617u
48. Bernardos, A.; Mondragón, L.; Aznar, E.; Marcos, M. D.; Martínez-Máñez, R.; Sancenón, F.; Soto, J.; Barat, J. M.; Pérez-Payá, E.; Guillem, C. et al. Enzyme-Responsive Intracellular Controlled Release Using Nanometric Silica Mesoporous Supports Capped with "Saccharides ACS Nano 2010, 4 (11) 6353-6368 10.1021/nn101499d
49. Fischel-Ghodsian, F.; Brown, L.; Mathiowitz, E.; Brandenburg, D.; Langer, R. Enzymatically Controlled Drug Delivery Proc. Natl. Acad. Sci. U. S. A. 1988, 85 (7) 2403-2406 10.1073/pnas.85.7.2403
50. Sun, W.; Jiang, T.; Lu, Y.; Reiff, M.; Mo, R.; Gu, Z. Cocoon-Like Self-Degradable DNA Nanoclew for Anticancer Drug Delivery J. Am. Chem. Soc. 2014, 136 (42) 14722-14725 10.1021/ja5088024
51. Choi, S. W.; Zhang, Y.; Xia, Y. A Temperature-Sensitive Drug Release System Based on Phase-Change Materials Angew. Chem., Int. Ed. 2010, 49 (43) 7904-7908 10.1002/anie.201004057
52. Yoo, J.-W.; Mitragotri, S. Polymer Particles that Switch Shape in Response to a Stimulus Proc. Natl. Acad. Sci. U. S. A. 2010, 107 (25) 11205-11210 10.1073/pnas.1000346107
53. Jeong, B.; Kim, S. W.; Bae, Y. H. Thermosensitive Sol-Gel Reversible Hydrogels Adv. Drug Delivery Rev. 2002, 54 (1) 37-51 10.1016/S0169-409X(01)00242-3
54. Timko, B. P.; Dvir, T.; Kohane, D. S. Remotely Triggerable Drug Delivery Systems Adv. Mater. 2010, 22 (44) 4925-4943 10.1002/adma.201002072
55. Rai, P.; Mallidi, S.; Zheng, X.; Rahmanzadeh, R.; Mir, Y.; Elrington, S.; Khurshid, A.; Hasan, T. Development and Applications of Photo-Triggered Theranostic Agents Adv. Drug Delivery Rev. 2010, 62 (11) 1094-1124 10.1016/j.addr.2010.09.002
56. Melancon, M. P.; Zhou, M.; Li, C. Cancer Theranostics with Near-Infrared Light-Activatable Multimodal Nanoparticles Acc. Chem. Res. 2011, 44 (10) 947-956 10.1021/ar200022e
57. Zhang, Y.; Yin, Q.; Yin, L.; Ma, L.; Tang, L.; Cheng, J. Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability Angew. Chem., Int. Ed. 2013, 52 (25) 6435-6439 10.1002/anie.201300497
58. Dobson, J. Magnetic Micro-and Nano-Particle-Based Targeting for Drug and Gene Delivery Nanomedicine 2006, 1 (1) 31-37 10.2217/17435889.1.1.31
59. Polyak, B.; Friedman, G. Magnetic Targeting for Site-Specific Drug Delivery: Applications and Clinical Potential Expert Opin. Drug Delivery 2009, 6 (1) 53-70 10.1517/17425240802662795
60. Cai, K.; Luo, Z.; Hu, Y.; Chen, X.; Liao, Y.; Yang, L.; Deng, L. Magnetically Triggered Reversible Controlled Drug Delivery from Microfabricated Polymeric Multireservoir Devices Adv. Mater. 2009, 21 (40) 4045-4049 10.1002/adma.200900593
61. Stanley, S. A.; Gagner, J. E.; Damanpour, S.; Yoshida, M.; Dordick, J. S.; Friedman, J. M. Radio-Wave Heating of Iron Oxide Nanoparticles Can Regulate Plasma Glucose in Mice Science 2012, 336 (6081) 604-608 10.1126/science.1216753
62. Lakshmanan, S.; Gupta, G. K.; Avci, P.; Chandran, R.; Sadasivam, M.; Jorge, A. E. S.; Hamblin, M. R. Physical Energy for Drug Delivery; Poration, Concentration and Activation Adv. Drug Delivery Rev. 2014, 71, 98-114 10.1016/j.addr.2013.05.010
63. Ge, J.; Neofytou, E.; Cahill, T. J., III; Beygui, R. E.; Zare, R. N. Drug Release from Electric-Field-Responsive Nanoparticles ACS Nano 2012, 6 (1) 227-233 10.1021/nn203430m
64. Murdan, S. Electro-Responsive Drug Delivery from Hydrogels J. Controlled Release 2003, 92 (1) 1-17 10.1016/S0168-3659(03)00303-1
65. Callister, W. D.; Rethwisch, D. G. Materials Science and Engineering: An Introduction; Wiley: New York, 2007; pp 665-715.
66. Bird, J.; Ross, C. Mechanical Engineering Principles; Routledge: Abingdon, U.K., 2014; pp 45-167.
67. Ariga, K.; Mori, T.; Hill, J. P. Mechanical Control of Nanomaterials and Nanosystems Adv. Mater. 2012, 24 (2) 158-176 10.1002/adma.201102617
68. Wiggins, K. M.; Brantley, J. N.; Bielawski, C. W. Methods for Activating and Characterizing Mechanically Responsive Polymers Chem. Soc. Rev. 2013, 42 (17) 7130-7147 10.1039/c3cs35493h
69. McGinnis, P. M. Biomechanics of Sport and Exercise; Human Kinetics: Champaign, IL, 2013; pp 239-262.
70. Davies, P. F. Flow-Mediated Endothelial Mechanotransduction Physiol. Rev. 1995, 75 (3) 519-560
71. Holme, M. N.; Fedotenko, I. A.; Abegg, D.; Althaus, J.; Babel, L.; Favarger, F.; Reiter, R.; Tanasescu, R.; Zaffalon, P.-L.; Ziegler, A. et al. Shear-Stress Sensitive Lenticular Vesicles for Targeted Drug Delivery Nat. Nanotechnol. 2012, 7 (8) 536-543 10.1038/nnano.2012.84
72. Korin, N.; Kanapathipillai, M.; Matthews, B. D.; Crescente, M.; Brill, A.; Mammoto, T.; Ghosh, K.; Jurek, S.; Bencherif, S. A.; Bhatta, D. et al. Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels Science 2012, 337 (6095) 738-742 10.1126/science.1217815
73. Frenkel, V. Ultrasound Mediated Delivery of Drugs and Genes to Solid Tumors Adv. Drug Delivery Rev. 2008, 60 (10) 1193-1208 10.1016/j.addr.2008.03.007
74. Hernot, S.; Klibanov, A. L. Microbubbles in Ultrasound-Triggered Drug and Gene Delivery Adv. Drug Delivery Rev. 2008, 60 (10) 1153-1166 10.1016/j.addr.2008.03.005
75. Sirsi, S. R.; Borden, M. A. State-of-the-Art Materials for Ultrasound-Triggered Drug Delivery Adv. Drug Delivery Rev. 2014, 72, 3-14 10.1016/j.addr.2013.12.010
76. Thévenot, J.; Oliveira, H.; Sandre, O.; Lecommandoux, S. Magnetic Responsive Polymer Composite Materials Chem. Soc. Rev. 2013, 42 (17) 7099-7116 10.1039/c3cs60058k
77. Hoffman, A. S. Bioconjugates of Intelligent Polymers and Recognition Proteins for Use in Diagnostics and Affinity Separations Clin. Chem. 2000, 46 (9) 1478-1486
78. Caruso, M. M.; Davis, D. A.; Shen, Q.; Odom, S. A.; Sottos, N. R.; White, S. R.; Moore, J. S. Mechanically-Induced Chemical Changes in Polymeric Materials Chem. Rev. 2009, 109 (11) 5755-5798 10.1021/cr9001353
79. Moghadam, M. N.; Kolesov, V.; Vogel, A.; Klok, H.-A.; Pioletti, D. P. Controlled Release from a Mechanically-Stimulated Thermosensitive Self-Heating Composite Hydrogel Biomaterials 2014, 35 (1) 450-455 10.1016/j.biomaterials.2013.09.065
80. Lee, K. Y.; Peters, M. C.; Anderson, K. W.; Mooney, D. J. Controlled Growth Factor Release from Synthetic Extracellular Matrices Nature 2000, 408 (6815) 998-1000 10.1038/35050141
81. Lee, K. Y.; Peters, M.; Mooney, D. Controlled Drug Delivery from Polymers by Mechanical Signals Adv. Mater. 2001, 13 (11) 837-839 10.1002/1521-4095(200106)13:11<837::AID-ADMA837>3.0.CO;2-D
82. Xiao, L.; Zhu, J.; Londono, J. D.; Pochan, D. J.; Jia, X. Mechano-Responsive Hydrogels Crosslinked by Block Copolymer Micelles Soft Matter 2012, 8 (40) 10233-10237 10.1039/c2sm26566d
83. Xiao, L.; Tong, Z.; Chen, Y.; Pochan, D. J.; Sabanayagam, C. R.; Jia, X. Hyaluronic Acid-Based Hydrogels Containing Covalently Integrated Drug Depots: Implication for Controlling Inflammation in Mechanically Stressed Tissues Biomacromolecules 2013, 14 (11) 3808-3819 10.1021/bm4011276
84. Hyun, D. C.; Moon, G. D.; Park, C. J.; Kim, B. S.; Xia, Y.; Jeong, U. Strain-Controlled Release of Molecules from Arrayed Microcapsules Supported on an Elastomer Substrate Angew. Chem., Int. Ed. 2011, 50 (3) 724-727 10.1002/anie.201004838
85. Di, J.; Yao, S.; Ye, Y.; Cui, Z.; Yu, J.; Ghosh, T. K.; Zhu, Y.; Gu, Z. Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots ACS Nano 2015, 9 (9) 9407-9415 10.1021/acsnano.5b03975
86. Kim, B.; Yoo, S.; Kim, Y. J.; Park, J.; Kang, B.; Haam, S.; Kang, S. W.; Kang, K.; Jeong, U. A Strain-Regulated, Refillable Elastic Patch for Controlled Release Adv. Mater. Interfaces 2016, 3 (9 1500803 10.1002/admi.201500803
87. Wang, J.; Kaplan, J. A.; Colson, Y. L.; Grinstaff, M. W. Stretch-Induced Drug Delivery from Superhydrophobic Polymer Composites: Use of Crack Propagation Failure Modes for Controlling Release Rates Angew. Chem. 2016, 128 (8) 2846-2850 10.1002/ange.201511052
88. Mertz, D.; Vogt, C.; Hemmerlé, J.; Mutterer, J.; Ball, V.; Voegel, J.-C.; Schaaf, P.; Lavalle, P. Mechanotransductive Surfaces for Reversible Biocatalysis Activation Nat. Mater. 2009, 8 (9) 731-735 10.1038/nmat2504
89. Mertz, D.; Hemmerlé, J.; Mutterer, J.; Ollivier, S.; Voegel, J.-C.; Schaaf, P.; Lavalle, P. Mechanically Responding Nanovalves Based on Polyelectrolyte Multilayers Nano Lett. 2007, 7 (3) 657-662 10.1021/nl062657+
90. Barthes, J.; Mertz, D.; Bach, C.; Metz-Boutigue, M.-H. l. n.; Senger, B.; Voegel, J.-C.; Schaaf, P.; Lavalle, P. Stretch-Induced Biodegradation of Polyelectrolyte Multilayer Films for Drug Release Langmuir 2012, 28 (38) 13550-13554 10.1021/la302550q
91. Vogt, C.; Mertz, D.; Benmlih, K.; Hemmerle, J.; Voegel, J.-C.; Schaaf, P.; Lavalle, P. Layer-by-Layer Enzymatic Platform for Stretched-Induced Reactive Release ACS Macro Lett. 2012, 1 (7) 797-801 10.1021/mz3000896
92. Brantley, J. N.; Bailey, C. B.; Wiggins, K. M.; Keatinge-Clay, A. T.; Bielawski, C. W. Mechanobiochemistry: Harnessing Biomacromolecules for Force-Responsive Materials Polym. Chem. 2013, 4 (14) 3916-3928 10.1039/c3py00001j
93. Davis, D. A.; Hamilton, A.; Yang, J.; Cremar, L. D.; Van Gough, D.; Potisek, S. L.; Ong, M. T.; Braun, P. V.; Martínez, T. J.; White, S. R. et al. Force-Induced Activation of Covalent Bonds in Mechanoresponsive Polymeric Materials Nature 2009, 459 (7243) 68-72 10.1038/nature07970
94. Larsen, M. B.; Boydston, A. J. Successive Mechanochemical Activation and Small Molecule Release in an Elastomeric Material J. Am. Chem. Soc. 2014, 136 (4) 1276-1279 10.1021/ja411891x
95. Izawa, H.; Kawakami, K.; Sumita, M.; Tateyama, Y.; Hill, J. P.; Ariga, K. β-Cyclodextrin-Crosslinked Alginate Gel for Patient-Controlled Drug Delivery Systems: Regulation of Host-Guest Interactions with Mechanical Stimuli J. Mater. Chem. B 2013, 1 (16) 2155-2161 10.1039/c3tb00503h
96. Malek, A. M.; Alper, S. L.; Izumo, S. Hemodynamic Shear Stress and Its Role in Atherosclerosis JAMA 1999, 282 (21) 2035-2042 10.1001/jama.282.21.2035
97. Nesbitt, W. S.; Westein, E.; Tovar-Lopez, F. J.; Tolouei, E.; Mitchell, A.; Fu, J.; Carberry, J.; Fouras, A.; Jackson, S. P. A Shear Gradient-Dependent Platelet Aggregation Mechanism Drives Thrombus Formation Nat. Med. 2009, 15 (6) 665-673 10.1038/nm.1955
98. Strony, J.; Beaudoin, A.; Brands, D.; Adelman, B. Analysis of Shear Stress and Hemodynamic Factors in a Model of Coronary Artery Stenosis and Thrombosis Am. J. Physiol. Heart Circ. Physiol. 1993, 265 (5) H1787-H1796
99. Wootton, D. M.; Ku, D. N. Fluid Mechanics of Vascular Systems, Diseases, and Thrombosis Annu. Rev. Biomed. Eng. 1999, 1 (1) 299-329 10.1146/annurev.bioeng.1.1.299
100. Bark, D. L.; Ku, D. N. Wall Shear over High Degree Stenoses Pertinent to Atherothrombosis J. Biomech. 2010, 43 (15) 2970-2977 10.1016/j.jbiomech.2010.07.011
101. Madamanchi, N. R.; Runge, M. S. Redox Signaling in Cardiovascular Health and Disease Free Radical Biol. Med. 2013, 61, 473-501 10.1016/j.freeradbiomed.2013.04.001
102. Sutton, J. T.; Haworth, K. J.; Pyne-Geithman, G.; Holland, C. K. Ultrasound-Mediated Drug Delivery for Cardiovascular Disease Expert Opin. Drug Delivery 2013, 10 (5) 573-592 10.1517/17425247.2013.772578
103. Fitzgerald, K. T.; Holladay, C. A.; McCarthy, C.; Power, K. A.; Pandit, A.; Gallagher, W. M. Standardization of Models and Methods Used to Assess Nanoparticles in Cardiovascular Applications Small 2011, 7 (6) 705-717 10.1002/smll.201001347
104. Galvin, P.; Thompson, D.; Ryan, K. B.; McCarthy, A.; Moore, A. C.; Burke, C. S.; Dyson, M.; MacCraith, B. D.; Gun'ko, Y. K.; Byrne, M. T. et al. Nanoparticle-Based Drug Delivery: Case Studies for Cancer and Cardiovascular Applications Cell. Mol. Life Sci. 2012, 69 (3) 389-404 10.1007/s00018-011-0856-6
105. Bowey, K.; Tanguay, J.-F.; Tabrizian, M. Liposome Technology for Cardiovascular Disease Treatment and Diagnosis Expert Opin. Drug Delivery 2012, 9 (2) 249-265 10.1517/17425247.2012.647908
106. Rao, S.; Tan, A.; Thomas, N.; Prestidge, C. A. Perspective and Potential of Oral Lipid-Based Delivery to Optimize Pharmacological Therapies against Cardiovascular Diseases J. Controlled Release 2014, 193, 174-187 10.1016/j.jconrel.2014.05.013
107. Nieuwlaat, R.; Schwalm, J.-D.; Khatib, R.; Yusuf, S. Why Are We Failing to Implement Effective Therapies in Cardiovascular Disease? Eur. Heart J. 2013, 34 (17) 1262-1269 10.1093/eurheartj/ehs481
108. Cicha, I.; Singh, R.; Garlichs, C. D.; Alexiou, C. Nano-Biomaterials for Cardiovascular Applications: Clinical Perspective J. Controlled Release 2016, 229, 23-36 10.1016/j.jconrel.2016.03.015
109. Wootton, D. M.; Alevriadou, B. R. The Shear Stress of Busting Blood Clots N. Engl. J. Med. 2012, 367 (14) 1361-1363 10.1056/NEJMcibr1207994
110. Lavik, E.; Ustin, J. Leveraging Shear Stress to Bust Clots with Nanoparticles Science 2012, 337 (6095) 658-659 10.1126/science.1227097
111. Barenholz, Y. Nanomedicine: Shake up the Drug Containers Nat. Nanotechnol. 2012, 7 (8) 483-484 10.1038/nnano.2012.132
112. Ruggeri, Z. M. Platelets in Atherothrombosis Nat. Med. 2002, 8 (11) 1227-1234 10.1038/nm1102-1227
113. Chen, C.; Li, S.; Liu, K.; Ma, G.; Yan, X. Co-Assembly of Heparin and Polypeptide Hybrid Nanoparticles for Biomimetic Delivery and Anti-Thrombus Therapy Small 2016, 12 (34) 4719-4725 10.1002/smll.201600328
114. Zanina, A.; Vilesov, A.; Budtova, T. Shear-Induced Solvent Release from Gel Particles: Application to Drug-Delivery Systems Int. J. Pharm. 2002, 242 (1) 137-146 10.1016/S0378-5173(02)00185-0
115. Zeo, U.; Tarabukina, E.; Budtova, T. Kinetics of Shear-Induced Gel Deswelling/Solvent Release J. Controlled Release 2005, 108 (1) 73-83 10.1016/j.jconrel.2005.07.012
116. Tarabukina, E.; Zoolshoev, Z.; Melenevskaya, E.; Budtova, T. Delivery of Fullerene-Containing Complexes via Microgel Swelling and Shear-Induced Release Int. J. Pharm. 2010, 384 (1) 9-14 10.1016/j.ijpharm.2009.09.022
117. Doshi, N.; Orje, J. N.; Molins, B.; Smith, J. W.; Mitragotri, S.; Ruggeri, Z. M. Platelet Mimetic Particles for Targeting Thrombi in Flowing Blood Adv. Mater. 2012, 24 (28) 3864-3869 10.1002/adma.201200607
118. Anselmo, A. C.; Modery-Pawlowski, C. L.; Menegatti, S.; Kumar, S.; Vogus, D. R.; Tian, L. L.; Chen, M.; Squires, T. M.; Sen Gupta, A.; Mitragotri, S. Platelet-Like Nanoparticles: Mimicking Shape, Flexibility, and Surface Biology of Platelets to Target Vascular Injuries ACS Nano 2014, 8 (11) 11243-11253 10.1021/nn503732m
119. Sharei, A.; Zoldan, J.; Adamo, A.; Sim, W. Y.; Cho, N.; Jackson, E.; Mao, S.; Schneider, S.; Han, M.-J.; Lytton-Jean, A. et al. A Vector-Free Microfluidic Platform for Intracellular Delivery Proc. Natl. Acad. Sci. U. S. A. 2013, 110 (6) 2082-2087 10.1073/pnas.1218705110
120. Pommella, A.; Caserta, S.; Guido, S. Dynamic Flow Behaviour of Surfactant Vesicles under Shear Flow: Role of a Multilamellar Microstructure Soft Matter 2013, 9 (31) 7545-7552 10.1039/c3sm50617g
121. Hosta-Rigau, L.; Städler, B. Shear Stress and Its Effect on the Interaction of Myoblast Cells with Nanosized Drug Delivery Vehicles Mol. Pharmaceutics 2013, 10 (7) 2707-2712 10.1021/mp4001298
122. Teo, B. M.; van der Westen, R.; Hosta-Rigau, L.; Städler, B. Cell Response to PEGylated Poly (dopamine) Coated Liposomes Considering Shear Stress Biochim. Biophys. Acta, Gen. Subj. 2013, 1830 (10) 4838-4847 10.1016/j.bbagen.2013.06.022
123. Björnmalm, M.; Yan, Y.; Caruso, F. Engineering and Evaluating Drug Delivery Particles in Microfluidic Devices J. Controlled Release 2014, 190, 139-149 10.1016/j.jconrel.2014.04.030
124. Godoy-Gallardo, M.; Ek, P.; Jansman, M.; Wohl, B.; Hosta-Rigau, L. Interaction between Drug Delivery Vehicles and Cells under the Effect of Shear Stress Biomicrofluidics 2015, 9 (5) 052605 10.1063/1.4923324
125. Han, J.; Zern, B. J.; Shuvaev, V. V.; Davies, P. F.; Muro, S.; Muzykantov, V. Acute and Chronic Shear Stress Differently Regulate Endothelial Internalization of Nanocarriers Targeted to Platelet-Endothelial Cell Adhesion Molecule-1 ACS Nano 2012, 6 (10) 8824-8836 10.1021/nn302687n
126. Han, J.; Shuvaev, V. V.; Davies, P. F.; Eckmann, D. M.; Muro, S.; Muzykantov, V. R. Flow Shear Stress Differentially Regulates Endothelial Uptake of Nanocarriers Targeted to Distinct Epitopes of PECAM-1 J. Controlled Release 2015, 210, 39-47 10.1016/j.jconrel.2015.05.006
127. Lin, A.; Sabnis, A.; Kona, S.; Nattama, S.; Patel, H.; Dong, J. F.; Nguyen, K. T. Shear-Regulated Uptake of Nanoparticles by Endothelial Cells and Development of Endothelial-Targeting Nanoparticles J. Biomed. Mater. Res., Part A 2010, 93A (3) 833-842 10.1002/jbm.a.32592
128. Kona, S.; Dong, J.-F.; Liu, Y.; Tan, J.; Nguyen, K. T. Biodegradable Nanoparticles Mimicking Platelet Binding as a Targeted and Controlled Drug Delivery System Int. J. Pharm. 2012, 423 (2) 516-524 10.1016/j.ijpharm.2011.11.043
129. Lentacker, I.; De Smedt, S. C.; Sanders, N. N. Drug Loaded Microbubble Design for Ultrasound Triggered Delivery Soft Matter 2009, 5 (11) 2161-2170 10.1039/b823051j
130. Coussios, C. C.; Roy, R. A. Applications of Acoustics and Aavitation to Noninvasive Therapy and Drug Delivery Annu. Rev. Fluid Mech. 2008, 40, 395-420 10.1146/annurev.fluid.40.111406.102116
131. Hynynen, K. Ultrasound for Drug and Gene Delivery to the Brain Adv. Drug Delivery Rev. 2008, 60 (10) 1209-1217 10.1016/j.addr.2008.03.010
132. Schroeder, A.; Kost, J.; Barenholz, Y. Ultrasound, Liposomes, and Drug Delivery: Principles for Using Ultrasound to Control the Release of Drugs from Liposomes Chem. Phys. Lipids 2009, 162 (1) 1-16 10.1016/j.chemphyslip.2009.08.003
133. Deelman, L. E.; Declèves, A.-E.; Rychak, J. J.; Sharma, K. Targeted Renal Therapies through Microbubbles and Ultrasound Adv. Drug Delivery Rev. 2010, 62 (14) 1369-1377 10.1016/j.addr.2010.10.002
134. Azagury, A.; Khoury, L.; Enden, G.; Kost, J. Ultrasound Mediated Transdermal Drug Delivery Adv. Drug Delivery Rev. 2014, 72, 127-143 10.1016/j.addr.2014.01.007
135. Mitragotri, S. Healing Sound: the Use of Ultrasound in Drug Delivery and Other Therapeutic Applications Nat. Rev. Drug Discovery 2005, 4 (3) 255-260 10.1038/nrd1662
136. Kost, J.; Leong, K.; Langer, R. Ultrasound-Enhanced Polymer Degradation and Release of Incorporated Substances Proc. Natl. Acad. Sci. U. S. A. 1989, 86 (20) 7663-7666 10.1073/pnas.86.20.7663
137. Liu, Y.; Miyoshi, H.; Nakamura, M. Encapsulated Ultrasound Microbubbles: Therapeutic Application in Drug/Gene Delivery J. Controlled Release 2006, 114 (1) 89-99 10.1016/j.jconrel.2006.05.018
138. Ferrara, K. W.; Borden, M. A.; Zhang, H. Lipid-Shelled Vehicles: Engineering for Ultrasound Molecular Imaging and Drug Delivery Acc. Chem. Res. 2009, 42 (7) 881-892 10.1021/ar8002442
139. Unga, J.; Hashida, M. Ultrasound Induced Cancer Immunotherapy Adv. Drug Delivery Rev. 2014, 72, 144-153 10.1016/j.addr.2014.03.004
140. Kwok, C. S.; Mourad, P. D.; Crum, L. A.; Ratner, B. D. Self-Assembled Molecular Structures as Ultrasonically-Responsive Barrier Membranes for Pulsatile Drug Delivery J. Biomed. Mater. Res. 2001, 57 (2) 151-164 10.1002/1097-4636(200111)57:2<151::AID-JBM1154>3.0.CO;2-5
141. Mitragotri, S.; Kost, J. Low-Frequency Sonophoresis: a Noninvasive Method of Drug Delivery and Diagnostics Biotechnol. Prog. 2000, 16 (3) 488-492 10.1021/bp000024+
142. Ogura, M.; Paliwal, S.; Mitragotri, S. Low-Frequency Sonophoresis: Current Status and Future Prospects Adv. Drug Delivery Rev. 2008, 60 (10) 1218-1223 10.1016/j.addr.2008.03.006
143. Mitragotri, S.; Edwards, D. A.; Blankschtein, D.; Langer, R. A Mechanistic Study of Ultrasonically-Enhanced Transdermal Drug Delivery J. Pharm. Sci. 1995, 84 (6) 697-706 10.1002/jps.2600840607
144. Prausnitz, M. R.; Mitragotri, S.; Langer, R. Current Status and Future Potential of Transdermal Drug Delivery Nat. Rev. Drug Discovery 2004, 3 (2) 115-124 10.1038/nrd1304
145. Mitragotri, S.; Blankschtein, D.; Langer, R. Ultrasound-Mediated Transdermal Protein Delivery Science 1995, 269 (5225) 850-853 10.1126/science.7638603
146. Mitragotri, S.; Kost, J. Transdermal Delivery of Heparin and Low-Molecular Weight Heparin Using Low-Frequency Ultrasound Pharm. Res. 2001, 18 (8) 1151-1156 10.1023/A:1010979010907
147. Polat, B. E.; Deen, W. M.; Langer, R.; Blankschtein, D. A Physical Mechanism to Explain the Delivery of Chemical Penetration Enhancers into Skin During Transdermal Sonophoresis-Insight into the Observed Synergism J. Controlled Release 2012, 158 (2) 250-260 10.1016/j.jconrel.2011.11.008
148. Schoellhammer, C. M.; Schroeder, A.; Maa, R.; Lauwers, G. Y.; Swiston, A.; Zervas, M.; Barman, R.; DiCiccio, A. M.; Brugge, W. R.; Anderson, D. G. et al. Ultrasound-Mediated Gastrointestinal Drug Delivery Sci. Transl. Med. 2015, 7 (310 310ra168 10.1126/scitranslmed.aaa5937
149. Sboros, V. Response of Contrast Agents to Ultrasound Adv. Drug Delivery Rev. 2008, 60 (10) 1117-1136 10.1016/j.addr.2008.03.011
150. Paliwal, S.; Mitragotri, S. Ultrasound-Induced Cavitation: Applications in Drug and Gene Delivery Expert Opin. Drug Delivery 2006, 3 (6) 713-726 10.1517/17425247.3.6.713
151. Wu, J.; Nyborg, W. L. Ultrasound, Cavitation Bubbles and Their Interaction with Cells Adv. Drug Delivery Rev. 2008, 60 (10) 1103-1116 10.1016/j.addr.2008.03.009
152. Foley, J. L.; Vaezy, S.; Crum, L. A. Applications of High-Intensity Focused Ultrasound in Medicine: Spotlight on Neurological Applications Applied acoustics 2007, 68 (3) 245-259 10.1016/j.apacoust.2005.09.009
153. Blomley, M. J.; Cooke, J. C.; Unger, E. C.; Monaghan, M. J.; Cosgrove, D. O. Microbubble Contrast Agents: a New Era in Ultrasound Br. Med. J. 2001, 322 (7296) 1222 10.1136/bmj.322.7296.1222
154. Sirsi, S. R.; Borden, M. A. Advances in Ultrasound Mediated Gene Therapy Using Microbubble Contrast Agents Theranostics 2012, 2 (12) 1208-1222 10.7150/thno.4306
155. Unger, E.; Porter, T.; Lindner, J.; Grayburn, P. Cardiovascular Drug Delivery with Ultrasound and Microbubbles Adv. Drug Delivery Rev. 2014, 72, 110-126 10.1016/j.addr.2014.01.012
156. Polat, B. E.; Hart, D.; Langer, R.; Blankschtein, D. Ultrasound-Mediated Transdermal Drug Delivery: Mechanisms, Scope, and Emerging Trends J. Controlled Release 2011, 152 (3) 330-348 10.1016/j.jconrel.2011.01.006
157. Morgan, K. E.; Allen, J. S.; Dayton, P. A.; Chomas, J. E.; Klibaov, A.; Ferrara, K. W. Experimental and Theoretical Evaluation of Microbubble Behavior: Effect of Transmitted Phase and Bubble Size IEEE Trans. Ultrason. Ferroelectr. Freq. Control 2000, 47 (6) 1494-1509 10.1109/58.883539
158. Geers, B.; Dewitte, H.; De Smedt, S. C.; Lentacker, I. Crucial Factors and Emerging Concepts in Ultrasound-Triggered Drug Delivery J. Controlled Release 2012, 164 (3) 248-255 10.1016/j.jconrel.2012.08.014
159. Lum, A. F.; Borden, M. A.; Dayton, P. A.; Kruse, D. E.; Simon, S. I.; Ferrara, K. W. Ultrasound Radiation Force Enables Targeted Deposition of Model Drug Carriers Loaded on Microbubbles J. Controlled Release 2006, 111 (1) 128-134 10.1016/j.jconrel.2005.11.006
160. Kooiman, K.; Vos, H. J.; Versluis, M.; de Jong, N. Acoustic Behavior of Microbubbles and Implications for Drug Delivery Adv. Drug Delivery Rev. 2014, 72, 28-48 10.1016/j.addr.2014.03.003
161. Rychak, J. J.; Klibanov, A. L. Nucleic Acid Delivery with Microbubbles and Ultrasound Adv. Drug Delivery Rev. 2014, 72, 82-93 10.1016/j.addr.2014.01.009
162. Rapoport, N. Y.; Kennedy, A. M.; Shea, J. E.; Scaife, C. L.; Nam, K.-H. Controlled and Targeted Tumor Chemotherapy by Ultrasound-Activated Nanoemulsions/Microbubbles J. Controlled Release 2009, 138 (3) 268-276 10.1016/j.jconrel.2009.05.026
163. Aryal, M.; Arvanitis, C. D.; Alexander, P. M.; McDannold, N. Ultrasound-Mediated Blood-Brain Barrier Disruption for Targeted Drug Delivery in the Central Nervous System Adv. Drug Delivery Rev. 2014, 72, 94-109 10.1016/j.addr.2014.01.008
164. Cloughesy, T. F.; Black, K. L. Pharmacological Blood-Brain Barrier Modification for Selective Drug Delivery J. Neuro-Oncol. 1995, 26 (2) 125-132 10.1007/BF01060218
165. Khil, M. S.; Kolozsvary, A.; Apple, M.; Kim, J. H. Increased Tumor Cures Using Combined Radiosurgery and BCNU in the Treatment of 9L Glioma in the Rat Brain Int. J. Radiat. Oncol., Biol., Phys. 2000, 47 (2) 511-516 10.1016/S0360-3016(00)00428-4
166. Hynynen, K.; McDannold, N.; Vykhodtseva, N.; Jolesz, F. A. Noninvasive MR Imaging-guided Focal Opening of the Blood-Brain Barrier in Rabbits 1 Radiology 2001, 220 (3) 640-646 10.1148/radiol.2202001804
167. Kang, J.; Wu, X.; Wang, Z.; Ran, H.; Xu, C.; Wu, J.; Wang, Z.; Zhang, Y. Antitumor Effect of Docetaxel-Loaded Lipid Microbubbles Combined with Ultrasound-Targeted Microbubble Activation on VX2 Rabbit Liver Tumors J. Ultrasound Med. 2010, 29 (1) 61-70
168. Mitragotri, S. Devices for Overcoming Biological Barriers: the Use of Physical Forces to Disrupt the Barriers Adv. Drug Delivery Rev. 2013, 65 (1) 100-103 10.1016/j.addr.2012.07.016
169. Ting, C.-Y.; Fan, C.-H.; Liu, H.-L.; Huang, C.-Y.; Hsieh, H.-Y.; Yen, T.-C.; Wei, K.-C.; Yeh, C.-K. Concurrent Blood-Brain Barrier Opening and Local Drug Delivery Using Drug-Carrying Microbubbles and Focused Ultrasound for Brain Glioma Treatment Biomaterials 2012, 33 (2) 704-712 10.1016/j.biomaterials.2011.09.096
170. Li, P.; Zheng, Y.; Ran, H.; Tan, J.; Lin, Y.; Zhang, Q.; Ren, J.; Wang, Z. Ultrasound Triggered Drug Release from 10-Hydroxycamptothecin-Loaded Phospholipid Microbubbles for Targeted Tumor Therapy in Mice J. Controlled Release 2012, 162 (2) 349-354 10.1016/j.jconrel.2012.07.009
171. Fan, C.-H.; Ting, C.-Y.; Lin, H.-J.; Wang, C.-H.; Liu, H.-L.; Yen, T.-C.; Yeh, C.-K. SPIO-Conjugated, Doxorubicin-Loaded Microbubbles for Concurrent MRI and Focused-Ultrasound Enhanced Brain-Tumor Drug Delivery Biomaterials 2013, 34 (14) 3706-3715 10.1016/j.biomaterials.2013.01.099
172. Fan, C.-H.; Ting, C.-Y.; Liu, H.-L.; Huang, C.-Y.; Hsieh, H.-Y.; Yen, T.-C.; Wei, K.-C.; Yeh, C.-K. Antiangiogenic-Targeting Drug-Loaded Microbubbles Combined with Focused Ultrasound for Glioma Treatment Biomaterials 2013, 34 (8) 2142-2155 10.1016/j.biomaterials.2012.11.048
173. Kovacs, Z.; Werner, B.; Rassi, A.; Sass, J. O.; Martin-Fiori, E.; Bernasconi, M. Prolonged Survival upon Ultrasound-Enhanced Doxorubicin Delivery in Two Syngenic Glioblastoma Mouse Models J. Controlled Release 2014, 187, 74-82 10.1016/j.jconrel.2014.05.033
174. Niu, C.; Wang, Z.; Lu, G.; Krupka, T. M.; Sun, Y.; You, Y.; Song, W.; Ran, H.; Li, P.; Zheng, Y. Doxorubicin Loaded Superparamagnetic PLGA-Iron Oxide Multifunctional Microbubbles for Dual-Mode US/MR Imaging and Therapy of Metastasis in Lymph Nodes Biomaterials 2013, 34 (9) 2307-2317 10.1016/j.biomaterials.2012.12.003
175. Eggen, S.; Fagerland, S.-M.; Mørch, Ý.; Hansen, R.; Søvik, K.; Berg, S.; Furu, H.; Bøhn, A. D.; Lilledahl, M. B.; Angelsen, A. et al. Ultrasound-Enhanced Drug Delivery in Prostate Cancer Xenografts by Nanoparticles Stabilizing Microbubbles J. Controlled Release 2014, 187, 39-49 10.1016/j.jconrel.2014.05.020
176. Liu, L.; Chang, S.; Sun, J.; Zhu, S.; Yin, M.; Zhu, Y.; Wang, Z.; Xu, R. X. Ultrasound-Mediated Destruction of Paclitaxel and Oxygen Loaded Lipid Microbubbles for Combination Therapy in Ovarian Cancer Xenografts Cancer Lett. 2015, 361 (1) 147-154 10.1016/j.canlet.2015.02.052
177. Shih, C.-P.; Chen, H.-C.; Chen, H.-K.; Chiang, M.-C.; Sytwu, H.-K.; Lin, Y.-C.; Li, S.-L.; Shih, Y.-F.; Liao, A.-H.; Wang, C.-H. Ultrasound-Aided Microbubbles Facilitate the Delivery of Dugs to the Inner Ear via the Round Window Membrane J. Controlled Release 2013, 167 (2) 167-174 10.1016/j.jconrel.2013.01.028
178. Sanches, P. G.; Mühlmeister, M.; Seip, R.; Kaijzel, E.; Löwik, C.; Böhmer, M.; Tiemann, K.; Grüll, H. Ultrasound-Mediated Gene Delivery of Naked Plasmid DNA in Skeletal Muscles: a Case for Bolus Injections J. Controlled Release 2014, 195, 130-137 10.1016/j.jconrel.2014.06.033
179. Kheirolomoom, A.; Dayton, P. A.; Lum, A. F.; Little, E.; Paoli, E. E.; Zheng, H.; Ferrara, K. W. Acoustically-Active Microbubbles Conjugated to Liposomes: Characterization of a Proposed Drug Delivery Vehicle J. Controlled Release 2007, 118 (3) 275-284 10.1016/j.jconrel.2006.12.015
180. Klibanov, A. L.; Shevchenko, T. I.; Raju, B. I.; Seip, R.; Chin, C. T. Ultrasound-Triggered Release of Materials Entrapped in Microbubble-Liposome Constructs: a Tool for Targeted Drug Delivery J. Controlled Release 2010, 148 (1) 13-17 10.1016/j.jconrel.2010.07.115
181. De Temmerman, M.-L.; Dewitte, H.; Vandenbroucke, R. E.; Lucas, B.; Libert, C.; Demeester, J.; De Smedt, S. C.; Lentacker, I.; Rejman, J. mRNA-Lipoplex Loaded Microbubble Contrast Agents for Ultrasound-Assisted Transfection of Dendritic Cells Biomaterials 2011, 32 (34) 9128-9135 10.1016/j.biomaterials.2011.08.024
182. Geers, B.; Lentacker, I.; Sanders, N. N.; Demeester, J.; Meairs, S.; De Smedt, S. C. Self-Assembled Liposome-Loaded Microbubbles: The Missing Link for Safe and Efficient Ultrasound Triggered Drug-Delivery J. Controlled Release 2011, 152 (2) 249-256 10.1016/j.jconrel.2011.02.024
183. Geers, B.; De Wever, O.; Demeester, J.; Bracke, M.; De Smedt, S. C.; Lentacker, I. Targeted Liposome-Loaded Microbubbles for Cell-Specific Ultrasound-Triggered Drug Delivery Small 2013, 9 (23) 4027-4035 10.1002/smll.201300161
184. Cool, S. K.; Geers, B.; Roels, S.; Stremersch, S.; Vanderperren, K.; Saunders, J. H.; De Smedt, S. C.; Demeester, J.; Sanders, N. N. Coupling of Drug Containing Liposomes to Microbubbles Improves Ultrasound Triggered Drug Delivery in Mice J. Controlled Release 2013, 172 (3) 885-893 10.1016/j.jconrel.2013.09.014
185. Huang, S.-L. Liposomes in Ultrasonic Drug and Gene Delivery Adv. Drug Delivery Rev. 2008, 60 (10) 1167-1176 10.1016/j.addr.2008.03.003
186. Hitchcock, K. E.; Caudell, D. N.; Sutton, J. T.; Klegerman, M. E.; Vela, D.; Pyne-Geithman, G. J.; Abruzzo, T.; Cyr, P. E.; Geng, Y.-J.; McPherson, D. D. Ultrasound-Enhanced Delivery of Targeted Echogenic Liposomes in a Novel Ex Vivo Mouse Aorta Model J. Controlled Release 2010, 144 (3) 288-295 10.1016/j.jconrel.2010.02.030
187. Unger, E.; Shen, D.-K.; Fritz, T.; Lund, P.; Wu, G.-L.; Kulik, B.; DeYoung, D.; Standen, J.; Ovitt, T.; Matsunaga, T. Gas-Filled Liposomes as Echocardiographic Contrast Agents in Rabbits with Myocardial Infarcts Invest. Radiol. 1993, 28 (12) 1155-1159 10.1097/00004424-199312000-00015
188. Alkan-Onyuksel, H.; Demos, S. M.; Lanza, G. M.; Vonesh, M. J.; Klegerman, M. E.; Kane, B. J.; Kuszak, J.; McPherson, D. D. Development of Inherently Echogenic Liposomes as an Ultrasonic Contrast Agent J. Pharm. Sci. 1996, 85 (5) 486-490 10.1021/js950407f
189. Lin, H.-Y.; Thomas, J. L. PEG-Lipids and Oligo (Ethylene Glycol) Surfactants Enhance the Ultrasonic Permeabilizability of Liposomes Langmuir 2003, 19 (4) 1098-1105 10.1021/la026604t
190. Kabalnov, A.; Klein, D.; Pelura, T.; Schutt, E.; Weers, J. Dissolution of Multicomponent Microbubbles in the Bloodstream: 1. Theory Ultrasound Med. Biol. 1998, 24 (5) 739-749 10.1016/S0301-5629(98)00034-9
191. Kabalnov, A.; Bradley, J.; Flaim, S.; Klein, D.; Pelura, T.; Peters, B.; Otto, S.; Reynolds, J.; Schutt, E.; Weers, J. Dissolution of Multicomponent Microbubbles in the Bloodstream: 2. Experiment Ultrasound Med. Biol. 1998, 24 (5) 751-760 10.1016/S0301-5629(98)00033-7
192. De Jong, N.; Emmer, M.; Chin, C. T.; Bouakaz, A.; Mastik, F.; Lohse, D.; Versluis, M. Compression-Only" Behavior of Phospholipid-Coated Contrast Bubbles Ultrasound Med. Biol. 2007, 33 (4) 653-656 10.1016/j.ultrasmedbio.2006.09.016
193. Buchanan, K. D.; Huang, S.; Kim, H.; MacDonald, R. C.; McPherson, D. D. Echogenic Liposome Compositions for Increased Retention of Ultrasound Reflectivity at Physiologic Temperature J. Pharm. Sci. 2008, 97 (6) 2242-2249 10.1002/jps.21173
194. Suzuki, R.; Takizawa, T.; Negishi, Y.; Hagisawa, K.; Tanaka, K.; Sawamura, K.; Utoguchi, N.; Nishioka, T.; Maruyama, K. Gene Delivery by Combination of Novel Liposomal Bubbles with Perfluoropropane and Ultrasound J. Controlled Release 2007, 117 (1) 130-136 10.1016/j.jconrel.2006.09.008
195. Wang, Y.; Li, X.; Zhou, Y.; Huang, P.; Xu, Y. Preparation of Nanobubbles for Ultrasound Imaging and Intracelluar Drug Delivery Int. J. Pharm. 2010, 384 (1) 148-153 10.1016/j.ijpharm.2009.09.027
196. Suzuki, R.; Namai, E.; Oda, Y.; Nishiie, N.; Otake, S.; Koshima, R.; Hirata, K.; Taira, Y.; Utoguchi, N.; Negishi, Y. et al. Cancer Gene Therapy by IL-12 Gene Delivery Using Liposomal Bubbles and Tumoral Ultrasound Exposure J. Controlled Release 2010, 142 (2) 245-250 10.1016/j.jconrel.2009.10.027
197. Negishi, Y.; Matsuo, K.; Endo-Takahashi, Y.; Suzuki, K.; Matsuki, Y.; Takagi, N.; Suzuki, R.; Maruyama, K.; Aramaki, Y. Delivery of an Angiogenic Gene into Ischemic Muscle by Novel Bubble Liposomes Followed by Ultrasound Exposure Pharm. Res. 2011, 28 (4) 712-719 10.1007/s11095-010-0286-4
198. Negishi, Y.; Endo-Takahashi, Y.; Matsuki, Y.; Kato, Y.; Takagi, N.; Suzuki, R.; Maruyama, K.; Aramaki, Y. Systemic Delivery systems of Angiogenic Gene by Novel Bubble Liposomes Containing Cationic Lipid and Ultrasound Exposure Mol. Pharmaceutics 2012, 9 (6) 1834-1840 10.1021/mp200554c
199. Lin, C.-Y.; Javadi, M.; Belnap, D. M.; Barrow, J. R.; Pitt, W. G. Ultrasound Sensitive eLiposomes Containing Doxorubicin for Drug Targeting Therapy Nanomedicine 2014, 10 (1) 67-76 10.1016/j.nano.2013.06.011
200. Javadi, M.; Pitt, W. G.; Belnap, D. M.; Tsosie, N. H.; Hartley, J. M. Encapsulating Nanoemulsions inside eLiposomes for Ultrasonic Drug Delivery Langmuir 2012, 28 (41) 14720-14729 10.1021/la303464v
201. Javadi, M.; Pitt, W. G.; Tracy, C. M.; Barrow, J. R.; Willardson, B. M.; Hartley, J. M.; Tsosie, N. H. Ultrasonic Gene and Drug Delivery Using eLiposomes J. Controlled Release 2013, 167 (1) 92-100 10.1016/j.jconrel.2013.01.009
202. Yang, F.-Y.; Wong, T.-T.; Teng, M.-C.; Liu, R.-S.; Lu, M.; Liang, H.-F.; Wei, M.-C. Focused Ultrasound and Interleukin-4 Receptor-Targeted Liposomal Doxorubicin for Enhanced Targeted Drug Delivery and Antitumor Effect in Glioblastoma Multiforme J. Controlled Release 2012, 160 (3) 652-658 10.1016/j.jconrel.2012.02.023
203. Evjen, T. J.; Nilssen, E. A.; Rögnvaldsson, S.; Brandl, M.; Fossheim, S. L. Distearoylphosphatidylethanolamine-Based Liposomes for Ultrasound-Mediated Drug Delivery Eur. J. Pharm. Biopharm. 2010, 75 (3) 327-333 10.1016/j.ejpb.2010.04.012
204. Evjen, T. J.; Nilssen, E. A.; Barnert, S.; Schubert, R.; Brandl, M.; Fossheim, S. L. Ultrasound-Mediated Destabilization and Drug Release from Liposomes Comprising Dioleoylphosphatidylethanolamine Eur. J. Pharm. Sci. 2011, 42 (4) 380-386 10.1016/j.ejps.2011.01.002
205. Husseini, G. A.; Pitt, W. G. Micelles and Nanoparticles for Ultrasonic Drug and Gene Gelivery Adv. Drug Delivery Rev. 2008, 60 (10) 1137-1152 10.1016/j.addr.2008.03.008
206. Husseini, G. A.; Myrup, G. D.; Pitt, W. G.; Christensen, D. A.; Rapoport, N. Y. Factors Affecting Acoustically Triggered Release of Drugs from Polymeric Micelles J. Controlled Release 2000, 69 (1) 43-52 10.1016/S0168-3659(00)00278-9
207. Marin, A.; Sun, H.; Husseini, G. A.; Pitt, W. G.; Christensen, D. A.; Rapoport, N. Y. Drug Delivery in Pluronic Micelles: Effect of High-Frequency Ultrasound on Drug Release from Micelles and Intracellular Uptake J. Controlled Release 2002, 84 (1) 39-47 10.1016/S0168-3659(02)00262-6
208. Husseini, G. A.; Velluto, D.; Kherbeck, L.; Pitt, W. G.; Hubbell, J. A.; Christensen, D. A. Investigating the Acoustic Release of Doxorubicin from Targeted Micelles Colloids Surf., B 2013, 101, 153-155 10.1016/j.colsurfb.2012.05.025
209. Zhang, H.; Xia, H.; Wang, J.; Li, Y. High Intensity Focused Ultrasound-Responsive Release Behavior of PLA-b-PEG Copolymer Micelles J. Controlled Release 2009, 139 (1) 31-39 10.1016/j.jconrel.2009.05.037
210. Li, Y.; Tong, R.; Xia, H.; Zhang, H.; Xuan, J. High Intensity Focused Ultrasound and Redox Dual Responsive Polymer Micelles Chem. Commun. 2010, 46 (41) 7739-7741 10.1039/c0cc02628j
211. Hosseinkhani, H.; Tabata, Y. Ultrasound Enhances In Vivo Tumor Expression of Plasmid DNA by PEG-Introduced Cationized Dextran J. Controlled Release 2005, 108 (2) 540-556 10.1016/j.jconrel.2005.08.027
212. Zhou, Q.-H.; Miller, D. L.; Carlisle, R. C.; Seymour, L. W.; Oupicky, D. Ultrasound-Enhanced Transfection Activity of HPMA-Stabilized DNA Polyplexes with Prolonged Plasma Circulation J. Controlled Release 2005, 106 (3) 416-427 10.1016/j.jconrel.2005.05.002
213. Chumakova, O. V.; Liopo, A. V.; Andreev, V. G.; Cicenaite, I.; Evers, B. M.; Chakrabarty, S.; Pappas, T. C.; Esenaliev, R. O. Composition of PLGA and PEI/DNA Nanoparticles Improves Ultrasound-Mediated Gene Delivery in Solid Tumors In Vivo Cancer Lett. 2008, 261 (2) 215-225 10.1016/j.canlet.2007.11.023
214. Wang, T.-Y.; Choe, J. W.; Pu, K.; Devulapally, R.; Bachawal, S.; Machtaler, S.; Chowdhury, S. M.; Luong, R.; Tian, L.; Khuri-Yakub, B. et al. Ultrasound-Guided Delivery of microRNA loaded Nanoparticles into Cancer J. Controlled Release 2015, 203, 99-108 10.1016/j.jconrel.2015.02.018
215. Lopez, R. F.; Seto, J. E.; Blankschtein, D.; Langer, R. Enhancing the Transdermal Delivery of Rigid Nanoparticles Using the Simultaneous Application of Ultrasound and Sodium Lauryl Sulfate Biomaterials 2011, 32 (3) 933-941 10.1016/j.biomaterials.2010.09.060
216. Milgroom, A.; Intrator, M.; Madhavan, K.; Mazzaro, L.; Shandas, R.; Liu, B.; Park, D. Mesoporous Silica Nanoparticles as a Breast-Cancer Targeting Ultrasound Contrast Agent Colloids Surf., B 2014, 116, 652-657 10.1016/j.colsurfb.2013.10.038
217. Kripfgans, O. D.; Fowlkes, J. B.; Miller, D. L.; Eldevik, O. P.; Carson, P. L. Acoustic Droplet Vaporization for Therapeutic and Diagnostic Applications Ultrasound Med. Biol. 2000, 26 (7) 1177-1189 10.1016/S0301-5629(00)00262-3
218. Chen, C. C.; Sheeran, P. S.; Wu, S.-Y.; Olumolade, O. O.; Dayton, P. A.; Konofagou, E. E. Targeted Drug Delivery with Focused Ultrasound-Induced Blood-Brain Barrier Opening Using Acoustically-Activated Nanodroplets J. Controlled Release 2013, 172 (3) 795-804 10.1016/j.jconrel.2013.09.025
219. Wang, C.-H.; Kang, S.-T.; Lee, Y.-H.; Luo, Y.-L.; Huang, Y.-F.; Yeh, C.-K. Aptamer-Conjugated and Drug-Loaded Acoustic Droplets for Ultrasound Theranosis Biomaterials 2012, 33 (6) 1939-1947 10.1016/j.biomaterials.2011.11.036
220. Chen, W.-T.; Kang, S.-T.; Lin, J.-L.; Wang, C.-H.; Chen, R.-C.; Yeh, C.-K. Targeted Tumor Theranostics Using Folate-Conjugated and Camptothecin-Loaded Acoustic Nanodroplets in a Mouse Xenograft Model Biomaterials 2015, 53, 699-708 10.1016/j.biomaterials.2015.02.122
221. Wang, C.-H.; Kang, S.-T.; Yeh, C.-K. Superparamagnetic Iron Oxide and Drug Complex-Embedded Acoustic Droplets for Ultrasound Targeted Theranosis Biomaterials 2013, 34 (7) 1852-1861 10.1016/j.biomaterials.2012.11.037
222. Sarker, D. K. Engineering of Nanoemulsions for Drug Delivery Curr. Drug Delivery 2005, 2 (4) 297-310 10.2174/156720105774370267
223. Rapoport, N.; Nam, K.-H.; Gupta, R.; Gao, Z.; Mohan, P.; Payne, A.; Todd, N.; Liu, X.; Kim, T.; Shea, J. et al. Ultrasound-Mediated Tumor Imaging and Nanotherapy Using Drug Loaded, Block Copolymer Stabilized Perfluorocarbon Nanoemulsions J. Controlled Release 2011, 153 (1) 4-15 10.1016/j.jconrel.2011.01.022
224. Chen, H.; Li, J.; Wan, J.; Weitz, D. A.; Stone, H. A. Gas-Core Triple Emulsions for Ultrasound Triggered Release Soft Matter 2013, 9 (1) 38-42 10.1039/C2SM26992A
225. Rao, K. J.; Li, F.; Meng, L.; Zheng, H.; Cai, F.; Wang, W. A Force to Be Reckoned With: A Review of Synthetic Microswimmers Powered by Ultrasound Small 2015, 11 (24) 2836-2846 10.1002/smll.201403621
226. Paxton, W. F.; Kistler, K. C.; Olmeda, C. C.; Sen, A.; St. Angelo, S. K.; Cao, Y.; Mallouk, T. E.; Lammert, P. E.; Crespi, V. H. Catalytic Nanomotors: Autonomous Movement of Striped Nanorods J. Am. Chem. Soc. 2004, 126 (41) 13424-13431 10.1021/ja047697z
227. Mallouk, T. E.; Sen, A. Powering Nanorobots Sci. Am. 2009, 300 (5) 72-77 10.1038/scientificamerican0509-72
228. Sengupta, S.; Ibele, M. E.; Sen, A. Fantastic Voyage: Designing Self-Powered Nanorobots Angew. Chem., Int. Ed. 2012, 51 (34) 8434-8445 10.1002/anie.201202044
229. Guix, M.; Mayorga-Martinez, C. C.; Merkoci, A. Nano/Micromotors In (Bio) Chemical Science Applications Chem. Rev. 2014, 114 (12) 6285-6322 10.1021/cr400273r
230. Sundararajan, S.; Lammert, P. E.; Zudans, A. W.; Crespi, V. H.; Sen, A. Catalytic Motors for Transport of Colloidal Cargo Nano Lett. 2008, 8 (5) 1271-1276 10.1021/nl072275j
231. Baraban, L.; Makarov, D.; Streubel, R.; Mönch, I.; Grimm, D.; Sanchez, S.; Schmidt, O. G. Catalytic Janus Motors on Microfluidic Chip: Deterministic Motion for Targeted Cargo Delivery ACS Nano 2012, 6 (4) 3383-3389 10.1021/nn300413p
232. Wang, W.; Castro, L. A.; Hoyos, M.; Mallouk, T. E. Autonomous Motion of Metallic Microrods Propelled by Ultrasound ACS Nano 2012, 6 (7) 6122-6132 10.1021/nn301312z
233. Wang, W.; Li, S.; Mair, L.; Ahmed, S.; Huang, T. J.; Mallouk, T. E. Acoustic Propulsion of Nanorod Motors Inside Living Cells Angew. Chem., Int. Ed. 2014, 53 (12) 3201-3204 10.1002/anie.201309629
234. Kagan, D.; Benchimol, M. J.; Claussen, J. C.; Chuluun-Erdene, E.; Esener, S.; Wang, J. Acoustic Droplet Vaporization and Propulsion of Perfluorocarbon-Loaded Microbullets for Targeted Tissue Penetration and Deformation Angew. Chem. 2012, 124 (30) 7637-7640 10.1002/ange.201201902
235. Garcia-Gradilla, V.; Orozco, J.; Sattayasamitsathit, S.; Soto, F.; Kuralay, F.; Pourazary, A.; Katzenberg, A.; Gao, W.; Shen, Y.; Wang, J. Functionalized Ultrasound-Propelled Magnetically Guided Nanomotors: Toward Practical Biomedical Applications ACS Nano 2013, 7 (10) 9232-9240 10.1021/nn403851v
236. Garcia-Gradilla, V.; Sattayasamitsathit, S.; Soto, F.; Kuralay, F.; Yardlmcl, C.; Wiitala, D.; Galarnyk, M.; Wang, J. Ultrasound-Propelled Nanoporous Gold Wire for Efficient Drug Loading and Release Small 2014, 10 (20) 4154-4159 10.1002/smll.201401013
237. Wu, Z.; Wu, Y.; He, W.; Lin, X.; Sun, J.; He, Q. Self-Propelled Polymer-Based Multilayer Nanorockets for Transportation and Drug Release Angew. Chem., Int. Ed. 2013, 52 (27) 7000-7003 10.1002/anie.201301643
238. Wu, Z.; Li, T.; Li, J.; Gao, W.; Xu, T.; Christianson, C.; Gao, W.; Galarnyk, M.; He, Q.; Zhang, L. et al. Turning Erythrocytes into Functional Micromotors ACS Nano 2014, 8 (12) 12041-12048 10.1021/nn506200x
239. Lensen, D.; Gelderblom, E. C.; Vriezema, D. M.; Marmottant, P.; Verdonschot, N.; Versluis, M.; De Jong, N.; Van Hest, J. C. Biodegradable Polymeric Microcapsules for Selective Ultrasound-Triggered Drug Release Soft Matter 2011, 7 (11) 5417-5422 10.1039/c1sm05324h
240. Wang, C.-Y.; Yang, C.-H.; Lin, Y.-S.; Chen, C.-H.; Huang, K.-S. Anti-Inflammatory Effect with High Intensity Focused Ultrasound-Mediated Pulsatile Delivery of Diclofenac Biomaterials 2012, 33 (5) 1547-1553 10.1016/j.biomaterials.2011.10.047
241. Kolesnikova, T. A.; Gorin, D. A.; Fernandes, P.; Kessel, S.; Khomutov, G. B.; Fery, A.; Shchukin, D. G.; Möhwald, H. Nanocomposite Microcontainers with High Ultrasound Sensitivity Adv. Funct. Mater. 2010, 20 (7) 1189-1195 10.1002/adfm.200902233
242. Di, J.; Kim, J.; Hu, Q.; Jiang, X.; Gu, Z. Spatiotemporal Drug Delivery Using Laser-Generated-Focused Ultrasound System J. Controlled Release 2015, 220, 592-599 10.1016/j.jconrel.2015.08.033
243. Di, J.; Price, J.; Gu, X.; Jiang, X.; Jing, Y.; Gu, Z. Ultrasound-Triggered Regulation of Blood Glucose Levels Using Injectable Nano-Network Adv. Healthcare Mater. 2014, 3 (6) 811-816 10.1002/adhm.201300490
244. Epstein-Barash, H.; Orbey, G.; Polat, B. E.; Ewoldt, R. H.; Feshitan, J.; Langer, R.; Borden, M. A.; Kohane, D. S. A Microcomposite Hydrogel for Repeated On-Demand Ultrasound-Triggered Drug Delivery Biomaterials 2010, 31 (19) 5208-5217 10.1016/j.biomaterials.2010.03.008
245. Huebsch, N.; Kearney, C. J.; Zhao, X.; Kim, J.; Cezar, C. A.; Suo, Z.; Mooney, D. J. Ultrasound-Triggered Disruption and Self-Healing of Reversibly Cross-Linked Hydrogels for Drug Delivery and Enhanced Chemotherapy Proc. Natl. Acad. Sci. U. S. A. 2014, 111 (27) 9762-9767 10.1073/pnas.1405469111
246. Yohe, S. T.; Kopechek, J. A.; Porter, T. M.; Colson, Y. L.; Grinstaff, M. W. Triggered Drug Release from Superhydrophobic Meshes using High-Intensity Focused Ultrasound Adv. Healthcare Mater. 2013, 2 (9) 1204-1208 10.1002/adhm.201200381
247. Dai, Q.; Nelson, A. Magnetically-Responsive Self Assembled Composites Chem. Soc. Rev. 2010, 39 (11) 4057-4066 10.1039/b812669k
248. Zrínyi, M.; Barsi, L.; Büki, A. Deformation of Ferrogels Induced by Nonuniform Magnetic Fields J. Chem. Phys. 1996, 104 (21) 8750-8756 10.1063/1.471564
249. Francois, N. J.; Allo, S.; Jacobo, S. E.; Daraio, M. E. Composites of Polymeric Gels and Magnetic Nanoparticles: Preparation and Drug Release Behavior J. Appl. Polym. Sci. 2007, 105 (2) 647-655 10.1002/app.26321
250. Liu, T.-Y.; Hu, S.-H.; Liu, K.-H.; Liu, D.-M.; Chen, S.-Y. Study on Controlled Drug Permeation of Magnetic-Sensitive Ferrogels: Effect of Fe 3 O 4 and PVA J. Controlled Release 2008, 126 (3) 228-236 10.1016/j.jconrel.2007.12.006
251. Muzzalupo, R.; Tavano, L.; Rossi, C. O.; Picci, N.; Ranieri, G. A. Novel pH Sensitive Ferrogels as New Approach in Cancer Treatment: Effect of the Magnetic Field on Swelling and Drug Delivery Colloids Surf., B 2015, 134, 273-278 10.1016/j.colsurfb.2015.06.065
252. Liu, T.-Y.; Hu, S.-H.; Liu, T.-Y.; Liu, D.-M.; Chen, S.-Y. Magnetic-Sensitive Behavior of Intelligent Ferrogels for Controlled Release of Drug Langmuir 2006, 22 (14) 5974-5978 10.1021/la060371e
253. Hoare, T. R.; Kohane, D. S. Hydrogels in Drug Delivery: Progress and Challenges Polymer 2008, 49 (8) 1993-2007 10.1016/j.polymer.2008.01.027
254. Qin, J.; Asempah, I.; Laurent, S.; Fornara, A.; Muller, R. N.; Muhammed, M. Injectable Superparamagnetic Ferrogels for Controlled Release of Hydrophobic Drugs Adv. Mater. 2009, 21 (13) 1354-1357 10.1002/adma.200800764
255. Zhao, X.; Kim, J.; Cezar, C. A.; Huebsch, N.; Lee, K.; Bouhadir, K.; Mooney, D. J. Active Scaffolds for On-Demand Drug and Cell Delivery Proc. Natl. Acad. Sci. U. S. A. 2011, 108 (1) 67-72 10.1073/pnas.1007862108
256. Hu, S. H.; Chen, S. Y.; Liu, D. M.; Hsiao, C. S. Core/Single-Crystal-Shell Nanospheres for Controlled Drug Release via a Magnetically Triggered Rupturing Mechanism Adv. Mater. 2008, 20 (14) 2690-2695 10.1002/adma.200800193
257. Li, Z.; Yin, S.; Cheng, L.; Yang, K.; Li, Y.; Liu, Z. Magnetic Targeting Enhanced Theranostic Strategy Based on Multimodal Imaging for Selective Ablation of Cancer Adv. Funct. Mater. 2014, 24 (16) 2312-2321 10.1002/adfm.201303345
258. Li, Z.; Wang, C.; Cheng, L.; Gong, H.; Yin, S.; Gong, Q.; Li, Y.; Liu, Z. PEG-Functionalized Iron Oxide Nanoclusters Loaded with Chlorin e6 for Targeted, NIR Light Induced, Photodynamic Therapy Biomaterials 2013, 34 (36) 9160-9170 10.1016/j.biomaterials.2013.08.041
259. Wang, C.; Sun, X.; Cheng, L.; Yin, S.; Yang, G.; Li, Y.; Liu, Z. Multifunctional Theranostic Red Blood Cells For Magnetic-Field-Enhanced in vivo Combination Therapy of Cancer Adv. Mater. 2014, 26 (28) 4794-4802 10.1002/adma.201400158
260. Jokerst, J. V.; Gambhir, S. S. Molecular Imaging with Theranostic Nanoparticles Acc. Chem. Res. 2011, 44 (10) 1050-1060 10.1021/ar200106e
261. Terreno, E.; Uggeri, F.; Aime, S. Image Guided Therapy: the Advent of Theranostic Agents J. Controlled Release 2012, 161 (2) 328-337 10.1016/j.jconrel.2012.05.028
262. Son, S.; Min, H. S.; You, D. G.; Kim, B. S.; Kwon, I. C. Echogenic Nanoparticles for Ultrasound Technologies: Evolution from Diagnostic Imaging Modality to Multimodal Theranostic Agent Nano Today 2014, 9 (4) 525-540 10.1016/j.nantod.2014.06.002
263. Kiessling, F.; Fokong, S.; Bzyl, J.; Lederle, W.; Palmowski, M.; Lammers, T. Recent Advances in Molecular, Multimodal and Theranostic Ultrasound Imaging Adv. Drug Delivery Rev. 2014, 72, 15-27 10.1016/j.addr.2013.11.013
264. Barnett, S. B.; Ter Haar, G. R.; Ziskin, M. C.; Rott, H.-D.; Duck, F. A.; Maeda, K. International Recommendations and Guidelines for the Safe Use of Diagnostic Ultrasound in Medicine Ultrasound Med. Biol. 2000, 26 (3) 355-366 10.1016/S0301-5629(00)00204-0
265. Miller, D. L.; Smith, N. B.; Bailey, M. R.; Czarnota, G. J.; Hynynen, K.; Makin, I. R. S.; Medicine, B. C. o. t. A. I. o. U. i. Overview of Therapeutic Ultrasound Applications and Safety Considerations J. Ultrasound Med. 2012, 31 (4) 623-634
266. Lentacker, I.; De Cock, I.; Deckers, R.; De Smedt, S.; Moonen, C. Understanding Ultrasound Induced Sonoporation: Definitions and Underlying Mechanisms Adv. Drug Delivery Rev. 2014, 72, 49-64 10.1016/j.addr.2013.11.008
267. Traverso, G.; Langer, R. Engineering Precision Sci. Transl. Med. 2015, 7 (289 289ed6 10.1126/scitranslmed.aab1943
268. Kim, D.-H.; Lu, N.; Ma, R.; Kim, Y.-S.; Kim, R.-H.; Wang, S.; Wu, J.; Won, S. M.; Tao, H.; Islam, A. et al. Epidermal Electronics Science 2011, 333 (6044) 838-843 10.1126/science.1206157
269. Tee, B. C.-K.; Chortos, A.; Berndt, A.; Nguyen, A. K.; Tom, A.; McGuire, A.; Lin, Z. C.; Tien, K.; Bae, W.-G.; Wang, H. et al. A Skin-Inspired Organic Digital Mechanoreceptor Science 2015, 350 (6258) 313-316 10.1126/science.aaa9306
270. Gao, W.; Emaminejad, S.; Nyein, H. Y. Y.; Challa, S.; Chen, K.; Peck, A.; Fahad, H. M.; Ota, H.; Shiraki, H.; Kiriya, D. et al. Fully Integrated Wearable Sensor Arrays for Multiplexed In Situ Perspiration analysis Nature 2016, 529 (7587) 509-514 10.1038/nature16521
271. Gough, D. A.; Kumosa, L. S.; Routh, T. L.; Lin, J. T.; Lucisano, J. Y. Function of an Implanted Tissue Glucose Sensor for More Than 1 year in Animals Sci. Transl. Med. 2010, 2 (42) 42ra53-42ra53 10.1126/scitranslmed.3001148
272. Farra, R.; Sheppard, N. F.; McCabe, L.; Neer, R. M.; Anderson, J. M.; Santini, J. T.; Cima, M. J.; Langer, R. First-in-Human Testing of a Wirelessly Controlled Drug Delivery Microchip Sci. Transl. Med. 2012, 4 (122 122ra21 10.1126/scitranslmed.3003276
273. Kang, S.-K.; Murphy, R. K.; Hwang, S.-W.; Lee, S. M.; Harburg, D. V.; Krueger, N. A.; Shin, J.; Gamble, P.; Cheng, H.; Yu, S. et al. Bioresorbable Silicon Electronic Sensors for the Brain Nature 2016, 530 (7588) 71-76 10.1038/nature16492