Low-frequency sonophoresis: A noninvasive method of drug delivery and diagnostics

Biotechnology Progress

Volumn 16, Issue 3, 2000, Pages 488-492

  Mitragotri, Samir ^a   Kost, Joseph ^b,c  

^a University of California at Santa Barbara   (United States)

^b Sontra Medical   (United States)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

DIAGNOSTIC TEST; DRUG DELIVERY SYSTEM; GLUCOSE; INTERSTITIAL FLUID; INULIN; MANNITOL; MODEL; PERMEABILITY; SKIN; SONOPHORESIS;

BODY FLUIDS; CONTROLLED DRUG DELIVERY; DIAGNOSIS; DIAGNOSTIC PRODUCTS; DRUG PRODUCTS; GLUCOSE; ULTRASONIC APPLICATIONS;

LOW FREQUENCY SONOPHORESIS; SKIN PERMEABILITY; TRANSDERMAL DRUG DELIVERY;

BIOTECHNOLOGY;

ADMINISTRATION, CUTANEOUS; ANIMALS; DIAGNOSTIC TECHNIQUES AND PROCEDURES; DRUG DELIVERY SYSTEMS; GLUCOSE; RATS; RATS, SPRAGUE-DAWLEY; SKIN ABSORPTION; ULTRASONICS;

EID: 0034080281     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp000024+     Document Type: Article

References (17)

1. Bronaugh, R. L.; Maibach, H. I. E., Percutaneous Absorption: Mechanisms-Methodology-Drug Delivery; Marcel Dekker: New York, 1989.
2. Mitragotri, S.; Edwards, D.; Blankschtein, D.; Langer, R. A Mechanistic study of Ultrasonically Enhanced Transdermal Drug Delivery. J. Pharm. Sci. 1995, 84, 697-706.
3. Mitragotri, S.; Blankschtein, D.; Langer, R. Ultrasound-Mediated Transdermal Protein Delivery. Science 1995, 269, 850-853.
4. Mitragotri, S.; Blankschtein, D.; Langer, R. Transdermal Drug Delivery using Low-Frequency Sonophoresis. Pharm. Res. 1996, 13, 411-420.
5. Tachibana, K. Transdermal Delivery of Insulin to Alloxan-Diabetic Rabbits by Ultrasound Exposure. Pharm. Res. 1992, 9, 952-954.
6. Kost, J.; Levy, D.; Langer, R., Ultrasound as a Transdermal Enhancer. In Percutaneous Absorption: Mechanisms-Methodology-Drug Delivery; Bronaugh, R., Maibach, H. I. E., Eds.; Marcel Dekker Inc.: New York and Basel, 1989; pp 595-601.
7. Bommannan, D.; Okuyama, H.; Stauffer, P.; Guy, R. H. Sonophoresis. I. The Use of High-Frequency Ultrasound to Enhance Transdermal drug Delivery. Pharm. Res. 1992, 9, 559-564.
8. Bommannan, D.; Menon, G. K.; Okuyama, H.; Elias, P. M.; Guy, R. H. Sonophoresis. II. Examination of the mechanism(s) of Ultrasound-enhanced Transdermal Drug Delivery. Pharm. Res. 1992, 9, 1043-1047.
9. Johnson, M. E.; Mitragotri, S.; Patel, A.; Blankschtein, D.; Langer, R. Synergistic Effect of Ultrasound and Chemical Enhancers on Transdermal Drug Delivery. J. Pharm. Sci. 1996, 85, 670-679.
10. Johnson, M. E. Biophysical Aspects of Transdermal Drug Delivery and Chemical Enhncement. In Chemical Engineering; Masachusetts Institute of Technology: Cambridge, 1996; p 260.
11. Green, P. G.; Flalagan, M.; Shroot, B.; Guy, R. H., Iontophoretic Drug Delivery. In Pharmaceutical Skin Penetration Enhancement; Walters, K. A., Hadgraft, J., Eds.; Marcel Dekker: New York, 1993.
12. Prausnitz, M. R.; Bose, V.; Langer, R.; Weaver, J. C. Electroporation of Mammalian Skin: A Mechanism to enhance Transdermal Drug Delivery. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 10504-10508.
13. Levy, D.; Kost, J.; Meshulam, Y.; Langer, R. Effect of Ultrasound on transdermal Drug Delivery to Rats and Guinea Pigs. J. Clin. Invest. 1989, 83, 2974-2078.
14. Mitragotri, S.; Farrell, J.; Tang, H.; Terahara, T.; Kost, J.; Langer, R. Determination of Threshold Energy Dose for Ultrasound-Induced Transdermal Drug Transport. J. Control Rel. 2000, 63, 41-52.
15. Tang, H.; Mitragotri, S.; Blankschtein, D.; Kost, J.; Langer, R. The Role of Convection and Skin Alteration in Low-Frequency Sonophoresis of Hydrophilic Drugs. Proc. Int. Symp. Controlled Release Bioact. Mater. 1999, 26, 395-396.
16. Mitragotri, S.; Coleman, M.; Kost, J.; Langer, R. Transdermal Analyte Extraction Using Low-Frequency Ultrasound. Pharm. Res., 2000, 17(4), 466-470.
17. Kost, J.; Mitragotri, S.; Gabbay, R.; Pishko, M.; Langer, R. Transdermal Extraction of Glucose and Other Analytes using Ultrasound. Nature Med. 2000, 6, 347-350.