A physical mechanism to explain the delivery of chemical penetration enhancers into skin during transdermal sonophoresis - Insight into the observed synergism

Journal of Controlled Release

Volumn 158, Issue 2, 2012, Pages 250-260

  Polat, Baris E ^a   Deen, William M ^a   Langer, Robert ^a   Blankschtein, Daniel ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Chemical penetration enhancers; Diffusion; Sonophoresis; Synergism; Transdermal; Ultrasound

Indexed keywords

ACOUSTIC CAVITATIONS; AMPHIPHILIC MOLECULES; AMPHIPHILICS; CAVITATION BUBBLE; CHEMICAL PENETRATION ENHANCER; CONVECTIVE FLUX; FLUX EQUATIONS; FLUX MODEL; LOW FREQUENCY; MICRO JET; NON-AMPHIPHILIC; NONIONIC; OCTYL GLUCOSIDES; PHYSICAL MECHANISM; PROPYLENE GLYCOLS; SKIN SURFACES; SODIUM LAURYL SULFATES; SONOPHORESIS; SYNERGISM; TRANSDERMAL;

DIFFUSION; SKIN; SURFACE ACTIVE AGENTS; ULTRASONICS;

CAVITATION;

AMPHOPHILE; CHEMICAL PENETRATION ENHANCER; DODECYL SULFATE SODIUM; OCTYL GLUCOSIDE; PENETRATION ENHANCING AGENT; PROPYLENE GLYCOL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG DELIVERY SYSTEM; DRUG POTENTIATION; FEMALE; LOW FREQUENCY SONOPHORESIS; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SKIN PERMEABILITY; SKIN SURFACE; SURFACE TENSION;

ACOUSTICS; ADMINISTRATION, CUTANEOUS; ANIMALS; DRUG DELIVERY SYSTEMS; FEMALE; GLUCOSIDES; MODELS, BIOLOGICAL; PROPYLENE GLYCOL; SKIN; SKIN ABSORPTION; SODIUM DODECYL SULFATE; SURFACE-ACTIVE AGENTS; SWINE;

EID: 84858697767     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.11.008     Document Type: Article

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