Glucose-responsive microgels integrated with enzyme nanocapsules for closed-loop insulin delivery

ACS Nano

Volumn 7, Issue 8, 2013, Pages 6758-6766

  Gu, Zhen ^a,b,c,d,e   Dang, Tram T ^a,b,c   Ma, Minglin ^a,b,c   Tang, Benjamin C ^a,b,c   Cheng, Hao ^a,b   Jiang, Shan ^a,b   Dong, Yizhou ^a,b,c   Zhang, Yunlong ^a,b,c   Anderson, Daniel G ^a,b,c  

^a Massachusetts Institute of Technology   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d Biomedical Research Imaging Center   (United States)

^e UNC Hamner Institute for Drug Safety Sciences   (United States)

Author keywords

diabetes; drug delivery; glucose responsive; insulin; microgels; nanocapsules

Indexed keywords

BLOOD GLUCOSE LEVEL; CHITOSAN MATRICES; CLOSED-LOOP INSULIN DELIVERIES; ENZYMATIC CONVERSIONS; ENZYMATIC STABILITY; GLUCOSE-RESPONSIVE; MICRO-GELS; TYPE 1 DIABETES MELLITUS;

CHITOSAN; DRUG DELIVERY; ENZYMES; GLUCOSE; INSULIN; MEDICAL PROBLEMS; NANOCAPSULES;

GELS;

CHITOSAN; DRUG CARRIER; ENZYME; GEL; GLUCONIC ACID; GLUCOSE; GLUCOSE BLOOD LEVEL; INSULIN; NANOCAPSULE; RECOMBINANT PROTEIN;

ANALYSIS; ANIMAL; CATALYSIS; CHEMISTRY; DISEASE MODEL; DRUG DELIVERY SYSTEM; GEL; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; MOUSE; PH; TIME; TRANSMISSION ELECTRON MICROSCOPY; ARTICLE;

ANIMALS; BLOOD GLUCOSE; CATALYSIS; CHITOSAN; DISEASE MODELS, ANIMAL; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; ENZYMES; GELS; GLUCONATES; GLUCOSE; HUMANS; HYDROGEN-ION CONCENTRATION; HYPERGLYCEMIA; INSULIN; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; NANOCAPSULES; RECOMBINANT PROTEINS; TIME FACTORS;

EID: 84883208896     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn401617u     Document Type: Article

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