메뉴 건너뛰기




Volumn 112, Issue 3, 2006, Pages 630-648

Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery

Author keywords

Cancer targeted therapy; Drug delivery; Gene and siRNA delivery; Nanotechnology; Photodynamic therapy; Polymeric micelles

Indexed keywords

4 PHENYL 1 BUTANOLATE; 6 [4 DEOXY 4 (2,4 TETRADECADIENOYLGLYCYLAMINO) GLYCERO BETA MANNOHEPTOPYRANOSYLAMINO] 9H PURINE; AMPHOTERICIN B; ANTIBODY; ANTIHISTAMINIC AGENT; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; BENZOPORPHYRIN DERIVATIVE; CISPLATIN; COPOLYMER; DOXORUBICIN; DRUG CARRIER; FATTY ACID DERIVATIVE; LIPOSOME; MACROGOL; NK 105; NK 911; OXALIPLATIN; PACLITAXEL; PEPTIDE; PHOTOSENSITIZING AGENT; PLASMID DNA; PLATINUM 1,2 DIAMINOCYCLOHEXANE MALONATE; POLOXAMER; POLYETHYLENEGLYCOL BLOCK POLY(ASPARTIC ACID); POLYETHYLENEIMINE; POLYMER; SMALL INTERFERING RNA; SPICAMYCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 33750136313     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2006.05.006     Document Type: Review
Times cited : (988)

References (134)
  • 1
    • 0025789143 scopus 로고
    • Pharmacokinetics of stealth versus conventional liposomes: effect of dose
    • Allen T.M., and Hansen C. Pharmacokinetics of stealth versus conventional liposomes: effect of dose. Biochim Biophys Acta 1068 (1991) 133-141
    • (1991) Biochim Biophys Acta , vol.1068 , pp. 133-141
    • Allen, T.M.1    Hansen, C.2
  • 3
    • 0142119372 scopus 로고    scopus 로고
    • Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change
    • Bae Y., Fukushima S., Harada A., and Kataoka K. Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change. Angew Chem Int Ed 42 (2003) 4640-4643
    • (2003) Angew Chem Int Ed , vol.42 , pp. 4640-4643
    • Bae, Y.1    Fukushima, S.2    Harada, A.3    Kataoka, K.4
  • 4
    • 12344269847 scopus 로고    scopus 로고
    • Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy
    • Bae Y., Nishiyama N., Fukushima S., Koyama H., Matsumura Y., and Kataoka K. Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy. Bioconjug Chem 16 (2005) 122-130
    • (2005) Bioconjug Chem , vol.16 , pp. 122-130
    • Bae, Y.1    Nishiyama, N.2    Fukushima, S.3    Koyama, H.4    Matsumura, Y.5    Kataoka, K.6
  • 5
    • 26644464129 scopus 로고    scopus 로고
    • Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery
    • Bae Y., Jang W.-D., Nishiyama N., Fukushima S., and Kataoka K. Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery. Mol Biosyst 1 (2005) 242-250
    • (2005) Mol Biosyst , vol.1 , pp. 242-250
    • Bae, Y.1    Jang, W.-D.2    Nishiyama, N.3    Fukushima, S.4    Kataoka, K.5
  • 6
    • 0035556313 scopus 로고    scopus 로고
    • Mechanism of sensitization of MDR cancer cells by Pluronic block copolymers: selective energy depletion
    • Batrakova E.V., Li S., Elmquist W.F., Miller D.W., Alakhov V.Y., and Kabanov A.V. Mechanism of sensitization of MDR cancer cells by Pluronic block copolymers: selective energy depletion. Br J Cancer 85 (2001) 1987-1997
    • (2001) Br J Cancer , vol.85 , pp. 1987-1997
    • Batrakova, E.V.1    Li, S.2    Elmquist, W.F.3    Miller, D.W.4    Alakhov, V.Y.5    Kabanov, A.V.6
  • 7
    • 78650476432 scopus 로고    scopus 로고
    • The proton sponge. A trick to enter cells the viruses did not exploit
    • Behr J.P. The proton sponge. A trick to enter cells the viruses did not exploit. Chimia 51 (1997) 34-36
    • (1997) Chimia , vol.51 , pp. 34-36
    • Behr, J.P.1
  • 8
    • 0033559618 scopus 로고    scopus 로고
    • Photochemical internalization: a novel technology for delivery of macromolecules into cytosol
    • Berg K., Selbo P.K., Prasmikaite L., Tjelle T.E., Sandvig K., Moan J., et al. Photochemical internalization: a novel technology for delivery of macromolecules into cytosol. Cancer Res 59 (1999) 1180-1183
    • (1999) Cancer Res , vol.59 , pp. 1180-1183
    • Berg, K.1    Selbo, P.K.2    Prasmikaite, L.3    Tjelle, T.E.4    Sandvig, K.5    Moan, J.6
  • 9
    • 11844290850 scopus 로고    scopus 로고
    • Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer
    • Boeckle S., von Gersdorff K., van der Piepen S., Culmsee C., Wagner E., and Ogris M. Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer. J Gene Med 6 (2004) 1102-1111
    • (2004) J Gene Med , vol.6 , pp. 1102-1111
    • Boeckle, S.1    von Gersdorff, K.2    van der Piepen, S.3    Culmsee, C.4    Wagner, E.5    Ogris, M.6
  • 10
    • 10044271109 scopus 로고    scopus 로고
    • Preparation and biological properties of dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt)-loaded polymeric micelles
    • Cabral H., Nishiyama N., Okazaki S., Koyama H., and Kataoka K. Preparation and biological properties of dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt)-loaded polymeric micelles. J Control Release 101 (2005) 223-232
    • (2005) J Control Release , vol.101 , pp. 223-232
    • Cabral, H.1    Nishiyama, N.2    Okazaki, S.3    Koyama, H.4    Kataoka, K.5
  • 11
    • 0037531126 scopus 로고    scopus 로고
    • Oxaliplatin for colorectal cancer in the United States: better late than never
    • Chau I., and Cunningham D. Oxaliplatin for colorectal cancer in the United States: better late than never. J Clin Oncol 21 (2003) 2049-2051
    • (2003) J Clin Oncol , vol.21 , pp. 2049-2051
    • Chau, I.1    Cunningham, D.2
  • 12
    • 0028831997 scopus 로고
    • Calcium signaling
    • Clapham D.E. Calcium signaling. Cell 80 (1995) 259-268
    • (1995) Cell , vol.80 , pp. 259-268
    • Clapham, D.E.1
  • 15
    • 0038387390 scopus 로고    scopus 로고
    • The dawning era of polymer therapeutics
    • Duncan R. The dawning era of polymer therapeutics. Nat Rev Drug Discov 2 (2003) 347-360
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 347-360
    • Duncan, R.1
  • 16
    • 0029004025 scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
    • Dvorak H.F., Brown L.F., Detmar M., and Dvorak A.M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146 (1995) 1029-1039
    • (1995) Am J Pathol , vol.146 , pp. 1029-1039
    • Dvorak, H.F.1    Brown, L.F.2    Detmar, M.3    Dvorak, A.M.4
  • 17
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., and Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411 (2001) 494-498
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 18
    • 14644439267 scopus 로고    scopus 로고
    • Cancer nanotechnology: opportunities and challenges
    • Ferrari M. Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer 5 (2005) 161-171
    • (2005) Nat Rev Cancer , vol.5 , pp. 161-171
    • Ferrari, M.1
  • 19
    • 14844309624 scopus 로고    scopus 로고
    • PEGylated polyplex micelles from triblock catiomers with spatially ordered layering of condensed pDNA and buffering units for enhanced intracellular gene delivery
    • Fukushima S., Miyata K., Nishiyama N., Kanayama N., Yamasaki Y., and Kataoka K. PEGylated polyplex micelles from triblock catiomers with spatially ordered layering of condensed pDNA and buffering units for enhanced intracellular gene delivery. J Am Chem Soc 127 (2005) 2810-2811
    • (2005) J Am Chem Soc , vol.127 , pp. 2810-2811
    • Fukushima, S.1    Miyata, K.2    Nishiyama, N.3    Kanayama, N.4    Yamasaki, Y.5    Kataoka, K.6
  • 20
    • 0033152928 scopus 로고    scopus 로고
    • HPMA copolymer platinates as novel antitumor agents: in vitro properties, pharmacokinetics and antitumor activity in vivo
    • Gianasi E., Wasil M., Evagarou E.G., Keddle A., Wilson G., and Duncan D. HPMA copolymer platinates as novel antitumor agents: in vitro properties, pharmacokinetics and antitumor activity in vivo. Eur J Cancer 35 (1999) 994-1002
    • (1999) Eur J Cancer , vol.35 , pp. 994-1002
    • Gianasi, E.1    Wasil, M.2    Evagarou, E.G.3    Keddle, A.4    Wilson, G.5    Duncan, D.6
  • 21
    • 0035879099 scopus 로고    scopus 로고
    • Recurrent epithelial ovarian carcinoma: a randomized phase III study of pegylated liposomal doxorubicin vs. topotecan
    • Gordon A.N., Fleagle J.T., Guthrie D., Parkin D.E., Gore M.E., and Lacave A.J. Recurrent epithelial ovarian carcinoma: a randomized phase III study of pegylated liposomal doxorubicin vs. topotecan. J Clin Oncol 19 (2001) 3312-3322
    • (2001) J Clin Oncol , vol.19 , pp. 3312-3322
    • Gordon, A.N.1    Fleagle, J.T.2    Guthrie, D.3    Parkin, D.E.4    Gore, M.E.5    Lacave, A.J.6
  • 23
    • 0020173068 scopus 로고
    • Type I and type II mechanisms in the photosensitized lysis of phosphatidylcholine liposomes by hematoporphyrin
    • Grossweiner L.I., Patel A.S., and Grossweiner J.B. Type I and type II mechanisms in the photosensitized lysis of phosphatidylcholine liposomes by hematoporphyrin. Photochem Photobiol 36 (1982) 159-167
    • (1982) Photochem Photobiol , vol.36 , pp. 159-167
    • Grossweiner, L.I.1    Patel, A.S.2    Grossweiner, J.B.3
  • 24
    • 20944450473 scopus 로고    scopus 로고
    • NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumor activity and reduce the neurotoxicity of paclitaxel
    • Hamaguchi T., Mastumura Y., Suzuki M., Shimizu K., Goda R., Nakamura I., et al. NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumor activity and reduce the neurotoxicity of paclitaxel. Br J Cancer 92 (2005) 1240-1246
    • (2005) Br J Cancer , vol.92 , pp. 1240-1246
    • Hamaguchi, T.1    Mastumura, Y.2    Suzuki, M.3    Shimizu, K.4    Goda, R.5    Nakamura, I.6
  • 25
    • 0032508679 scopus 로고    scopus 로고
    • Multicellular spheroids as an in vitro tumor model
    • Hamilton G. Multicellular spheroids as an in vitro tumor model. Cancer Lett 131 (1998) 29-34
    • (1998) Cancer Lett , vol.131 , pp. 29-34
    • Hamilton, G.1
  • 26
    • 0029344655 scopus 로고
    • Formation of polyion complex micelles in aqueous milieu from a pair of oppositely-charged block copolymers with poly(ethylene glycol) segments
    • Harada A., and Kataoka K. Formation of polyion complex micelles in aqueous milieu from a pair of oppositely-charged block copolymers with poly(ethylene glycol) segments. Macromolecules 28 (1995) 5294-5299
    • (1995) Macromolecules , vol.28 , pp. 5294-5299
    • Harada, A.1    Kataoka, K.2
  • 27
    • 0032957466 scopus 로고    scopus 로고
    • Chain length recognition: core-shell supermolecular assembly from oppositely charged block copolymers
    • Harada A., and Kataoka K. Chain length recognition: core-shell supermolecular assembly from oppositely charged block copolymers. Science 283 (1999) 65-67
    • (1999) Science , vol.283 , pp. 65-67
    • Harada, A.1    Kataoka, K.2
  • 28
    • 85047695467 scopus 로고    scopus 로고
    • Polyion complex micelles as vectors in gene therapy - pharmacokinetics and in vivo gene transfer
    • Harada-Shiba M., Yamauchi K., Harada A., Takamisawa I., Shimokado K., and Kataoka K. Polyion complex micelles as vectors in gene therapy - pharmacokinetics and in vivo gene transfer. Gene Ther 9 (2002) 407-414
    • (2002) Gene Ther , vol.9 , pp. 407-414
    • Harada-Shiba, M.1    Yamauchi, K.2    Harada, A.3    Takamisawa, I.4    Shimokado, K.5    Kataoka, K.6
  • 30
    • 0034630145 scopus 로고    scopus 로고
    • Photochemical transfection: a new technology for light-induced, site-directed gene delivery
    • Høgset A., Prasmickaite L., Tjelle T.E., and Berg K. Photochemical transfection: a new technology for light-induced, site-directed gene delivery. Hum Gene Ther 11 (2000) 869-880
    • (2000) Hum Gene Ther , vol.11 , pp. 869-880
    • Høgset, A.1    Prasmickaite, L.2    Tjelle, T.E.3    Berg, K.4
  • 33
    • 30644472892 scopus 로고    scopus 로고
    • Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer
    • Ideta R., Tasaka F., Jang W.-D., Nishiyama N., Zhang G.-D., Harada A., et al. Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer. Nano Lett 5 (2005) 2426-2431
    • (2005) Nano Lett , vol.5 , pp. 2426-2431
    • Ideta, R.1    Tasaka, F.2    Jang, W.-D.3    Nishiyama, N.4    Zhang, G.-D.5    Harada, A.6
  • 34
    • 0036057165 scopus 로고    scopus 로고
    • Evaluation by fluorescence resonance energy transfer of the stability of nonviral gene delivery vectors under physiological conditions
    • Itaka K., Harada A., Nakamura K., Kawaguchi H., and Kataoka K. Evaluation by fluorescence resonance energy transfer of the stability of nonviral gene delivery vectors under physiological conditions. Biomacromolecules 3 (2002) 841-845
    • (2002) Biomacromolecules , vol.3 , pp. 841-845
    • Itaka, K.1    Harada, A.2    Nakamura, K.3    Kawaguchi, H.4    Kataoka, K.5
  • 35
    • 0042061163 scopus 로고    scopus 로고
    • Polyion complex micelles from plasmid DNA and poly(ethylene glycol)-poly(l-lysine) block copolymer as serum-tolerable polyplex system: physiological properties of micelles relevant to gene transfection efficiency
    • Itaka K., Yamauchi K., Harada A., Nakamura K., Kawaguchi H., and Kataoka K. Polyion complex micelles from plasmid DNA and poly(ethylene glycol)-poly(l-lysine) block copolymer as serum-tolerable polyplex system: physiological properties of micelles relevant to gene transfection efficiency. Biomaterials 24 (2003) 4495-4506
    • (2003) Biomaterials , vol.24 , pp. 4495-4506
    • Itaka, K.1    Yamauchi, K.2    Harada, A.3    Nakamura, K.4    Kawaguchi, H.5    Kataoka, K.6
  • 37
    • 0035291243 scopus 로고    scopus 로고
    • Delivery of molecular and cellular medicine to solid tumors
    • Jain R.K. Delivery of molecular and cellular medicine to solid tumors. Adv Drug Deliv Rev 46 (2001) 149-168
    • (2001) Adv Drug Deliv Rev , vol.46 , pp. 149-168
    • Jain, R.K.1
  • 38
    • 19944431237 scopus 로고    scopus 로고
    • Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy
    • Jang W.D., Nishiyama N., Zhang G.D., Harada A., Jiang D.L., Kawauchi S., et al. Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy. Angew Chem Int Ed 44 (2005) 419-423
    • (2005) Angew Chem Int Ed , vol.44 , pp. 419-423
    • Jang, W.D.1    Nishiyama, N.2    Zhang, G.D.3    Harada, A.4    Jiang, D.L.5    Kawauchi, S.6
  • 39
    • 0026122420 scopus 로고
    • Protein-surface interactions in the presence of polyethylene oxide: I. Simplified theory
    • Jeon S.I., Lee J.H., Andrade J.D., and De Gennes P.G. Protein-surface interactions in the presence of polyethylene oxide: I. Simplified theory. J Colloid Interface Sci 142 (1991) 149-158
    • (1991) J Colloid Interface Sci , vol.142 , pp. 149-158
    • Jeon, S.I.1    Lee, J.H.2    Andrade, J.D.3    De Gennes, P.G.4
  • 42
    • 0033537026 scopus 로고    scopus 로고
    • Environment-sensitive stabilization of core-shell structured polyion complex micelle by reversible cross-linking of the core through disulfide bond
    • Kakizawa Y., Harada A., and Kataoka K. Environment-sensitive stabilization of core-shell structured polyion complex micelle by reversible cross-linking of the core through disulfide bond. J Am Chem Soc 121 (1999) 11247-11248
    • (1999) J Am Chem Soc , vol.121 , pp. 11247-11248
    • Kakizawa, Y.1    Harada, A.2    Kataoka, K.3
  • 43
    • 2442591847 scopus 로고    scopus 로고
    • Size-controlled formation of a calcium phosphate-based organic-inorganic hybrid vector for gene delivery using poly(ethylene glycol)-block-poly(aspartic acid)
    • Kakizawa Y., Miyata K., Furukawa S., and Kataoka K. Size-controlled formation of a calcium phosphate-based organic-inorganic hybrid vector for gene delivery using poly(ethylene glycol)-block-poly(aspartic acid). Adv Mater 16 (2004) 699-702
    • (2004) Adv Mater , vol.16 , pp. 699-702
    • Kakizawa, Y.1    Miyata, K.2    Furukawa, S.3    Kataoka, K.4
  • 44
    • 2942548218 scopus 로고    scopus 로고
    • Block copolymer-coated calcium-phosphate nanoparticles sensing intracellular environment for oligodeoxynucleotide and siRNA delivery
    • Kakizawa Y., Furukawa S., and Kataoka K. Block copolymer-coated calcium-phosphate nanoparticles sensing intracellular environment for oligodeoxynucleotide and siRNA delivery. J Control Release 97 (2004) 345-356
    • (2004) J Control Release , vol.97 , pp. 345-356
    • Kakizawa, Y.1    Furukawa, S.2    Kataoka, K.3
  • 46
    • 0012501354 scopus 로고    scopus 로고
    • Targetable polymeric drugs (Chap. 4)
    • Park K. (Ed), ACS, Washington, DC
    • Kataoka K. Targetable polymeric drugs (Chap. 4). In: Park K. (Ed). Controlled Drug Delivery: The Next Generation (1996), ACS, Washington, DC
    • (1996) Controlled Drug Delivery: The Next Generation
    • Kataoka, K.1
  • 47
    • 0030385934 scopus 로고    scopus 로고
    • Spontaneous formation of polyion complex micelles with narrow distribution from antisense oligonucleotide and cationic block copolymer in physiological saline
    • Kataoka K., Togawa H., Harada A., Yasugi K., Matsumoto T., and Katayose S. Spontaneous formation of polyion complex micelles with narrow distribution from antisense oligonucleotide and cationic block copolymer in physiological saline. Macromolecules 29 (1996) 8556-8557
    • (1996) Macromolecules , vol.29 , pp. 8556-8557
    • Kataoka, K.1    Togawa, H.2    Harada, A.3    Yasugi, K.4    Matsumoto, T.5    Katayose, S.6
  • 48
    • 0035937592 scopus 로고    scopus 로고
    • Block copolymer micelles for drug delivery: design, characterization and biological significance
    • Kataoka K., Harada A., and Nagasaki Y. Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv Drug Deliv Rev 47 (2001) 113-131
    • (2001) Adv Drug Deliv Rev , vol.47 , pp. 113-131
    • Kataoka, K.1    Harada, A.2    Nagasaki, Y.3
  • 49
    • 0035923456 scopus 로고    scopus 로고
    • A polymer micelle responding to the protein kinase A signal
    • Katayama Y., Sonoda T., and Maeda M. A polymer micelle responding to the protein kinase A signal. Macromolecules 34 (2001) 8569-8573
    • (2001) Macromolecules , vol.34 , pp. 8569-8573
    • Katayama, Y.1    Sonoda, T.2    Maeda, M.3
  • 50
    • 0031239718 scopus 로고    scopus 로고
    • Water-soluble polyion complex associates of DNA and poly(ethylene glycol)-p(l-lysine) block copolymer
    • Katayose S., and Kataoka K. Water-soluble polyion complex associates of DNA and poly(ethylene glycol)-p(l-lysine) block copolymer. Bioconjug Chem 8 (1997) 702-707
    • (1997) Bioconjug Chem , vol.8 , pp. 702-707
    • Katayose, S.1    Kataoka, K.2
  • 51
    • 0026459937 scopus 로고
    • Pathways of macromolecular tracer transport across venules and small veins
    • Kohn S., Nagy J.A., Dvorak H.F., and Dvorak A.M. Pathways of macromolecular tracer transport across venules and small veins. Lab Invest 67 (1992) 596-607
    • (1992) Lab Invest , vol.67 , pp. 596-607
    • Kohn, S.1    Nagy, J.A.2    Dvorak, H.F.3    Dvorak, A.M.4
  • 52
    • 0032846607 scopus 로고    scopus 로고
    • Control of adriamycin cytotoxic activity using thermally responsive polymeric micelles composed of poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-poly(d,l-lactide )
    • Kohori F., Sakai K., Aoyagi T., Yokoyama M., Yamato M., Sakurai Y., et al. Control of adriamycin cytotoxic activity using thermally responsive polymeric micelles composed of poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-poly(d,l-lactide ). Colloids Surf B Biointerfaces 16 (1999) 195-205
    • (1999) Colloids Surf B Biointerfaces , vol.16 , pp. 195-205
    • Kohori, F.1    Sakai, K.2    Aoyagi, T.3    Yokoyama, M.4    Yamato, M.5    Sakurai, Y.6
  • 53
    • 0035906856 scopus 로고    scopus 로고
    • 3D microvascular architecture of pre-cancerous lesions and invasive carcinomas of the colon
    • Konerding M.A., Fait E., and Gaumann A. 3D microvascular architecture of pre-cancerous lesions and invasive carcinomas of the colon. Br J Cancer 84 (2001) 1354-1362
    • (2001) Br J Cancer , vol.84 , pp. 1354-1362
    • Konerding, M.A.1    Fait, E.2    Gaumann, A.3
  • 54
    • 0028346185 scopus 로고
    • Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly(ethylene oxide-aspartate) block copolymer-Adriamycin conjugate
    • Kwon G.S., Suwa S., Yokoyama M., Okano T., Sakurai Y., and Kataoka K. Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly(ethylene oxide-aspartate) block copolymer-Adriamycin conjugate. J Control Release 29 (1994) 17-23
    • (1994) J Control Release , vol.29 , pp. 17-23
    • Kwon, G.S.1    Suwa, S.2    Yokoyama, M.3    Okano, T.4    Sakurai, Y.5    Kataoka, K.6
  • 55
    • 0002960925 scopus 로고    scopus 로고
    • Preparation and characterization of the micelle-forming polymeric drug: Indomethacin-incorporated poly(ethylene oxide)-poly(β-benzyl l-aspartate) block copolymer micelles
    • La S.B., Okano T., and Kataoka K. Preparation and characterization of the micelle-forming polymeric drug: Indomethacin-incorporated poly(ethylene oxide)-poly(β-benzyl l-aspartate) block copolymer micelles. J Pharm Sci 85 (1996) 85-90
    • (1996) J Pharm Sci , vol.85 , pp. 85-90
    • La, S.B.1    Okano, T.2    Kataoka, K.3
  • 56
    • 0034579152 scopus 로고    scopus 로고
    • Micelles of poly(ethylene oxide)-block-poly(N-alkyl stearate l-aspartamide): synthetic analogues of lipoproteins for drug delivery
    • Lavasanifar A., Samuel J., and Kwon G.S. Micelles of poly(ethylene oxide)-block-poly(N-alkyl stearate l-aspartamide): synthetic analogues of lipoproteins for drug delivery. J Biomed Mater Res 52 (2000) 831-835
    • (2000) J Biomed Mater Res , vol.52 , pp. 831-835
    • Lavasanifar, A.1    Samuel, J.2    Kwon, G.S.3
  • 57
    • 0037148656 scopus 로고    scopus 로고
    • Poly(ethylene oxide)-block-poly(l-amino acid) micelles for drug delivery
    • Lavasanifar A., Sanuel J., and Kwon G.S. Poly(ethylene oxide)-block-poly(l-amino acid) micelles for drug delivery. Adv Drug Deliv Rev 54 (2002) 169-190
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 169-190
    • Lavasanifar, A.1    Sanuel, J.2    Kwon, G.S.3
  • 58
    • 0035994313 scopus 로고    scopus 로고
    • Optimizing pH-responsive polymeric micelles for drug delivery in a cancer photodynamic therapy model
    • Le Garrec D., Taillefer J., Van Lier J.E., Lenaerts V., and Leroux J.C. Optimizing pH-responsive polymeric micelles for drug delivery in a cancer photodynamic therapy model. J Drug Target 10 (2002) 429-437
    • (2002) J Drug Target , vol.10 , pp. 429-437
    • Le Garrec, D.1    Taillefer, J.2    Van Lier, J.E.3    Lenaerts, V.4    Leroux, J.C.5
  • 59
    • 0347996095 scopus 로고    scopus 로고
    • Increased accumulation of PEG-PE micelles in the area of experimental myocardial infarction in rabbits
    • Lukyanov A.N., Hartner W.C., and Torchilin V.P. Increased accumulation of PEG-PE micelles in the area of experimental myocardial infarction in rabbits. J Control Release 4 (2004) 187-193
    • (2004) J Control Release , vol.4 , pp. 187-193
    • Lukyanov, A.N.1    Hartner, W.C.2    Torchilin, V.P.3
  • 60
    • 0141921483 scopus 로고    scopus 로고
    • Polymeric micelle for tumor pH and folate-mediated targeting
    • Lee E.S., Na K., and Bae Y.H. Polymeric micelle for tumor pH and folate-mediated targeting. J Control Release 91 (2003) 103-113
    • (2003) J Control Release , vol.91 , pp. 103-113
    • Lee, E.S.1    Na, K.2    Bae, Y.H.3
  • 61
    • 0034044578 scopus 로고    scopus 로고
    • A combination of poloxamers increases gene expression of plasmid DNA in skeletal muscle
    • Lemieux P., Guerin G., Paradis G., Proulx R., Chistyakova L., Kabanov A., et al. A combination of poloxamers increases gene expression of plasmid DNA in skeletal muscle. Gene Ther 7 (2000) 986-991
    • (2000) Gene Ther , vol.7 , pp. 986-991
    • Lemieux, P.1    Guerin, G.2    Paradis, G.3    Proulx, R.4    Chistyakova, L.5    Kabanov, A.6
  • 62
    • 0034006169 scopus 로고    scopus 로고
    • Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells
    • Lewin M., Carlesso N., Tung C.-H., Tang X.W., Cory D., Scadden D.T., et al. Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat Biotechnol 18 (2000) 410-414
    • (2000) Nat Biotechnol , vol.18 , pp. 410-414
    • Lewin, M.1    Carlesso, N.2    Tung, C.-H.3    Tang, X.W.4    Cory, D.5    Scadden, D.T.6
  • 63
    • 0034893552 scopus 로고    scopus 로고
    • Nanostructured materials designed for cell binding and transduction
    • Liu J., Zhang Q., Remsen E.E., and Wooley K.L. Nanostructured materials designed for cell binding and transduction. Biomacromolecules 2 (2001) 362-368
    • (2001) Biomacromolecules , vol.2 , pp. 362-368
    • Liu, J.1    Zhang, Q.2    Remsen, E.E.3    Wooley, K.L.4
  • 65
    • 0035291191 scopus 로고    scopus 로고
    • SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy
    • Maeda H. SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy. Adv Drug Deliv Rev 46 (2001) 169-185
    • (2001) Adv Drug Deliv Rev , vol.46 , pp. 169-185
    • Maeda, H.1
  • 66
    • 0032824375 scopus 로고    scopus 로고
    • Possibility of active targeting to tumor tissues with liposomes
    • Maruyama K., Ishida O., Takizawa T., and Moribe K. Possibility of active targeting to tumor tissues with liposomes. Adv Drug Deliv Rev 40 (1999) 89-102
    • (1999) Adv Drug Deliv Rev , vol.40 , pp. 89-102
    • Maruyama, K.1    Ishida, O.2    Takizawa, T.3    Moribe, K.4
  • 67
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent Smancs
    • Matsumura Y., and Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent Smancs. Cancer Res 46 (1986) 6387-6392
    • (1986) Cancer Res , vol.46 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 68
    • 10844293438 scopus 로고    scopus 로고
    • Phase I clinical trial and pharmacokinetic evaluation of NK911, micelle-encapsulated doxorubicin
    • Matsumura Y., Hamaguchi T., Ura T., Muro K., Yamada Y., Shimada Y., et al. Phase I clinical trial and pharmacokinetic evaluation of NK911, micelle-encapsulated doxorubicin. Br J Cancer 91 (2004) 1775-1781
    • (2004) Br J Cancer , vol.91 , pp. 1775-1781
    • Matsumura, Y.1    Hamaguchi, T.2    Ura, T.3    Muro, K.4    Yamada, Y.5    Shimada, Y.6
  • 69
    • 23644432241 scopus 로고    scopus 로고
    • New-generation platinum drugs in the treatment of cisplatin-resistant cancers
    • McKeage M.J. New-generation platinum drugs in the treatment of cisplatin-resistant cancers. Expert Opin Investig Drugs 14 (2005) 1033-1046
    • (2005) Expert Opin Investig Drugs , vol.14 , pp. 1033-1046
    • McKeage, M.J.1
  • 70
    • 0141681120 scopus 로고    scopus 로고
    • Pegylated polyethylenimine-Fab′ antibody fragment conjugates for targeted gene delivery to human ovarian carcinoma cells
    • Merdan T., Callahan J., Peterson H., Kunath K., Bakowsky U., Kopeckova P., et al. Pegylated polyethylenimine-Fab′ antibody fragment conjugates for targeted gene delivery to human ovarian carcinoma cells. Bioconjug Chem 14 (2003) 989-996
    • (2003) Bioconjug Chem , vol.14 , pp. 989-996
    • Merdan, T.1    Callahan, J.2    Peterson, H.3    Kunath, K.4    Bakowsky, U.5    Kopeckova, P.6
  • 71
    • 0032766043 scopus 로고    scopus 로고
    • Comparison of the anticancer effect of free and HPMA copolymer-bound adriamycin in human ovarian carcinoma cells
    • Minko T., Kopeckova P., and Kopecek J. Comparison of the anticancer effect of free and HPMA copolymer-bound adriamycin in human ovarian carcinoma cells. Pharm Res 16 (1999) 986-996
    • (1999) Pharm Res , vol.16 , pp. 986-996
    • Minko, T.1    Kopeckova, P.2    Kopecek, J.3
  • 72
    • 0034049291 scopus 로고    scopus 로고
    • Efficacy of the chemotherapeutic action of HPMA copolymer-bound doxorubicin in a solid tumor model of ovarian carcinoma
    • Minko T., Kopeckova P., and Kopecek J. Efficacy of the chemotherapeutic action of HPMA copolymer-bound doxorubicin in a solid tumor model of ovarian carcinoma. Int J Cancer 86 (2000) 108-117
    • (2000) Int J Cancer , vol.86 , pp. 108-117
    • Minko, T.1    Kopeckova, P.2    Kopecek, J.3
  • 73
    • 21744444124 scopus 로고    scopus 로고
    • Pluronic block copolymers alter apoptoric signal transduction of doxorubicin in drug-resistant cancer cells
    • Minko T., Batrakova E.V., Li S., Pakunlu R.I., Alakhov V.Y., and Kabanov A.V. Pluronic block copolymers alter apoptoric signal transduction of doxorubicin in drug-resistant cancer cells. J Control Release 105 (2005) 269-278
    • (2005) J Control Release , vol.105 , pp. 269-278
    • Minko, T.1    Batrakova, E.V.2    Li, S.3    Pakunlu, R.I.4    Alakhov, V.Y.5    Kabanov, A.V.6
  • 74
    • 0025355670 scopus 로고
    • Comparison of the cytotoxic effects of the high-and low-molecular weight anticancer agents on multidrug-resistant Chinese hamster ovary cells in vitro
    • Miyamoto Y., and Maeda H. Comparison of the cytotoxic effects of the high-and low-molecular weight anticancer agents on multidrug-resistant Chinese hamster ovary cells in vitro. Cancer Res 50 (1990) 1571-1575
    • (1990) Cancer Res , vol.50 , pp. 1571-1575
    • Miyamoto, Y.1    Maeda, H.2
  • 75
    • 1542306939 scopus 로고    scopus 로고
    • Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression
    • Miyata K., Kakizawa Y., Nishiyama N., Harada A., Yamasaki Y., Koyama H., et al. Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression. J Am Chem Soc 126 (2004) 2355-2361
    • (2004) J Am Chem Soc , vol.126 , pp. 2355-2361
    • Miyata, K.1    Kakizawa, Y.2    Nishiyama, N.3    Harada, A.4    Yamasaki, Y.5    Koyama, H.6
  • 76
    • 28444488285 scopus 로고    scopus 로고
    • Practically applicable cross-linked polyplex micelle with high tolerability against freeze-drying for in vivo gene delivery
    • Miyata K., Kakizawa Y., Nishiyama N., Yamasaki Y., Watanabe T., Kohara M., et al. Practically applicable cross-linked polyplex micelle with high tolerability against freeze-drying for in vivo gene delivery. J Control Release 109 (2005) 15-23
    • (2005) J Control Release , vol.109 , pp. 15-23
    • Miyata, K.1    Kakizawa, Y.2    Nishiyama, N.3    Yamasaki, Y.4    Watanabe, T.5    Kohara, M.6
  • 77
    • 0035889833 scopus 로고    scopus 로고
    • Relationship between complement activation, cellular uptake and surface physicochemical aspects of novel PEG-modified nanoparticles
    • Mosqueria V.C.F., Legrand P., Gulik A., Bourdon O., Gref R., Labarre D., et al. Relationship between complement activation, cellular uptake and surface physicochemical aspects of novel PEG-modified nanoparticles. Biomaterials 22 (2001) 2967-2979
    • (2001) Biomaterials , vol.22 , pp. 2967-2979
    • Mosqueria, V.C.F.1    Legrand, P.2    Gulik, A.3    Bourdon, O.4    Gref, R.5    Labarre, D.6
  • 78
    • 0035286282 scopus 로고    scopus 로고
    • Liposomal encapsulated anthracyclines: new therapeutic horizons
    • Muggia F.M. Liposomal encapsulated anthracyclines: new therapeutic horizons. Curr Oncol Rep 3 (2001) 156-162
    • (2001) Curr Oncol Rep , vol.3 , pp. 156-162
    • Muggia, F.M.1
  • 79
    • 0031055830 scopus 로고    scopus 로고
    • Phase II study of liposomal doxorubicin in refractory ovarian cancer: antitumor activity and toxicity modification by liposomal encapsulation
    • Muggia F.M., Hamsworth J.L., Jeffers S., Miller P., Groshen S., Tan M., et al. Phase II study of liposomal doxorubicin in refractory ovarian cancer: antitumor activity and toxicity modification by liposomal encapsulation. J Clin Oncol 15 (1996) 987-993
    • (1996) J Clin Oncol , vol.15 , pp. 987-993
    • Muggia, F.M.1    Hamsworth, J.L.2    Jeffers, S.3    Miller, P.4    Groshen, S.5    Tan, M.6
  • 80
    • 0035668767 scopus 로고    scopus 로고
    • Sugar-installed block copolymer micelles: their preparation and specific interaction with lectin molecules
    • Nagasaki Y., Yasugi K., Yamamoto Y., Harada A., and Kataoka K. Sugar-installed block copolymer micelles: their preparation and specific interaction with lectin molecules. Biomacromolecules 2 (2001) 1067-1070
    • (2001) Biomacromolecules , vol.2 , pp. 1067-1070
    • Nagasaki, Y.1    Yasugi, K.2    Yamamoto, Y.3    Harada, A.4    Kataoka, K.5
  • 81
    • 0037122694 scopus 로고    scopus 로고
    • Artery wall binding peptide-poly(ethylene glycol)-grafted-poly(l-lysine)-based gene delivery to artery wall cells
    • Nah J.-W., Yu L., Han S.-O., Ahn C.-H., and Kim S.W. Artery wall binding peptide-poly(ethylene glycol)-grafted-poly(l-lysine)-based gene delivery to artery wall cells. J Control Release 78 (2002) 273-284
    • (2002) J Control Release , vol.78 , pp. 273-284
    • Nah, J.-W.1    Yu, L.2    Han, S.-O.3    Ahn, C.-H.4    Kim, S.W.5
  • 82
    • 0028886521 scopus 로고
    • Transcellular gaps in microvascular walls of frog and rat when permeability is increased by perfusion with the ionophore
    • Neal C.R., and Michel C.C. Transcellular gaps in microvascular walls of frog and rat when permeability is increased by perfusion with the ionophore. J Physiol 488 (1995) 427-437
    • (1995) J Physiol , vol.488 , pp. 427-437
    • Neal, C.R.1    Michel, C.C.2
  • 83
    • 0032958135 scopus 로고    scopus 로고
    • Comparative pharmacokinetics, tissue distribution, and therapeutic effectiveness of cisplatin encapsulated in long circulating, pegylated liposomes (SPI-077) in tumor-bearing mice
    • Newman M.S., Colbern G.T., Working P.K., Engbers C., and Amantea M.A. Comparative pharmacokinetics, tissue distribution, and therapeutic effectiveness of cisplatin encapsulated in long circulating, pegylated liposomes (SPI-077) in tumor-bearing mice. Cancer Chemother Pharmacol 43 (1999) 1-7
    • (1999) Cancer Chemother Pharmacol , vol.43 , pp. 1-7
    • Newman, M.S.1    Colbern, G.T.2    Working, P.K.3    Engbers, C.4    Amantea, M.A.5
  • 84
    • 33746307391 scopus 로고    scopus 로고
    • Nanostructured devices based on block copolymer assemblies for drug delivery: designing structures for enhanced drug function
    • Nishiyama N., and Kataoka K. Nanostructured devices based on block copolymer assemblies for drug delivery: designing structures for enhanced drug function. Adv Polym Sci 193 (2006) 67-101
    • (2006) Adv Polym Sci , vol.193 , pp. 67-101
    • Nishiyama, N.1    Kataoka, K.2
  • 85
    • 0032803387 scopus 로고    scopus 로고
    • Preparation and characterization of self-assembled polymer-metal complex micelle from cis-dichlorodiammineplatinum(II) and poly(ethylene glycol)-poly(aspartic acid) block copolymer in an aqueous medium
    • Nishiyama N., Yokoyama M., Aoyagi T., Okano T., Sakurai Y., and Kataoka K. Preparation and characterization of self-assembled polymer-metal complex micelle from cis-dichlorodiammineplatinum(II) and poly(ethylene glycol)-poly(aspartic acid) block copolymer in an aqueous medium. Langmuir 15 (1999) 377-383
    • (1999) Langmuir , vol.15 , pp. 377-383
    • Nishiyama, N.1    Yokoyama, M.2    Aoyagi, T.3    Okano, T.4    Sakurai, Y.5    Kataoka, K.6
  • 86
    • 0034867065 scopus 로고    scopus 로고
    • Cisplatin-loaded polymer-metal complex micelle with time-modulated decaying property as a novel drug delivery system
    • Nishiyama N., Kato Y., Sugiyama Y., and Kataoka K. Cisplatin-loaded polymer-metal complex micelle with time-modulated decaying property as a novel drug delivery system. Pharm Res 18 (2001) 1035-1041
    • (2001) Pharm Res , vol.18 , pp. 1035-1041
    • Nishiyama, N.1    Kato, Y.2    Sugiyama, Y.3    Kataoka, K.4
  • 87
    • 0037254696 scopus 로고    scopus 로고
    • Light-harvesting ionic dendrimer porphyrins as new photosensitizers for photodynamic therapy
    • Nishiyama N., Stapert H.R., Zhang G.D., Takasu D., Jiang D.-L., Nagano T., et al. Light-harvesting ionic dendrimer porphyrins as new photosensitizers for photodynamic therapy. Bioconjug Chem 14 (2003) 58-66
    • (2003) Bioconjug Chem , vol.14 , pp. 58-66
    • Nishiyama, N.1    Stapert, H.R.2    Zhang, G.D.3    Takasu, D.4    Jiang, D.-L.5    Nagano, T.6
  • 88
    • 0037344002 scopus 로고    scopus 로고
    • Differential gene expression profile between PC-14 cells treated with free cisplatin- and cisplatin-incorporated polymeric micelles
    • Nishiyama N., Koizumi F., Okazaki S., Matsumura Y., Nishio K., and Kataoka K. Differential gene expression profile between PC-14 cells treated with free cisplatin- and cisplatin-incorporated polymeric micelles. Bioconjug Chem 14 (2003) 449-457
    • (2003) Bioconjug Chem , vol.14 , pp. 449-457
    • Nishiyama, N.1    Koizumi, F.2    Okazaki, S.3    Matsumura, Y.4    Nishio, K.5    Kataoka, K.6
  • 89
    • 0344412936 scopus 로고    scopus 로고
    • Free and N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-bound geldanamycin derivative induce different stress responses in A2780 human ovarian carcinoma cells
    • Nishiyama N., Nori A., Malugin A., Kasuya Y., Kopecková P., and Kopecek J. Free and N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-bound geldanamycin derivative induce different stress responses in A2780 human ovarian carcinoma cells. Cancer Res 63 (2003) 7876-7882
    • (2003) Cancer Res , vol.63 , pp. 7876-7882
    • Nishiyama, N.1    Nori, A.2    Malugin, A.3    Kasuya, Y.4    Kopecková, P.5    Kopecek, J.6
  • 90
    • 0346059586 scopus 로고    scopus 로고
    • Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice
    • Nishiyama N., Okazaki S., Cabral H., Miyamoto M., Kato Y., Sugiyama Y., et al. Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice. Cancer Res 63 (2003) 8977-8983
    • (2003) Cancer Res , vol.63 , pp. 8977-8983
    • Nishiyama, N.1    Okazaki, S.2    Cabral, H.3    Miyamoto, M.4    Kato, Y.5    Sugiyama, Y.6
  • 91
    • 33344455281 scopus 로고    scopus 로고
    • Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer
    • Nishiyama N., Iiyama A., Jang W.-D., Miyata K., Itaka K., Inoue Y., et al. Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer. Nat Mater 4 (2005) 934-941
    • (2005) Nat Mater , vol.4 , pp. 934-941
    • Nishiyama, N.1    Iiyama, A.2    Jang, W.-D.3    Miyata, K.4    Itaka, K.5    Inoue, Y.6
  • 93
    • 13644254495 scopus 로고    scopus 로고
    • Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile β-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells
    • Oishi M., Nagasaki Y., Itaka K., Nishiyama N., and Kataoka K. Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile β-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells. J Am Chem Soc 127 (2005) 1624-1625
    • (2005) J Am Chem Soc , vol.127 , pp. 1624-1625
    • Oishi, M.1    Nagasaki, Y.2    Itaka, K.3    Nishiyama, N.4    Kataoka, K.5
  • 94
    • 0032580444 scopus 로고    scopus 로고
    • Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate
    • Omelyanenko V., Kopeckova P., Gentry C., and Kopecek J. Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate. J Control Release 53 (1998) 25-37
    • (1998) J Control Release , vol.53 , pp. 25-37
    • Omelyanenko, V.1    Kopeckova, P.2    Gentry, C.3    Kopecek, J.4
  • 96
    • 0035324349 scopus 로고    scopus 로고
    • Evaluation of different photosensitizers for use in photochemical gene transfection
    • Prasmickaite L., Høgset A., and Berg K. Evaluation of different photosensitizers for use in photochemical gene transfection. Photochem Photobiol 73 (2001) 388-395
    • (2001) Photochem Photobiol , vol.73 , pp. 388-395
    • Prasmickaite, L.1    Høgset, A.2    Berg, K.3
  • 97
    • 0035980354 scopus 로고    scopus 로고
    • Photosensitizer delivery for photodynamic therapy of choroidal neovascularization
    • Renno R.Z., and Miller J.W. Photosensitizer delivery for photodynamic therapy of choroidal neovascularization. Adv Drug Deliv Rev 52 (2001) 63-78
    • (2001) Adv Drug Deliv Rev , vol.52 , pp. 63-78
    • Renno, R.Z.1    Miller, J.W.2
  • 98
    • 0031045279 scopus 로고    scopus 로고
    • Neovascular induced by vascular endothelial growth factor is fenestrated
    • Roberts W.G., and Palade G.E. Neovascular induced by vascular endothelial growth factor is fenestrated. Cancer Res 57 (1997) 765-772
    • (1997) Cancer Res , vol.57 , pp. 765-772
    • Roberts, W.G.1    Palade, G.E.2
  • 99
    • 84974993880 scopus 로고
    • Platinum complexes for the treatment of cancer
    • Rosenberg B. Platinum complexes for the treatment of cancer. Interdisc Sci Rev 3 (1978) 134-147
    • (1978) Interdisc Sci Rev , vol.3 , pp. 134-147
    • Rosenberg, B.1
  • 100
    • 0038176513 scopus 로고    scopus 로고
    • Oligomers of the arginine-rich motif of the HIV-1 TAT protein are capable of transferring plasmid DNA into cells
    • Rudolph C., Plank C., Lausier J., Schillinger U., Muller R.H., and Rosenecker J. Oligomers of the arginine-rich motif of the HIV-1 TAT protein are capable of transferring plasmid DNA into cells. J Biol Chem 278 (2003) 11411-11418
    • (2003) J Biol Chem , vol.278 , pp. 11411-11418
    • Rudolph, C.1    Plank, C.2    Lausier, J.3    Schillinger, U.4    Muller, R.H.5    Rosenecker, J.6
  • 101
    • 0242584817 scopus 로고    scopus 로고
    • Micellar nanocontainers distribute to defined cytoplasmic organelles
    • Savic R., Luo L., Eisenberg A., and Maysinger D. Micellar nanocontainers distribute to defined cytoplasmic organelles. Science 300 (2003) 615-618
    • (2003) Science , vol.300 , pp. 615-618
    • Savic, R.1    Luo, L.2    Eisenberg, A.3    Maysinger, D.4
  • 102
    • 0023450012 scopus 로고
    • Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats
    • Seymour L.W., Duncan R., Strohalm J., and Kopecek J. Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats. J Biomed Mater Res 21 (1987) 1341-1358
    • (1987) J Biomed Mater Res , vol.21 , pp. 1341-1358
    • Seymour, L.W.1    Duncan, R.2    Strohalm, J.3    Kopecek, J.4
  • 103
    • 1942503173 scopus 로고    scopus 로고
    • Endosomes as a route for drug delivery in the real world
    • Sheff D. Endosomes as a route for drug delivery in the real world. Adv Drug Deliv Rev 56 (2004) 927-930
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 927-930
    • Sheff, D.1
  • 104
    • 0023265524 scopus 로고
    • The comparative pharmacokinetics of carboplatin and cisplatin in mice and rats
    • Siddik Z.H., Newell D.R., Boxall F.E., and Harrap K.R. The comparative pharmacokinetics of carboplatin and cisplatin in mice and rats. Biochem Pharmacol 36 (1987) 1925-1932
    • (1987) Biochem Pharmacol , vol.36 , pp. 1925-1932
    • Siddik, Z.H.1    Newell, D.R.2    Boxall, F.E.3    Harrap, K.R.4
  • 105
    • 0034300888 scopus 로고    scopus 로고
    • Polyion complex micelles encapsulating light-harvesting ionic dendirmer zinc porphyrins
    • Stapert H.R., Nishiyama N., Jiang D.-L., Aida T., and Kataoka K. Polyion complex micelles encapsulating light-harvesting ionic dendirmer zinc porphyrins. Langmuir 16 (2000) 8182-8188
    • (2000) Langmuir , vol.16 , pp. 8182-8188
    • Stapert, H.R.1    Nishiyama, N.2    Jiang, D.-L.3    Aida, T.4    Kataoka, K.5
  • 106
    • 0031941991 scopus 로고    scopus 로고
    • Randomized comparative trial of pegylated liposomal doxorubicin vs. bleomycin and vincristine in the treatment of AIDS-related Kaposi's sarcoma. International Pegylated Liposomal Doxorubicin Study Group
    • Stewart S., Jablonowski H., Goebel F.D., Arasteh K., Spittle M., Rios A., et al. Randomized comparative trial of pegylated liposomal doxorubicin vs. bleomycin and vincristine in the treatment of AIDS-related Kaposi's sarcoma. International Pegylated Liposomal Doxorubicin Study Group. J Clin Oncol 16 (1998) 683-691
    • (1998) J Clin Oncol , vol.16 , pp. 683-691
    • Stewart, S.1    Jablonowski, H.2    Goebel, F.D.3    Arasteh, K.4    Spittle, M.5    Rios, A.6
  • 107
    • 0029360711 scopus 로고
    • Long circulating microparticulate drug carriers
    • Stolnik S., Illum L., and Davis S.S. Long circulating microparticulate drug carriers. Adv Drug Deliv Rev 16 (1995) 195-214
    • (1995) Adv Drug Deliv Rev , vol.16 , pp. 195-214
    • Stolnik, S.1    Illum, L.2    Davis, S.S.3
  • 108
    • 0024281372 scopus 로고
    • Cell and environment interactions in tumor microregions: the multicell spheroid model
    • Sutherland R.M. Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 240 (1988) 177-184
    • (1988) Science , vol.240 , pp. 177-184
    • Sutherland, R.M.1
  • 109
    • 0036480513 scopus 로고    scopus 로고
    • Guidelines for using verteporfin (visudyne) in photodynamic therapy to treat choroidal neovascularization due to age-related macular degeneration and other causes
    • TAP and VIP Study Group
    • TAP and VIP Study Group. Guidelines for using verteporfin (visudyne) in photodynamic therapy to treat choroidal neovascularization due to age-related macular degeneration and other causes. Retina 22 (2002) 6-18
    • (2002) Retina , vol.22 , pp. 6-18
  • 110
    • 10744231307 scopus 로고    scopus 로고
    • Mechanism of cyototoxicity in human ovarian carcinoma cells exposed to free Mce6 or HPMA copolymer Mce6 conjugates
    • Tijerina M., Kopeckova P., and Kopecek J. Mechanism of cyototoxicity in human ovarian carcinoma cells exposed to free Mce6 or HPMA copolymer Mce6 conjugates. Photochem Photobiol 77 (2003) 645-652
    • (2003) Photochem Photobiol , vol.77 , pp. 645-652
    • Tijerina, M.1    Kopeckova, P.2    Kopecek, J.3
  • 111
    • 0037148667 scopus 로고    scopus 로고
    • PEG-based micelles as carriers of contrast agents for different imaging modalities
    • Torchilin V.P. PEG-based micelles as carriers of contrast agents for different imaging modalities. Adv Drug Deliv Rev 54 (2002) 235-252
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 235-252
    • Torchilin, V.P.1
  • 113
    • 0036807955 scopus 로고    scopus 로고
    • Pharmaceutical and biomedical differences between micellar doxorubicin (NK911) and liposomal doxorubicin (Doxil)
    • Tsukioka Y., Matsumura Y., Hamaguchi T., Koike H., Moriyasu F., and Kakizoe T. Pharmaceutical and biomedical differences between micellar doxorubicin (NK911) and liposomal doxorubicin (Doxil). Jpn J Cancer Res 93 (2002) 1145-1153
    • (2002) Jpn J Cancer Res , vol.93 , pp. 1145-1153
    • Tsukioka, Y.1    Matsumura, Y.2    Hamaguchi, T.3    Koike, H.4    Moriyasu, F.5    Kakizoe, T.6
  • 114
    • 27144472720 scopus 로고    scopus 로고
    • Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats
    • Uchino H., Matsumura Y., Negishi T., Koizumi F., Hayashi T., Honda T., et al. Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats. Br J Cancer 93 (2005) 678-687
    • (2005) Br J Cancer , vol.93 , pp. 678-687
    • Uchino, H.1    Matsumura, Y.2    Negishi, T.3    Koizumi, F.4    Hayashi, T.5    Honda, T.6
  • 115
    • 0030598282 scopus 로고    scopus 로고
    • Direct measurement of the extravasation of polyethylene glycol-coated liposomes into solid tumour tissue by in vivo fluorescence microscopy
    • Unezaki S., Maruyama K., Hosoda J., Nagai I., Koyanagi Y., Nakata M., et al. Direct measurement of the extravasation of polyethylene glycol-coated liposomes into solid tumour tissue by in vivo fluorescence microscopy. Int J Pharmacol 144 (1996) 11-17
    • (1996) Int J Pharmacol , vol.144 , pp. 11-17
    • Unezaki, S.1    Maruyama, K.2    Hosoda, J.3    Nagai, I.4    Koyanagi, Y.5    Nakata, M.6
  • 116
    • 2342553444 scopus 로고    scopus 로고
    • Application of nanoparticle technology for the prevention of restenosis after balloon injury in rats
    • Uwatoku T., Shimokawa H., Abe K., Matsumoto Y., Hattori T., Oi K., et al. Application of nanoparticle technology for the prevention of restenosis after balloon injury in rats. Circ Res 92 (2003) e62-e69
    • (2003) Circ Res , vol.92
    • Uwatoku, T.1    Shimokawa, H.2    Abe, K.3    Matsumoto, Y.4    Hattori, T.5    Oi, K.6
  • 117
    • 0029038996 scopus 로고
    • Liposomal doxorubicin: antitumor activity and unique toxicities during two complementary phase I studies
    • Uziely B., Jeffers S., Isacson R., Kutsch K., Wei-Taso D., Yehoshua Z., et al. Liposomal doxorubicin: antitumor activity and unique toxicities during two complementary phase I studies. J Clin Oncol 13 (1995) 1777-1785
    • (1995) J Clin Oncol , vol.13 , pp. 1777-1785
    • Uziely, B.1    Jeffers, S.2    Isacson, R.3    Kutsch, K.4    Wei-Taso, D.5    Yehoshua, Z.6
  • 118
    • 0030928619 scopus 로고    scopus 로고
    • Gene therapy-promises, problems and prospects
    • Verma I.M., and Somia N. Gene therapy-promises, problems and prospects. Nature 389 (1997) 239-242
    • (1997) Nature , vol.389 , pp. 239-242
    • Verma, I.M.1    Somia, N.2
  • 119
    • 0033199351 scopus 로고    scopus 로고
    • Polyion complex micelles with protein-modified corona for receptor-mediated delivery of oligonucleotides into cells
    • Vinogradov S., Batrakova E., Li S., and Kabanov A. Polyion complex micelles with protein-modified corona for receptor-mediated delivery of oligonucleotides into cells. Bioconjug Chem 10 (1999) 851-860
    • (1999) Bioconjug Chem , vol.10 , pp. 851-860
    • Vinogradov, S.1    Batrakova, E.2    Li, S.3    Kabanov, A.4
  • 120
    • 0035871674 scopus 로고    scopus 로고
    • Systemic circulation of poly(l-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA: differential circulation in mice and rats and the implications for human gene therapy
    • Ward C.M., Read M.L., and Seymour L.W. Systemic circulation of poly(l-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA: differential circulation in mice and rats and the implications for human gene therapy. Blood 97 (2001) 2221-2229
    • (2001) Blood , vol.97 , pp. 2221-2229
    • Ward, C.M.1    Read, M.L.2    Seymour, L.W.3
  • 121
    • 1542509565 scopus 로고    scopus 로고
    • Lactose-conjugated polyion complex micelles incorporating plasmid DNA as a targetable gene vector system: their preparation and gene transfecting efficiency against cultured HepG2 cells
    • Wakebayashi D., Nishiyama N., Yamasaki Y., Itaka K., Kanayama N., Harada A., et al. Lactose-conjugated polyion complex micelles incorporating plasmid DNA as a targetable gene vector system: their preparation and gene transfecting efficiency against cultured HepG2 cells. J Control Release 95 (2004) 653-664
    • (2004) J Control Release , vol.95 , pp. 653-664
    • Wakebayashi, D.1    Nishiyama, N.2    Yamasaki, Y.3    Itaka, K.4    Kanayama, N.5    Harada, A.6
  • 122
    • 0026752798 scopus 로고
    • Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues
    • Weitman S.D., Lark R.H., Coney L.R., Fort D.W., Frasca V., Zurawski Jr. V.R., et al. Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues. Cancer Res 52 (1992) 3396-3401
    • (1992) Cancer Res , vol.52 , pp. 3396-3401
    • Weitman, S.D.1    Lark, R.H.2    Coney, L.R.3    Fort, D.W.4    Frasca, V.5    Zurawski Jr., V.R.6
  • 124
    • 0035834269 scopus 로고    scopus 로고
    • Long-circulating poly(ethylene glycol)-poly(d,l-lactide) block copolymer micelles with modulated surface charge
    • Yamamoto Y., Nagasaki Y., Kato Y., Sugiyama Y., and Kataoka K. Long-circulating poly(ethylene glycol)-poly(d,l-lactide) block copolymer micelles with modulated surface charge. J Control Release 77 (2001) 27-38
    • (2001) J Control Release , vol.77 , pp. 27-38
    • Yamamoto, Y.1    Nagasaki, Y.2    Kato, Y.3    Sugiyama, Y.4    Kataoka, K.5
  • 125
    • 0037151328 scopus 로고    scopus 로고
    • Temperature-related change in the properties relevant to drug delivery of poly(ethylene glycol)-poly(d,l-lactide) block copolymer micelles in aqueous milieu
    • Yamamoto Y., Yasugi K., Harada A., Nagasaki Y., and Kataoka K. Temperature-related change in the properties relevant to drug delivery of poly(ethylene glycol)-poly(d,l-lactide) block copolymer micelles in aqueous milieu. J Control Release 82 (2002) 359-371
    • (2002) J Control Release , vol.82 , pp. 359-371
    • Yamamoto, Y.1    Yasugi, K.2    Harada, A.3    Nagasaki, Y.4    Kataoka, K.5
  • 126
    • 0001252124 scopus 로고
    • Molecular design for missile drugs: synthesis of adriamycin conjugated with immunoglobulin G using poly(ethylene glycol)-block-poly(aspartic acid) as intermediate carrier
    • Yokoyama M., Inoue S., Kataoka K., Yui N., Okano T., and Sakurai Y. Molecular design for missile drugs: synthesis of adriamycin conjugated with immunoglobulin G using poly(ethylene glycol)-block-poly(aspartic acid) as intermediate carrier. Makromol Chem 190 (1989) 2041-2054
    • (1989) Makromol Chem , vol.190 , pp. 2041-2054
    • Yokoyama, M.1    Inoue, S.2    Kataoka, K.3    Yui, N.4    Okano, T.5    Sakurai, Y.6
  • 127
    • 0025015189 scopus 로고
    • Polymer micelles as novel drug carriers: adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer
    • Yokoyama M., Miyauchi M., Yamada N., Okano T., Kataoka K., and Inoue S. Polymer micelles as novel drug carriers: adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. J Control Release 11 (1990) 269-278
    • (1990) J Control Release , vol.11 , pp. 269-278
    • Yokoyama, M.1    Miyauchi, M.2    Yamada, N.3    Okano, T.4    Kataoka, K.5    Inoue, S.6
  • 128
    • 0025343062 scopus 로고
    • Characterization and anti-cancer activity of micelle-forming polymeric anti-cancer drug, adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer
    • Yokoyama M., Miyauchi M., Yamada N., Okano T., Sakurai Y., Kataoka K., et al. Characterization and anti-cancer activity of micelle-forming polymeric anti-cancer drug, adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. Cancer Res 50 (1990) 1693-1700
    • (1990) Cancer Res , vol.50 , pp. 1693-1700
    • Yokoyama, M.1    Miyauchi, M.2    Yamada, N.3    Okano, T.4    Sakurai, Y.5    Kataoka, K.6
  • 129
    • 0025874282 scopus 로고
    • Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood
    • Yokoyama M., Okano T., Sakurai Y., Ekimoto H., Shibazaki C., and Kataoka K. Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood. Cancer Res 51 (1991) 3229-3236
    • (1991) Cancer Res , vol.51 , pp. 3229-3236
    • Yokoyama, M.1    Okano, T.2    Sakurai, Y.3    Ekimoto, H.4    Shibazaki, C.5    Kataoka, K.6
  • 130
    • 0027263356 scopus 로고
    • Analysis of micelle formation of an adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer by gel permeation chromatography
    • Yokoyama M., Sugiyama T., Okano T., Sakurai Y., Naito M., and Kataoka K. Analysis of micelle formation of an adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer by gel permeation chromatography. Pharm Res 10 (1993) 895-899
    • (1993) Pharm Res , vol.10 , pp. 895-899
    • Yokoyama, M.1    Sugiyama, T.2    Okano, T.3    Sakurai, Y.4    Naito, M.5    Kataoka, K.6
  • 131
    • 0028135121 scopus 로고
    • Improved synthesis of adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer and formation of unimodal micellar structure with controlled amount of physically entrapped adriamycin
    • Yokoyama M., Okano T., Sakurai Y., and Kataoka K. Improved synthesis of adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer and formation of unimodal micellar structure with controlled amount of physically entrapped adriamycin. J Control Release 32 (1994) 269-277
    • (1994) J Control Release , vol.32 , pp. 269-277
    • Yokoyama, M.1    Okano, T.2    Sakurai, Y.3    Kataoka, K.4
  • 132
    • 0031722638 scopus 로고    scopus 로고
    • Incorporation of water-insoluble anticancer drug into polymeric micelles and control of their particle size
    • Yokoyama M., Satoh A., Sakurai Y., Okano T., Matsumura Y., Kakizoe T., et al. Incorporation of water-insoluble anticancer drug into polymeric micelles and control of their particle size. J Control Release 55 (1998) 219-229
    • (1998) J Control Release , vol.55 , pp. 219-229
    • Yokoyama, M.1    Satoh, A.2    Sakurai, Y.3    Okano, T.4    Matsumura, Y.5    Kakizoe, T.6
  • 133
    • 0033233187 scopus 로고    scopus 로고
    • Selective delivery of adriamycin to a solid tumor using a polymeric micelle carrier system
    • Yokoyama M., Okano T., Sakurai Y., Fukushima S., Okamoto K., and Kataoka K. Selective delivery of adriamycin to a solid tumor using a polymeric micelle carrier system. J Drug Target 7 (1999) 171-186
    • (1999) J Drug Target , vol.7 , pp. 171-186
    • Yokoyama, M.1    Okano, T.2    Sakurai, Y.3    Fukushima, S.4    Okamoto, K.5    Kataoka, K.6
  • 134
    • 0029949160 scopus 로고    scopus 로고
    • Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
    • Yuan F., Chen Y., Dellian M., Safabakhsh N., Ferrara N., and Jain R.K. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc Natl Acad Sci U S A 93 (1996) 14765-14770
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 14765-14770
    • Yuan, F.1    Chen, Y.2    Dellian, M.3    Safabakhsh, N.4    Ferrara, N.5    Jain, R.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.