Applications of acoustics and cavitation to noninvasive therapy and drug delivery

Annual Review of Fluid Mechanics

Volumn 40, Issue , 2008, Pages 395-420

  Coussios, Constantin C ^a   Roy, Ronald A ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b BOSTON UNIVERSITY   (United States)

Author keywords

High intensity focused ultrasound (HIFU); Inertial cavitation; Microstreaming; Stable cavitation; Thrombolysis

Indexed keywords

CAVITATION; DRUG DELIVERY; MASS TRANSFER; MONITORING; ULTRASONICS;

HIGH-INTENSITY FOCUSED ULTRASOUND; INERTIAL CAVITATION; THROMBOLYSIS;

BIOMEDICAL ENGINEERING;

BIOMEDICAL ENGINEERING; CAVITATION; DRUG DELIVERY; MASS TRANSFER; MONITORING; ULTRASONICS;

ACOUSTICS; CAVITATION; MASS TRANSPORT; OSCILLATION; WAVE GENERATION; WAVE PROPAGATION;

EID: 39049103980     PISSN: 00664189     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.fluid.40.111406.102116     Document Type: Article

References (106)

1. Allen JS, May DJ, Ferrara KW. 2002. Dynamics of therapeutic ultrasound contrast agents. Ultrasound Med. Biol. 28:805-16
2. Allen TM, Cullis PR. 2004. Drug delivery systems: entering the mainstream. Science 303:1818-22
3. Am. Natl. Stand. Inst. 2002. Bubble detection and cavitation monitoring. ANSI Tech. Rep. ANSI S1.24 TR-2002. Melville, NY: Acoust. Soc. Am.
4. Arora M, Ohl CD. 2005. Bubble assisted drug-delivery. J. Control. Release 101:363-65
5. Bailey MR, Khokhlova VA, Sapozhnikov OA, Kargl SG, Crum LA. 2003. Physical mechanisms of the therapeutic effect of ultrasound: a review. Acoust. Phys. 49:369-88
6. Bao SP, Thrall BD, Miller DL. 1997. Transfection of a reporter plasmid into cultured cells by sonoporation in vitro. Ultrasound Med. Biol. 23:953-59
7. Borden MA, Kruse DE, Caskey CF, Zhao SK, Dayton PA, Ferrara KW. 2005. Influence of lipid shell physicochemical properties on ultrasound-induced microbubble destruction. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 52:1992-2002
8. Bremond N, Arora M, Ohl CD, Lohse D. 2005. Cavitation on surfaces. J. Phys. Condens. Matter 7:S3603-8
9. Bremond N, Arora M, Ohl CD, Lohse D. 2006. Controlled multibubble surface cavitation. Phys. Rev. 96:224501
10. Chavrier F, Chapelon J, Gel et al, Cathignol D. 2000. Modeling of high-intensity focused ultrasound-induced lesions in the prescence of cavitation bubbles. J. Acoust. Soc. Am. 108:42-40
11. Chen WS, Lafon C, Matula TJ, Vaezy S, Crum LA. 2003. Mechanisms of lesion formation in high intensity focused ultrasound therapy. Acoust. Res. Lett. Online 4:41-46
12. Church CC. 2002. Spontaneous homogeneous nucleation, inertial cavitation and the safety of diagnostic ultrasound. Ultrasound Med. Biol. 28:1349-64
13. Coussios CC, Collin JRT, Muckle AJ. 2006. Non-invasive monitoring and control of inertial cavitation dynamics during HIFU exposure in vitro. 6th Int. Symp. Ther. Ultrasound, pp. 316-21. Oxford: Am. Inst. Phys.
14. Coussios CC, Farny CH, ter Haar GR, Roy RA, 2007. Role of acoustic cavitation in the delivery and monitoring of cancer treatment by high-intensity focused ultrasound (HIFU). Int. J. Hyperth. 23:105-20
15. Crum LA. 1982. Nucleation and stabilization of microbubbles in liquids. Appl. Sci. Res. 38:101-15
16. Crum LA, Eller AI. 1970. Motion of bubbles in a stationary sound field. J. Acoust. Soc. Am. 48:191-89.
17. Datta S, Coussios CC, McAdory LE, Tan J, Porter T, et al. 2006. Correlation of cavitation with ultrasound enhancement of thrombolysis. Ultrasound Med Biol 32:1257-67
18. Devin CJ. 1959. Survey of thermal radiation, and viscous damping of pulsating air bubbles in water. J. Acoust. Soc. Am. 31:1654-67
19. Elder SA. 1959. Cavitation microstreaming. J. Acoust. Soc. Am. 31:54-64
20. Eller A, Flynn HG. 1968. Rectified diffusion during nonlinear pulsations of cavitation bubbles. J. Acoust. Soc. Am. 37:493-503
21. Eller A, Flynn HG. 1968. Generation of subharmonics of order one-half by bubbles in a sound field. J. Acoust. Soc. Am. 46:722-27
22. Eller AI, 1974. Subharmonic response of bubbles to underwater sound. J. Acoust. Soc. Am. 55:871-73
23. Eller AI, Crum LA. 1970. Instability of motion of a pulsating bubble in a sound field. J. Acoust. Soc. Am. 47:762-67
24. Everbach EC, Francis CW. 2000. Cavitational mechanisms in ultrasound-accelerated thrombolysis at 1 MHz. Ultrasound Med. Biol. 26:1153-60
25. Falk MH, Issels RD. 2001. Hyperthermia in oncology. Int. J. Hyperth. 17:1-18
26. Farny CH, Wu TM, Holt RG, Murray TW, Roy RA. 2005. Nucleating cavitation from laser-illuminated nano-particles. Acoust. Res. Lett. Online 6:138-43
27. Frinking PJA, Bouakaz A, de Jong N, Ten Cate FJ, Keating S. 1998. Effect of ultrasound on the release of microencapsulated drugs. Ultrasonics 36:709-12
28. Garbin V, Cojoc D, Ferrari E, Di Fabrizio E, Overvelde MLJ, et al. 2007. Changes in microbubble dynamics near a boundary revealed by combined optical micro-manipulation and high-speed imaging. Appl. Phys. Lett. 90:114103
29. Goss SA, Frizzell LA, Dunn F. 1980. Dependence of the ultrasonic properties of biological tissue. J. Acoust. Soc. Am. 67:1041-44
30. Goss SA, Johnston RL, Dunn F. 1978. Comprehensive compilation of empirical ultrasonic properties of mammalian tissues. J. Acoust. Soc. Am. 64:423-57
31. Guzman HR, McNamara AJ, Nguyen DX, Prausnitz MR. 2003. Bioeffects caused by changes in acoustic cavitation bubble density and cell concentration: a unified explanation based on cell-to-bubble ratio and blast radius. Ultrasound Med. Biol. 29:1211-22
32. Hallow DM, Mahajan AD, McCutchen TE, Prausnitz MR. 2006. Measurement and correlation of acoustic cavitation with cellular bioeffects. Ultrasound Med. Biol. 32:1111-22
33. Hamilton MF, Blackstock DT. 1998. Nonlinear Acousics: Theory and Applications. San Diego: Academic
34. Hilgenfeldt S, Lohse D. 2000. The acoustics of diagnostic microbubbles: dissipative effects and heat deposition. Ultrasonics 38:99-104
35. Hilgenfeldt S, Lohse D, Zomack M. 2000. Sound scattering and localized heat deposition of pulse-driven microbubbles. J. Acoust. Soc. Am. 107:3530-39
36. Holt RG, Roy RA. 2001. Measurements of bubble-enhanced heating from focused, MHz-frequency ultrasound in a tissue-mimicking material. Ultrasound Med. Biol. 27:1399-412
37. Holt RG, Roy RA. 2005. Bubble dynamics in therapeutic ultrasound. In Bubble and Particle Dynamics in Acoustic Fields: Modern Trends and Applications, ed. A Dionikov, pp. 108-229. Kerala, India: Transw. Res. Netw.
38. Huang J, Holt RG, Cleveland RO, Roy RA. 2004. Experimental validation of a tractable numerical model for focused ultrasound heating in flow-through tissue phantoms. J. Acoust. Soc. Am. 116:2451-58
39. Hynynen K, McDannold N, Sheikov NA, Jolesz FA, Vykhodtseva N. 2005. Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications. Neuroimage 24:12-20
40. Jang SH, Wientjes MG, Lu D, Au JLS. 2003. Drug delivery and transport to solid tumors. Pharm. Res. 20:1337-50
41. Jeffers J, Feng RQ, Fowlkes JB, Brenner DE, Cain CA. 1991. Sonodynamic therapy: activation of anticancer agents with ultrasound. Ultrason. Symp. 1991 Proc. IEEE, pp. 1367-70. Orlando, FL: IEEE
42. Kamath V, Prosperetti A. 1989. Numerical-integration methods in gas-bubble dynamics. J. Acoust. Soc. Am. 85:1538-48
43. Keller JB, Miksis M. 1980. Bubble oscillations of large amplitude. J. Acoust. Soc. Am. 68:628-33
44. Kennedy JE. 2005. High-intensity focused ultrasound in the treatment of solid tumours. Nat. Rev. Cancer 5:321-27
45. Khokhlova VA, Bailey MR, Reed JA, Cunitz BW, Kaczkowski PJ, Crum LA. 2006. Effects of nonlinear propagation, cavitation, and boiling in lesion formation by high intensity focused ultrasound in a gel phantom. J. Acoust. Soc. Am. 119:1834-48
46. Kinoshita M, Hynynen K. 2006. Mechanism of porphyrin-induced sonodynamic effect: possible role of hyperthermia. Radiat. Res. 165:299-306
47. Lafon C, Zderic V, Noble ML, Yuen JC, Kaczkowski PJ, et al. 2005. Gel phantom for use in high-intensity focused ultrasound dosimetry. Ultrasound Med. Biol. 31:1383-89
48. Lauer CG, Burge R, Tang DB, Bass BG, Gomez ER, Alving BM. 1992. Effect of ultrasound on tissue-type plasminogen activator-induced thrombolysis. Circulation 86:1257-64
49. Leighton TG. 1994. The Acoustic Bubble. London: Academic
50. Leighton TG. 1997 A strategy for the development and standardisation of measurement methods for high power/cavitating ultrasonic fields: review of cavitation monitoring techniques. Tech. Rep., Inst. Sound Vib. Res., Univ. Southampton
51. Leighton TG, Walton AJ, Pickworth MJW. 1990. Primary Bjerknes forces. Eur J. Phys. 11:47-50
52. Leslie TA, Kennedy JE. 2007. High intensity focused ultrasound in the treatment of abdominal and gynaecological diseases. Int. J. Hyperth. 23:173-82
53. Liu RH, Hang J, Pindera MZ, Athavale M, Grodzinski P. 2002. Bubble-induced acoustic micromixing. Lab Chip 2:151-57
54. Longuet-Higgins MS. 1990. Bubble noise spectra. J. Acoust. Soc. Am. 87:652-61
55. Longuet-Higgins MS. 2006. Monopole emission of sound by asymmetric bubble oscillations. Part 1: normal modes. J. Fluid Mech. Digit. Archive 201:525-41
56. Maksimov AO, Leighton TG. 2001. Transient processes near the acoustic threshold of parametrically-driven bubble shape oscillations. Acustica 87:322-32
57. Madanshetty SI, Roy R, Apfel RE. 1991. Acoustic microcavitation: its active and passive acoustic detection. J. Acoust. Soc. Am. 90:1515-26
58. Marin A, Muniruzzaman M, Rapoport N. 2001. Mechanism of the ultrasonic activation of micellar drug delivery. J. Control. Release 75:69-81
59. Marmottant P, Van Der Meer S, Emmer M, Versluis M, de Jong N, et al. 2005. A model for large amplitude oscillations of coated bubbles accounting for buckling and rupture. J. Acoust. Soc. Am. 118:3499-505
60. McDannold N, Vykhodtseva N, Hynynen K. 2006. Targeted disruption of the blood-brain barrier with focused ultrasound: association with cavitation activity. Phys. Med. Biol. 51:793-807
61. McPherson DD, Holland CK. 2003. Seizing the science of ultrasound: beyond imaging and into physiology and therapeutics. J. Am. Coll. Cardiol. 41:1628-30
62. Mesiwala AH, Farrell L, Wenzel HJ, Silbergeld DL, Crum LA, et al. 2002. High-intensity focused ultrasound selectively disrupts the blood-brain barrier in vivo. Ultrasound Med. Biol. 28:389-400
63. Miller DL, Kripfgans OD, Fowlkes JB, Carson PL. 2000. Cavitation nucleation agents for nonthermal ultrasound therapy. J. Acoust. Soc. Am. 107:3480-86
64. Miller DL, Thomnas RM. 1995. Ultrasound contrast agents nucleate inertial cavitation in vitro. Ultrasound Med. Biol. 21:1059-65
65. Minnaert M. 1933. On musical air bubbles and the sounds of running water. Philos. Mag. 16:235-48
66. Molema G, de Leij L, Meijer DKF. 1997. Tumor vascular endothelium: barrier or target in tumor directed drug delivery and immunotherapy. Pharm. Res. 14:2-10
67. Munshi N, Rapoport N, Pitt WG. 1997. Ultrasonic activated drug delivery from pluronic P-105 micelles. Cancer Lett. 118:13-19
68. Neppiras EA, Noltingk BE. 1951. Cavitation produced by ultrasonics: theoretical conditions for the onset of cavitation. Proc. Phys. Soc. B 64:1032-38
69. Nyborg WL. 1965. Acoustic streaming. In Physical Acoustics, ed. WP Mason, pp. 265-331. New York: Academic
70. Ohl CD, Arora M, Ikink R, de Jong N, Versluis M, et al. 2006. Sonoporation from jetting cavitation bubbles. Biophys. J. 91:4285-95
71. Parsons JE, Cain CA, Abrams GD, Fowlkes JB. 2006. Pulsed cavitational ultrasound therapy for controlled tissue homogenization. Ultrasound Med. Biol. 32:115-29
72. Pennes HH. 1948. Analysis of tissue and arterial blood temperatures in the resting human forearm. J. Appl. Physiol. 1:93-122
73. Phelps AD, Leighton TG. 1997. The subharmonic oscillations and combination-frequency emissions from a resonant bubble: their properties and generation mechanisms. Acta Acoust. 83:59-66
74. Pierce AD. 1981. Acoustics: An Introduction to Its Physical Principles and Applications. New York: McGraw-Hill
75. Prentice P, Cuschieri A, Dholakia K, Prausnitz M, Campbell P. 2005. Membrane disruption by optically controlled microbubble cavitation. Nat. Phys. 1:107-10
76. Prokop AF, Soltani A, Roy RA. 2007. Cavitational mechanisms in ultrasound-accelerated fibrinolysis. Ultrasound Med. Biol. 33:924-33
77. Prosperetti A. 1975. Nonlinear oscillations of gas-bubbles in liquids: transient solutions and connection between subharmonic signal and cavitation. J. Acoust. Soc. Am. 57:810-21
78. Prosperetti A. 1977. Thermal effects and damping mechanisms in forced radial oscillations of gas-bubbles in liquids. J. Acoust. Soc. Am. 61:17-27
79. Prosperetti A, Crum LA, Commander KW. 1988. Nonlinear bubble dynamics. J. Acoust. Soc. Am. 83-502-14
80. Rabkin BA, Zderic V, Vaezy S. 2005. Hyperecho in ultrasound images of HIFU therapy: involvement of cavitation. Ultrasound Med. Biol. 31:947-56
81. Rapoport N, Gao Z, Kennedy A. 2007. Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy. J. Natl. Cancer Inst. 99:1095-106
82. Rivens I, Shaw A, Civale J, Morris H. 2007. Treatment monitoring and thermometry for therapeutic focused ultrasound. Int. J. Hyperth. 23:121-39
83. Roberts WW, Hall TL, Ives K, Wolf JS, Fowlkes JB, Cain CA. 2006. Pulsed cavitational ultrasound: a noninvasive technology for controlled tissue ablation (histotripsy) in the rabbit kidney. J. Urol. 175:734-38
84. Schlicher RK, Radhakrishna H, Tolentino TP, Apkarian RP, Zarnitsyn V, Prausnitz MR. 2006. Mechanism of intracellular delivery by acoustic cavitation. Ultrasound Med. Biol. 32:915-24
85. Sokka SD, Gauthier TP, Hynynen K 2005. Theoretical and experimental validation of a dual-frequency excitation method for spatial control of cavitation. Phys. Med. Biol. 50:2167-79
86. Sokka SD, King R, Hynynen K. 2003. MRI-guided gas bubble enhanced ultrasound heating in in vivo rabbit thigh. Phys. Med. Biol. 48:223-41
87. Stride E, Saffari N. 2003. On the destruction of microbubble ultrasound contrast agents. Ultrasound Med. Biol. 29:563-73
88. Tartis MS, McCallan J, Lum AFH, LaBell R, Stieger SM, et al. 2006. Therapeutic effects of paclitaxel-containing ultrasound contrast agents. Ultrasound Med. Biol. 32:1771-80
89. ter Haar GR, Coussios C. 2007. High intensity focused ultrasound: physical principles and devices. Int. J. Hyperth. 23:89-104
90. Tho P, Manasseh R, Ooi A. 2007. Cavitation microstreaming patterns in single and multiple bubble systems. J. Fluid Mech. 576:191-233
91. Thomas CR, Farny CH, Coussios CC, Roy RA, Holt RG. 2005. Dynamics and control of cavitation during high-intensity focused ultrasound application. Acoust. Res. Lett. Online 6:182-87
92. Tran BC, Seo J, Hall TL, Fowlkes JB, Cain CA. 2003. Microbubble-enhanced cavitation for noninvasive ultrasound surgery. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 50:1296-304
93. Trubestein G, Engel C, Etzel F, Sobbe A, Cremer H, Stumpff U. 1976. Thrombolysis by ultrasound. Clin. Sci. Mol. Med. Suppl. 3:S697-98
94. Tu J, Hwang JH, Matula TJ, Brayman AA, Crum LA. 2006a. Intravascular inertial cavitation activity detection and quantification in vivo with optison. Ultrasound Med. Biol. 32:1601-9
95. Tu J, Matula TJ, Brayman AA, Crum LA. 2006b. Inertial cavitation dose produced in ex vivo rabbit ear arteries with optison® by 1-MHz pulsed ultrasound. Ultrasound Med. Biol. 32:281-88
96. Vaezy S, Zderic V. 2007. Hemorrhage control using high intensity focused ultrasound. Int. J. Hyperth. 23:203-11
97. van Wamel A, Bouakaz A, Bernard B, ten Cate F, de Jong N. 2005. Controlled drug delivery with ultrasound and gas microbubbles. J. Control. Release 101:389-91
98. van Wamel A, Kooiman K, Harteveld M, Emmer M, ten Cate FJ, et al. 2006. Vibrating microbubbles poking individual cells: drug transfer into cells via sonoporation. J. Control. Release 112:149-55
99. Vykhodtseva NI, Hynynen K, Damianou C. 1995. Histologic effects of high-intensity pulsed ultrasound exposure with subharmonic emission in rabbit brain in vivo. Ultrasound Med. Biol. 21:969-79
100. Watson YE, Birkin PR, Leighton TG. 2003. Electrochemical detection of bubble oscillation. Ultrason. Sonochem. 10:65-69
101. Wu J, Chappelow J, Yang J, Weimann L. 1998. Defects generated in human stratum corneum specimens by ultrasound. Ultrasound Med. Biol. 24:705-10
102. Xu Z, Fowlkes JB, Cain CA. 2006. A new strategy to enhance cavitational tissue erosion using a high-intensity, initiating sequence. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 53:1412-24
103. Xu Z, Fowlkes JB, Ludomirsky A, Cain CA. 2005. Investigation of intensity thresholds for ultrasound tissue erosion. Ultrasound Med. Biol. 31:1673-82
104. Yang X, Church CC. 2005. A model for the dynamics of gas bubbles in soft tissue. J. Acoust. Soc. Am. 118:3595-606
105. Yang XM, Church CC. 2006. A simple viscoelastic model for soft tissues in the frequency range 6-20 MHz. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 53:1404-11
106. Yang XM, Roy RA, Holt RG. 2004. Bubble dynamics and size distributions during focused ultrasound insonation. J. Acoust. Soc. Am. 116:3423-31