Ultrasound-triggered disruption and self-healing of reversibly cross-linked hydrogels for drug delivery and enhanced chemotherapy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 27, 2014, Pages 9762-9767

  Huebsch, Nathaniel ^a,b,c,f   Kearney, Cathal J ^a,b   Zhao, Xuanhe ^a,b,d   Kim, Jaeyun ^a,b,e   Cezar, Christine A ^a,b   Suo, Zhigang ^a   Mooney, David J ^a,b  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD UNIVERSITY   (United States)

^c HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^d Duke University   (United States)

^e Sungkyunkwan University   (South Korea)

^f GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

Author keywords

Alginate; On demand delivery; Self healing materials; Sonophoresis

Indexed keywords

ALGINIC ACID; CYTOKINE; MITOXANTRONE; NAPROXEN; OLIGONUCLEOTIDE; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER CELL LINE; BREAST TUMOR; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER SIZE; CELL FATE; CONTROLLED STUDY; CROSS LINKING; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG EXPOSURE; DRUG POTENCY; DRUG RELEASE; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL; SUSTAINED DRUG RELEASE; TUMOR XENOGRAFT; ULTRASOUND;

ALGINATE; ON-DEMAND DELIVERY; SELF-HEALING MATERIALS; SONOPHORESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG CARRIERS; HUMANS; HYDROGELS; MICE; MITOXANTRONE; ULTRASONICS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84903978307     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1405469111     Document Type: Article

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