Ultrasound-aided microbubbles facilitate the delivery of drugs to the inner ear via the round window membrane

Journal of Controlled Release

Volumn 167, Issue 2, 2013, Pages 167-174

  Shih, Cheng Ping ^a,b   Chen, Hsin Chien ^b   Chen, Hang Kang ^b   Chiang, Min Chang ^b   Sytwu, Huey Kang ^a   Lin, Yi Chun ^b   Li, Shiue Li ^b   Shih, Yu Fan ^c   Liao, Ai Ho ^c   Wang, Chih Hung ^a,b  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Cochlea; Delivery; Inner ear; Microbubble; Round window membrane; Ultrasound

Indexed keywords

ACOUSTIC CAVITATIONS; AUDITORY BRAINSTEM RESPONSE; COCHLEA; DELIVERY; FUTURE APPLICATIONS; INNER EAR; MICRO-BUBBLE; ULTRASOUND EXPOSURE;

AUDITION; BIOACOUSTICS; COENZYMES; DAMAGE DETECTION;

ULTRASONICS;

BIOTIN; FLUORESCEIN ISOTHIOCYANATE; GENTAMICIN; PHALLOIDIN; TRACER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDITORY THRESHOLD; COCHLEA FENESTRA; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG UPTAKE; ECHOGRAPH; EVOKED BRAIN STEM AUDITORY RESPONSE; GUINEA PIG; HAIR CELL; INNER EAR; MEMBRANE PERMEABILITY; MICROBUBBLE; NONHUMAN; PRIORITY JOURNAL; ULTRASOUND; ULTRASOUND TRANSDUCER;

ACOUSTICS; ANIMALS; BIOTIN; DRUG DELIVERY SYSTEMS; EAR, INNER; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; FLUORESCEIN-5-ISOTHIOCYANATE; GENTAMICINS; GUINEA PIGS; MICROBUBBLES; XANTHENES;

EID: 84874397514     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.01.028     Document Type: Article

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